Acute effects of ghrelin on insulin secretion and glucose disposal rate in gastrectomized patients

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 7, 2006, Pages 2574-2581

  Damjanovic, Svetozar S ^a,b   Lalic, Nebojsa M ^a   Pesko, Predrag M ^a   Petakov, Milan S ^a   Jotic, Aleksandra ^a   Miljic, Dragana ^a   Lalic, Katarina S ^a   Lukic, Ljiljana ^a   Djurovic, Marina ^a   Djukic, Vojko B ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b Institute of Endocrinology Diabetes and Diseases of Metabolism   (Yugoslavia)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; C PEPTIDE; FATTY ACID; GHRELIN; GLUCAGON; GLUCOSE; GROWTH HORMONE; HYDROCORTISONE; LEPTIN; SODIUM CHLORIDE; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG INFUSION; FATTY ACID BLOOD LEVEL; FEMALE; GASTRECTOMY; GLUCAGON BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; HOSPITAL BASED CASE CONTROL STUDY; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPERINSULINEMIA; INSULIN RELEASE; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; VAGOTOMY;

ADIPONECTIN; ADULT; BLOOD GLUCOSE; BODY MASS INDEX; C-PEPTIDE; DOUBLE-BLIND METHOD; FATTY ACIDS, NONESTERIFIED; FEMALE; GASTRECTOMY; GLUCAGON; GLUCOSE CLAMP TECHNIQUE; HUMAN GROWTH HORMONE; HUMANS; HYDROCORTISONE; INSULIN; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; KINETICS; LEPTIN; MALE; MIDDLE AGED; PEPTIDE HORMONES; PLACEBOS;

EID: 33745790094     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2005-1482     Document Type: Article

References (53)

1. Tschop M, Smiley DL, Heiman ML 2000 Ghrelin induces adiposity in rodents. Nature 407:908-913
2. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S 2001Arole for ghrelin in the central regulation of feeding. Nature 409:194-198
3. Horvath TL, Diano S, Sotonyi P, Heiman M, Tschop M 2001 Ghrelin and the regulation of energy balance: a hypothalamic perspective. Endocrinology 142:4163-4169
4. Ukkola O, Poykko S 2002 Ghrelin, growth and obesity. Ann Med 34:102-108
5. Gnanapavan S, Kola B, Bustin SA, Morris DG, McGee P, Fairclough P, Bhattacharyia S, Carpenter R, Grossman AB, Kobornits M 2002 The tissue distribution of the mRNA of ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 87:2988-2991
6. Sudo T, Ishiyama K, Takemoto M, Kawamura M, Umemuar H, Shiraha S, Kuyama T, Suzuki T, Tobe T 1982 Pancreatic endocrine function after total gastrectomy and truncal vagotomy. Am J Surg 144:539-544
7. Salehi A, Chen D, Håkanson R, Nordin G, Lundqist I 1999 Gastrectomy induces impaired insulin and glucagon secretion: evidence for a gastro-insular axis in mice. J Physiol 514:579-591
8. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660
9. Ariyasu H, Takaya K, Tagami T, Ogawa Y, Hosoda K, Akamizu T, Suda M, Koh T, Natsui K, Toyooka S, Shirakami G, Usui T, Shimatsu A, Doi K, Hosoda H, Kojima M, Kangawa K, Nakao K 2001 Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab 86:4753-4758
10. Shiiya T, Nakazato M, Mizuta M, Date Y, Mondal MS, Tanaka M, Nozoe S-I, Hosoda H, Kangawa K, Matsukura S 2002 Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab 87:240-244
11. Nakagawa E, Nagaya N, Okumura H, Enomoto M, Oya H, Ono F, Hosoda H, Kojima M, Kangawa K 2002 Hyperglycemia suppresses the secretion of ghrelin, a novel growth-hormone-releasing peptide: responses to the intravenous and oral administration of glucose. Clin Sci (Lond) 103:325-328
12. Date Y, Nakazato M, Hashiguchi S, Dezaki K, Mondal MS, Hosoda H, Mojima M, Kangawa K, Arima T, Matsuo H, Yada T, Matsukura S 2002 Ghrelin is present in pancreatic α-cells of humans and rats, and stimulates insulin secretion. Diabetes 51:124-129
13. Adeghate E, Ponery AS 2002 Ghrelin stimulates insulin secretion from the rat pancreas of normal and diabetic rats. J Neuroendocrinol 14:555-560
14. Egido EM, Rodriguez-Gallardo J, Silvestre RA, Marco J 2002 Inhibitory effect of ghrelin on insulin and pancreatic somatostatin secretion. Eur J Endocrinol 146:241-244
15. Broglio F, Arvat E, Benso A, Gottero C, Muccioli G, Papotti M, Van Der Lely AJ, Deghenghi R, Ghigo E 2001 Ghrelin, a natural GH secretagogue produced by stomach, induces hyperglycemia and reduces insulin secretion in humans. J Clin Endocrinol Metab 86:5083-5086
16. Broglio F, Gottero C, Prodam F, Gauna C, Muccioli G, Papotti M, Abribat AJ, Van Der Lely AJ, Ghigo E 2004 Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans. J Clin Endocrinol Metab 89:3062-3065
17. Flanagan DE, Evans ML, Monsod TP, Rife F, Heptulla RA, Tamborlane WV, Shervin R 2001 The influence of insulin on circulating ghrelin. Am J Physiol Endocrinol Metab 284:E313-E316
18. Saad MF, Bemaba B, Hwu CM, Jinagouda S, Fahmi S, Kogosov E, Boyadjian R 2002 Insulin regulates plasma ghrelin concentration. J Clin Endocrinol Metab 87:3997-4000
19. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR 2001 Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86:5992-5995
20. Itaya K, Michio U 1965 Colorimetric determination of free fatty acids in biological fluids. J Lipid Res 6:16-20
21. DeFronzo RA, Tobin JD, Andres R 1979 Glucose clamp technique: a method for quantifying insulin secretion and sensitivity. Am J Physiol Endocrinol Metab Gastrointest Physiol 237:E214-E223
22. Deibert DC, DeFronzo RA 1980 Epinephrine-induced resistance in man. J Clin Invest 65:717-721
23. Engström BE, Burman P, Holdstock C, Karlsson FA 2003 Effects of growth hormone (GH) on ghrelin, leptin and adiponectin in GH-deficient patients. J Clin Endocrinol Metab 88:5193-5198
24. Nordback I, Harju E 1991 Immediate effect of vagotomy on pancreatic insulin secretion. Gut 32:303-305
25. Nagaya N, Kojima M, Uematsu M, Yamagishi M, Hosoda H, Oya H, Hayashi Y, Kangawa K 2001 Hemodynamic and hormonal effects of human ghrelin in healthy volunteers. Am J Physiol Integr Comp Physiol 280:R1483-R1487
26. Matsumura K, Tsuchihashi T, Fujii K, Abe I, Iida M 2002 Central ghrelin modulates sympathetic activity in conscious rabbits. Hypertension 40:694-699
27. Matsumura K, Tsuchihashi T, Fujii K, Iida M 2003 Neural regulation of blood pressure by leptin and related peptides. Regul Pept 114:79-86
28. Yasuda T, Masaki T, Kakuma H, Yoshimatsu H 2003 Centrally administered ghrelin suppresses sympathetic nerve activity in brown adipose tissue of rats. Neurosci Lett 349:75-78
29. Okumura H, Nagaya N, Enomoto M, Nakagawa E, Oya H, Kangawa K 2002 Vasodilatory effect of ghrelin, an endogenous peptide from stomach. J Cardiovasc Pharmacol 39:779-783
30. Salehi A, de la Cour CD, Håkanson R, Lundquist I 2004 Effects of ghrelin on insulin and glucagon secretion: a study of isolated pancreatic islets and intact mice. Regul Pept 118:143-150
31. Gustavson SM, Chu CA, Nishizawa M, Farmer B, Neal D, Yang Y, Donahue P, Flakoll P, Cherrington AD 2003 Interaction of glucagon and epinephrine in the control of hepatic glucose production in the conscious dog. Am J Physiol Endocrinol Metab 284:E695-E707
32. Murata M, Okimura Y, Iida K, Matsumoto M, Sowa H, Kaji H, Kojima M, Kangawa K, Chihara K 2002 Ghrelin modulates the downstream of insulin signaling in hepatoma cells. J Biol Chem 277:5667-5674
33. Muller AF, Janssen JA, Hofland LJ, Lamberts SW, Bidlingmaier M, Strasburger CJ, van der Lely AJ 2001 Blockade of the growth hormone (GH) receptor unmasks rapid GH-releasing peptide-6-mediated tissue-specific insulin resistance. J Clin Endocrinol Metab 86:590-593
34. Hotta K, Funahashi T, Bodkin NL, Ortmeyer HK, Arita Y, Hansen BC, Matsuzawa Y 2001 Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50:1126-1133
35. Stefan N, Vozarova B, Funahashi T, Matsuzawa Y, Weyer C, Lindsay RS, Youngren JF, Havel PJ, Pratley RE, Bogardus C, Tataranni PA 2002 Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans. Diabetes 51:1884-1888
36. Tschritter O, Fritsche A, Thamer C, Haap M, Shirkavand F, Rahe S, Staiger H, Maerker A, Häring H, Stumvoll M 2003 Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism. Diabetes 52:239-249
37. Kolaczynski JW, Nyce MR, Considine RV, Boden G, Nolan JJ, Henry R, Mudaliar SR, Olefsky J, Caro JF 1996 Acute and chronic effects of insulin on leptin production in humans: studies in vivo and in vitro. Diabetes 45:699-701
38. Saad MF, Khan A, Sharma A, Michael R, Riad-Gabriel M, Boyadjian R, Jinagouda SD, Steil GM, Kamdar V 1998 Physiological insulinemia acutely modulates plasma leptin. Diabetes 47:544-549
39. Pöykkö SM, Kellokoski E, Hörkkö S, Kauma H, Kesäniemi YA, Ukkola O 2003 Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes. Diabetes 52:2546-2553
40. Purnell JQ, Wiegle DS, Breen P, Cummings DE 2003 Ghrelin correlate with insulin levels, insulin resistance, and high-density lipoprotein cholesterol, but not with gender, menopausal status, or cortisol levels in humans. J Clin Endocrinol Metab 88:5747-5752
41. Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, Tataranni PA 2001 Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86:1930-1935
42. Kern PA, Di Gregorio GB, Lu T, Rassuoli N, Ranganathan G 2003 Adiponectin expression from human adipose tissue: relation to obesity, insulin resistance, and tumor necrosis factor-α expression. Diabetes 52:1779-1785
43. Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, Mori K, Komatsu Y, Usui T, Shimatsu A, Ogawa Y, Hosoda K, Akamizu T, Kojima M, Kangawa K, Nakao K 2000 Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab 85:4908-4911
44. Fineberg SE, Merimee TJ 1974 Acute effects of human growth hormone. Diabetes 23:499-504
45. Bratush-Marrian PR, Smith D, DeFronzo RA 1992 The effect of growth hormone on glucose metabolism and insulin secretion in man. Diabetologia 21:387-393
46. O'Neal DN, Kalfas A, Dunning PL, Christopher MJ, Sawyer SD, Ward GM, Alford FP 1994 The effect of 3 months of recombinant human growth hormone (GH) on insulin and glucose-mediated glucose disposal and insulin secretion in GH-deficient adults: a minimal model analysis. J Clin Endocrinol Metab 79:975-983
47. Foss MC, Saad MJA, Paccola GM, Paula FJ, Piccinato CE, Moriera AC 1991 Peripheral glucose metabolism in acromegaly. J Clin Endocrinol Metab 72:1048-1053
48. Hansen I, Tsalikian E, Beaufrere B, Gerich J, Haymond M, Rizza R 1986 Insulin resistance in acromegaly: defects in both hepatic and extrahepatic insulin action. Am J Physiol 250:E269-E273
49. Beard JC, Halter JB, Best JD, Pfeiffer MA, Porte Jr D 1984 Dexamethasone-induced insulin resistance enhances B cell responsiveness to glucose level in normal men. Am J Physiol 247:E592-E596
50. Rebuffe-Scrive M, Krotkiewski M, Elfverson J, Björntorp P 1988 Muscle and adipose tissue morphology and metabolism in Cushing's syndrome. J Clin Endocrinol Metab 67:1122-1128
51. Widjaja A, Schürmeyer TH, Von Zur Mühlen A, Brabant G 1998 Determinants of serum leptin levels in Cushing's syndrome. J Clin Endocrinol Metab 83:600-603
52. Popovic V, Miljic D, Pekic S, Pesko P, Djurovic M, Doknic M, Damjanovic S, Micic D, Cvijovic G, Glodic J, Dieguez C, Casanueva FF 2005 Low plasma ghrelin level in gastrectomized patients is accompanied by enhanced sensitivity to the ghrelin-induced growth hormone release. J Clin Endocrinol Metab 90:2187-2191
53. Grinspoon S, Miller KK, Herzog DB, Grieco KA, Klibanski A 2004 Effects of estrogen and recombinant human insulin-like growth factor-I on ghrelin secretion in severe undernutrition. J Clin Endocrinol Metab 89:3988-3993