Structural basis for pure antagonism of integrin α Vβ 3 by a high-affinity form of fibronectin

Nature Structural and Molecular Biology

Volumn 21, Issue 4, 2014, Pages 383-388

  Van Agthoven, Johannes F ^a   Xiong, Jian Ping ^a   Alonso, José Luis ^a   Rui, Xianliang ^a   Adair, Brian D ^a   Goodman, Simon L ^b   Arnaout, M Amin ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MERCK KGAA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRONECTIN; LIGAND; PARTIAL AGONIST; VITRONECTIN RECEPTOR; ALPHA5 BETA3 INTEGRIN INHIBITOR; ARGINYLGLYCYLASPARTIC ACID; BARBOURIN; DISINTEGRIN; EPTIFIBATIDE; FIBRINOGEN RECEPTOR AFFECTING AGENT; MUTANT PROTEIN; PEPTIDOMIMETIC AGENT; PROTEIN INHIBITOR; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN STRUCTURE; RECEPTOR AFFINITY; WILD TYPE; BETA CHAIN; BINDING AFFINITY; DRUG ANTAGONISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; EMBRYO; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION;

BINDING SITES; CELL ADHESION; CRYSTALLOGRAPHY, X-RAY; FIBRONECTINS; HUMANS; INTEGRIN ALPHAVBETA3; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY;

EID: 84897973151     PISSN: 15459993     EISSN: 15459985     Source Type: Journal    
DOI: 10.1038/nsmb.2797     Document Type: Article

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