Seasonal variation of the main individual phenolics and juglone in walnut (Juglans regia) leaves

Pharmaceutical Biology

Volumn 52, Issue 5, 2014, Pages 575-580

  Cosmulescu, Sina ^a   Trandafir, Ion ^b   Nour, Violeta ^a  

^a Department of Horticulture and Food Science Agriculture and Horticulture Faculty   (Romania)

^b UNIVERSITY OF CRAIOVA   (Romania)

Author keywords

Ellagic acid; HPLC DAD; Myricetin; Rutin

Indexed keywords

ELLAGIC ACID; JUGLONE; MYRICETIN; PHENOL DERIVATIVE; RUTOSIDE; FLAVONOID; HYDROXYBENZOIC ACID DERIVATIVE; NAPHTHOQUINONE; PHENOLIC ACID;

ARTICLE; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; JUGLANS REGIA; NONHUMAN; PLANT LEAF; SEASONAL VARIATION; CHEMISTRY; GROWTH, DEVELOPMENT AND AGING; ISOLATION AND PURIFICATION; ROMANIA; SEASON; WALNUT;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLAVONOIDS; HYDROXYBENZOATES; JUGLANS; NAPHTHOQUINONES; PLANT LEAVES; ROMANIA; SEASONS;

EID: 84898449899     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2013.853813     Document Type: Article

References (42)

1. Amaral JS, Seabra RM, Andrade PB. (2004). Phenolic profile in the quality control of walnut (Juglans regia L.) leaves. Food Chem 88: 373-9.
2. Anderson KJ, Teuber SS, Gobeille A, et al. (2001). Walnut polyphenolics inhibit in vitro human plasma and LDL oxidation. J Nutr 131: 2837-42.
3. Borazjani A, Graves CH, Hedin PA. (1985). Occurrence of juglone in various tissues of pecan and related species. Physiol Biochem 75: 1419-21.
4. Cartea ME, Francisco M, Soengas P, Velasco P. (2011). Phenolic compounds in Brassica vegetables. Molecules 16:251-80.
5. Clark AM, Jurgens TM, Hufford CD. (1990). Antimicrobial activity of juglone. Phytother Res 4:11-14.
6. Coder KD. (1983). Seasonal changes of juglone potential in leaves of black walnut (Juglans nigra L.). J Chem Ecol 9:1203-12.
7. Colaric M, Veberic R, Solar A, et al. (2005). Phenolic acids, syringaldehyde, and juglone in fruits of different cultivars of Juglans regia L. J Agr Food Chem 53:6390-6.
8. Colaric M, Stampar F, Hudina M. (2007). Bending affects phenolic content of William pear leaves. Acta Agr Scand, B Plant Soil Sci 57: 187-92.
9. Cosmulescu S, Trandafir I, Achim G, et al. (2010). Phenolics of green husk in mature walnut fruits. Not Bot Horti Agrobo 38:53-6.
10. Cosmulescu S, Trandafir I. (2011a). Seasonal variation of total phenols in leaves of walnut (Juglans regia L.). J Med Plants Res 5: 4938-42.
11. Cosmulescu S, Trandafir I. (2011b). Variation of phenols content in walnut (Juglans regia L.). South West J Hortic Biol Environ 2: 25-33.
12. Cosmulescu S, Trandafir I, Achim G, Baciu A. (2011). Juglone content in leaf and green husk of five walnut (Juglans regia L.) cultivars. Not Bot Horti Agrobo 39:237-40.
13. Cosmulescu S, Trandafir I. (2012). Anti-oxidant activities and total phenolics contents of leaf extracts from 14 cultivars of walnut (Juglans regia). J Hortic Sci Biotech 87:504-8.
14. 4-induced oxidative damage in rats. Pharm Biol 51:558-65.
15. Festa F, Aglitti T, Duranti G, et al. (2001). Strong antioxidant activity of ellagic acid in mammalian cells in vitro revealed by the comet assay. Anticancer Res 21:3903-8.
16. Geleijnse JM, Hollman PCh. (2008). Flavonoids and cardiovascular health: Which compounds, what mechanisms? Am J Clin Nutr 88: 12-13.
17. Hertog MGL, Hollman PCH, Katan MB. (1992). Content of potentially anticarcinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands. J Agr Food Chem 40: 2379-83.
18. Hirano R, Sasamoto W, Matsumoto A, et al. (2001). Antioxidant ability of various flavonoids against DPPH radicals and LDL oxidation. J Nutr Sci Vitaminol 47:357-62.
19. Kang NJ, Jung SK, Lee KW, Lee HJ. (2011). Myricetin is a potent chemopreventive phytochemical in skin carcinogenesis. Ann NY Acad Sci 1229:124-32.
20. Kaumar S, Harkonen PL, Arora S, Kaur M. (2003). Studies on correlation of antimutagenic and antiproliferative activities of Juglans regia L. J Environ Pathol Toxicol Oncol 22:59-67.
21. Kreft I, Fabjan N, Germ M. (2003). Rutin in buckwheat-Protection of plants and its importance for the production of functional food. Fagopyrum 20:7-11.
22. La Casa C, Villegas I, Lastra CA, et al. (2000). Evidence for protective and antioxidant properties of rutin, a natural flavone, against ethanol induced gastric lesions. J Ethnopharmacol 71:45-53.
23. Mahmoodi M, Eghbali H, Hosseini Zijoud SM, et al. (2011). Study of the effects of walnut leaf on some blood biochemical parameters in hypercholesterolemic rats. Biochem Anal Biochem 11-14.
24. Mertens-Talcott SU, Talcott ST, Percival SS. (2003). Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells. J Nutr 133:2669-74.
25. Narayanan B, Geoffroy O, Willingham MC, et al. (1999). (WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells. Cancer Lett 136:215-21.
26. Nour V, Trandafir I, Cosmulescu S. (2013). HPLC determination of some phenolic acids, flavonoids and juglone in walnut leaves. J Chromatogr Sci 51:883-90.
27. Oliveira I, Sousa A, Ferreira I, et al. (2008). Total phenols, antioxidant potential and antimicrobial activity of walnut (Juglans regia L.) green husks. Food Chem Toxicol 46:2326-31.
28. Ozcan F, Ozmen A, Akkaya B, et al. (2012). Beneficial effect of myricetin on renal functions in streptozotocin-induced diabetes. Clin Exp Med 12:265-72.
29. Papoutsi Z, Kassi E, Chinou I, et al. (2008). Walnut extract (Juglans regia L.) and its component ellagic acid exhibit anti-inflammatory activity in human aortaendothelial cells and osteoblastic activity in the cell line KS483. Brit J Nutr 99:715-22.
30. Pereira JA, Oliveira I, Sousa A, et al. (2007). Walnut (Juglans regia L.) leaves: Phenolic compounds, antibacterial activity and anti-oxidant potential of different cultivars. Food Chem Toxicol 45: 2287-95.
31. Petkovsek MM, Stampar F, Veberic R. (2009). Seasonal changes in phenolic compounds in the leaves of scab-resistant and susceptible apple cultivars. Can J Plant Sci 89:745-53.
32. Prasad RBN. (2003). Walnuts and pecans. In: Caballero B, Trugo LC, Finglas PM, eds. Encyclopaedia of Food Sciences and Nutrition. London: Academic Press, 6071-9.
33. Salimi M, Majd A, Sepahdar Z, et al. (2012). Cytotoxicity effects of various Juglans regia (walnut) leaf extracts in human cancer cell lines. Pharm Biol 50:1416-22.
34. Saling SC, Comar JF, Mito MS, et al. (2011). Actions of juglone on energy metabolism in the rat liver. Toxicol Appl Pharm 257:319-27.
35. Solar A, Colaric M, Hudina M, Stampar F. (2005). Phenolic content of walnut fruit as affected by cultivar and developmental stage. Acta Hort 705:231-40.
36. Solar A, Colaric M, Usenik V, Stampar F. (2006). Seasonal variations of selected flavonoids, phenolic acids and quinones in annual shoots of common walnut (Juglans regia L.). Plant Sci 170:453-61.
37. Spencer JPE, Vauzour D, Vafeiadou K, et al. (2008). The beneficial effects of dietary flavonoids: Sources, bioavailability and biological functions. In: Health Benefits of Organic Food: Effects of the Environment. CAB International, 207-39.
38. Stampar F, Solar A, Hudina M, et al. (2006). Traditional walnut liqueur-cocktail of phenolics. Food Chem 95:627-31.
39. Sugie S, Okamoto K, Rahman KMW, et al. (1998). Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinogenesis in rats. Cancer Lett 127:177-83.
40. Thakur A, Cahalan C. (2011). Geographical variation of Juglans regia L. in juglone content: Rapid analysis using micro plate reader. Curr Sci 100:1483-5.
41. Thakur A. (2011). Juglone: A therapeutic phytochemical from Juglans regia L. J Med Plants Res 5:5324-30.
42. Usenik V, Mikulic Petkovsek M, et al. (2004). Flavonols of leaves in relation to apple scab resistance. Z Pflanzenkr Pflanzenschutz 111:137-44.