Mutation of a conserved asparagine in the I-like domain promotes constitutively active integrins αLβ2 and αIIbβ3

Journal of Biological Chemistry

Volumn 282, Issue 25, 2007, Pages 18225-18232

  Cheng, Ming ^a   Foo, Shen Yun ^a   Shi, Min Long ^a   Tang, Ren Hong ^a   Kong, Le Sheng ^b   Law, S K Alex ^a   Tan, Suet Mien ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY CONFORMERS; ASPARAGINE; INTEGRINS;

ANTIGEN-ANTIBODY REACTIONS; CELL ADHESION; LIGANDS; MONOCLONAL ANTIBODIES; MUTAGENESIS; PROTEINS;

AMINO ACIDS;

ALPHA2BBETA 3 INTEGRIN; ALPHALBETA2 INTEGRIN; ASPARAGINE; FIBRINOGEN; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 3; LIGAND; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY KIM127; MONOCLONAL ANTIBODY MEM148; UNCLASSIFIED DRUG;

ADHESION; ARTICLE; BETA CHAIN; CELL STRAIN HEK293; CONTROLLED STUDY; EMBRYO; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LEUKOCYTE ADHESION DEFICIENCY; LIGAND BINDING; MUTAGENESIS; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STABILITY; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANTIGENS, CD; ASPARAGINE; CELL ADHESION; CELL ADHESION MOLECULES; CELL MEMBRANE; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MUTATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

EID: 34547106059     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M701386200     Document Type: Article

References (48)

1. Hynes, R. O. (2002) Cell 110, 673-687
2. Arnaout, M. A., Mahalingam, B., and Xiong, J. P. (2005) Annu. Rev. Cell Dev. Biol. 21, 381-410
3. Luo, B. H., Carman, C. V., and Springer, T. A. (2007) Annu. Rev. Immunol. 25, 619-647
4. Takagi, J., DeBottis, D. P., Erickson, H. P., and Springer, T. A. (2002) Biochemistry 41, 4339-4347
5. Chen, J., Salas, A., and Springer, T. A. (2003) Nat. Struct. Biol. 10, 995-1001
6. Chen, J., Takagi, J., Xie, C., Xiao, T., Luo, B. H., and Springer, T. A. (2004) J. Biol. Chem. 279, 55556-55561
7. Mould, A. P., Barton, S. J., Askari, J. A., Craig, S. E., and Humphries, M. J. (2003) J. Biol. Chem. 278, 51622-51629
8. Lee, J. O., Bankston, L. A., Arnaout, M. A., and Liddington, R. C. (1995) Structure 3, 1333-1340
9. Lee, J. O., Rieu, P., Arnaout, M. A., and Liddington, R. (1995) Cell 80, 631-638
10. Qu, A., and Leahy, D. J. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 10277-10281
11. Shimaoka, M., Xiao, T., Liu, J. H., Yang, Y., Dong, Y., Jun, C. D., McCormack, A., Zhang, R., Joachimiak, A., Takagi, J., Wang, J. H., and Springer, T. A. (2003) Cell 112, 99-111
12. Shimaoka, M., Lu, C., Palframan, R. T., von Andrian, U. H., McCormack, A., Takagi, J., and Springer, T. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 6009-6014
13. Shimaoka, M., Lu, C., Salas, A., Xiao, T., Takagi, J., and Springer, T. A. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 16737-16741
14. Xiong, J. P., Stehle, T., Diefenbach, B., Zhang, R., Dunker, R., Scott, D. L., Joachimiak, A., Goodman, S. L., and Arnaout, M. A. (2001) Science 294, 339-345
15. Xiao, T., Takagi, J., Coller, B. S., Wang, J. H., and Springer, T. A. (2004) Nature 432, 59-67
16. Yang, W., Shimaoka, M., Salas, A., Takagi, J., and Springer, T. A. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 2906-2911
17. Hogg, N., and Bates, P. A. (2000) Matrix Biol. 19, 211-222
18. Hogg, N., Stewart, M. P., Scarth, S. L., Newton, R., Shaw, J. M., Law, S. K., and Klein, N. (1999) J. Clin. Investig. 103, 97-106
19. Mathew, E. C., Shaw, J. M., Bonilla, F. A., Law, S. K., and Wright, D. A. (2000) Clin. Exp. Immunol. 121, 133-138
20. Nelson, C., Rabb, H., and Arnaout, M. A. (1992) J. Biol. Chem. 267, 3351-3357
21. Tng, E., Tan, S. M., Ranganathan, S., Cheng, M., and Law, S. K. (2004) J. Biol. Chem. 279, 54334-54339
22. Tang, R. H., Tng, E., Law, S. K., and Tan, S. M. (2005) J. Biol. Chem. 280, 29208-29216
23. Nishida, N., Xie, C., Shimaoka, M., Cheng, Y., Walz, T., and Springer, T. A. (2006) Immunity 25, 583-594
24. Simmons, D. L. (1993) in Cellular Interactions in Development (Hartley, D., ed) pp. 93-127, Oxford University Press, UK
25. Hildreth, J. E., Gotch, F. M., Hildreth, P. D., and McMichael, A. J. (1983) Eur. J. Immunol. 13, 202-208
26. Hildreth, J. E., and August, J. T. (1985) J. Immunol. 134, 3272-3280
27. Robinson, M. K., Andrew, D., Rosen, H., Brown, D., Ortlepp, S., Stephens, P., and Butcher, E. C. (1992) J. Immunol. 148, 1080-1085
28. Stephens, P., Romer, J. T., Spitali, M., Shock, A., Ortlepp, S., Figdor, C. G., and Robinson, M. K. (1995) Cell Adhes. Commun. 3, 375-384
29. Coller, B. S., Peerschke, E. I., Scudder, L. E., and Sullivan, C. A. (1983) J. Clin. Investig. 72, 325-338
30. Luo, B. H., Takagi, J., and Springer, T. A. (2004) J. Biol. Chem. 279, 10215-10221
31. Artoni, A., Li, J., Mitchell, B., Ruan, J., Takagi, J., Springer, T. A., French, D. L., and Coller, B. S. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 13114-13120
32. Shaw, J. M., Al-Shamkhani, A., Boxer, L. A., Buckley, C. D., Dodds, A. W., Klein, N., Nolan, S. M., Roberts, I., Roos, D., Scarth, S. L., Simmons, D. L., Tan, S. M., and Law, S. K. (2001) Clin. Exp. Immunol. 126, 311-318
33. Barclay, A. N., Brown, M. H., Law, S. K., McKnight, A. J., Tomlinson, M. G., and van der Merwe, P. A. (1997) The Leucocyte Antigen Facts Book, Second Ed., Academic press, London, UK
34. DuBridge, R. B., Tang, P., Hsia, H. C., Leong, P. M., Miller, J. H., and Calos, M. P. (1987) Mol. Cell. Biol. 7, 379-387
35. Tan, S. M., Hyland, R. H., Al-Shamkhani, A., Douglass, W. A., Shaw, J. M., and Law, S. K. (2000) J. Immunol. 165, 2574-2581
36. Collaborative Computational Project, Number 4 (1994) Acta Crystallogr. Sect. D Biol. Crystallogr. 50, 760-763
37. Xiong, J. P., Stehle, T., Zhang, R., Joachimiak, A., Frech, M., Goodman, S. L., and Arnaout, M. A. (2002) Science 296, 151-155
38. Emsley, J., Knight, C. G., Farndale, R. W., Barnes, M. J., and Liddington, R. C. (2000) Cell 101, 47-56
39. Lu, C., Ferzly, M., Takagi, J., and Springer, T. A. (2001) J. Immunol. 166, 5629-5637
40. Beglova, N., Blacklow, S. C., Takagi, J., and Springer, T. A. (2002) Nat. Struct. Biol. 9, 282-287
41. Lu, C., Shimaoka, M., Zang, Q., Takagi, J., and Springer, T. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 2393-2398
42. Anderson, D. C., and Springer, T. A. (1987) Annu. Rev. Med. 38, 175-194
43. Brower, D. L., Brower, S. M., Hayward, D. C., and Ball, E. E. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 9182-9187
44. Xiong, J. P., Stehle, T., Goodman, S. L., and Arnaout, M. A. (2004) J. Biol. Chem. 279, 40252-40254
45. Luo, B. H., and Springer, T. A. (2006) Curr. Opin. Cell Biol. 18, 579-586
46. Takagi, J., Petre, B. M., Walz, T., and Springer, T. A. (2002) Cell 110, 599-611
47. Salas, A., Shimaoka, M., Kogan, A. N., Harwood, C., von Andrian, U. H., and Springer, T. A. (2004) Immunity 20, 393-406
48. Yang, W., Shimaoka, M., Chen, J., and Springer, T. A. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 2333-2338