Overexpression of TGF-β1 in esophageal (Barrett's) adenocarcinoma is associated with advanced stage of disease and poor prognosis

Molecular Carcinogenesis

Volumn 45, Issue 10, 2006, Pages 786-794

  Von Rahden, Burkhard H A ^a,b   Stein, Hubert J ^a,b   Feith, Marcus ^b   Pühringer, Franziska ^c   Theisen, Jörg ^b   Siewert, J Rüdiger ^b   Sarbia, Mario ^c  

^a PARACELSUS MEDICAL UNIVERSITY   (Austria)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Barrett's cancer; Esophageal adenocarcinoma; Prognosis; Stage of disease; Survival; Transforming growth factor beta

Indexed keywords

MESSENGER RNA; PARAFFIN; TRANSFORMING GROWTH FACTOR BETA1; TGFB1 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ADVANCED CANCER; AGED; ARTICLE; BARRETT ESOPHAGUS; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CELL INFILTRATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; ESOPHAGEAL ADENOCARCINOMA; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; LOG RANK TEST; LYMPH NODE; LYMPH VESSEL; MALE; MULTIVARIATE ANALYSIS; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FAMILY; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SQUAMOUS EPITHELIUM; TUMOR GROWTH; UNIVARIATE ANALYSIS; ADENOCARCINOMA; ESOPHAGUS TUMOR; GENE EXPRESSION REGULATION; GENETICS; MIDDLE AGED; PATHOLOGY; SURVIVAL RATE;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; BARRETT ESOPHAGUS; ESOPHAGEAL NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; SURVIVAL RATE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 33749259074     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20259     Document Type: Article

References (23)

1. Spechler SJ. Clinical practice. Barrett's Esophagus. N Engl J Med 2002;346:836-842.
2. Devesa SS, Blot WJ, Fraumeni JF. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer 1998;83:2049-2053.
3. Siewert JR, Stein HJ, Feith M, Brücher BLDM, Bartels H, Fink U. Tumor cell type is an independent prognostic parameter in esophageal cancer: Lessons learned from more than 1000 consecutive resections at a single institution in the Western world. Ann Surg 2001;234:360-369.
4. Morales CP, Souza RF, Spechler SJ. Hallmarks of cancer progression in Barrett's oesophagus. Lancet 2002;360:1587-1589.
5. Elliott RL, Blobe GC. Role of transforming growth factor Beta in human cancer. J Clin Oncol 2005;23:2078-2093.
6. Siegel PM, Massague J. Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer 2003;3:807-821.
7. Massague J, Blain SW, Lo RS. TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 2000;103:295-309.
8. de Caestecker MP, Piek E, Roberts AB. Role of transforming growth factor-beta signaling in cancer. J Natl Cancer Inst 2000;92:1388-13402.
9. Shi Y, Massague J. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003;113:685-700.
10. Benson JR. Role of transforming growth factor beta in breast carcinogenesis. Lancet Oncol 2004;5:229-239.
11. Fukai Y, Fukuchi M, Masuda N, et al. Reduced expression of transforming growth factor-beta receptors is an unfavorable prognostic factor in human esophageal squamous cell carcinoma. Int J Cancer 2003;104:161-166.
12. Natsugoe S, Xiangming C, Matsumoto M, et al. Smad4 and transforming growth factor beta 1 expression in patients with squamous cell carcinoma of the esophagus. Clin Cancer Res 2002;8:1838-1842.
13. Torquati A, O'rear L, Longobardi L, Spagnoli A, Richards WO, Daniel Beauchamp R. RUNX3 inhibits cell proliferation and induces apoptosis by reinstating transforming growth factor beta responsiveness in esophageal adenocarcinoma cells. Surgery 2004;136:310-316.
14. Kim AH, Lebman DA, Dietz CM, Snyder SR, Eley KW, Chung TD. Transforming growth factor-beta is an endogenous radioresistance factor in the esophageal adenocarcinoma cell line OE-33. Int J Oncol 2003;23:1593-1599.
15. Onwuegbusi BA, Aitchison A, Chin SF, et al. Impaired TGF{beta} signalling in Barrett's carcinogenesis due to frequent SMAD4 inactivation. Gut 2005; [Epub ahead of print].
16. Sobin LH, Wittekind Ch, editors. TNM Classification of Malignant Tumors, 6th edition. New York: Wiley-Liss; 2002.
17. Hamilton SR, Aaltonen LA, editors. Pathology and genetics of tumours of the digestive system. Tumours of small intestine. Lyon: IARC Press; 2000. pp 69-91.
18. Specht K, Richter T, Muller U, Walch A, Werner M, Höfler H. Quantitative gene expression analysis in microdissected archival formalin-fixed and paraffin-embedded tumortissue. Am J Pathol 2001;158:419-429.
19. Koliopanos A, Friess H, di Mola FF, et al. Connective tissue growth factor gene expression alters tumor progression in esophageal cancer. World J Surg 2002;26:420-427.
20. Brabender J, Marjoram P, Salonga D, et al. A multigene expression panel for the molecular diagnosis of Barrett's esophagus and Barrett's adenocarcinoma of the esophagus. Oncogene 2004;23:4780-4788.
21. Saito H, Tsujitani S, Oka S, et al. The expression of transforming growth factor-beta1 is significantly correlated with the expression of vascular endothelial growth factor and poor prognosis of patients with advanced gastric carcinoma. Cancer 1999;86:1455-1462.
22. Maehara Y, Kakeji Y, Kabashima A, et al. Role of transforming growth factor-beta 1 in invasion and metastasis in gastric carcinoma. J Clin Oncol 1999;17:607-614.
23. Wiedmann MW, Caca K. Molecularly targeted therapy for gastrointestinal cancer. Curr Cancer Drug Targets 2005;5:171-193.