Mechanism of tetrodotoxin block and resistance in sodium channels

Biochemical and Biophysical Research Communications

Volumn 446, Issue 1, 2014, Pages 370-374

  Chen, Rong ^a   Chung, Shin Ho ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

Hydrogen bond network; Ion channel block; Molecular dynamics; Sodium channel

Indexed keywords

GUANIDINE; SODIUM CHANNEL NAV1.4; TETRODOTOXIN; TYROSINE; VOLTAGE GATED SODIUM CHANNEL;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; HYDROGEN BOND; MOLECULAR DYNAMICS; MUTAGENESIS; PRIORITY JOURNAL; SODIUM CONDUCTANCE; STATIC ELECTRICITY;

BACTERIA (MICROORGANISMS); MAMMALIA;

HYDROGEN BOND NETWORK; ION CHANNEL BLOCK; MOLECULAR DYNAMICS; NA(V)AB; SODIUM CHANNEL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; COMPUTER SIMULATION; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NAV1.4 VOLTAGE-GATED SODIUM CHANNEL; PROTEIN CONFORMATION; SODIUM CHANNEL BLOCKERS; STATIC ELECTRICITY; TETRODOTOXIN;

EID: 84897998566     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.02.115     Document Type: Article

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