Induced cell death pathway post photodynamic therapy using a metallophthalocyanine photosensitizer in breast cancer cells

Photomedicine and Laser Surgery

Volumn 32, Issue 4, 2014, Pages 205-211

  Mfouo Tynga, Ivan ^a   Houreld, Nicolette N ^a   Abrahamse, Heidi ^a  

^a UNIVERSITY OF JOHANNESBURG   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENTATION FACTORS; GENE EXPRESSION ANALYSIS; IMMUNOSORBENT ASSAYS; METALLOPHTHALOCYANINES; NUCLEAR FRAGMENTATION; PHOTODYNAMIC THERAPY (PDT); PROGRAMMED CELL DEATHS; ZINC PHTHALOCYANINES;

CELL CULTURE; GENE EXPRESSION; ONCOLOGY; PHOTODYNAMIC THERAPY; PHOTOSENSITIZERS; ZINC COMPOUNDS;

CELL DEATH;

INDOLE DERIVATIVE; ORGANOMETALLIC COMPOUND; PHOTOSENSITIZING AGENT; ZN(II)-PHTHALOCYANINE;

APOPTOSIS; BREAST NEOPLASMS; CELL CULTURE; CELL DEATH; FEMALE; HUMAN; PATHOLOGY; PHOTOCHEMOTHERAPY; PHYSIOLOGY; PROCEDURES;

APOPTOSIS; BREAST NEOPLASMS; CELL DEATH; CELLS, CULTURED; FEMALE; HUMANS; INDOLES; ORGANOMETALLIC COMPOUNDS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS;

EID: 84898060997     PISSN: 15495418     EISSN: None     Source Type: Journal    
DOI: 10.1089/pho.2013.3650     Document Type: Article

References (50)

1. American Cancer Society (2013). Cancer facts and figures. Atlanta: American Cancer Society.
2. DeSantos, C., Naishadham, D., and Jemal, A. (2013). Cancer statistics for African Americans. CA Cancer J. Clin. 64, 151-166.
3. Jemal, A., Bray, F., Center, M.M., Ferlay, J., Ward, E., and Forman, D. (2011). Global cancer statistics. CA Cancer J. Clin. 61, 134-139.
4. Ziegler, V., Kiesslich, T., Krammer, B., and Plaetzer, K. (2013). Photosensitizer adhered to cell culture microplates induces phototoxicity in carcinoma cells. Biomed. Res. Int. 2013:549498.
5. Tynga, I.M., Houreld, N.N., and Abrahamse, H. (2013). The primary subcellular localizationof Zinc Phthalocyanine and its cellular impacts on viability, proliferation and structures of breast cancer (MCF-7) cells. J. Photochem. Photobiol. B. 120, 171-176.
6. Manoto, S.L., and Abrahamse, H. (2011). Effect of a newly synthesized Zn sulfophthalocyanine derivative on cell morphology, viability, proliferation and cytotoxicity in human lung cancer cell line (A549). Lasers Med. Sci. 43, 333-342.
7. Agostinis, P., Berg, K., Cengel, K.A., Foster, T.H., Girotti, A.W., Gollnick, S.O., et al. (2011). Photodynamic therapy of cancer: An update. CA Cancer J. Clin. 61, 250-281.
8. Mroz, P., Szokalska, A., Wu, M.X., and Hamblin, M.R. (2010). PDT of tumours can lead to development of systemic antigen specific immune response. PLos One 5, e15,194-15,201.
9. Robertson, C.A., Evans, D.H., and Abrahamse, H. (2009). Photodynamic therapy (PDT): a short review on cellular mechanisms and cancer research applications for PDT. J Photochem. Photobiol. B. 96, 1-8.
10. Panzarini, E., Inguscio, V., and Dini, L. (2013). Immunogenic cell death: can it be exploited in photodynamic therapy for cancer? Biomed. Res. Int. 2013:482160.
11. Moserova, I., and Kralova, J. (2012). Role of ER stress response in photodynamic therapy: ros generated in different subcellular compartments trigger diverse cell death pathways. PLoS One 7, e32972-e32988.
12. Josefsen, L.B., and Boyle, R.W. (2008). Photodynamic therapy: novel third generation photosensitizers one step closer? Br. J. Pharmacol. 154, 1-3.
13. Ogunsipe, A., Chen, J.-Y., and Nyokong, T. (2004). Photophysical and photochemical studies of zinc (II) phthalocyanine derivatives-effects on substituents and solvents. New J. Chem. 28, 822-827.
14. Kessel, D., and Oleinick, N.L. (2010). Photodynamic therapy and cell death pathways. Methods Mol. Biol. 635, 35-40.
15. Seotsanyana, M.I., Kresfelder, T., Abrahamse, H., and Nyokong, T. (2006). The effects of Ge, Si and Sn phthalocyanine photosensitizers on cell proliferation and viability of human oesophageal carcinoma cells. J. Photochem. Photobiol. B. 83, 56-62.
16. Jemal, A., Siegel, R., Xu, J., and Ward, E. (2010). Cancer statistics. CA Cancer J. Clin. 60, 277-300.
17. Manifold, R.N., and Anderson, C.D. (2011). Increased cutaneous oxygen availability by topical application of hydrogen peroxide cream enhances the photodynamic therapy reaction to topical 5-ALA-methyl-esther. Arch. Dermatol. Res. 303, 285-292.
18. Wilson, B.C. (2012). Photodynamic therapy for cancer. Can. J. Gastroenterol. 16, 393-396.
19. Koopman, G., Reutelingsperger, C.P., Kuijten, G.A., Keehnen, R.M., Pals, S.T., and van Oers, M.H. (1994). Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84, 1415-1420.
20. Martin, S.J., O'Brien, G.A., Nishioka, W.K., McGahon, A.J., Mahboubi, A., Saido, T.C., and Green, D.R. (1995). Proteolysis of fodrin (non-erythroid spectrin) during apoptosis. J. Biol. Chem. 270, 6425-6428.
21. Lecoeur, H. (2002). Nuclear apoptosis detection by flow cytometry: influence of endogenous endonucleases. Exp. Cell. Res. 277, 1-14.
22. Chiu, S.M., Xue, L.Y., Usuda, J., Azizuddin, K., and Oleinick, N.L. (2003). Bax is essential for mitochondrion mediated apoptosis but not for cell death caused by PDT. Br. J. Cancer 89, 1590-1597.
23. Wei, M.C., Zong, W.X., Cheng, E.H., Lindsten, T., Panoutsakopoulou, V., Ross, A.J., et al. (2001). Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292, 727-730.
24. Chen, B., Xu, Y., Roskams, T., Delarey, E., Agostinis, P., Vandenheede, J.R., and de Witte, P.A.M. (2001). Efficacy of antitumoral PDT with Hypericin: relationship between biodistribution and photodynamic effects in the RIF-1 mouse tumor model. Int. J. Cancer 93, 275-282.
25. Buytaert, W., Sevink, J., and Leeuw, B.D. (2005). Clay mineralogy of the soils in the south Ecuadorian páramo region. Geoderma 127,114-129.
26. Fulda, S. (2009). Caspase 8 in cancer biology and therapy. Cancer Lett. 28, 128-133.
27. Coleman, C.A., Barbara, E.H., McDougal, J.N., and Rogers, J.V. (2003). The effect of m-xylene on cytotoxicity and cellular antioxidant status in rat dermal equivalents. Toxicol. Lett.142, 133-142.
28. Ajiro, K. (2000). Histone H2B phosphorylation in mammalian apoptotic cells: an association with DNA fragmentation. J. Biol. Chem. 275, 439-443.
29. Gad, F., Viaug, G., Boushira, M., Bertrand, R., and Bissonnette, R. (2001). PDT with 5-Aminolevulinic acid induces apoptosis and caspase activation in malignant T cells. J. Cutan. Med. Surg. 5, 8-13.
30. Kessel, D., and Luo, Y. (1999). Delayed oxidative photodamage induced by PDT. Photochem. Photobiol. 64, 601-604.
31. Lui, X., Zou, H., Shanghter, C., and Wang, X. (1997). DFF, a heterodimeric protein that functions downstream of caspase- 3 to trigger DNA fragmentation during apoptosis. Cell Death Differ. 8, 124-128.
32. Yan, B., Wang, H., Peng, Y., Hu, Y., Wang, H., Zhang, X., et al. (2006). A unique role of DNA fragmentation factor in maintaining genomic stability. PNAS 103, 1504-1509.
33. Alnemri, E.S., Livingston, D.J., Nicholson, D.W., Salvesen, G., Thornberry, N.A., Wong, W.W., and Yuang, J. (1996). Human ICE/CED-3 protease nomenclature. Cell 87, 171-176.
34. Manzl, C., Peintner, L., Krumschnabel, G., Bock, F., Labi, V., Drach, M., et al. (2012). PIDDosome independent tumor suppressor by caspase-2. Cell Death Differ. 19, 1722-1732.
35. Bouchier-Hayes, L. (2010). The role of caspase-2 in stress induce apoptosis. J. Cell Mol. Med. 14, 1212-1224.
36. Yang, J., Liu, X., Bhalla, K., Kim, C.N., Ibrado, A.M., Cai, J., et al. (1997). Preventing of apoptosis by Bcl-2: release of cytochrome C from mitochondria blocked. Science 275, 1129-1132.
37. Manzl, C., Krumschnabel, G., Bock, F., Sohm, B., Labi, V., Baumgartner, F., et al. (2009). Caspase-2 activation in the absence of PIDDosome formation. J. Cell Biol. 185, 291-303.
38. Ren, K., Lu, T., Porollo, A., and Du, C. (2012). Tumor suppressing function of caspase-2 requires catalytic site cys-320 and site ser-139 in Mice. J. Biol. Chem. 285, 14,792-14,802.
39. Wang, Q.E., Han, C., Zhang, B., Sabapathy, K., and Wani, A.A. (2012). Nucleotide excision repair factor XPC enhances DNA damages induced apoptosis by downregulating the antiapoptotic short isoform of caspase-2. Cancer Res. 72, 666-675.
40. Baptiste-Okoh, N., Barsotti, A.M., and Prives. C. (2008). A role for caspase 2 and PIDD in the process of p53-mediated apoptosis. Proc. Natl. Acad. Sci. U.S.A. 105, 1937-1942.
41. Tynga, I.M., and Abrahamse, H. (2012). Caspase-8 properties, functions and regulation during photodynamic therapy, In: Advances in Genetics Research, vol. 9. K.V. Urbano (ed.). New York: Nova Sciences Publishers, pp. 107-119.
42. Lasern, B.D., Rampalli, S., Burns, L.E., Brunette, S., Dilworth, F.J., and Megeney, L.A. (2007). Caspase-3/Caspase activated DNase promotes cell differentiation by inducing DNA strand breaks. Proc. Natl. Acad. Sci. U.S.A. 207, 4230-4235.
43. Cao, G., Pei, W., Lan, J., Stetler, R.A., Luo, Y., Nagayama, T., et al. (2001). Caspase-activated DNase/DNA fragmentation factor 40 mediates apoptotic DNA fragmentation in transient cerebral ischemia and in neuronal cultures. J. Neurosci. 21, 46,781-46,790.
44. Nagata, S. (2000). Apoptotic DNA fragmentation. Exp. Cell. Res. 256, 12-8.
45. Elkholi, R., Floros, K.V., and Chipuk, J.E. (2011). The role of BH3-only proteins in tumor cell development, signaling, and treatment. Genes Cancer 2, 523-537.
46. Taylor, R.C., Cullen, S.P., and Martin, S.J. (2008). Apoptosis: controlled demolition at cellular level. Nat. Rev. Mol. Cell. Biol. 9, 231-241.
47. Gustaffson, A.B., and Gottlieb, R.A. (2007). Bcl-2 family members and apoptosis, taken to heart. Am. J. Cell Physiol. 292, 45-51.
48. Hengartner, M.O. (2000). The biochemistry of apoptosis. Nature 407, 770-776.
49. Susin, S.A., Daugas, E., Ravagnan, L., Samejima, K., Zamzami, N., Loeffler, M., et al. (2000). Two distinct pathways leading to nuclear apoptosis. J. Exp. Med. 192, 571-580.
50. Zamzami, N., and Kroemer, G. (2005). p53 in apoptosis control: an introduction. Biochem. Biophys. Res. Commun. 331, 685-687.