From bench to humans: Formulation development of a poorly water soluble drug to mitigate food effect

AAPS PharmSciTech

Volumn 15, Issue 2, 2014, Pages 407-416

  Pandey, Preetanshu ^a   Hamey, Rhye ^a   Bindra, Dilbir S ^a   Huang, Zongyun ^a   Mathias, Neil ^a   Eley, Timothy ^b   Crison, John ^a   Yan, Brian ^a   Perrone, Robert ^a   Vemavarapu, Chandra ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b Translational Research   (United States)

Author keywords

bioavailability; food effect; in vivo in vitro models; vitamin E TPGS; wet granulation

Indexed keywords

LIPID; SURFACTANT; TOCOFERSOLAN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG GRANULATION; DRUG SOLUBILITY; EXPERIMENTAL DOG; FAT CONTENT; FOOD COMPOSITION; FOOD DRUG INTERACTION; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; TABLET FORMULATION; ANIMAL; DOG; MEDICINAL CHEMISTRY; SOLUBILITY;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; DOGS; FOOD-DRUG INTERACTIONS; HUMANS; SOLUBILITY;

EID: 84898040916     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-013-0069-4     Document Type: Article

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