Expression of transforming growth factor β1 and E-cadherin proteins in pulmonary adenocarcinoma: Its significance in tumor progression

Cancer Research and Treatment

Volumn 45, Issue 2, 2013, Pages 118-125

  Kim, Chi Hong ^a   Park, Sonya Youngju ^b   Yoo, Jinyoung ^a  

^a The Catholic University of Korea   (South Korea)

^b The Catholic University of Korea   (South Korea)

Author keywords

Adenocarcinoma; Cadherins; Lung; Transforming growth factor beta1

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA1; UVOMORULIN;

ADULT; AGED; ARTICLE; CANCER GROWTH; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG ALVEOLUS; MAJOR CLINICAL STUDY; MALE; MORPHOLOGY; PROTEIN EXPRESSION; TUMOR INVASION; UPREGULATION;

EID: 84886294623     PISSN: 15982998     EISSN: 20059256     Source Type: Journal    
DOI: 10.4143/crt.2013.45.2.118     Document Type: Article

References (18)

1. Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC. World Health Organization classification of tumours: pathology and genetics of tumours of the lung, pleura, thymus and heart. Lyon: IARC Press; 2004.
2. Yoshizawa A, Motoi N, Riely GJ, Sima CS, Gerald WL, Kris MG, et al. Impact of proposed IASLC/ATS/ERS classification of lung adenocarcinoma: prognostic subgroups and implications for further revision of staging based on analysis of 514 stage I cases. Mod Pathol. 2011;24:653-64.
3. Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, et al. International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol. 2011;6:244-85.
4. Soh J, Toyooka S, Ichihara S, Asano H, Kobayashi N, Suehisa H, et al. Sequential molecular changes during multistage pathogenesis of small peripheral adenocarcinomas of the lung. J Thorac Oncol. 2008;3:340-7.
5. Aviel-Ronen S, Coe BP, Lau SK, da Cunha Santos G, Zhu CQ, Strumpf D, et al. Genomic markers for malignant progression in pulmonary adenocarcinoma with bronchioloalveolar features. Proc Natl Acad Sci U S A. 2008;105:10155-60.
6. Aoyagi Y, Yokose T, Minami Y, Ochiai A, Iijima T, Morishita Y, et al. Accumulation of losses of heterozygosity and multistep carcinogenesis in pulmonary adenocarcinoma. Cancer Res. 2001;61:7950-4.
7. Derynck R, Akhurst RJ, Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet. 2001; 29:117-29.
8. Roberts AB, Wakefield LM. The two faces of transforming growth factor beta in carcinogenesis. Proc Natl Acad Sci U S A. 2003;100:8621-3.
9. Cao M, Seike M, Soeno C, Mizutani H, Kitamura K, Minegishi Y, et al. MiR-23a regulates TGF-beta-induced epithelialmesenchymal transition by targeting E-cadherin in lung cancer cells. Int J Oncol. 2012;41:869-75.
10. Herfs M, Hubert P, Kholod N, Caberg JH, Gilles C, Berx G, et al. Transforming growth factor-beta1-mediated Slug and Snail transcription factor up-regulation reduces the density of Langerhans cells in epithelial metaplasia by affecting Ecadherin expression. Am J Pathol. 2008;172:1391-402.
11. Saito H, Tsujitani S, Oka S, Kondo A, Ikeguchi M, Maeta M, et al. The expression of transforming growth factor-beta1 is significantly correlated with the expression of vascular endothelial growth factor and poor prognosis of patients with advanced gastric carcinoma. Cancer. 1999;86:1455-62.
12. Awaya H, Takeshima Y, Amatya VJ, Ishida H, Yamasaki M, Kohno N, et al. Loss of expression of E-cadherin and betacatenin is associated with progression of pulmonary adenocarcinoma. Pathol Int. 2005;55:14-8.
13. Hasegawa Y, Takanashi S, Kanehira Y, Tsushima T, Imai T, Okumura K. Transforming growth factor-beta1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma. Cancer. 2001;91:964-71.
14. Takanami I, Imamura T, Hashizume T, Kikuchi K, Yamamoto Y, Kodaira S. Transforming growth factor beta 1 as a prognostic factor in pulmonary adenocarcinoma. J Clin Pathol. 1994;4 7:1098-100.
15. Saji H, Nakamura H, Awut I, Kawasaki N, Hagiwara M, Ogata A, et al. Significance of expression of TGF-beta in pulmonary metastasis in non-small cell lung cancer tissues. Ann Thorac Cardiovasc Surg. 2003;9:295-300.
16. Borczuk AC, Kim HK, Yegen HA, Friedman RA, Powell CA. Lung adenocarcinoma global profiling identifies type II transforming growth factor-beta receptor as a repressor of invasiveness. Am J Respir Crit Care Med. 2005;172:729-37.
17. Kalogeraki A, Bouros D, Zoras O, Karabekios S, Chalkiadakis G, Stathopoulos E, et al. E-cadherin expression on fine-needle aspiration biopsies in primary lung adenocarcinomas is related to tumor differentiation and invasion. Anticancer Res. 2003;23:3367-71.
18. Zhang HJ, Wang HY, Zhang HT, Su JM, Zhu J, Wang HB, et al. Transforming growth factor-beta1 promotes lung adenocarcinoma invasion and metastasis by epithelial-to-mesenchymal transition. Mol Cell Biochem. 2011;355:309-14.