Berberine - A novel approach to cholesterol lowering

Expert Opinion on Investigational Drugs

Volumn 14, Issue 5, 2005, Pages 683-685

  Doggrell, Sheila A ^a,b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b Doggrell Biomedical Communications   (New Zealand)

Author keywords

Berberine; Clinical trial; Hypercholesterolaemia; LDL receptors; LDL cholesterol; Statins

Indexed keywords

BERBERINE; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; PLACEBO; TRIACYLGLYCEROL;

ANIMAL MODEL; ANTIARRHYTHMIC ACTIVITY; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; FEMALE; HAMSTER; HUMAN; HYPERCHOLESTEROLEMIA; INOTROPISM; LIPID DIET; MAJOR CLINICAL STUDY; MALE; MORBIDITY; MORTALITY; NONHUMAN; RECEPTOR UPREGULATION; RNA STABILITY;

ANIMALS; ANTICHOLESTEREMIC AGENTS; BERBERINE; CLINICAL TRIALS; CRICETINAE; DRUGS, INVESTIGATIONAL; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; MALE;

EID: 20344390752     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.14.5.683     Document Type: Article

References (5)

1. KONG W, WEI J, ABIDI P et al.: Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat. Med. (2005) 12:1344-1351.
2. CANNON CP, BRAUNWALD E, McCABE CH et al.: Intensive versus moderate lipid lowering statins after acute coronary syndromes. N. Engl. J. Med. (2004) 350:1495-1504.
3. GRAND-PERRET T, BOUILLOT A, PERROT A et al.: SCAP ligands are potent new lipid-lowering drugs. Nat. Med. (2001) 7:1332-1338.
4. LIU J, AHLBORN TE, BRIGGS MR, KRAEMER FB: Identification of a novel sterol-independent regulatory element in the human low density lipoprotein receptor promoter. J. Biol. Chem. (2000) 275:5214-5221.
5. ZENG X-H, ZENG X-J, LI Y-Y. Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am. J. Cardiol. (2003) 92:173-176.