Flavonoids from Herba epimedii selectively activate estrogen receptor alpha (ERα) and stimulate ER-dependent osteoblastic functions in UMR-106 cells

Journal of Steroid Biochemistry and Molecular Biology

Volumn 143, Issue , 2014, Pages 141-151

  Xiao, Hui Hui ^a,b   Fung, Chung Yan ^b   Mok, Sao King ^b   Wong, Ka Chun ^b   Ho, Ming Xian ^b   Wang, Xin Luan ^c   Yao, Xin Sheng ^a   Wong, Man Sau ^b  

^a JINAN UNIVERSITY   (China)

^b HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

Estrogen receptor; Flavonoids; Herba epimedii; Osteoblastic cells; Phytoestrogens

Indexed keywords

ALKALINE PHOSPHATASE; BAOHUOSIDE I; EPIMEDIN B; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FLAVONOID; ICARIIN; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; SAGITTATOSIDE A; UNCLASSIFIED DRUG; DITERPENE; ESTROGEN RECEPTOR ALPHA, HUMAN; GLUCOSIDE; HERBACEOUS AGENT; SAGITTARIOSIDE A;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ENZYME ACTIVITY; ESTROGEN ACTIVITY; HERBA EPIMEDII; IMMUNOBLOTTING; IN VITRO STUDY; MEDICINAL PLANT; NONHUMAN; OSTEOBLAST; OSTEOCLASTOGENESIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ANIMAL; CELL CULTURE; CYTOLOGY; DNA RESPONSIVE ELEMENT; DRUG EFFECTS; ENZYME IMMUNOASSAY; GENETICS; METABOLISM; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELLS, CULTURED; DITERPENES; DRUGS, CHINESE HERBAL; ESTROGEN RECEPTOR ALPHA; ESTROGENS; FLAVONOIDS; GLUCOSIDES; IMMUNOENZYME TECHNIQUES; OSTEOBLASTS; RATS; REAL-TIME POLYMERASE CHAIN REACTION; RESPONSE ELEMENTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84897849947     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2014.02.019     Document Type: Article

References (41)

1. B. Dawson-Hughes, A.C. Looker, A.N. Tosteson, H. Johansson, J.A. Kanis, and L.J. Melton 3rd. The potential impact of the national osteoporosis foundation guidance on treatment eligibility in the USA: an update in NHANES 2005-2008 Osteoporos. Int. 23 2012 811 820
2. U.H. Lerner Bone remodeling in post-menopausal osteoporosis J. Dental Res. 85 2006 584 595
3. M. Notelovitz Estrogen therapy and osteoporosis: principles and practice Am. J. Med. Sci. 313 1997 2 12
4. Writing Group for the Women's Health Initiative Investigators Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial J. Am. Med. Assoc. 288 2002 321 333
5. Million Women Study Collaborators Breast cancer and hormone-replacement therapy in the Million Women Study Lancet 362 2003 419 427
6. P. Albertazzi, and D.W. Purdie The nature and utility of the phytoestrogens: a review of the evidence Eur. Menopause J. 42 2002 173 185
7. Y.F. Lin Effects of Chinese herbs for invigorating kidney on bone mineral density, osteoprotegerin and tumor necrosis factor alpha in the blood serum of women with postmenopausaul osteoporosis Chin. J. Clin. Rehab. 10 2006 51 53
8. L.N. Zhao Clinical preventional and curative effect evaluation of Herba epimedii on osteoporosis Modern J. Integr. Trad. Chin. West. Med. 12 2003 922 923
9. F. Xie, C.F. Wu, W.P. Lai, X.J. Yang, P.Y. Cheung, X.S. Yao, P.C. Leung, and M.S. Wong The osteoporotective effect of Herba epimedii (HEP) extract in vivo and in vitro Evid. Based Complement. Alternat. Med. 2 2005 353 361
10. Y. Sun, S.M. Lee, Y.M. Wong, C.P. Lau, P.C. Shaw, L. Qin, P.C. Leung, and K.P. Fung Dosing effects of an antiosteoporosis herbal formula-a preclinical investigation using a rat model Phytother. Res. 22 2008 267 273
11. H. Nian, L.P. Qin, Q.Y. Zhang, H.C. Zheng, Y. Yu, and B.K. Huang Antiosteoporotic activity of ER-Xian decoction, a traditional Chinese herbal formula, in ovariectomized rats J. Ethnopharmacol. 108 2008 96 102
12. H.M. Zhu, L. Qin, P. Garnero, H.K. Genant, G. Zhang, K. Dai, X. Yao, G. Gu, Y. Hao, Z. Li, Y. Zhao, W. Li, J. Yang, X. Zhao, D. Shi, T. Fuerst, Y. Lu, H. Li, X. Zhang, C. Li, J. Zhao, Q. Wu, and S.J. Zhao The first multicenter and randomized clinical trial of herbal Fufang for treatment of postmenopausal osteoporosis Osteop. Int. 23 2012 1317 1327
13. D.W. Zhang, Y. Cheng, N.L. Wang, J.C. Zhang, M.S. Yang, and X.S. Yao Effects of total flavonoids and flavonol glycosides from Epimedium koreanum Nakai on the proliferation and differentiation of primary osteoblasts Phytomedicine 15 2008 55 61
14. J.F. Zhang, G. Li, C.L. Meng, Q. Dong, C.Y. Chan, M.L. He, P.C. Leung, Y.O. Zhang, and H.F. Kung Total flavonoids of Herba epimedii improves osteogenesis and inhibits osteoclastogenesis of human mesenchymal stem cells Phytomedicine 16 2009 521 529
15. W.F. Chen, S.K. Mok, X.L. Wang, K.H. Lai, W.P. Lai, H.K. Luk, P.C. Leung, X.S. Yao, and M.S. Wong Total flavonoid fraction of the Herba epimedii extract suppress urinary calcium exertion and improves bone properties in ovariectomised mice Br. J. Nutr. 105 2011 180 189
16. B.J. Cheskis, J.G. Nagpal, and L.P. Freedman Signaling by estrogens J. Cell. Physiol. 213 2007 610 617
17. S. Kato, H. Endoh, Y. Masuhiro, T. Kitamoto, S. Uchiyama, H. Sasaki, S. Masushige, Y. Gotoh, E. Nishida, H. Kawashima, D. Metzger, and P. Chambon Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase Science 270 1995 1491 1494
18. D.A. Lannigan Estrogen receptor phosphorylation Steroids 68 2003 1 9
19. S.K. Mok, W.F. Chen, W.P. Lai, P.C. Leung, X.L. Wang, X.S. Yao, and S.W. Man Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functions in UMR-106 cells Br. J. Pharmacol. 159 2010 939 949
20. W.Y. Pang, X.L. Wang, S.K. Mok, W.P. Lai, H.K. Chow, P.C. Leung, X.S. Yao, and M.S. Wong Naringin improves bone properties in ovariectomized mice and exerts oestrogen-like activities in rat osteoblast-like (UMR-106) cells Br. J. Pharmacol. 159 2010 1693 1703
21. P.Y. Sun, J.F. Zhao, Y. Wen, Y.P. Pei, G.F. Zhang, Z.X. Wang, and Y.J. Chen A study on the active constituents of epimedium koreanum nakai J. Shenyang Pharm. Univ. 12 1995 266 369
22. F. Li, and Y.L. Liu The isolation and identification of baohuoside I, VI, VII and baohuosu Pharmacol. Sinica 23 1988 739 748
23. X.H. Zheng, and L.Y. Kong Chemical constituents from Epimedium koreanum Nakai Chin. Trad. Herbal Drugs 33 2002 964 967
24. M. Mizuno, N. Sakakibara, S. Hanioka, M. Linuma, T. Tanaka, X.S. Liu, and D.W. Shi Flavonol glycosides from Epimedium sagittatum Phytochemistry 27 1988 3541 3643
25. B.A. Scheven, C.A. Damen, N.J. Hamilton, H.J. Verhaar, and S.A. Duursma Stimulatory effects of estrogen and progesterone on proliferation and differentiation of normal human osteoblast-like cell in vitro Biochem. Biophys. Res. Commun. 186 1992 54 60
26. S. Khosla Minireview: the OPG/RANKL/RANK system Endocrinology 142 2001 5050 5055
27. J. Huang, L. Yuan, X. Wang, T.L. Zhang, and K. Wang Icariin and its glycosides enhance osteoblastic, but suppress osteoclastic, differentiation and activity in vitro Life Sci. 81 2007 832 840
28. J. Zhao, S. Ohba, M. Shinkai, U. Chung, and T. Nagamune Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner Biochem. Biophys. Res. Commun. 369 2008 4444 4448
29. H. Cao, Y. Ke, Y. Zhang, C.J. Zhang, W. Qian, and G.L. Zhang Icariin stimulates MC3T3-E1 cell proliferation and differentiation through up-regulation of bone morphogenetic protein-2 Int. J. Mol. Med. 29 2012 435 439
30. F.H. Meng, Y.B. Li, Z.L. Xiong, Z.M. Jiang, and F.M. Li Osteoblastic proliferation activity of Epimedium brevicornum Maxim Phytomedicine 12 2005 189 193
31. D.W. Zhang, Y. Cheng, N.L. Wang, J.C. Zhang, M.S. Yang, and X.S. Yao Effect of total flavonoids and flavonol glycosides from Epimedium koreanum Nakai on the proliferation and differentiation of primary osteoblasts Phytomedicine 15 2008 55 61
32. S. Nilsson, S. Mäkelä, E. Treuter, M. Tujague, J. Thomsen, G. Andersson, E. Enmark, M. Warner, and J.A. Gustafsson Mechanism of estrogen action Physiol. Rev. 81 2001 1535 1565
33. G.G. Kuiper, J.G. Lemmen, B. Carlsson, J.C. Corton, S.H. Safe, P.T. van der Saag, B. van der Burg, and J.A. Gustafsson Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta Endocrinology 139 1998 4252 4263
34. J. An, C. Tzagarakis-Foster, T.C. Scharschmidt, N. Lomri, and D.C. Leitman Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens J. Biol. Chem. 276 2001 17808 17814
35. H. van der Woude, M.G. Ter Veld, N. Jacobs, P.T. van der Saag, A.J. Murk, and I.M. Rietjens The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor Mol. Nutr. Food Res. 49 2005 763 771
36. S.H. Windahl, L. Saxon, A.E. Börjesson, M.K. Lagerquist, B. Frenkel, P. Henning, U.H. Lerner, G.L. Galea, L.B. Meakin, C. Engdahl, K. Sjögren, M.C. Antal, A. Krust, P. Chambon, L.E. Lanyon, J.S. Price, and C. Ohlsson Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2 J. Bone Min. Res. 28 2013 291 301
37. S.H. Windahl, M.K. Lagerquist, N. Andersson, C. Jochems, A. Kallkopf, C. Håkansson, J. Inzunza, J.A. Gustafsson, P.T. vander Saag, H. Carlsten, K. Pettersson, and C. Ohlsson Identification of target cells for the genomic effects of estrogens in bone Endocrinology 148 2007 5688 5695
38. P.B. Joel, A.M. Traish, and D.A. Lannigan Estradiol-induced phosphorylation of serine 118 in the estrogen receptor is independent of p42/p44 mitogen-activated protein kinase J. Biol. Chem. 273 1998 13317 13323
39. D. Chen, E. Wanshbrook, N. Sarwar, G.J. Bates, P.E. Pace, V. Thirunuvakkarasu, J. Taylor, R.J. Epstein, F.V. Fuller-Pace, J.M. Egly, R.C. Coombes, and S. Ali Phosphorylation of human estrogen receptor α at serine 118 by two distinct signal transduction pathways revealed by phosphorylation-specific antisera Oncogene 21 2002 4921 4931
40. H.L. Jessop, M. Sjöberg, M.Z. Cheng, G. Zaman, C.P.D. Wheeler-Jones, and L.E. Lanyon Mechanical strain and estrogen activate estrogen receptor α in bone cells J. Bone Min. Res. 16 2001 1045 1055
41. M. Almeida, S. Lyer, M. Martin-Millan, S.M. Bartell, E. Ambrogini, M. Onal, J. Xiong, R.S. Weinstein, C.A. O'Brien, and S.C. Manolagas Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrual J. Clin. Invest. 123 2013 394 404