Dietary fish oil improves endothelial function and lowers blood pressure via suppression of sphingolipid-mediated contractions in spontaneously hypertensive rats

Journal of Hypertension

Volumn 32, Issue 5, 2014, Pages 1050-1058

  Van Den Elsen, Lieke W J ^a   Spijkers, Léon J A ^b   Van Den Akker, Rob F P ^b   Van Winssen, Aggie M H ^a   Balvers, Martin ^c   Wijesinghe, Dayanjan S ^d,e   Chalfant, Charles E ^d,e,f   Garssen, Johan ^a,c   Willemsen, Linette E M ^a   Alewijnse, Astrid E ^b   Peters, Stephan L M ^b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c Nutricia Nederland   (Netherlands)

^d Veterans Administration   (United States)

^e VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^f VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

blood pressure; ceramide; endothelial function; fish oil; long chain n 3 polyunsaturated fatty acid; sphingolipid; spontaneously hypertensive rat

Indexed keywords

ARACHIDONIC ACID; CERAMIDE; DOCOSAHEXAENOIC ACID; FISH OIL; GLUCOSYLCERAMIDE; ICOSAPENTAENOIC ACID; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; METHACHOLINE; OMEGA 3 FATTY ACID; RANTES; SPHINGOLIPID; THROMBOXANE; THROMBOXANE A2; THROMBOXANE B2; EDIBLE OIL; SPHINGOMYELIN PHOSPHODIESTERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; BLOOD PRESSURE MEASUREMENT; BLOOD VESSEL FUNCTION; BLOOD VESSEL TONE; CAROTID ARTERY; CELL MEMBRANE; CONTROLLED STUDY; CYTOKINE RELEASE; DIET SUPPLEMENTATION; DIET THERAPY; ERYTHROCYTE; ERYTHROCYTE MEMBRANE; ESSENTIAL HYPERTENSION; EX VIVO STUDY; HYPERTENSION; IN VIVO STUDY; LIPID COMPOSITION; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; T LYMPHOCYTE; THORACIC AORTA; VASOCONSTRICTION; ANIMAL; BLOOD; DRUG EFFECTS; LIQUID CHROMATOGRAPHY; METABOLISM; MUSCLE CONTRACTION; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ANIMALS; BLOOD PRESSURE; CHROMATOGRAPHY, LIQUID; DIETARY FATS, UNSATURATED; ENDOTHELIUM, VASCULAR; FISH OILS; MASS SPECTROMETRY; MUSCLE CONTRACTION; RATS; RATS, INBRED SHR; SPHINGOLIPIDS; SPHINGOMYELIN PHOSPHODIESTERASE; THROMBOXANE B2;

EID: 84898409238     PISSN: 02636352     EISSN: 14735598     Source Type: Journal    
DOI: 10.1097/HJH.0000000000000131     Document Type: Article

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