Elucidation of the structural basis of interaction of the BCR-ABL kinase inhibitor, nilotinib (Tasigna) with the human ABC drug transporter P-glycoprotein

Leukemia

Volumn 28, Issue 4, 2014, Pages 961-964

  Shukla, S ^a   Chufan, E E ^a   Singh, S ^b   Skoumbourdis, A P ^c   Kapoor, K ^a   Boxer, M B ^c   Duveau, D Y ^c   Thomas, C J ^c   Talele, T T ^b   Ambudkar, S V ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b ST JOHN'S UNIVERSITY   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; BREAST CANCER RESISTANCE PROTEIN; IMATINIB; MULTIDRUG RESISTANCE PROTEIN; NILOTINIB;

CANCER CELL; CANCER CHEMOTHERAPY; DRUG BINDING SITE; DRUG BIOAVAILABILITY; HELA CELL; HUMAN; HYDROGEN BOND; HYDROPHILICITY; LETTER; MOLECULAR DOCKING; NONHUMAN; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

BENZAMIDES; BINDING SITES; FUSION PROTEINS, BCR-ABL; HUMANS; P-GLYCOPROTEIN; PIPERAZINES; PROTEIN KINASE INHIBITORS; PYRIMIDINES;

EID: 84898438902     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2014.21     Document Type: Letter

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