Nucleotide excision repair factor XPC enhances DNA damage-induced apoptosis by downregulating the antiapoptotic short isoform of caspase-2

Cancer Research

Volumn 72, Issue 3, 2012, Pages 666-675

  Wang, Qi En ^a   Han, Chunhua ^a   Zhang, Bo ^a   Sabapathy, Kanaga ^c   Wani, Altaf A ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c DIVISION OF MEDICAL ONCOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 2 SHORT ISOFORM; CASPASE 6; CASPASE 9; CISPLATIN; ISOPROTEIN; MESSENGER RNA; PROTEIN P53; UNCLASSIFIED DRUG; XERODERMA PIGMENTOSUM GROUP C PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER RESISTANCE; CANCER SUSCEPTIBILITY; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; ENZYME ACTIVATION; EXCISION REPAIR; HUMAN; HUMAN CELL; MITOCHONDRIAL PERMEABILITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN TARGETING; RNA INTERFERENCE; TUMOR GROWTH; ULTRAVIOLET RADIATION; UPREGULATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 2; CASPASE 6; CASPASE 9; CELL LINE; CELL LINE, TUMOR; CISPLATIN; DNA DAMAGE; DNA-BINDING PROTEINS; DOWN-REGULATION; ENZYME ACTIVATION; FLOW CYTOMETRY; HCT116 CELLS; HUMANS; ISOENZYMES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 84863050847     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-11-2774     Document Type: Article

References (35)

1. Friedberg EC. DNA repair and mutagenesis. AVM Press: Washington; 1995.
2. Van Hoffen A, Natarajan AT, Mayne LV, Van Zeeland AA, Mullenders LHF, Venema J. Deficient repair of the transcribed strand of active genes in Cockayne's syndrome cells. Nucleic Acids Res 1993;21:5890-5. (Pubitemid 24023703)
3. Andera L, Wasylyk B. Transcription abnormalities potentiate apoptosis of normal human fibroblasts. Mol Med 1997;3:852-63. (Pubitemid 28086581)
4. Ljungman M, Zhang F. Blockage of RNA polymerase as a possible trigger for u.v. light-induced apoptosis. Oncogene 1996;13:823-31. (Pubitemid 26312910)
5. McKay BC, Ljungman M, Rainbow AJ. Persistent DNA damage induced by ultraviolet light inhibits p21waf1 and bax expression: implications for DNA repair, UV sensitivity and the induction of apoptosis. Oncogene 1998;17:545-55. (Pubitemid 28401023)
6. Furuta T, Ueda T, Aune G, Sarasin A, Kraemer KH, Pommier Y. Transcription-coupled nucleotide excision repair as a determinant of cisplatin sensitivity of human cells. Cancer Res 2002;62:4899-902. (Pubitemid 34984411)
7. McKay BC, Becerril C, Ljungman M. P53 plays a protective role against UV- and cisplatin-induced apoptosis in transcription-coupled repair proficient fibroblasts. Oncogene 2001;20:6805-8. (Pubitemid 33020609)
8. -/- keratinocyte cultures. DNA Repair (Amst) 2005;4:1337-44.
9. Batista LF, Kaina B, Meneghini R, Menck CF. How DNA lesions are turned into powerful killing structures: insights from UV-induced apoptosis. Mutat Res 2009;681:197-208.
10. Uchida A, Sugasawa K, Masutani C, Dohmae N, Araki M, Yokoi M, et al. The carboxy-terminal domain of the XPC protein plays a crucial role in nucleotide excision repair through interactions with transcription factor IIH. DNA Repair (Amst) 2002;1:449-61. (Pubitemid 34615695)
11. Araki M, Masutani C, Takemura M, Uchida A, Sugasawa K, Kondoh J, et al. Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair. J Biol Chem 2001;276:18665-72.
12. Nishi R, Okuda Y, Watanabe E, Mori T, Iwai S, Masutani C, et al. Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein. Mol Cell Biol 2005;25:5664-74. (Pubitemid 40853600)
13. Sugasawa K, Ng JMY, Masutani C, Iwai S, Van der Spek P, Eker A, et al. Xeroderma pigmentosum group C complex is the initiator of global genome nucleotide excision repair. Mol Cell 1998;2:223-32. (Pubitemid 128373647)
14. Le MN, Mota-Fernandes D, Velez-Cruz R, Iltis I, Biard D, Egly JM. NER factors are recruited to active promoters and facilitate chromatin modification for transcription in the absence of exogenous genotoxic attack. Mol Cell 2010;38:54-66.
15. Frechet M, Warrick E, Vioux C, Chevallier O, Spatz A, Benhamou S, et al. Overexpression of matrix metalloproteinase 1 in dermal fibroblasts from DNA repair-deficient/cancer-prone xeroderma pigmentosum group C patients. Oncogene 2008;27:5223-32.
16. Vakifahmetoglu-Norberg H, Zhivotovsky B. The unpredictable caspase-2: what can it do? Trends Cell Biol 2010;20:150-9.
17. Kumar S, Kinoshita M, Noda M, Copeland NG, Jenkins NA. Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1β-converting enzyme. Genes Dev 1994;8:1613-26. (Pubitemid 24236241)
18. Wang L, Miura M, Bergeron L, Zhu H, Yuan J. Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell 1994;78:739-50.
19. Wang QE, Milum K, Han C, Huang YW, Wani G, Thomale J, et al. Differential contributory roles of nucleotide excision and homologous recombination repair for enhancing cisplatin sensitivity in human ovarian cancer cells. Mol Cancer 2011;10:24.
20. Legerski R, Peterson C. Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C. Nature 1992;359:70-3.
21. Logette E, Wotawa A, Solier S, Desoche L, Solary E, Corcos L. The human caspase-2 gene: alternative promoters, pre-mRNA splicing and AUG usage direct isoform-specific expression. Oncogene 2003;22:935-46. (Pubitemid 36255829)
22. Toh WH, Logette E, Corcos L, Sabapathy K. TAp73beta and DNp73beta activate the expression of the pro-survival caspase-2S. Nucleic Acids Res 2008;36:4498-509.
23. Baptiste-Okoh N, Barsotti AM, Prives C. A role for caspase 2 and PIDD in the process of p53-mediated apoptosis. Proc Natl Acad Sci U S A 2008;105:1937-42. (Pubitemid 351439443)
24. Zhu Q, Wani G, Yao J, Patnaik S, Wang QE, El-Mahdy MA, et al. The ubiquitin-proteasome system regulates p53-mediated transcription at p21waf1 promoter. Oncogene 2007;26:4199-208. (Pubitemid 46975792)
25. Lassus P, Opitz-Araya X, Lazebnik Y. Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization. Science 2002;297:1352-4. (Pubitemid 34913174)
26. Kraemer KH, Lee MM, Scotto J. Xeroderma pigmentosum. Cutaneous, ocular, and neurologic abnormalities in 830 published cases. Arch Dermatol 1987;123:241-50. (Pubitemid 17002499)
27. Thielmann HW, Popanda O, Edler L, Jung EG. Clinical symptoms and DNA repair characteristics of xeroderma pigmentosum patients from Germany. Cancer Res 1991;51:3456-70.
28. Sands AT, Abuin A, Sanchez A, Conti CJ, Bradley A. High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC. Nature 1995;377:162-5.
29. Cheo DL, Burns DK, Meira LB, Houle JF, Friedberg EC. Mutational inactivation of the xeroderma pigmentosum group C gene confers predisposition to 2-acetylaminofluorene-induced liver and lung cancer and to spontaneous testicular cancer in Trp53-/- mice. Cancer Res 1999;59:771-5. (Pubitemid 29086724)
30. Hollander MC, Philburn RT, Patterson AD, Velasco-Miguel S, Friedberg EC, Linnoila RI, et al. Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis. Proc Natl Acad Sci U S A 2005;102:13200-5. (Pubitemid 41325001)
31. Despras E, Pfeiffer P, Salles B, Calsou P, Kuhfittig-Kulle S, Angulo JF, et al. Long-term XPC silencing reduces DNA double-strand break repair. Cancer Res 2007;67:2526-34. (Pubitemid 46548937)
32. Chen Z, Yang J, Wang G, Song B, Li J, Xu Z. Attenuated expression of xeroderma pigmentosum group C is associated with critical events in human bladder cancer carcinogenesis and progression. Cancer Res 2007;67:4578-85. (Pubitemid 46910162)
33. Lee JH, Sancar A. Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis. Proc Natl Acad Sci U S A 2011;108:10668-72.
34. Kitevska T, Spencer DM, Hawkins CJ. Caspase-2: controversial killer or checkpoint controller? Apoptosis 2009;14:829-48.
35. Droin N, Rebe C, Bichat F, Hammann A, Bertrand R, Solary E. Modulation of apoptosis by procaspase-2 short isoform: selective inhibition of chromatin condensation, apoptotic body formation and phosphatidylserine externalization. Oncogene 2001;20:260-9. (Pubitemid 32150271)