F-box protein complex FBXL19 regulates TGFβ1-induced E-cadherin down-regulation by mediating Rac3 ubiquitination and degradation

Molecular Cancer

Volumn 13, Issue 1, 2014, Pages

  Dong, Su ^a,b,c   Zhao, Jing ^c   Wei, Jianxin ^c   Bowser, Rachel K ^c   Khoo, Andrew ^c   Liu, Zhonghui ^a   Luketich, James D ^d   Pennathur, Arjun ^d   Ma, Haichun ^b   Zhao, Yutong ^c  

^a Basic Medical College   (China)

^b THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

E cadherin; E3 ligase; Protein stability; Small GTPase protein; TGF 1; Ubiquitin proteasome system

Indexed keywords

F BOX PROTEIN; FBXL19 PROTEIN; LYSINE; PROTEASOME; PROTEIN; RAC PROTEIN; RAC3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; UVOMORULIN; CADHERIN; DNA BINDING PROTEIN; FBXL19 PROTEIN, HUMAN; RAC3 PROTEIN, HUMAN; TGFB1 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CANCER CELL; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CONTROLLED STUDY; DOWN REGULATION; ESOPHAGUS CANCER; GENE OVEREXPRESSION; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; PHENOTYPE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN TARGETING; UBIQUITINATION; BIOSYNTHESIS; ESOPHAGUS TUMOR; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

CADHERINS; CELL LINE, TUMOR; DNA-BINDING PROTEINS; ESOPHAGEAL NEOPLASMS; F-BOX PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PROTEOLYSIS; RAC GTP-BINDING PROTEINS; TRANSFORMING GROWTH FACTOR BETA1; UBIQUITINATION;

EID: 84897942238     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-13-76     Document Type: Article

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