Methotrexate-bestatin interaction: Involvement of P-glycoprotein and organic anion transporters in rats

International Journal of Pharmaceutics

Volumn 465, Issue 1-2, 2014, Pages 368-377

  Zhu, Yanna ^a   Meng, Qiang ^a   Wang, Changyuan ^a   Liu, Qi ^a   Huo, Xiaokui ^a   Zhang, Aijie ^a   Sun, Pengyuan ^a   Sun, Huijun ^a   Li, Hua ^a   Liu, Kexin ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Bestatin; Drug drug interaction; Methotrexate; Organic anion transporter; P glycoprotein

Indexed keywords

BESTATIN; CILOSTAZOL; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN; ORGANIC ANION TRANSPORTER; ANTINEOPLASTIC AGENT; LEUCINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CELL LEVEL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EXCRETION; DRUG HALF LIFE; DRUG MECHANISM; DRUG UPTAKE; IC 50; IN VITRO STUDY; IN VIVO STUDY; INTESTINE MUCOSA; INTESTINE PERFUSION; KIDNEY CLEARANCE; KIDNEY SLICE; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PHARMACOKINETICS; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY; THERAPY EFFECT; TIME TO MAXIMUM PLASMA CONCENTRATION; URINARY EXCRETION; ANIMAL CELL; CELL VIABILITY; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IC50; MTT ASSAY; PLASMA CONCENTRATION-TIME CURVE; ANALOGS AND DERIVATIVES; ANIMAL; BINDING COMPETITION; CELL PROLIFERATION; CELL SURVIVAL; DOG; DRUG EFFECTS; DRUG INTERACTION; ERYTHROLEUKEMIA; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; INTESTINE ABSORPTION; INTRAVENOUS DRUG ADMINISTRATION; K562 CELL LINE; KIDNEY; KIDNEY TUBULE ABSORPTION; MDCK CELL LINE; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; BINDING, COMPETITIVE; CELL PROLIFERATION; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; DRUG INTERACTIONS; HEK293 CELLS; HUMANS; IN VITRO TECHNIQUES; INJECTIONS, INTRAVENOUS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; K562 CELLS; KIDNEY; LEUCINE; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MADIN DARBY CANINE KIDNEY CELLS; MALE; METHOTREXATE; ORGANIC ANION TRANSPORTERS; P-GLYCOPROTEIN; RATS, WISTAR; RENAL REABSORPTION; TANDEM MASS SPECTROMETRY; TRANSFECTION;

EID: 84897954176     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.02.020     Document Type: Article

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