Drug delivery systems employing 1,6-elimination: Releasable poly(ethylene glycol) conjugates of proteins

Bioconjugate Chemistry

Volumn 12, Issue 2, 2001, Pages 163-169

  Lee, S ^a   Greenwald, R B ^a   McGuire, J ^a   Yang, K ^a   Shi, C ^a  

^a Enzon Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CONTROLLED DRUG DELIVERY; ENZYMES; TARGETED DRUG DELIVERY;

AMINO GROUP; DRUG-DELIVERY SYSTEMS; ENZYMATIC ACTIVITIES; HIGH PH; LYSINE RESIDUES; NATIVE PROTEINS; PEGYLATION; PH BUFFERS; PROTEIN SUBSTRATE; RAT PLASMA;

POLYETHYLENE GLYCOLS;

ANIMALIA; GALLUS GALLUS;

EID: 0035082444     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc000064z     Document Type: Article

References (28)

1. The conjugation of proteins with polyethylene glycol and other polymers: Altering properties of proteins to enhance their therapeutic potential
2. Review: Poly(ethylene glycols)s with reactive endgroups. II. Practical consideration for the preparation of protein-PEG conjugates
3. Prolonged circulating lives of single-chain Fv proteins conjugated with polyethylene glycol: A comparison of conjugation chemistries of conjugation chemistries and compounds
4. Preparation of long acting superoxide dismutase using high molecular weight polyethylene glycol (41,000-72,000 Daltons)
5. Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers
6. Intramolecular catalysis of amide hydrolysis by the carboxy group. Rate determining proton transfers from external general acids in the hydrolysis substituted maleomic acids
7. Carboxylic acid participation in amide hydrolysis. Reactivity of intermediates in the internally catalyzed hydrolysis of N-substituted 2,3-dimethylmaleomic acids
8. Reversible blocking of amino groups with citraconic anhydride
9. Ready separation of proteins from nucleoprotein complexes by reversible modification of lysine residues
10. Reaction of proteins with citraconic anhydride
11. Effects of temperature and pH on the regeneration of the amino groups of ovalbumin after modification with citraconic and dimethylmaleic anhydrides
12. Enzymic and immunochemical properties of lysozyme. Evaluation of several amino group reversible blocking reagents
13. The preparation and properties of novel reversible polymer-protein conjugates. 2-ω-methoxypolyethylene (5000) glycoxymethylene-3-methylmaleyl conjugates of plasminogen activators
14. Protected thiol-polyethylene glycosyl: A new activated polymer for reversible protein modification
15. Attachment of degradable poly(ethylene glycol) to proteins has the potential to increase therapeutic efficacy
16. A hydrolyzable linkage for PEG-proteins
17. Phenyl carbamates of amino acids as prodrug forms for protecting phenols against first-pass metabolism
18. Drug delivery systems employing 1,4- or 1,6-elimination: Poly(ethylene glycol) prodrugs of amine-containing compounds
19. Chemoenzymatic synthesis of N-Ras lipopeptides
20. A simplified method for the preparation of succinimidyl carbonate polyethylene glycol for coupling to proteins
21. Peptide mapping of complex proteins at the low-picomole level with capillary electrophoretic separations
22. Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol
23. Situation of monomethoxypolyethylene glycol covalently attached to lysozyme
24. Lysozymes' esterase activity
25. PEG thiazolidine-2-thione, a novel reagent for facile protein modification: Conjugation of bovine hemoglobin
26. Drug delivery systems based on trimethyl lock lactonization: Poly(ethylene glycol) prodrugs of amino-containing compounds
27. Ehanced antitumor potency of polyethylene glycolylated tumor necrosis factor-α: A novel polymer-conjugation technique with a reversible amino-protective reagent