A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage

Cell Death and Differentiation

Volumn 21, Issue 5, 2014, Pages 748-760

  Brasacchio, D ^a,b   Noori, T ^a,b   House, C ^a,b   Brennan, A J ^a,b   Simpson, K J ^a,b   Susanto, O ^a,b,c   Bird, P I ^d   Johnstone, R W ^a,b   Trapani, J A ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b PETER MACCALLUM CANCER CENTRE   (Australia)

^c BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^d MONASH UNIVERSITY   (Australia)

Author keywords

ADA3; Bid; cell death; granzyme B; PCAF; perforin

Indexed keywords

ADAPTOR PROTEIN; CELL PROTEIN; CYTOCHROME C; GRANZYME B; HISTONE ACETYLTRANSFERASE PCAF; LENTIVIRUS VECTOR; MICRORNA; PERFORIN; PHOSPHOFURIN ACIDIC-CLUSTER SORTING PROTEIN 2; PROTEIN BID; SHORT HAIRPIN RNA; TRANSCRIPTIONAL ADAPTOR 3 PROTEIN; UNCLASSIFIED DRUG; BID PROTEIN, HUMAN; GRANZYME; P300-CBP-ASSOCIATED FACTOR; TADA3 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

APOPTOSIS; ARTICLE; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL SELECTION; CONTROLLED STUDY; EPIGENETIC REPRESSION; FEMALE; FUNCTIONAL GENOMICS; GENE EXPRESSION; GENE IDENTIFICATION; GENE SILENCING; GENE TARGETING; GENETIC SCREENING; GENETIC TRANSDUCTION; HELA CELL; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECTS; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; GENOMICS; HCT116 CELL LINE; HELA CELL LINE; METABOLISM; MITOCHONDRION; MOUSE; PHYSIOLOGY; PROCEDURES;

ANIMALS; APOPTOSIS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; GENOMICS; GRANZYMES; HCT116 CELLS; HELA CELLS; HUMANS; MICE; MITOCHONDRIA; P300-CBP TRANSCRIPTION FACTORS; PERFORIN; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 84898044534     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2013.203     Document Type: Article

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