2-Amino-3-(phenylsulfanyl)norbornane-2-carboxylate: An appealing scaffold for the design of Rac1-Tiam1 protein-protein interaction inhibitors

Journal of Medicinal Chemistry

Volumn 57, Issue 7, 2014, Pages 2953-2962

  Ruffoni, Alessandro ^a   Ferri, Nicola ^a,b   Bernini, Sergio K ^a   Ricci, Chiara ^a   Corsini, Alberto ^a   Maffucci, Irene ^a   Clerici, Francesca ^a   Contini, Alessandro ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b IRCCS MULTIMEDICA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 (PHENYLSULFANYL)NORBORNANE 2 CARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; ETHYL 2 AMINO 5 [3 [(4 AMINOPHENYL)AMINO]PHENYL] 3 (PHENYLSULFANYL)BICYCLO[2.2.1]HEPTANE 2 CARBOXYLIC ACID; ETHYL 2 AMINO 6 [3 [(4 AMINOPHENYL)AMINO]PHENYL] 3 (PHENYLSULFANYL)BICYCLO[2.2.1]HEPTANE 2 CARBOXYLIC ACID; ETHYL 2 [(TERT BUTOXYCARBONYL)AMINO] 3 (PHENYLSULFANYL)BICYCLO[2.2.1]HEPT 5 ENE 2 CARBOXYLIC ACID; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HYDROLASE INHIBITOR; PALLADIUM; RAC1 PROTEIN; TIAM1 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYCLOADDITION; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; MIGRATION INHIBITION; PHARMACOPHORE; PROTEIN PROTEIN INTERACTION; SCALE UP; SMOOTH MUSCLE FIBER; STEREOCHEMISTRY;

CELL MOVEMENT; CELLS, CULTURED; DIPHENYLAMINE; DRUG DESIGN; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HETEROCYCLIC COMPOUNDS; HUMANS; MICROSCOPY, VIDEO; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYOCYTES, SMOOTH MUSCLE; NORBORNANES; PROTEIN INTERACTION DOMAINS AND MOTIFS; RAC1 GTP-BINDING PROTEIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84898432538     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401924s     Document Type: Article

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