Cleavable carbamate linkers for controlled protein delivery from hydrogels

Journal of Controlled Release

Volumn 183, Issue 1, 2014, Pages 67-76

  Hammer, Nadine ^a   Brandl, Ferdinand P ^a,b   Kirchhof, Susanne ^a   Goepferich, Achim M ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Cleavable linker; Hydrogel; Keywords; Poly(ethylene glycol); Protein tethering; Release; Reversible PEGylation

Indexed keywords

CHAINS; CIRCULAR DICHROISM SPECTROSCOPY; ELECTROPHORESIS; ENZYMES; POLYETHYLENE GLYCOLS; PROTEINS; SODIUM DODECYL SULFATE;

CLEAVABLE LINKER; KEYWORDS; PEGYLATION; PROTEIN DELIVERY; PROTEIN PEGYLATION; RELEASE; SECONDARY PROTEIN STRUCTURE; SODIUM DODECYL SULFATE-POLYACRYLAMIDE GEL ELECTROPHORESIS;

HYDROGELS;

CARBAMIC ACID; LYSOZYME; MACROGOL; PHENYL GROUP; CARBAMIC ACID DERIVATIVE; DRUG CARRIER; HYDROGEL; MACROGOL DERIVATIVE;

ARTICLE; CHEMICAL STRUCTURE; CIRCULAR DICHROISM; CONTROLLED STUDY; CYCLOADDITION; ELIMINATION REACTION; ENZYME ACTIVITY; ENZYME IMMOBILIZATION; HYDROGEL; HYDROLYSIS; LYSIS; MOLECULE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN SECRETION; PROTON NUCLEAR MAGNETIC RESONANCE; CHEMISTRY; DRUG RELEASE; SYNTHESIS; TIME;

CARBAMATES; CIRCULAR DICHROISM; DRUG CARRIERS; DRUG LIBERATION; HYDROGELS; MOLECULAR STRUCTURE; MURAMIDASE; POLYETHYLENE GLYCOLS; PROTEIN STRUCTURE, SECONDARY; TIME FACTORS;

EID: 84898024112     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.03.031     Document Type: Article

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