Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice

Cell Death and Differentiation

Volumn 21, Issue 5, 2014, Pages 676-684

  Vandenberg, C J ^a,b   Josefsson, E C ^a,b   Campbell, K J ^a,b,c   James, C ^a,b,d,e,f   Lawlor, K E ^a,b   Kile, B T ^a,b   Cory, S ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^d BORDEAUX UNIVERSITY HOSPITAL   (France)

^e UNIVERSITÉ DE BORDEAUX   (France)

^f Bordeaux Segalen University   (France)

Author keywords

apoptosis; Bak; Bcl 2; haemopoiesis; Mcl 1; thrombocytopaenia

Indexed keywords

CYTOTOXIC AGENT; DEXAMETHASONE; IMMUNOGLOBULIN; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN BAK; PROTEIN BCL 2; PROTEIN MCL 1; RAG1 PROTEIN; BAK1 PROTEIN, MOUSE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEMATOPOIESIS; IN VITRO STUDY; KINETICS; LYMPHOCYTE FUNCTION; LYMPHOCYTOSIS; LYMPHOID CELL; MOUSE; NONHUMAN; OVERALL SURVIVAL; PHENOTYPE; PRE T LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; SPLENECTOMY; THROMBOCYTE COUNT; THROMBOCYTE LIFESPAN; THROMBOCYTOPENIA; THROMBOCYTOSIS; THYMOCYTE; WESTERN BLOTTING; ANIMAL; BLOOD; C57BL MOUSE; CYTOLOGY; DEFICIENCY; GENETICS; MALE; METABOLISM; PATHOLOGY; PROTO ONCOGENE; THROMBOCYTE; TRANSGENIC MOUSE;

MUS; MUS MUSCULUS;

ANIMALS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BLOOD PLATELETS; GENES, BCL-2; LYMPHOCYTOSIS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS C-BCL-2; THROMBOCYTOPENIA; THYMOCYTES;

EID: 84898022515     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2013.201     Document Type: Article

References (46)

1. Strasser A, Cory S, Adams JM. Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases. EMBO J 2011; 30: 3667-3683.
2. Llambi F, Moldoveanu T, Tait SW, Bouchier-Hayes L, Temirov J, McCormick LL et al. A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria. Mol Cell 2011; 44: 517-531.
3. Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 1984; 226: 1097-1099. (Pubitemid 15217831)
4. Cleary ML, Sklar J. Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18. Proc Natl Acad Sci USA 1985; 82: 7439-7443. (Pubitemid 16196835)
5. H on chromosome 14 and near a transcriptional unit on 18. Cell 1985; 41: 899-906. (Pubitemid 15243395)
6. Vaux DL, Cory S, Adams JM. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 1988; 335: 440-442.
7. L-Bak peptide complex: recognition between regulators of apoptosis. Science 1997; 275: 983-986. (Pubitemid 27087715)
8. L/Bad peptide complex formation from structure, mutagenesis, and biophysical studies. Protein Sci 2000; 9: 2528-2534. (Pubitemid 32105735)
9. L/Bim fragment complex: Implications for Bim function. Immunity 2003; 19: 341-352. (Pubitemid 37153411)
10. Lindsten T, Ross AJ, King A, Zong W, Rathmell JC, Shiels HA et al. The combined functions of proapoptotic Bcl-2 family members Bak and Bax are essential for normal development of multiple tissues. Mol Cell 2000; 6: 1389-1399. (Pubitemid 32045931)
11. Mason KD, Carpinelli MR, Fletcher JI, Collinge JE, Hilton AA, Ellis S et al. Programmed anuclear cell death delimits platelet life span. Cell 2007; 128: 1173-1186. (Pubitemid 46427871)
12. Josefsson EC, James C, Henley KJ, Debrincat MA, Rogers KL, Dowling MR et al. Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets. J Exp Med 2011; 208: 2017-2031.
13. Dunkle A, Dzhagalov I, He YW. Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2. Cell Death Differ 2010; 17: 994-1002.
14. Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI et al. Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Gene Dev 2005; 19: 1294-1305. (Pubitemid 41003019)
15. Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE et al. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 2007; 315: 856-859.
16. Uren RT, Dewson G, Chen L, Coyne SC, Huang DCS, Adams JM et al. Mitochondrial permeabilization relies on BH3 ligands engaging multiple pro-survival Bcl-2 relatives, not Bak. J Cell Biol 2007; 177: 277-287. (Pubitemid 46658639)
17. Ogilvy S, Metcalf D, Print CG, Bath ML, Harris AW, Adams JM. Constitutive bcl-2 expression throughout the hematopoietic compartment affects multiple lineages and enhances progenitor cell survival. Proc Natl Acad Sci USA 1999; 96: 14943-14948. (Pubitemid 30019744)
18. Campbell KJ, Bath ML, Turner ML, Vandenberg CJ, Bouillet P, Metcalf D et al. Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance. Blood 2010; 116: 3197-3207.
19. Ogilvy S, Metcalf D, Gibson L, Bath ML, Harris AW, Adams JM. Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment. Blood 1999; 94: 1855-1863. (Pubitemid 29430401)
20. Egle A, Harris AW, Bath ML, O'Reilly L, Cory S. VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia. Blood 2004; 103: 2276-2283. (Pubitemid 38326247)
21. Merino D, Khaw SL, Glaser SP, Anderson DJ, Belmont LD, Wong C et al. Bcl-2, Bcl-x(L), and Bcl-w are not equivalent targets of ABT-737 and navitoclax (ABT-263) in lymphoid and leukemic cells. Blood 2012; 119: 5807-5816.
22. Pobezinsky LA, Angelov GS, Tai X, Jeurling S, Van Laethem F, Feigenbaum L et al. Clonal deletion and the fate of autoreactive thymocytes that survive negative selection. Nat Immunol 2012; 13: 569-578.
23. Campbell KJ, Gray DH, Anstee N, Strasser A, Cory S. Elevated Mcl-1 inhibits thymocyte apoptosis and alters thymic selection. Cell Death Differ 2012; 19: 1962-1971.
24. Strasser A, Harris AW, Cory S. Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 1991; 67: 889-899. (Pubitemid 121001503)
25. McCaughtry TM, Hogquist KA. Central tolerance: what have we learned from mice? Semin Immunopathol 2008; 30: 399-409.
26. Bouillet P, Purton JF, Godfrey DI, Zhang L-C, Coultas L, Puthalakath H et al. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 2002; 415: 922-926. (Pubitemid 34174755)
27. Leeksma CH, Cohen JA. Determination of the life of human blood platelets using labelled diisopropylfluorophosphanate. Nature 1955; 175: 552-553.
28. Ault KA, Knowles C. In vivo biotinylation demonstrates that reticulated platelets are the youngest platelets in circulation. Exp Hematol 1995; 23: 996-1001.
29. Stewart DP, Koss B, Bathina M, Perciavalle RM, Bisanz K, Opferman JT. Ubiquitin-independent degradation of antiapoptotic MCL-1. Mol Cell Biol 2010; 30: 3099-3110.
30. Kozuma Y, Yuki S, Ninomiya H, Nagasawa T, Kojima H. Caspase activation is involved in early megakaryocyte differentiation but not in platelet production from megakaryocytes. Leukemia 2009; 23: 1080-1086.
31. Schaefer BC, Schaefer ML, Kappler JW, Marrack P, Kedl RM. Observation of antigen-dependent CD8 T-cell/dendritic cell interactions in vivo. Cell Immunol 2001; 214: 110-122. (Pubitemid 34499465)
32. White MJ, Kile BT. Apoptotic processes in megakaryocytes and platelets. Semin Hematol 2010; 47: 227-234.
33. Mombaerts P, Iacomini J, Johnson RS, Herrup K, Tonegawa S, Papaioannou VE. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 1992; 68: 869-877.
34. Gray DH, Kupresanin F, Berzins SP, Herold MJ, O'Reilly LA, Bouillet P et al. The BH3-only proteins Bim and Puma cooperate to impose deletional tolerance of organ-specific antigens. Immunity 2012; 37: 451-462.
35. Bouillet P, Metcalf D, Huang DCS, Tarlinton DM, Kay TWH, Köntgen F et al. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 1999; 286: 1735-1738. (Pubitemid 129515880)
36. Merino D, Giam M, Hughes PD, Siggs OM, Heger K, O'Reilly LA et al. The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins. J Cell Biol 2009; 186: 355-362.
37. Ren D, Tu HC, Kim H, Wang GX, Bean GR, Takeuchi O et al. BID, BIM, and PUMA are essential for activation of the BAX-and BAK-dependent cell death program. Science 2010; 330: 1390-1393.
38. Czabotar PE, Lessene G, Strasser A, Adams JM. Control of apoptosis by the BCL-2 protein family and its therapeutic targeting. Nat Rev Mol Cell Biol 2013; 15: 49-63.
39. Zauli G, Vitale M, Falcieri E, Gibellini D, Bassini A, Celeghini C et al. In vitro senescence and apoptotic cell death of human megakaryocytes. Blood 1997; 90: 2234-2243. (Pubitemid 27392707)
40. Debrincat MA, Josefsson EC, James C, Henley KJ, Ellis S, Lebois M et al. Mcl-1 and Bcl-x(L) coordinately regulate megakaryocyte survival. Blood 2012; 119: 5850-5858.
41. Kodama T, Hikita H, Kawaguchi T, Shigekawa M, Shimizu S, Hayashi Y et al. Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages. Cell Death Differ 2012; 19: 1856-1869.
42. Kodama T, Takehara T, Hikita H, Shimizu S, Li W, Miyagi T et al. Thrombocytopenia exacerbates cholestasis-induced liver fibrosis in mice. Gastroenterology 2010; 138: 2487-2498; 2498 e1-7.
43. Kelly PN, White MJ, Goschnick MW, Fairfax KA, Tarlinton DM, Kinkel SA et al. Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development. Cell Death Differ 2010; 17: 1655-1664.
44. Mombaerts P, Iacomini J, Johnson RS, Herrup K, Tonegawa S, Papaioannou VE. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 1992; 68: 869-877.
45. Knudson CM, Tung KSK, Tourtellotte WG, Brown GAJ, Korsmeyer SJ. Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 1995; 270: 96-99.
46. Pezzella F, Tse AGD, Cordell JL, Pulford KAF, Gatter KC, Mason DY. Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation. Am J Pathol 1990; 137: 225-232. (Pubitemid 20232982)