Aminopeptidase inhibitors inhibit proliferation and induce apoptosis of K562 and STI571-resistant K562 cell lines through the MAPK and GSK-3β pathways

Leukemia and Lymphoma

Volumn 44, Issue 11, 2003, Pages 1987-1996

  Sawafuji, Kanoko ^a   Miyakawa, Yoshitaka ^a   Weisberg, Ellen ^b   Griffin, James D ^b   Ikeda, Yasuo ^a   Kizaki, Masahiro ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Aminopeptidase inhibitors; CML; Drug resistance; STI571

Indexed keywords

ACTINONIN; AMINOPEPTIDASE; BESTATIN; CASPASE 3; CYCLIN D1; GLYCOGEN SYNTHASE KINASE 3BETA; IMATINIB; MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN; PEPTIDE HYDROLASE INHIBITOR; SERINE;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL STRAIN K 562; CHRONIC MYELOID LEUKEMIA; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS RESISTANCE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

AMINOPEPTIDASES; ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASES; CELL DIVISION; CYCLIN D1; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; GLYCOGEN SYNTHASE KINASE 3; HUMANS; HYDROXAMIC ACIDS; K562 CELLS; LEUCINE; LEUKEMIA, MYELOID, CHRONIC; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PIPERAZINES; PROTEASE INHIBITORS; PYRIMIDINES; SERINE; SIGNAL TRANSDUCTION;

EID: 0242635646     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/1042819031000122033     Document Type: Article

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