The effect of the linker on the hydrolysis rate of drug-linked ester bonds

Journal of Controlled Release

Volumn 95, Issue 2, 2004, Pages 291-300

  Schoenmakers, Ronald G ^a   Van De Wetering, Petra ^a   Elbert, Donald L ^b   Hubbell, Jeffrey A ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b WASHINGTON UNIVERSITY IN ST LOUIS   (United States)

Author keywords

Conjugate addition; Drug release; Hydrogels; Poly(ethylene glycol); Prodrugs

Indexed keywords

ADDITION REACTIONS; CHEMICAL BONDS; ESTERS; HYDROGELS; HYDROLYSIS; PHOTOPOLYMERIZATION; POLYETHYLENE GLYCOLS; SYNTHESIS (CHEMICAL);

CONJUGATION METHODS; MACROMONOMERS;

DRUG PRODUCTS;

3 BENZOYLAMINO 2 HYDROXYLAMINO 2 HYDROXY 3 PHENYLPROPIONIC ACID; 3 BENZOYLAMINO 3 PHENYL 2 (3 SULFANYLPROPIONYLOXY)PROPIONIC ACID METHYL ESTER; 3 BENZOYLAMINO 3 PHENYL 2 (3 TRITYLSULFANYLPROPIONYLOXY)PROPIONIC ACID METHYL ESTER; 3 BENZOYLAMINO 3 PHENYL 2 (4 SULFANYLBUTYRYLOXY)PROPIONIC ACID METHYL ESTER; 3 BENZOYLAMINO 3 PHENYL 2 (4 TRITYLSULFANYLBUTYRYLOXY)PROPIONIC ACID METHYL ESTER; ACRYLAMIDE; ANTINEOPLASTIC AGENT; ESTER DERIVATIVE; MACROGOL; MONOMER; PACLITAXEL; POLYMER; THIOL; UNCLASSIFIED DRUG;

ADDITION REACTION; ARTICLE; DRUG CONJUGATION; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG RELEASE; DRUG SYNTHESIS; HYDROGEL; POLYMERIZATION; PRIORITY JOURNAL;

EID: 1242293727     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2003.12.009     Document Type: Article

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