The anti-obesity effects of the dietary combination of fermented red ginseng with levan in high fat diet mouse model

Phytotherapy Research

Volumn 28, Issue 4, 2014, Pages 617-622

  Oh, Jin Sun ^a   Lee, Seung Ri ^a   Hwang, Keum Taek ^a   Ji, Geun Eog ^a,b  

^a Seoul National University   (South Korea)

^b Bifido Co   (South Korea)

Author keywords

anti hyperlipidemia; anti obesity; fermented ginseng extract; high fat diet mouse model; insulin resistance; levan

Indexed keywords

BIOLOGICAL MARKER; CHOLESTEROL; GINSENG EXTRACT; GLUCOSE; LEPTIN; LEVAN; LIPID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIET THERAPY; FAT MASS; FERMENTATION; FERMENTED RED GINSENG; GINSENG; GLUCOSE BLOOD LEVEL; HORMONE RESISTANCE; INSULIN RESISTANCE; LIPID DIET; LIVER WEIGHT; MALE; MOUSE; MOUSE MODEL; NONHUMAN; OBESITY; WEIGHT REDUCTION; WHITE ADIPOSE TISSUE;

MUS; PANAX GINSENG;

ANTI-HYPERLIPIDEMIA; ANTI-OBESITY; FERMENTED GINSENG EXTRACT; HIGH FAT DIET MOUSE MODEL; INSULIN RESISTANCE; LEVAN;

ADIPOSE TISSUE, WHITE; ANIMALS; ANTI-OBESITY AGENTS; BLOOD GLUCOSE; BODY WEIGHT; CHOLESTEROL; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; FERMENTATION; FRUCTANS; HYPERLIPIDEMIAS; INSULIN; INSULIN RESISTANCE; LEPTIN; LIPIDS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; OBESITY; PANAX; PLANT EXTRACTS;

EID: 84898002331     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5042     Document Type: Article

References (44)

1. Ahmad FA, Mahmud S,. 2010. Acute pancreatitis following orlistat therapy: Report of Two Cases. JOP 11: 61-63
2. Attelt A, Wu J, Yuan C,. 1999. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 58: 1685-93
3. Attelt A, Zhou Y, Xie J, Wu J, Zhang L, et al,. 2002. Antidiabetic effects of panax ginseng berry extract and the identification of an effective component. Diabetes 51: 1851-8
4. Bjorntorp P,. 1997. Obesity. Lancet 350: 423-26
5. Bogardus C, Ravussin E, Robbins D, Wolfe R, Horton E, et al,. 1984. Effects of physical training and diet therapy on carbohydrate metabolism in patients with glucose intolerance and non-insulin-dependent diabetes mellitus. Diabetes 33: 311-8
6. Busserolles J, Gueux E, Rock E, Demigne C, Mazur A, et al,. 2003. Oligofructose protects against the hypertriglyceridemic and pro-oxidative effects of a high fructose diet in rats. J Nutr 133: 1903-08
7. Cani PD, Knauf C, Iglesias MA, Drucker DJ, Delzenne NM, et al,. 2006. Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor. Diabetes 55: 1484-90
8. Chang Y, Seo E, Gyllenhaal C, Block KI,. 2003. Panax ginseng: A Role in cancer Therapy? Integr Cancer Ther 2: 13-33
9. Cutfield W, Jefferies C, Jackson W, Robinson E, Hofman P,. 2003. Evaluation of HOMA and QUICKI as measures of insulin sensitivity in prepubertal children. Diabetes 4: 119-25
10. Delzenne NM, Cani PD, Neyrinck AM,. 2007. Modulation of glucagon-like peptide 1 and energy metabolism by inulin and oligofructose: experimental data. J Nutr 137: 2547S-51S
11. Fried S, Ricci M, Russell C, Laferrère B,. 2000. Regulation of leptin production in humans. J Nutr 130: 3127S-31S
12. Gibbs E, Stock J, McCoid S, Stukenbrok H, Pessin J, et al,. 1995. Glycemic improvement in diabetic db/db mice by overexpression of the human insulin-regulatable glucose transporter (GLUT4). J Clin Invest 95: 1512-18
13. Gu W, Kim K, Kim D,. 2013. Ginsenoside Rh1 ameliorates high fat diet-induced obesity in mice by inhibiting adipocyte differentiation. Biol Pharm Bull 36: 102-07
14. Gumbiner B, Polonsky K, Beltz W, Griver K, Wallace P, et al,. 1990. Effects of weight loss and reduces hyperglycemia on the kinetics of insulin secretion in obese non-insulin dependent diabetes mellitus. J Clin Endocrinol Metab 70: 1594-602
15. !Henry R, Wallace P, Olefsky J,. 1986. Effects of weight loss on mechanisms of hyperglycemia in obese non-insulin-dependent diabetes mellitus. Diabetes 35: 990-98
16. Hong K, Jang KH, Lee JC, Kim S, Kim M, et al,. 2005. Bacterial β-glucan exhibits potent hypoglycemic activity via decrease of serum lipids and adiposity, and increase of UCP mRNA expression. J Microbiol Biotechnol 15: 823-30
17. Kang S, Hong K, Kim S, Jang KH, Kim CH, Choue R,. 2002. Effects of dietary levan on adiposity, serum leptin and UCP expression in obese rats fed high fat diet. Korean J Nutr 35: 903-11
18. Kang S, Hong K, Jang K, Kim S, Lee K, et al,. 2004. Anti-obesity and hyolipidemic effects of dietary levan in high fat diet-induced obese rats. J Microbiol Biotechnol 14: 796-804
19. Kang S, Hong K, Jang KH, Kim YY, Choue R, et al,. 2006. Altered mRNA expression of hepatic lipogenic enzyme and PPARα in rats fed dietary levan from Zymomonas mobilis. J Nutr Biochem 17: 419-26
20. Karamadoukis L, Shivashankar G, Ludeman L, Williams A,. 2009. An unusual complication of treatment with orlistat. Clin Nephrol 71: 430-2
21. Karu N, Reifen R, Kerem Z,. 2007. Weight gain reduction in mice fed Panax ginseng saponin, a pancreatic lipase inhibitor. J Agric Food Chem 55: 2824-28
22. Kershaw EE, Flier JS,. 2004. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89: 2548-56
23. Kim SH, Park KS,. 2003. Effects of Panax ginseng extract on lipid metabolism in humans. Pharmacolo Res 48: 511-13
24. Kim Y, Kang K, Kim S,. 1990. Study on antitumor and immunomodulating activities of polysaccharide fractions from Panax ginseng: Comparison of effects of neutral and acidic polysaccharide fraction. Arch Pharm Res 13: 330-37
25. Kim J, Nolte L, Hansen P, Han D, Ferguson K, Thompson PA, et al,. 2000. High-fat diet-induced muscle insulin resistance: relationship to visceral fat mass. Am J Physiol Regul Integr Comp Physiol 279: R2057-65
26. Klop B, Elte JW, Cabezas MC,. 2013. Dyslipidemia in obesity: Mechanisms and potential targets. Nutritions 5: 1218-40
27. Kopelman P,. 2000. Obesity as a medical problem. Nature 404: 635-43
28. Kruszynska Y, Olefsky J,. 1996. Cellular and molecular mechanisms of non-insulin dependent diabetes mellitus. J Investig Med 44: 413-28
29. Kwak YS, Kyung JS, Kim JS, Cho JY, Rhee MH,. 2010. Anti-hyperlipidemic effects of red ginseng acidic polysaccharide from korean red ginseng. Biol Pharm Bull 33: 468-72
30. Lee YS, Cha BY, Yamaguchi K, Choi SS, Yonezawa T, et al,. 2010. Effects of korean white ginseng extracts on obesity in high-fat diet-induced obese mice. Cytotechnology 62: 367-76
31. Leonhardt M, Hrupka B, Langhans W,. 1999. New approaches in the pharmacological treatment of obesity. Eur J Nutr 38: 1-13
32. Lin S, Thomas T, Storlien L, Huang F,. 2000. Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice. Int J Obes 24: 639-46
33. Liu R, Zhang J, Liu W, Kimura Y, Zheng Y,. 2010. Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet. Fitoterapia 81: 1079-87
34. Mollah ML, Kim GS, Moon HK, Chung SK, Cheon YP, et al,. 2009. Antiobesity effects of wild ginseng (Panax ginseng C.A. Meyer) mediated by PPAR-gamma, GLUT4 and LPL in ob/ob mice. Phytother Res 23: 220-5
35. Niu J, Pi ZF, Yue H, Yang H, Wang Y, et al,. 2012. Effect of 20(S)-ginsenoside Rg3 on streptozotocin-induced experimental type 2 diabetic rats: a urinary metabonomics study by rapid-resolution liquid chromatography/mass spectrometry. Rapid Commun Mass Spectrom 26: 2683-9
36. Park D, Yoon M,. 2012. Compound K, a novel ginsenoside metabolite, inhibits adipocyte differentiation in 3T3-L1 cells: involvement of angiogenesis and MMPs. Biochem Biophys Res Commun 422: 263-7
37. Parnell JA, Reimer RA,. 2009. Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults. Am J Clin Nutr 89: 1751-9
38. Song YB, An YR, Kim SJ, Park HW, Jung JW, et al,. 2012. Lipid metabolic effect of Korean red ginseng extract in mice fed on a high-fat diet. J Sci Food Agric 92: 388-96
39. Spieglman B, Filer J,. 2001. Obesity and the regulation of energy balance. Cell 104: 531-43
40. Trinh H, Han S, Kim S, Lee Y, Kim D,. 2007. Bifidus fermentation increases hypolipidemic and hypoglycemic effects of Red Ginseng. J Microbiol Biotechnol 17: 1127-33
41. Vuksan V, Stavro M, Sievenpiper J, Koo V, Wong E, et al,. 2000. American ginseng improves glycemia in individuals with normal glucose tolerance: effect of dose and time escalation. J Am Coll Nutr 19: 738-44
42. Wallace T, Matthews D,. 2002. The assessment of insulin resistance in man. Diabet Med 19: 527-34
43. Xie J, Aung H, Wu J, Attel A, Yuan C,. 2002. Effects of American ginseng berry extract on blood glucose levels in ob/ob mice. Am J Chin Med 30: 187-94
44. Xiong Y, Shen L, Liu KJ, Tso P, Wang G, et al,. 2010. Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats. Diabetes 59: 2505-12