Amorphous solid dispersion of berberine with absorption enhancer demonstrates a remarkable hypoglycemic effect via improving its bioavailability

International Journal of Pharmaceutics

Volumn 467, Issue 1-2, 2014, Pages 50-59

  Zhaojie, Meng ^a   Ming, Zhang ^a   Shengnan, Wei ^a   Xiaojia, Bi ^a   Hatch, Grant M ^c   Jingkai, Gu ^b   Li, Chen ^a  

^a JILIN UNIVERSITY   (China)

^b THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^c UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Amorphous solid dispersion; Berberine; Bioavailability; Hypoglycemic effect; Sodium caprate; Type 2 diabetes

Indexed keywords

BERBERINE; GLUCOSE; INSULIN; LIPID; METFORMIN; ANTIDIABETIC AGENT; DECANOIC ACID; DECANOIC ACID DERIVATIVE; EXCIPIENT; GLUCOSE BLOOD LEVEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG BIOAVAILABILITY; DRUG SOLUBILITY; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUANG GUI SOLID DISPERSION; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; INSULIN BLOOD LEVEL; INTESTINE ABSORPTION; INTESTINE PERFUSION; LIPID BLOOD LEVEL; LIPID METABOLISM; MALE; MASS SPECTROMETRY; MELTING POINT; MEMBRANE TRANSPORT; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; TABLET; THERMOGRAPHY; X RAY DIFFRACTION; ANIMAL; BIOAVAILABILITY; BLOOD; CACO 2 CELL LINE; CHEMISTRY; COMPARATIVE STUDY; DIABETES MELLITUS, TYPE 2; DISEASE MODEL; DRUG EFFECTS; HUMAN; MEDICINAL CHEMISTRY; METABOLISM; ORAL DRUG ADMINISTRATION; PERMEABILITY; PHARMACEUTICS; POWDER DIFFRACTION; SOLUBILITY; WISTAR RAT; X RAY CRYSTALLOGRAPHY;

ADMINISTRATION, ORAL; ANIMALS; BERBERINE; BIOLOGICAL AVAILABILITY; BLOOD GLUCOSE; CACO-2 CELLS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DECANOIC ACIDS; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; EXCIPIENTS; HUMANS; HYPOGLYCEMIC AGENTS; INTESTINAL ABSORPTION; LIPIDS; MALE; MICROSCOPY, ELECTRON, SCANNING; PERMEABILITY; POWDER DIFFRACTION; RATS, WISTAR; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TECHNOLOGY, PHARMACEUTICAL;

EID: 84898431534     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.03.017     Document Type: Article

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