Characterizing the normal proteome of human ciliary body

Clinical Proteomics

Volumn 10, Issue 1, 2013, Pages

  Goel, Renu ^a,b   Murthy, Krishna R ^a,c,d   Srikanth, Srinivas M ^a,g   Pinto, Sneha M ^a,e   Bhattacharjee, Mitali ^a,c   Kelkar, Dhanashree S ^a,c   Madugundu, Anil K ^a   Dey, Gourav ^a   Mohan, Sujatha S ^a,b,f   Krishna, Venkatarangaiah ^b   Prasad, T S Keshava ^a,c,e   Chakravarti, Shukti ^h   Harsha, H C ^a   Pandey, Akhilesh ^h  

^a INSTITUTE OF BIOINFORMATICS   (India)

^b KUVEMPU UNIVERSITY   (India)

^c AMRITA UNIVERSITY   (India)

^d Vittala International Institute of Ophthalmology   (India)

^e MANIPAL UNIVERSITY   (India)

^f RIKEN YOKOHAMA INSTITUTE   (Japan)

^g PONDICHERRY UNIVERSITY   (India)

^h JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aqueous humor; Ciliary processes; Cyclitis and glaucoma; Non pigmented epithelial layer; Pigmented epithelial layer; Protein biomarkers; Proteome discoverer

Indexed keywords

ATLASTIN 2; B CELL RECEPTOR ASSOCIATED PROTEIN 29; CALPAIN 1; CD147 ANTIGEN; COPINE 6; FIBULIN 1; GALECTIN 1; IMPORTIN 5; INITIATION FACTOR 2ALPHA; KARYOPHERIN; MEMBRANE PROTEIN; PROTEOME; UBIQUITIN; UNCLASSIFIED DRUG;

AGED; AQUEOUS HUMOR; ARTICLE; CILIARY BODY; CONTROLLED STUDY; FEMALE; GLUCONEOGENESIS; GLYCOLYSIS; HUMAN; LIQUID CHROMATOGRAPHY; MALE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; VERY ELDERLY;

EID: 84898428766     PISSN: 15426416     EISSN: 15590275     Source Type: Journal    
DOI: 10.1186/1559-0275-10-9     Document Type: Article

References (83)

1. Kaufman PL, Alm A, Adler FH: Adler's physiology of the eye: Clinical application. 10th edition. St. Louis: Mosby; 2003.
2. Alm A, Bill A: Ocular and optic nerve blood flow at normal and increased intraocular pressures in monkeys (Macaca irus): A study with radioactively labelled microspheres including flow determinations in brain and some other tissues. Exp Eye Res 1973, 15:15-29.
3. Caprioli J, Sears M, Mead A: Ocular blood flow in phakic and aphakic monkey eyes. Exp Eye Res 1984, 39:1-7. (Pubitemid 14068007)
4. Do CW, Civan MM: Basis of chloride transport in ciliary epithelium. J Membr Biol 2004, 200:1-13. (Pubitemid 39193200)
5. To CH, Kong CW, Chan CY, Shahidullah M, Do CW: The mechanism of aqueous humour formation. Clin Exp Optom 2002, 85:335-349.
6. Mark HH: Aqueous humor dynamics in historical perspective. Surv Ophthalmol 2010, 55:89-100.
7. Anshu A, Price MO, Richardson MR, Segu ZM, Lai X, Yoder MC, Price FW Jr: Alterations in the aqueous humor proteome in patients with a glaucoma shunt device. Mol Vis 2011, 17:1891-1900.
8. Quigley HA: Glaucoma. Lancet 2011, 377:1367-1377.
9. Shen SC, Ho WJ, Wu SC, Yu KH, Lin HC, Lin YS, Tsay PK, Chu PH: Peripheral vascular endothelial dysfunction in glaucomatocyclitic crisis: A preliminary study. Invest Ophthalmol Vis Sci 2010, 51:272-276.
10. Torricelli AA, Junior JB, Santhiago MR, Bechara SJ: Surgical management of presbyopia. Clin Ophthalmol 2012, 6:1459-1466.
11. Goel M, Picciani RG, Lee RK, Bhattacharya SK: Aqueous humor dynamics: A review. Open Ophthalmol J 2010, 4:52-59.
12. Wu RY: Ma N: Expression of nitric oxide synthase and guanylate cyclase in the human ciliary body and trabecular meshwork. Chin Med J (Engl) 2012, 125:129-133.
13. Flugel-Koch C, Neuhuber WL, Kaufman PL, Lutjen-Drecoll E: Morphologic indication for proprioception in the human ciliary muscle. Invest Ophthalmol Vis Sci 2009, 50:5529-5536.
14. Pattwell DM, Sheridan CM, Le Goff M, Bishop PN, Hiscott P: Localisation of opticin in human proliferative retinal disease. Exp Eye Res 2010, 90:461-464.
15. Reardon AJ, Le Goff M, Briggs MD, McLeod D, Sheehan JK, Thornton DJ, Bishop PN: Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix. J Biol Chem 2000, 275:2123-2129. (Pubitemid 30060841)
16. Friedman JS, Ducharme R, Raymond V, Walter MA: Isolation of a novel iris-specific and leucine-rich repeat protein (oculoglycan) using differential selection. Invest Ophthalmol Vis Sci 2000, 41:2059-2066. (Pubitemid 30450973)
17. Ramesh S, Bonshek RE, Bishop PN: Immunolocalisation of opticin in the human eye. Br J Ophthalmol 2004, 88:697-702. (Pubitemid 38526656)
18. Friedman JS, Faucher M, Hiscott P, Biron VL, Malenfant M, Turcotte P, Raymond V, Walter MA: Protein localization in the human eye and genetic screen of opticin. Hum Mol Genet 2002, 11:1333-1342. (Pubitemid 34555531)
19. Acharya M, Mookherjee S, Bhattacharjee A, Thakur SK, Bandyopadhyay AK, Sen A, Chakrabarti S, Ray K: Evaluation of the OPTC gene in primary open angle glaucoma: functional significance of a silent change. BMC Mol Biol 2007, 8:21.
20. Maatta M, Heljasvaara R, Pihlajaniemi T, Uusitalo M: Collagen XVIII/endostatin shows a ubiquitous distribution in human ocular tissues and endostatincontaining fragments accumulate in ocular fluid samples. Graefes Arch Clin Exp Ophthalmol 2007, 245:74-81. (Pubitemid 46766733)
21. Ohlmann AV, Ohlmann A, Welge-Lussen U, May CA: Localization of collagen XVIII and endostatin in the human eye. Curr Eye Res 2005, 30:27-34. (Pubitemid 40327688)
22. Saarela J, Ylikarppa R, Rehn M, Purmonen S, Pihlajaniemi T: Complete primary structure of two variant forms of human type XVIII collagen and tissue-specific differences in the expression of the corresponding transcripts. Matrix Biol 1998, 16:319-328. (Pubitemid 28052585)
23. Doshi M, Marcus C, Bejjani BA, Edward DP: Immunolocalization of CYP1B1 in normal, human, fetal and adult eyes. Exp Eye Res 2006, 82:24-32. (Pubitemid 43063394)
24. Tanwar M, Sihota R, Dada T, Gupta V, Das TK, Yadav U, Dada R: Sturge-Weber syndrome with congenital glaucoma and cytochrome P450 (CYP1B1) gene mutations. J Glaucoma 2010, 19:398-404.
25. Lee MD, King LS: Agre P: The aquaporin family of water channel proteins in clinical medicine. Medicine (Baltimore) 1997, 76:141-156. (Pubitemid 27255818)
26. Yamaguchi Y, Watanabe T, Hirakata A, Hida T: Localization and ontogeny of aquaporin-1 and -4 expression in iris and ciliary epithelial cells in rats. Cell Tissue Res 2006, 325:101-109. (Pubitemid 44124302)
27. King LS, Kozono D, Agre P: From structure to disease: The evolving tale of aquaporin biology. Nat Rev Mol Cell Biol 2004, 5:687-698. (Pubitemid 39208179)
28. Hierro A, Rojas AL, Rojas R, Murthy N, Effantin G, Kajava AV, Steven AC, Bonifacino JS, Hurley JH: Functional architecture of the retromer cargo-recognition complex. Nature 2007, 449:1063-1067. (Pubitemid 350014597)
29. Bar H, Mucke N, Kostareva A, Sjoberg G, Aebi U, Herrmann H: Severe muscle disease-causing desmin mutations interfere with in vitro filament assembly at distinct stages. Proc Natl Acad Sci USA 2005, 102:15099-15104. (Pubitemid 41513341)
30. Kudo N, Khochbin S, Nishi K, Kitano K, Yanagida M, Yoshida M, Horinouchi S: Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins. J Biol Chem 1997, 272:29742-29751. (Pubitemid 27508069)
31. Liu H, Deng X, Shyu YJ, Li JJ, Taparowsky EJ, Hu CD: Mutual regulation of c-Jun and ATF2 by transcriptional activation and subcellular localization. EMBO J 2006, 25:1058-1069. (Pubitemid 43372119)
32. Sauer G, Korner R, Hanisch A, Ries A, Nigg EA, Sillje HH: Proteome analysis of the human mitotic spindle. Mol Cell Proteomics 2005, 4:35-43. (Pubitemid 40309323)
33. Fornerod M, Ohno M, Yoshida M, Mattaj IW: CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 1997, 90:1051-1060. (Pubitemid 27408519)
34. Rosorius O, Reichart B, Kratzer F, Heger P, Dabauvalle MC, Hauber J: Nuclear pore localization and nucleocytoplasmic transport of eIF-5A: evidence for direct interaction with the export receptor CRM1. J Cell Sci 1999, 112(Pt 14):2369-2380. (Pubitemid 29381027)
35. Schmitt I, Gerace L: In vitro analysis of nuclear transport mediated by the C-terminal shuttle domain of Tap. J Biol Chem 2001, 276:42355-42363.
36. Yang J, Bogerd HP, Wang PJ, Page DC, Cullen BR: Two closely related human nuclear export factors utilize entirely distinct export pathways. Mol Cell 2001, 8:397-406. (Pubitemid 32831556)
37. Laman H, Peters G, Jones N: Cyclin-mediated export of human Orc1. Exp Cell Res 2001, 271:230-237. (Pubitemid 33141204)
38. Singh BB, Patel HH, Roepman R, Schick D, Ferreira PA: The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1. J Biol Chem 1999, 274:37370-37378.
39. Yedavalli VS, Neuveut C, Chi YH, Kleiman L, Jeang KT: Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function. Cell 2004, 119:381-392. (Pubitemid 39423840)
40. Knauer SK, Bier C, Habtemichael N, Stauber RH: The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function. EMBO Rep 2006, 7:1259-1265. (Pubitemid 44835095)
41. Seimiya H, Sawada H, Muramatsu Y, Shimizu M, Ohko K, Yamane K, Tsuruo T: Involvement of 14-3-3 proteins in nuclear localization of telomerase. EMBO J 2000, 19:2652-2661. (Pubitemid 30323553)
42. Lapalombella R, Sun Q, Williams K, Tangeman L, Jha S, Zhong Y, Goettl V, Mahoney E, Berglund C, Gupta S, et al: Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia. Blood 2012, 120:4621-4634.
43. Muthusamy B, Hanumanthu G, Suresh S, Rekha B, Srinivas D, Karthick L, Vrushabendra BM, Sharma S, Mishra G, Chatterjee P, et al: Plasma Proteome Database as a resource for proteomics research. Proteomics 2005, 5:3531-3536. (Pubitemid 41192058)
44. Sacca SC, Centofanti M, Izzotti A: New proteins as vascular biomarkers in primary open angle glaucomatous aqueous humor. Invest Ophthalmol Vis Sci 2012, 53:4242-4253.
45. Chowdhury UR, Madden BJ, Charlesworth MC, Fautsch MP: Proteome analysis of human aqueous humor. Invest Ophthalmol Vis Sci 2010, 51:4921-4931.
46. Richardson MR, Price MO, Price FW, Pardo JC, Grandin JC, You J, Wang M, Yoder MC: Proteomic analysis of human aqueous humor using multidimensional protein identification technology. Mol Vis 2009, 15:2740-2750.
47. Bennett KL, Funk M, Tschernutter M, Breitwieser FP, Planyavsky M: Ubaida Mohien C, Muller A, Trajanoski Z, Colinge J, Superti-Furga G, Schmidt-Erfurth U: proteomic analysis of human cataract aqueous humour: Comparison of one-dimensional gel LCMS with two-dimensional LCMS of unlabelled and iTRAQ(R)-labelled specimens. J Proteomics 2011, 74:151-166.
48. Wistow G: The human crystallin gene families. Hum Genomics 2012, 6:26.
49. Vasiliou V, Thompson DC, Smith C, Fujita M, Chen Y: Aldehyde dehydrogenases: from eye crystallins to metabolic disease and cancer stem cells. Chem Biol Interact 2013, 202:2-10.
50. Ekstrom EJ, Sherwood V, Andersson T: Methylation and loss of Secreted Frizzled-Related Protein 3 enhances melanoma cell migration and invasion. PLoS One 2011, 6:e18674.
51. Lee JJ, Park JK, Jeong J, Jeon H, Yoon JB, Kim EE, Lee KJ: Complex of Fas-associated Factor 1 (FAF1) with Valosin-containing Protein (VCP)-Npl4-Ufd1 and Polyubiquitinated Proteins Promotes Endoplasmic Reticulum-associated Degradation (ERAD). J Biol Chem 2013, 288:6998-7011.
52. Goel R, Harsha HC, Pandey A, Prasad TS: Human Protein Reference Database and Human Proteinpedia as resources for phosphoproteome analysis. Mol Biosyst 2012, 8:453-463.
53. Kaiser P, Huang L: Global approaches to understanding ubiquitination. Genome Biol 2005, 6:233.
54. Reyes-Turcu FE, Ventii KH, Wilkinson KD: Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes. Annu Rev Biochem 2009, 78:363-397.
55. Harsha HC, Molina H, Pandey A: Quantitative proteomics using stable isotope labeling with amino acids in cell culture. Nat Protoc 2008, 3:505-516. (Pubitemid 351372235)
56. Venugopal AK, Ghantasala SS, Selvan LD, Mahadevan A, Renuse S, Kumar P, Pawar H, Sahasrabhuddhe NA, Suja MS, Ramachandra YL, et al: Quantitative proteomics for identifying biomarkers for Rabies. Clin Proteomics 2013, 10:3.
57. Kumar GS, Venugopal AK, Mahadevan A, Renuse S, Harsha HC, Sahasrabuddhe NA, Pawar H, Sharma R, Kumar P, Rajagopalan S, et al: Quantitative proteomics for identifying biomarkers for tuberculous meningitis. Clin Proteomics 2012, 9:12.
58. Mathivanan S, Ahmed M, Ahn NG, Alexandre H, Amanchy R, Andrews PC, Bader JS, Balgley BM, Bantscheff M, Bennett KL, et al: Human Proteinpedia enables sharing of human protein data. Nat Biotechnol 2008, 26:164-167. (Pubitemid 351225942)
59. Krueger B, Schlotzer-Schrehardt U, Haerteis S, Zenkel M, Chankiewitz VE, Amann KU, Kruse FE, Korbmacher C: Four subunits (alphabetagammadelta) of the epithelial sodium channel (ENaC) are expressed in the human eye in various locations. Invest Ophthalmol Vis Sci 2012, 53:596-604.
60. Gabriel LA, Wang LW, Bader H, Ho JC, Majors AK, Hollyfield JG, Traboulsi EI, Apte SS: ADAMTSL4, a secreted glycoprotein widely distributed in the eye, binds fibrillin-1 microfibrils and accelerates microfibril biogenesis. Invest Ophthalmol Vis Sci 2012, 53:461-469.
61. Yamanouchi K, Tsuruga E, Oka K, Sawa Y, Ishikawa H: Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro. Connect Tissue Res 2012, 53:14-20.
62. Chowdhury UR, Jea SY, Oh DJ, Rhee DJ, Fautsch MP: Expression profile of the matricellular protein osteopontin in primary open-angle glaucoma and the normal human eye. Invest Ophthalmol Vis Sci 2011, 52:6443-6451.
63. Russell-Randall KR, Dortch-Carnes J: Kappa opioid receptor localization and coupling to nitric oxide production in cells of the anterior chamber. Invest Ophthalmol Vis Sci 2011, 52:5233-5239.
64. Zhang Y, Patil RV, Marmorstein AD: Bestrophin 2 is expressed in human non-pigmented ciliary epithelium but not retinal pigment epithelium. Mol Vis 2010, 16:200-206.
65. Kraft ME, Glaeser H, Mandery K, Konig J, Auge D, Fromm MF, Schlotzer- Schrehardt U, Welge-Lussen U, Kruse FE, Zolk O: The prostaglandin transporter OATP2A1 is expressed in human ocular tissues and transports the antiglaucoma prostanoid latanoprost. Invest Ophthalmol Vis Sci 2010, 51:2504-2511.
66. Wang J, Wu Y, Heegaard S, Kolko M: Cyclooxygenase-2 expression in the normal human eye and its expression pattern in selected eye tumours. Acta Ophthalmol 2011, 89:681-685.
67. Yucel YH, Johnston MG, Ly T, Patel M, Drake B, Gumus E, Fraenkl SA, Moore S, Tobbia D, Armstrong D, et al: Identification of lymphatics in the ciliary body of the human eye: A novel "uveolymphatic" outflow pathway. Exp Eye Res 2009, 89:810-819.
68. Mao M, Solivan-Timpe F, Roos BR, Mullins RF, Oetting TA, Kwon YH, Brzeskiewicz PM, Stone EM, Alward WL, Anderson MG, Fingert JH: Localization of SH3PXD2B in human eyes and detection of rare variants in patients with anterior segment diseases and glaucoma. Mol Vis 2012, 18:705-713.
69. Ooi YH, Oh DJ, Rhee DJ: Analysis of alpha2-adrenergic receptors and effect of brimonidine on matrix metalloproteinases and their inhibitors in human ciliary body. Invest Ophthalmol Vis Sci 2009, 50:4237-4243.
70. Webb JG, Yang X, Crosson CE: Expression of the kallikrein/kinin system in human anterior segment. Exp Eye Res 2009, 89:126-132.
71. Pecorella I, Ciocci L, Modesti M, Appolloni R: Adenoma of the non-pigmented ciliary epithelium: A rare intraocular tumor with unusual immunohistochemical findings. Pathol Res Pract 2009, 205:870-875.
72. Marmorstein AD, Cross HE, Peachey NS: Functional roles of bestrophins in ocular epithelia. Prog Retin Eye Res 2009, 28:206-226.
73. Ostojic J, Grozdanic S, Syed NA, Hargrove MS, Trent JT 3rd, Kuehn MH, Kardon RH, Kwon YH, Sakaguchi DS: Neuroglobin and cytoglobin distribution in the anterior eye segment: A comparative immunohistochemical study. J Histochem Cytochem 2008, 56:863-872.
74. Assheton DC, Guerin EP, Sheridan CM, Bishop PN, Hiscott PS: Neoplastic transformation of ciliary body epithelium is associated with loss of opticin expression. Br J Ophthalmol 2007, 91:230-232. (Pubitemid 46202876)
75. Toyran S, Lin AY, Edward DP: Expression of growth differentiation factor-5 and bone morphogenic protein-7 in intraocular osseous metaplasia. Br J Ophthalmol 2005, 89:885-890. (Pubitemid 40904815)
76. Bishop PN: Takanosu M, Le Goff M, Mayne R: The role of the posterior ciliary body in the biosynthesis of vitreous humour. Eye (Lond) 2002, 16:454-460. (Pubitemid 34845974)
77. Wollensak G, Schaefer HE, Ihling C: An immunohistochemical study of endothelin-1 in the human eye. Curr Eye Res 1998, 17:541-545. (Pubitemid 28306510)
78. Sonsino J, Gong H, Wu P, Freddo TF: Co-localization of junction-associated proteins of the human blood-aqueous barrier: occludin, ZO-1 and F-actin. Exp Eye Res 2002, 74:123-129. (Pubitemid 34948272)
79. Hamann S, Zeuthen T, La Cour M, Nagelhus EA, Ottersen OP, Agre P, Nielsen S: Aquaporins in complex tissues: distribution of aquaporins 1-5 in human and rat eye. Am J Physiol 1998, 274:C1332-1345.
80. Wang TH, Lindsey JD, Weinreb RN: Laminin subtype distribution in the human ciliary body. Invest Ophthalmol Vis Sci 1994, 35:3776-3782. (Pubitemid 24337991)
81. Kumagai AK, Glasgow BJ, Pardridge WM: GLUT1 glucose transporter expression in the diabetic and nondiabetic human eye. Invest Ophthalmol Vis Sci 1994, 35:2887-2894. (Pubitemid 24149803)
82. Peress NS, Perillo E: TGF-beta 2 and TGF-beta 3 immunoreactivity within the ciliary epithelium [corrected]. Invest Ophthalmol Vis Sci 1994, 35:453-457.
83. Wistrand PJ, Schenholm M, Lonnerholm G: Carbonic anhydrase isoenzymes CA I and CA II in the human eye. Invest Ophthalmol Vis Sci 1986, 27:419-428. (Pubitemid 16129930)