Controlled release of proteins from their poly(ethylene glycol) conjugates: Drug delivery systems employing 1,6-elimination

Bioconjugate Chemistry

Volumn 14, Issue 2, 2003, Pages 395-403

  Greenwald, Richard B ^a   Yang, Karen ^a   Zhao, Hong ^a   Conover, Charles D ^a   Lee, Stanford ^a   Filpula, David ^a  

^a Enzon Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONTROLLED DRUG DELIVERY; PROTEINS; RATS; TARGETED DRUG DELIVERY;

CONTROLLED RELEASE; CYCLIZATIONS; DRUG-DELIVERY SYSTEMS; HALF LIVES; IN-VIVO; NATIVE PROTEINS; PRODRUGS; PROTEIN CONJUGATES; RAT PLASMA; STERIC HINDRANCES;

POLYETHYLENE GLYCOLS;

GREEN FLUORESCENT PROTEIN; INTERLEUKIN 2; LYSOZYME; MACROGOL; MACROGOL INTERLEUKIN 2 COMPLEX; POLYMER; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CYCLIZATION; DRUG DELIVERY SYSTEM; MOUSE; NONHUMAN; PLASMA; RAT;

ANIMALIA;

EID: 0037347155     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc025652m     Document Type: Article

References (11)

1. Lee, S., Greenwald, R. B., McGuire, J., Yang, K., and Shi, C. (2001) Drug Delivery Systems Employing 1,6-Elimination: Releasable Poly(ethylene glycol) Conjugates of Proteins. Bioconjugate Chem. 12, 163-169.
2. Carl, P. L., Chakravarty, P. K., and Katzenellenbogen, J. A. (1981)A Novel Connector Linkage Applicable in Prodrug Design. J. Med. Chem. 24, 479-480.
3. Miron, T., and Wilchek, M. (1993) Simplified Method for the Preparation of Succinimidyl Carbonate Polyethylene Glycol for Coupling to Proteins. Bioconjugate Chem. 4, 568-569.
4. Greenwald, R. B., Pendri, A., Martinez, A., Gilbert, C., and Bradley, P. (1996) PEG Thiazolidine-2-thione, a Novel Reagent for Facile Protein Modification of Bovine Hemoglobin. Bioconjugate Chem. 7, 638-641.
5. Greenwald, R. B., Pendri, A., Conover, C. D., Zhao, H., Choe, Y. H., Martinez, A., Shum, K., and Guan, S. (1999) Drug Delivery Systems Employing 1,4- or 1,6-Elimination: Poly (ethylene glycol) Prodrugs of Amine-Containing Compounds. J. Med. Chem. 42, 3657-3667.
6. See Greenwald, R. B., Pendri, A., Conover, C. D., Lee, C., Choe, Y. H., Gilbert, C., Martinez, A., Xia, J., Wu, D., and Hsue, M. (1998) Camptothecin-20-PEG Ester Transport Forms: The Effect of Spacer Groups on Antitumor Activity. Bioorg. Med. Chem. 6, 551-562, and references cited for other examples of anchimeric assistance.
7. Cremin, D. J., and Hegarty, A. F. (1977) Amide Group Catalysis of Ester Hydrolysis Tetrahedron 33, 1823-1826.
8. Conover, C. D., Zhao, H., Longley, C. B., Shum, K. L., and Greenwald, R. B. (2003) Bioconjugate Chem., in press.
9. Stocks, S. J., Jones, A. J. M., Ramey, C. W., and Brooks, D. E. (1986) A Flourometric Assay of the Degree of Modification of Protein Primary Amines with Polyethylene Glycol. Anal. Anal. Biochem. 154, 232-234.
10. Tsien, R. Y. (1998) The Green Fluorescent Protein. Annu. Rev. Biochem. 67, 509-544.
11. Harris, J. M., Martin, N. E., and Modi, M. (2001) Pegylation: A Novel Process for Modifying Pharmacokinetics. Clin. Pharmacokinet. 40, 539-551.