Gastric bypass surgery may improve beta cell apoptosis with ghrelin overexpression in patients with BMI ≥ 32.5 kg/m2

Obesity Surgery

Volumn 24, Issue 4, 2014, Pages 561-571

  Yang, Jian ^a   Feng, Xiao ^a   Zhong, Shuzhe ^a   Wang, Yong ^a   Liu, Jingang ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Beta cells; Calcium homeostasis; Ghrelin; Glucose; Roux en Y gastric bypass (RYGB); Type 2 diabetes mellitus (T2DM); Cells

Indexed keywords

GHRELIN; GLUCOSE; LIPOCORTIN 5; OBESTATIN; INSULIN;

ADULT; APOPTOSIS; ARTICLE; BODY MASS; BYPASS SURGERY; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM MOBILIZATION; CELL CULTURE; CELL SURVIVAL; CELL VIABILITY; CHINESE; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISEASE DURATION; FEMALE; FLOW CYTOMETRY; GENE OVEREXPRESSION; HUMAN; HYPERGLYCEMIA; MALE; MTT ASSAY; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; POSTPRANDIAL STATE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; ROUX EN Y GASTRIC BYPASS SURGERY; STOMACH BYPASS; TRANSMISSION ELECTRON MICROSCOPY; BLOOD; METABOLISM; MIDDLE AGED; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY; POSTOPERATIVE PERIOD; SIGNAL TRANSDUCTION;

ADULT; APOPTOSIS; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; FEMALE; GASTRIC BYPASS; GHRELIN; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; MIDDLE AGED; OBESITY; POSTOPERATIVE PERIOD; SIGNAL TRANSDUCTION;

EID: 84898034851     PISSN: 09608923     EISSN: 17080428     Source Type: Journal    
DOI: 10.1007/s11695-013-1135-4     Document Type: Article

References (65)

1. IDF diabetes atlas. 5th ed. Brussels: International Diabetes Federation, 2011 (http://www.idf.org/diabetesatlas).
2. Yang W, Lu J, Weng J, et al. Prevalence of diabetes among men and women in China. N Engl J Med. 2010;362:1090-101.
3. Buchwald H, Estok R, Fahrbach K, et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med. 2009;122(3):248.e5-56.e5.
4. Buchwald H, Avidor Y, Braunwald E, Fahrbach K, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292:1724-37.
5. Rubino F. Is type 2 diabetes an operable intestinal disease? A provocative yet reasonable hypothesis. J Diabetes Care. 2008;31(2):290-96.
6. Yu H, Zheng X, Zhang Z. Mechanism of Roux-en-Y gastric bypass treatment for type 2 diabetes in rats. J Gastrointest Surg. 2013;17(6):1073-83.
7. Shak JR, Roper J, Perez-Perez GI, et al. The effect of laparoscopic gastric banding surgery on plasma levels of appetite-control, insulinotropic, and digestive hormones. Obes Surg. 2008;18:1089-96.
8. Martins C, Kjelstrup L, Ingrid L, et al. Impact of sustained weight loss achieved through Roux-en-Y gastric bypass or a lifestyle intervention on ghrelin, obestatin, and ghrelin/obestatin ratio in morbidly obese patients. Obes Surg. 2011;21(6):751-8.
9. Holdstock C, Engstrom BE, Ohrvall M, et al. Ghrelin and adipose tissue regulatory peptides: effect of gastric bypass surgery in obese humans. J Clin Endocrinol Metab. 2003;88:3177-83.
10. Faraj M, Havel PJ, Phélis S, et al. Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass surgery in morbidly obese subjects. J Clin Endocrinol Metab. 2003;88:1594-602.
11. Fruhbeck G, Rotellar F, Hernández-Lizoain JL, et al. Fasting plasma ghrelin concentrations 6 months after gastric bypass are not determined by weight loss or changes in insulinemia. Obes Surg. 2004;14:1208-15.
12. Cummings DE, Weigle DS, Frayo RS, et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med. 2002;346(21):1623-30.
13. Morinigo R, Casamitjana R, Moize V, et al. Short-term effects of gastric bypass surgery on circulating ghrelin levels. Obes Res. 2004;12:1108-16.
14. Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature. 1999;402:656-60.
15. Abizaid A, Horvath TL. Ghrelin and the central regulation of feeding and energy balance. Indian J Endocrinol Metab. 2012;16 Suppl 3:S617-26.
16. González-Jiménez E, Schmidt Río-Valle J. Regulation of dietary intake and energy balance: factors and mechanisms involved. Nutr Hosp. 2012;27(6):1850-9.
17. Damjanovic SS, Lalic NM, Pesko PM, et al. Acute effects of ghrelin on insulin secretion and glucose disposal rate in gastrectomized patients. J Clin Endocrinol Metab. 2006;91(7):2574-81.
18. Kim SW, Kim KW, Shin CS, et al. Acylated ghrelin secretion is acutely suppressed by oral glucose load or insulin-induced hypoglycemia independently of basal growth hormone secretion in humans. Horm Res. 2007;67(5):211-9.
19. Kishimoto I, Tokudome T, Hosoda H, et al. Ghrelin and cardiovascular diseases. J Cardiol. 2012;59(1):8-13.
20. Korbonits M, Goldstone AP, Gueorguiev M, et al. Ghrelin - a hormone with multiple functions. Front Neuroendocrinol. 2004;25(1):27-68.
21. Soares JB, Leite-Moreira AF. Ghrelin, des-acyl ghrelin and obestatin: three pieces of the same puzzle. Peptides. 2008;29(7):1255-70.
22. Granata R, Baragli A, Settanni F, et al. Unraveling the role of the ghrelin gene peptides in the endocrine pancreas. J Mol Endocrinol. 2010;45(3):107-18.
23. Granata R, Isgaard J, Alloatti G, et al. Cardiovascular actions of the ghrelin gene-derived peptides and growth hormone-releasing hormone. Exp Biol Med (Maywood). 2011;236(5):505-14.
24. Holst B, Egerod KJ, et al. G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction. Endocrinology. 2009;150(6):2577-85.
25. Fujimiya M, Asakawa A, Ataka K, et al. Ghrelin, des-acyl ghrelin, and obestatin: regulatory roles on the gastrointestinal motility. Int J Pept. 2010;2010:305192.
26. Chanclón B, Luque RM, Córdoba-Chacón J, et al. Role of endogenous cortistatin in the regulation of ghrelin system expression at pancreatic level under normal and obese conditions. PLoS One. 2013;8(2):e57834.
27. Salehi A, Dornonville de la Cour C, Håkanson R, et al. Effects of ghrelin on insulin and glucagon secretion: a study of isolated pancreatic islets and intact mice. Regul Pept. 2004;118(3):143-50.
28. Peng Z, Xiaolei Z, Al-Sanaban H, et al. Ghrelin inhibits insulin release by regulating the expression of inwardly rectifying potassium channel 6.2 in islets. Am J Med Sci. 2012;343(3):215-9.
29. Cummings DE. Endocrine mechanisms mediating remission of diabetes after gastric bypass surgery. Int J Obes (Lond). 2009;33 Suppl 1:S33-40.
30. Merglen A, Theander S, Rubi B, et al. Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells. Endocrinology. 2004;145:667-78.
31. Asfari M, Janjic D, Meda P, et al. Establishment of 2-mercaptoethanol dependent differentiated insulin-secreting cell lines. Endocrinology. 1992;130:167-78.
32. Buse JB, Caprio S, Cefalu WT, et al. How do we define cure of diabetes? Diabetes Care. 2009;32:2133-5.
33. Pournaras DJ, Glicksman C, Vincent RP, et al. The role of bile after Roux-en-Y gastric bypass in promoting weight loss and improving glycaemic control. Endocrinology. 2012;153(8):3613-9.
34. 2. J Obes. 2012;2012:147256.
35. Schernthaner G, Brix JM, Kopp HP, et al. Cure of type 2 diabetes by metabolic surgery? A critical analysis of the evidence in 2010. Diabetes Care. 2011;34 Suppl 2:S355-60.
36. Oliván B, Teixeira J, Bose M, et al. Effect of weight loss by diet or gastric bypass surgery on peptide YY3-36 levels. Ann Surg. 2009;249(6):948-53.
37. Kelishadi R, Hashemipour M, Mohammadifard N, et al. Short- and long-term relationships of serum ghrelin with changes in body composition and the metabolic syndrome in prepubescent obese children following two different weight loss programmes. Clin Endocrinol. 2008;69(5):721-9.
38. Fruhbeck G, Diez-Caballero A, Gil M, et al. The decrease in plasma ghrelin concentrations following bariatric surgery depends on the functional integrity of the fundus. Obes Surg. 2004;14:606-12.
39. Ariyasu H, Takaya K, Tagami T, et al. Stomach is a major source of circulating ghrelin, and feeding determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab. 2001;86:4753-8.
40. Pournaras DJ, Carel W. Ghrelin and metabolic surgery. Int J Pept. 2010;2010:217267.
41. Akamizu T, Kangawa K. The physiological significance and potential clinical applications of ghrelin. Eur J Intern Med. 2012;23:197-202.
42. Moran TH, Dailey MJ. Intestinal feedback signaling and satiety. Physiol Behav. 2011;105(1):77-81.
43. Patriti A, Facchiano E, Gullà N, et al. Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann Surg. 2007;245(1):157-8.
44. Borg CM, le Roux CW, Ghatei MA, et al. Progressive rise in gut hormone levels after Roux-en-Y gastric bypass suggests gut adaptation and explains altered satiety. Br J Surg. 2006;93(2):210-5.
45. Zorrilla EP, Iwasaki S, Moss JA, et al. Vaccination against weight gain. Proc Natl Acad Sci U S A. 2006;103(35):13226-31.
46. Wiedmer P, Nogueiras R, Broglio F, et al. Ghrelin, obesity and diabetes. Nat Clin Pract Endocrinol Metab. 2007;3(10):705-12. Review.
47. Favaro E, Granata R, Miceli I, et al. The ghrelin gene products and exendin-4 promote survival of human pancreatic islet endothelial cells in hyperglycaemic conditions, through phosphoinositide 3-kinase/Akt, extracellular signal-related kinase (ERK)1/2 and cAMP/protein kinase A (PKA) signalling pathways. Diabetologia. 2012;55(4):1058-70.
48. Wang W, Zhang D, Zhao H, et al. Ghrelin inhibits cell apoptosis induced by lipotoxicity in pancreatic beta-cell line. Regul Pept. 2010;161(1-3):43-50.
49. Cai L, Li W, Wang G, et al. Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome c-mediated caspase-3 activation pathway. Diabetes. 2002;51:1938-48.
50. 2+ cycling proteins, NADPH oxidase, poly(ADP-Ribose) polymerase and myosin heavy chain isozyme. Free Radic Biol Med. 2006;40:1419-29.
51. Li J, Wang P, Yu S, et al. Calcium entry mediates hyperglycemia-induced apoptosis through Ca2+/calmodulin-dependent kinase II in retinal capillary endothelial cells. Mol Vis. 2012;18:2371-9.
52. 2+ signaling and gene transcription in glucose-stimulated insulinoma cells. Cell Calcium. 2012;52(2):137-51.
53. Younce CW, Burmeister MA, Ayala JE. Exendin-4 attenuates high glucose-induced cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and activation of SERCA2a. Am J Physiol Cell Physiol. 2013;304(6):C508-18.
54. 2+ homeostasis. Diabetes Obes Metab. 2012;14(3):136-42.
55. 2+ and apoptosis. Cell Calcium. 2012;52(1):36-43.
56. Xu G, Chen J, Jing G, Shalev A. Preventing β-cell loss and diabetes with calcium channel blockers. Diabetes. 2012;61(4):848-56.
57. Rudijanto A. Calcium channel blocker (diltiazem) inhibits apoptosis of vascular smooth muscle cell exposed to high glucose concentration through lectin-like oxidized low density lipoprotein receptor-1 (LOX-1) pathway. Acta Med Indones. 2010;42(2):59-65.
58. Wang Y, Gao L, Li Y, Sun Z, et al. Nifedipine protects INS-1 β-cell from high glucose-induced ER stress and apoptosis. Int J Mol Sci. 2011;12(11):7569-80.
59. Giorgi C, Baldassari F, Bononi A. Mitochondrial Ca(2+) and apoptosis. Cell Calcium. 2012;52(1):36-43.
60. Giorgi C, Agnoletto C, Bononi A, et al. Mitochondrial calcium homeostasis as potential target for mitochondrial medicine. Mitochondrion. 2012;12(1):77-85.
61. Wang Y, Nishi M, Doi A, et al. Ghrelin inhibits insulin secretion through the AMPK-UCP2 pathway in beta cells. FEBS Lett. 2010;584(8):1503-8.
62. Buschard K, Hy M, Bokvist K, et al. Sulfatide controls insulin secretion by modulation of ATP-sensitive K(+)-channel activity and Ca(2+)-dependent exocytosis in rat pancreatic beta-cells. Diabetes. 2002;51:2514-21.
63. Zhang CY, Baffy G, Perret P, et al. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell. 2001;105:745-55.
64. Lee SH, Lee HY, Kim SY, et al. Enhancing effect of taurine on glucose response in UCP2-overexpressing beta cells. Diabetes Res Clin Pract. 2004;66 Suppl 1:S69-74.
65. Ma X, Lin Y, Lin L, et al. Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice. Am J Physiol Endocrinol Metab. 2012;303(3):E422-31.