Sustained and controlled release of daunomycin from cross-linked poly(aldehyde guluronate) hydrogels

Journal of Pharmaceutical Sciences

Volumn 89, Issue 7, 2000, Pages 910-919

  Bouhadir, Kamal H ^a   Kruger, Geneveive M ^a   Lee, Kuen Yong ^a   Mooney, David J ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Controlled delivery; Covalent cross linking; Daunomycin; Hydrzogel; Poly(aldehyde guluronate)

Indexed keywords

DAUNORUBICIN; POLY(ALDEHYDE GULURONATE); POLYMER; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; CROSS LINKING; CYTOTOXICITY; DRUG DETERMINATION; HUMAN; HUMAN CELL; HYDROGEL; SUSTAINED DRUG RELEASE; SYNTHESIS;

EID: 0033818722     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/1520-6017(200007)89:7<910::aid-jps8>3.0.co;2-%23     Document Type: Article

References (40)

1. Toxicity of chemotherapy
2. Carcinogenic effects of chemotherapeutic compounds
3. Solid tumor-chemotherapy using implantable collagenpoly(HEMA) hydrogel containing 5-fluorouracil
4. Immobilization of L-asparaginase into a biocompatible poly(ethylene glycol)-albumin hydrogel. 1. Preparation and in vitro characterization
5. Polymer conjugates with anticancer activity
6. Characterization of physical entrapment and chemical conjugation of adriamycin in polymeric micelles and their design for in vivo delivery to a solid tumor
7. Electrochemotherapy: An emerging drug delivery method for the treatment of cancer
8. Enhanced tumor accumulation and prolonged circulation times of micelleforming poly(ethylene oxide-aspartate) block copolymer-adriamycin conjugates
9. Niosomes containing N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin (PK1): Effect of method of preparation and choice of surfactant on niosome characteristics and a preliminary study of body distribution
10. Transferrin conjugates of doxorubicin: Synthesis, characterization, cellular uptake, and in vitro efficacy
11. Cytotoxic and cytostatic effects of anti-Thy 1.2 targeted doxorubicin and cyclosporin A
12. Functionalized derivatives of hyaluronic acid oligosaccharides: Drug carriers and novel biomaterials
13. Biodegradable block copolymers as injectable drug delivery systems
14. Macroporous poly(sucrose acrylate) hydrogel for controlled release of macromolecules
15. Hydrogel systems for barriers and local drug delivery in the control of wound healing
16. Hydrophobically-modified bioadhesive poly-electrolyte hydrogel for drug delivery
17. Novel degradable poly(ethylene glycol) hydrogels for controlled release of protein
18. Photoscissable hydrogel synthesis via rapid photopolymerization of novel PEG-based polymers in the absence of photoinitiators
19. Alginates
20. Protein release from alginate matrices
21. Novel alginate sponges for cell culture and transplantation
22. In vitro and in vivo models for the reconstruction of intercellular signaling
23. Biocompatibility of mannuronic acid-rich alginates
24. Alginate as immobilization material. II: Determination of polyphenol contaminants by fluorescence spectroscopy, and evaluation of methods for their removal
25. Pulsed dextran release from calcium-alginate gel beads
26. Alginates as drug carriers: Covalent attachment of alginates to therapeutic agents containing primary amine groups
27. Additive effect of chondroitin sulfate and chitosan on drug release from calcium-induced alginate gel beads
28. Radioiodination of alginate via covalently-bound tyrosinamide allows for monitoring of its fate in vivo
29. Synthesis of cross-linked poly(aldehyde guluronate) hydrogels
30. Three-dimensional analysis of the synergistic cytotoxicity of ganciclovir and zidovudine
31. Degradation behavior of covalently cross-linked poly(aldehyde guluronate) hydrogels Macromolecules
32. Synthesis and antitumor activity of immunoconjugate BR96-Dox
33. Transferrin conjugates of doxorubicin: Synthesis, characterization, cellular uptake, and in vitro efficacy
34. Hydrazide pharmaceuticals as conjugates to polyaldehyde dextran: Syntheses, characterization, and stability
35. Acid pH in tumors and its potential for therapeutic exploitation
36. Cellular pH gradient in tumor versus normal tissue: Potential exploitation for the treatment of cancer
37. Evaluation in vitro of adriamycin immunoconjugates synthesized using an acid-sensitive hydrazone link
38. New hydrazone derivatives of adriamycin and their immunoconjugates-A correlation between acid stability and cytotoxicity
39. Stability study of epirubicin in NaCl 0.9% injection
40. Stability of doxorubicin hydrochloride and vincristine sulfate in two portable infusion-pump reservoirs