메뉴 건너뛰기




Volumn 73, Issue 2, 2014, Pages 271-277

Can resveratrol help to maintain metabolic health?

Author keywords

Ageing; Human subjects; Metabolic health; Mitochondria; Resveratrol

Indexed keywords

RESVERATROL; SIRTUIN 1; ENZYME ACTIVATOR; STILBENE DERIVATIVE;

EID: 84898430249     PISSN: 00296651     EISSN: 14752719     Source Type: Journal    
DOI: 10.1017/S0029665113003856     Document Type: Conference Paper
Times cited : (20)

References (61)
  • 2
    • 77955571859 scopus 로고    scopus 로고
    • Ectopic fat and cardiovascular disease: What is the link?
    • Gastaldelli A & Basta G (2010) Ectopic fat and cardiovascular disease: What is the link? Nutr Metab Cardiovasc Dis 20, 481-490
    • (2010) Nutr Metab Cardiovasc Dis , vol.20 , pp. 481-490
    • Gastaldelli, A.1    Basta, G.2
  • 3
    • 0032934826 scopus 로고    scopus 로고
    • Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: A 1H NMR spectroscopy study
    • Krssak M, Falk Petersen K, Dresner A, et al. (1999) Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: A 1H NMR spectroscopy study. Diabetologia 42, 113-116
    • (1999) Diabetologia , vol.42 , pp. 113-116
    • Krssak, M.1    Falk Petersen, K.2    Dresner, A.3
  • 4
    • 0029948212 scopus 로고    scopus 로고
    • Mechanism of free fatty acid-induced insulin resistance in humans
    • Roden M, Price TB, Perseghin G, et al. (1996) Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest 97, 2859-2865
    • (1996) J Clin Invest , vol.97 , pp. 2859-2865
    • Roden, M.1    Price, T.B.2    Perseghin, G.3
  • 5
    • 0030969532 scopus 로고    scopus 로고
    • Skeletal muscle triglyceride levels are inversely related to insulin action
    • Pan DA, Lillioja S, Kriketos AD, et al. (1997) Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 46, 983-989
    • (1997) Diabetes , vol.46 , pp. 983-989
    • Pan, D.A.1    Lillioja, S.2    Kriketos, A.D.3
  • 6
    • 0029984230 scopus 로고    scopus 로고
    • Insulin action and age european group for the study of insulin resistance (egir)
    • Ferrannini E, Vichi S, Beck-Nielsen H, et al. (1996) Insulin action and age. European Group for the Study of Insulin Resistance (EGIR). Diabetes 45, 947-953
    • (1996) Diabetes , vol.45 , pp. 947-953
    • Ferrannini, E.1    Vichi, S.2    Beck-Nielsen, H.3
  • 7
    • 0038025371 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in the elderly: Possible role in insulin resistance
    • Petersen KF, Befroy D, Dufour S, et al. (2003) Mitochondrial dysfunction in the elderly: Possible role in insulin resistance. Science 300, 1140-1142
    • (2003) Science , vol.300 , pp. 1140-1142
    • Petersen, K.F.1    Befroy, D.2    Dufour, S.3
  • 8
    • 78651269359 scopus 로고    scopus 로고
    • Familial longevity is marked by enhanced insulin sensitivity
    • Wijsman CA, Rozing MP, Streefland TC, et al. (2011) Familial longevity is marked by enhanced insulin sensitivity. Aging Cell 10, 114-121
    • (2011) Aging Cell , vol.10 , pp. 114-121
    • Wijsman, C.A.1    Rozing, M.P.2    Streefland, T.C.3
  • 9
    • 84856166531 scopus 로고    scopus 로고
    • Proton magnetic resonance spectroscopy shows lower intramyocellular lipid accumulation in middle-Aged subjects predisposed to familial longevity
    • Wijsman CA, van Opstal AM, Kan HE, et al. (2012) Proton magnetic resonance spectroscopy shows lower intramyocellular lipid accumulation in middle-Aged subjects predisposed to familial longevity. Am J Physiol Endocrinol Metab 302, E344-E348
    • (2012) Am J Physiol Endocrinol Metab , vol.302
    • Wijsman, C.A.1    Van Opstal, A.M.2    Kan, H.E.3
  • 10
    • 0033645223 scopus 로고    scopus 로고
    • Impaired oxidation of plasma-derived fatty acids in type 2 diabetic subjects during moderate-intensity exercise
    • Blaak EE, van Aggel-Leijssen DP, Wagenmakers AJ, et al. (2000) Impaired oxidation of plasma-derived fatty acids in type 2 diabetic subjects during moderate-intensity exercise. Diabetes 49, 2102-2107
    • (2000) Diabetes , vol.49 , pp. 2102-2107
    • Blaak, E.E.1    Van Aggel-Leijssen, D.P.2    Wagenmakers, A.J.3
  • 11
    • 0035514950 scopus 로고    scopus 로고
    • Plasma free fatty acid uptake and oxidation are already diminished in subjects at high risk for developing type 2 diabetes
    • Mensink M, Blaak EE, van Baak MA, et al. (2001) Plasma free fatty acid uptake and oxidation are already diminished in subjects at high risk for developing type 2 diabetes. Diabetes 50, 2548-2554
    • (2001) Diabetes , vol.50 , pp. 2548-2554
    • Mensink, M.1    Blaak, E.E.2    Van Baak, M.A.3
  • 12
    • 0032752951 scopus 로고    scopus 로고
    • Markers of capacity to utilize fatty acids in human skeletal muscle: Relation to insulin resistance and obesity and effects of weight loss
    • Simoneau JA, Veerkamp JH, Turcotte LP, et al. (1999) Markers of capacity to utilize fatty acids in human skeletal muscle: Relation to insulin resistance and obesity and effects of weight loss. FASEB J 13, 2051-2060
    • (1999) FASEB J , vol.13 , pp. 2051-2060
    • Simoneau, J.A.1    Veerkamp, J.H.2    Turcotte, L.P.3
  • 13
    • 0030740621 scopus 로고    scopus 로고
    • Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM
    • Simoneau JA & Kelley DE (1997) Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM. J Appl Physiol 83, 166-171
    • (1997) J Appl Physiol , vol.83 , pp. 166-171
    • Simoneau, J.A.1    Kelley, D.E.2
  • 14
    • 0036788293 scopus 로고    scopus 로고
    • Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
    • Kelley DE, He J, Menshikova EV, et al. (2002) Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 51, 2944-2950
    • (2002) Diabetes , vol.51 , pp. 2944-2950
    • Kelley, D.E.1    He, J.2    Menshikova, E.V.3
  • 15
    • 0038054341 scopus 로고    scopus 로고
    • PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    • Mootha VK, Lindgren CM, Eriksson KF, et al. (2003) PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34, 267-273
    • (2003) Nat Genet , vol.34 , pp. 267-273
    • Mootha, V.K.1    Lindgren, C.M.2    Eriksson, K.F.3
  • 16
    • 0037477855 scopus 로고    scopus 로고
    • Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    • Patti ME, Butte AJ, Crunkhorn S, et al. (2003) Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci USA 100, 8466-8471
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 8466-8471
    • Patti, M.E.1    Butte, A.J.2    Crunkhorn, S.3
  • 17
    • 33845947550 scopus 로고    scopus 로고
    • Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects
    • Schrauwen-Hinderling VB, Kooi ME, Hesselink MK, et al. (2007) Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects. Diabetologia 50, 113-120
    • (2007) Diabetologia , vol.50 , pp. 113-120
    • Schrauwen-Hinderling, V.B.1    Kooi, M.E.2    Hesselink, M.K.3
  • 18
    • 0018713379 scopus 로고
    • Resynthesis of creatine phosphate in human muscle after exercise in relation to intramuscular pH and availability of oxygen
    • Sahlin K, Harris RC & Hultman E (1979) Resynthesis of creatine phosphate in human muscle after exercise in relation to intramuscular pH and availability of oxygen. Scand J Clin Lab Invest 39, 551-558
    • (1979) Scand J Clin Lab Invest , vol.39 , pp. 551-558
    • Sahlin, K.1    Harris, R.C.2    Hultman, E.3
  • 19
    • 0028394314 scopus 로고
    • Quantitative interpretation of bioenergetic data from 31P and 1H magnetic resonance spectroscopic studies of skeletal muscle: An analytical review
    • Kemp GJ & Radda GK (1994) Quantitative interpretation of bioenergetic data from 31P and 1H magnetic resonance spectroscopic studies of skeletal muscle: An analytical review. Magn Reson Q 10, 43-63
    • (1994) Magn Reson Q , vol.10 , pp. 43-63
    • Kemp, G.J.1    Radda, G.K.2
  • 20
    • 58149346025 scopus 로고    scopus 로고
    • Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients
    • Phielix E, Schrauwen-Hinderling VB, Mensink M, et al. (2008) Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients. Diabetes 57, 2943-2949
    • (2008) Diabetes , vol.57 , pp. 2943-2949
    • Phielix, E.1    Schrauwen-Hinderling, V.B.2    Mensink, M.3
  • 21
    • 58149379936 scopus 로고    scopus 로고
    • Skeletal muscle "mitochondrial deficiency" does not mediate insulin resistance
    • Holloszy JO (2009) Skeletal muscle "mitochondrial deficiency" does not mediate insulin resistance. Am J Clin Nutr 89, 463S-466S.
    • (2009) Am J Clin Nutr , vol.89
    • Holloszy, J.O.1
  • 22
    • 84865405481 scopus 로고    scopus 로고
    • Muscle mitochondria and insulin resistance: A human perspective
    • Hoeks J & Schrauwen P (2012) Muscle mitochondria and insulin resistance: A human perspective. Trends Endocrinol Metab 23, 444-450
    • (2012) Trends Endocrinol Metab , vol.23 , pp. 444-450
    • Hoeks, J.1    Schrauwen, P.2
  • 23
    • 77349125802 scopus 로고    scopus 로고
    • Increased subsarcolemmal lipids in type 2 diabetes: Effect of training on localization of lipids, mitochondria, and glycogen in sedentary human skeletal muscle
    • Nielsen J, Mogensen M, Vind BF, et al. (2010) Increased subsarcolemmal lipids in type 2 diabetes: Effect of training on localization of lipids, mitochondria, and glycogen in sedentary human skeletal muscle. Am J Physiol Endocrinol Metab 298, E706-E713
    • (2010) Am J Physiol Endocrinol Metab , vol.298
    • Nielsen, J.1    Mogensen, M.2    Vind, B.F.3
  • 24
    • 77950349827 scopus 로고    scopus 로고
    • Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity
    • Meex RC, Schrauwen-Hinderling VB, Moonen-Kornips E, et al. (2010) Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity. Diabetes 59, 572-579
    • (2010) Diabetes , vol.59 , pp. 572-579
    • Meex, R.C.1    Schrauwen-Hinderling, V.B.2    Moonen-Kornips, E.3
  • 25
    • 77955508579 scopus 로고    scopus 로고
    • Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals
    • Phielix E, Meex R, Moonen-Kornips E, et al. (2010) Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals. Diabetologia 53, 1714-1721
    • (2010) Diabetologia , vol.53 , pp. 1714-1721
    • Phielix, E.1    Meex, R.2    Moonen-Kornips, E.3
  • 26
    • 77955556016 scopus 로고    scopus 로고
    • Effect of physical training on mitochondrial respiration and reactive oxygen species release in skeletal muscle in patients with obesity and type 2 diabetes
    • Hey-Mogensen M, Hojlund K, Vind BF, et al. (2010) Effect of physical training on mitochondrial respiration and reactive oxygen species release in skeletal muscle in patients with obesity and type 2 diabetes. Diabetologia 53, 1976-1985
    • (2010) Diabetologia , vol.53 , pp. 1976-1985
    • Hey-Mogensen, M.1    Hojlund, K.2    Vind, B.F.3
  • 27
    • 84866613200 scopus 로고    scopus 로고
    • High oxidative capacity due to chronic exercise training attenuates lipid-induced insulin resistance
    • Phielix E, Meex R, Ouwens DM, et al. (2012) High oxidative capacity due to chronic exercise training attenuates lipid-induced insulin resistance. Diabetes 61, 2472-2478
    • (2012) Diabetes , vol.61 , pp. 2472-2478
    • Phielix, E.1    Meex, R.2    Ouwens, D.M.3
  • 28
    • 33645526333 scopus 로고    scopus 로고
    • Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: A randomized controlled trial
    • Heilbronn LK, de Jonge L, Frisard MI, et al. (2006) Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: A randomized controlled trial. J Am Med Assoc 295, 1539-1548
    • (2006) J Am Med Assoc , vol.295 , pp. 1539-1548
    • Heilbronn, L.K.1    De Jonge, L.2    Frisard, M.I.3
  • 29
    • 44449171470 scopus 로고    scopus 로고
    • Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function
    • Larson-Meyer DE, Newcomer BR, Heilbronn LK, et al. (2008) Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function. Obesity (Silver Spring) 16, 1355-1362
    • (2008) Obesity (Silver Spring , vol.16 , pp. 1355-1362
    • Larson-Meyer, D.E.1    Newcomer, B.R.2    Heilbronn, L.K.3
  • 30
    • 33947710793 scopus 로고    scopus 로고
    • Calorie restriction increases muscle mitochondrial biogenesis in healthy humans
    • Civitarese AE, Carling S, Heilbronn LK, et al. (2007) Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med 4, e76
    • (2007) PLoS Med , vol.4
    • Civitarese, A.E.1    Carling, S.2    Heilbronn, L.K.3
  • 32
    • 0141719702 scopus 로고    scopus 로고
    • Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
    • Howitz KT, Bitterman KJ, Cohen HY, et al. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191-196
    • (2003) Nature , vol.425 , pp. 191-196
    • Howitz, K.T.1    Bitterman, K.J.2    Cohen, H.Y.3
  • 33
    • 77249156847 scopus 로고    scopus 로고
    • Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle
    • Canto C, Jiang LQ, Deshmukh AS, et al. (2010) Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle. Cell Metab 11, 213-219
    • (2010) Cell Metab , vol.11 , pp. 213-219
    • Canto, C.1    Jiang, L.Q.2    Deshmukh, A.S.3
  • 34
    • 84860477354 scopus 로고    scopus 로고
    • SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
    • Price NL, Gomes AP, Ling AJ, et al. (2012) SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab 15, 675-690
    • (2012) Cell Metab , vol.15 , pp. 675-690
    • Price, N.L.1    Gomes, A.P.2    Ling, A.J.3
  • 35
    • 59049088773 scopus 로고
    • Resveratrol, a new phenolic compound from Veratrum grandiflorum
    • (in Japanese
    • Takaoka M (1939) Resveratrol, a new phenolic compound from Veratrum grandiflorum. Nippon Kagaku Kaichi 60, 1090-1100 (in Japanese
    • (1939) Nippon Kagaku Kaichi , vol.60 , pp. 1090-1100
    • Takaoka, M.1
  • 36
    • 0002256765 scopus 로고
    • Concentration of the Phytoalexin resveratrol in wine
    • Siemann EH & Creasy LL (1992) Concentration of the Phytoalexin resveratrol in wine. Am J Enol Viticult 43, 49-52
    • (1992) Am J Enol Viticult , vol.43 , pp. 49-52
    • Siemann, E.H.1    Creasy, L.L.2
  • 37
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: The in vivo evidence
    • Baur JA & Sinclair DA (2006) Therapeutic potential of resveratrol: The in vivo evidence. Nat Rev Drug Disc 5, 493-506
    • (2006) Nat Rev Drug Disc , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 38
    • 79959261445 scopus 로고    scopus 로고
    • What is new for an old molecule? Systematic review and recommendations on the use of resveratrol
    • Vang O, Ahmad N, Baile CA, et al. (2011) What is new for an old molecule? Systematic review and recommendations on the use of resveratrol. PLoS ONE 6, e19881
    • (2011) PLoS ONE , vol.6
    • Vang, O.1    Ahmad, N.2    Baile, C.A.3
  • 39
    • 33751072349 scopus 로고    scopus 로고
    • Resveratrol improves health and survival of mice on a high-calorie diet
    • Baur JA, Pearson KJ, Price NL, et al. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444, 337-342
    • (2006) Nature , vol.444 , pp. 337-342
    • Baur, J.A.1    Pearson, K.J.2    Price, N.L.3
  • 40
    • 33845399894 scopus 로고    scopus 로고
    • Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    • Lagouge M, Argmann C, Gerhart-Hines Z, et al. (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127, 1109-1122
    • (2006) Cell , vol.127 , pp. 1109-1122
    • Lagouge, M.1    Argmann, C.2    Gerhart-Hines, Z.3
  • 41
    • 3943071801 scopus 로고    scopus 로고
    • Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    • Wood JG, Rogina B, Lavu S, et al. (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430, 686-689
    • (2004) Nature , vol.430 , pp. 686-689
    • Wood, J.G.1    Rogina, B.2    Lavu, S.3
  • 42
    • 78851470225 scopus 로고    scopus 로고
    • Resveratrol and life extension
    • Agarwal B & Baur JA (2011) Resveratrol and life extension. Ann N Y Acad Sci 1215, 138-143
    • (2011) Ann N y Acad Sci , vol.1215 , pp. 138-143
    • Agarwal, B.1    Baur, J.A.2
  • 43
    • 34848927457 scopus 로고    scopus 로고
    • Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans
    • Bass TM, Weinkove D, Houthoofd K, et al. (2007) Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mech Ageing Dev 128, 546-552
    • (2007) Mech Ageing Dev , vol.128 , pp. 546-552
    • Bass, T.M.1    Weinkove, D.2    Houthoofd, K.3
  • 44
    • 31944450272 scopus 로고    scopus 로고
    • Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate
    • Valenzano DR, Terzibasi E, Genade T, et al. (2006) Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol 16, 296-300
    • (2006) Curr Biol , vol.16 , pp. 296-300
    • Valenzano, D.R.1    Terzibasi, E.2    Genade, T.3
  • 45
    • 77953679841 scopus 로고    scopus 로고
    • Resveratrol suppresses body mass gain in a seasonal non-human primate model of obesity
    • Dal-Pan A, Blanc S & Aujard F (2010) Resveratrol suppresses body mass gain in a seasonal non-human primate model of obesity. BMC Physiol 10, 11
    • (2010) BMC Physiol , vol.10 , pp. 11
    • Dal-Pan, A.1    Blanc, S.2    Aujard, F.3
  • 46
    • 79952537457 scopus 로고    scopus 로고
    • Caloric restriction or resveratrol supplementation and ageing in a non-human primate: First-year outcome of the RESTRIKAL study in Microcebus murinus
    • Dal-Pan A, Terrien J, Pifferi F, et al. (2011) Caloric restriction or resveratrol supplementation and ageing in a non-human primate: First-year outcome of the RESTRIKAL study in Microcebus murinus. Age (Dordr) 33, 15-31
    • (2011) Age (Dordr , vol.33 , pp. 15-31
    • Dal-Pan, A.1    Terrien, J.2    Pifferi, F.3
  • 47
    • 76649084868 scopus 로고    scopus 로고
    • Resveratrol/SRT501 sirtuin SIRT1 activator treatment of type 2 diabetes
    • Elliott PJ, Walpole SM, Morelli L, et al. (2009) Resveratrol/SRT501 sirtuin SIRT1 activator treatment of type 2 diabetes. Drugs Future 34, 291-295
    • (2009) Drugs Future , vol.34 , pp. 291-295
    • Elliott, P.J.1    Walpole, S.M.2    Morelli, L.3
  • 48
    • 80052910300 scopus 로고    scopus 로고
    • Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients
    • Brasnyo P, Molnar GA, Mohas M, et al. (2011) Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Br J Nutr 106, 383-389
    • (2011) Br J Nutr , vol.106 , pp. 383-389
    • Brasnyo, P.1    Molnar, G.A.2    Mohas, M.3
  • 49
    • 84860131782 scopus 로고    scopus 로고
    • Pilot study of resveratrol in older adults with impaired glucose tolerance
    • Crandall JP, Oram V, Trandafirescu G, et al. (2012) Pilot study of resveratrol in older adults with impaired glucose tolerance. J Gerontol A Biol Sci Med Sci 67, 1307-1312
    • (2012) J Gerontol A Biol Sci Med Sci , vol.67 , pp. 1307-1312
    • Crandall, J.P.1    Oram, V.2    Trandafirescu, G.3
  • 50
    • 77956585215 scopus 로고    scopus 로고
    • An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol
    • Ghanim H, Sia CL, Abuaysheh S, et al. (2010) An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol. J Clin Endocrinol Metab 95, E1-E8
    • (2010) J Clin Endocrinol Metab , vol.95
    • Ghanim, H.1    Sia, C.L.2    Abuaysheh, S.3
  • 51
    • 80455143206 scopus 로고    scopus 로고
    • Calorie restriction-like effects of 30 days of Resveratrol (resVidaTM) supplementation on energy metabolism and metabolic profile in obese humans
    • Timmers S, Konings E, Bilet L, et al. (2011) Calorie restriction-like effects of 30 days of Resveratrol (resVidaTM) supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab 14, 612-622
    • (2011) Cell Metab , vol.14 , pp. 612-622
    • Timmers, S.1    Konings, E.2    Bilet, L.3
  • 52
    • 84875431034 scopus 로고    scopus 로고
    • High-dose resveratrol supplementation in obese men: An investigator-initiated, randomized, Placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition
    • Poulsen MM, Vestergaard PF, Clasen BF, et al. (2012) High-dose resveratrol supplementation in obese men: An investigator-initiated, randomized, Placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition. Diabetes 62, 1186-1195
    • (2012) Diabetes , vol.62 , pp. 1186-1195
    • Poulsen, M.M.1    Vestergaard, P.F.2    Clasen, B.F.3
  • 53
    • 84871445402 scopus 로고    scopus 로고
    • Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance
    • Yoshino J, Conte C, Fontana L, et al. (2012) Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance. Cell Metab 16, 658-664
    • (2012) Cell Metab , vol.16 , pp. 658-664
    • Yoshino, J.1    Conte, C.2    Fontana, L.3
  • 54
    • 84880349078 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol in obesity and type 2 diabetes: New avenues for health benefits?
    • Timmers S, Hesselink MK & Schrauwen P (2013) Therapeutic potential of resveratrol in obesity and type 2 diabetes: New avenues for health benefits? Ann N Y Acad Sci 1290, 83-89
    • (2013) Ann N y Acad Sci , vol.1290 , pp. 83-89
    • Timmers, S.1    Hesselink, M.K.2    Schrauwen, P.3
  • 55
    • 0035217707 scopus 로고    scopus 로고
    • Skeletal muscle lipid content and insulin resistance: Evidence for a paradox in endurance-Trained athletes
    • Goodpaster BH, He J, Watkins S, et al. (2001) Skeletal muscle lipid content and insulin resistance: Evidence for a paradox in endurance-Trained athletes. J Clin Endocrinol Metab 86, 5755-5761
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5755-5761
    • Goodpaster, B.H.1    He, J.2    Watkins, S.3
  • 56
    • 84872459305 scopus 로고    scopus 로고
    • PPARgamma coactivator-1alpha contributes to exerciseinduced regulation of intramuscular lipid droplet programming in mice and humans
    • Koves TR, Sparks LM, Kovalik JP, et al. (2013) PPARgamma coactivator-1alpha contributes to exerciseinduced regulation of intramuscular lipid droplet programming in mice and humans. J Lipid Res 54, 522-534
    • (2013) J Lipid Res , vol.54 , pp. 522-534
    • Koves, T.R.1    Sparks, L.M.2    Kovalik, J.P.3
  • 57
    • 0037102256 scopus 로고    scopus 로고
    • Transcriptional co-Activator PGC-1 alpha drives the formation of slow-Twitch muscle fibres
    • Lin J, Wu H, Tarr PT, et al. (2002) Transcriptional co-Activator PGC-1 alpha drives the formation of slow-Twitch muscle fibres. Nature 418, 797-801
    • (2002) Nature , vol.418 , pp. 797-801
    • Lin, J.1    Wu, H.2    Tarr, P.T.3
  • 58
    • 84868020505 scopus 로고    scopus 로고
    • Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels
    • Bosma M, Hesselink MK, Sparks LM, et al. (2012) Perilipin 2 improves insulin sensitivity in skeletal muscle despite elevated intramuscular lipid levels. Diabetes 61, 2679-2690
    • (2012) Diabetes , vol.61 , pp. 2679-2690
    • Bosma, M.1    Hesselink, M.K.2    Sparks, L.M.3
  • 59
    • 84873729674 scopus 로고    scopus 로고
    • Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity
    • Bosma M, Sparks LM, Hooiveld GJ, et al. (2013) Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intramyocellular lipid content without compromising insulin sensitivity. Biochim Biophys Acta 1831, 844-852
    • (2013) Biochim Biophys Acta , vol.1831 , pp. 844-852
    • Bosma, M.1    Sparks, L.M.2    Hooiveld, G.J.3
  • 60
    • 34249915334 scopus 로고    scopus 로고
    • Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance
    • Schenk S, & Horowitz JF (2007) Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance. J Clin Invest 117, 1690-1698
    • (2007) J Clin Invest , vol.117 , pp. 1690-1698
    • Schenk, S.1    Horowitz, J.F.2
  • 61
    • 84885405201 scopus 로고    scopus 로고
    • Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men
    • Gliemann L, Schmidt JF, Olesen J, et al. (2013) Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men. J Physiol 591, 5047-5059
    • (2013) J Physiol , vol.591 , pp. 5047-5059
    • Gliemann, L.1    Schmidt, J.F.2    Olesen, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.