Total flavonoid fraction of the Herba epimedii extract suppresses urinary calcium excretion and improves bone properties in ovariectomised mice

British Journal of Nutrition

Volumn 105, Issue 2, 2011, Pages 180-189

  Chen, Wen Fang ^a,b   Mok, Sao Keng ^a,c   Wang, Xin Luan ^d   Lai, Ka Hang ^a,c   Lai, Wan Ping ^a,c   Luk, Hon Kit ^a,c   Leung, Ping Chung ^e   Yao, Xin Sheng ^d,f   Wong, Man Sau ^a,c  

^a HONG KONG POLYTECHNIC UNIVERSITY   (Hong Kong)

^b QINGDAO UNIVERSITY MEDICAL COLLEGE   (China)

^c State Key Laboratory of Chinese Medicine and Molecular Pharmacology   (China)

^d SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^e CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^f JINAN UNIVERSITY   (China)

Author keywords

Herba epimedii; Osteoporosis; Ovariectomised mice; Total flavonoids

Indexed keywords

CALBINDIN; COLLAGEN TYPE 1; ESTRADIOL; FLAVONOID; HERBA EPIMEDII EXTRACT; INTERLEUKIN 6; MESSENGER RNA; OSTEOCALCIN; OSTEOPROTEGERIN; PLANT EXTRACT; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MASS; BONE STRENGTH; BONE STRUCTURE; CALCIUM ABSORPTION; CALCIUM EXCRETION; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; FEMALE; FEMUR; GENE EXPRESSION; HERB; HERBA EPIMEDII; MINERAL METABOLISM; MOUSE; NONHUMAN; OSTEOCLASTOGENESIS; OSTEOLYSIS; OSTEOPOROSIS; OVARIECTOMY; PROTEIN EXPRESSION; TRABECULAR BONE; URINARY EXCRETION;

ANIMALS; BASE SEQUENCE; BONE AND BONES; BONE DENSITY; CALCIUM; CALCIUM-BINDING PROTEINS; COLLAGEN TYPE I; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; ESTRADIOL; FEMALE; FLAVONOIDS; INTERLEUKIN-6; KIDNEY; MICE; MICE, INBRED C57BL; OSTEOCALCIN; OSTEOPOROSIS; OSTEOPROTEGERIN; OVARIECTOMY; PHYTOTHERAPY; RANK LIGAND; RECEPTORS, CALCITRIOL; RNA, MESSENGER; X-RAY MICROTOMOGRAPHY;

MUS;

EID: 79951680187     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114510003247     Document Type: Article

References (34)

1. Gambacciani M, Ciaponi M & Genazzani AR (2007) The HRT misuse and osteoporosis epidemic: a possible future scenario. Climacteric 10, 273-275. (Pubitemid 47123953)
2. Rossouw JE, Anderson GL, Prentice RL, et al. (2002) Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial. JAMA 288, 321-333. (Pubitemid 34761611)
3. Million Women Study Collaborators (2003) Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 362, 419-427.
4. Papaioannou A, Kennedy CC, Dolovich L, et al. (2007) Patient adherence to osteoporosis medications: problems, consequences and management strategies. Drugs Aging 24, 37-55. (Pubitemid 46148080)
5. An SJ, Li T & Li E (2002) Effect of kidney-tonifying herbs on ovary function and bone mass in postmenopausal women. Chin J Osteoporosis 6, 55-59.
6. Wang JS, Xu XJ, Jin JS, et al. (1997) Clinical study of treatment of female osteoporosis with Yishen Jiangu pills. Chin J Osteoporosis 3, 1-63.
7. Yu S, Chen K, Li S, et al. (1999) In vitro and in vivo studies of the effect of a Chinese herb medicine on osteoclastic bone resorption. Chin J Dent Res 2, 7-11.
8. Wang BL, Quan JX, Guo SY, et al. (2000) Effects of Epimedium on the expression of interleukin-6 mRNA in bone of OVX rat. Chin J Obstet Gynecol 35, 724-726.
9. Ji H, Liu K, Gong XJ, et al. (2001) Effect of Epimedium koreanum favoids on osteoporosis in ovariectomized rats. Chin J Osteoporosis 7, 4-8.
10. Jiang YN, Mo HY & Chen JM (2002) Effects of Epimedium total flavonoids phytosomes on preventing and treating bone loss of ovariectomized rats. Zhongguo Zhong Yao Za Zhi 27, 221-224.
11. Sun Y, Lee SM, Wong YM, et al. (2008) Dosing effects of an antiosteoporosis herbal formula - a preclinical investigation using a rat model. Phytother Res 22, 267-273. (Pubitemid 351363252)
12. Qian C, Zhang X, Lu L, et al. (2006) Regulation of Cbfa 1 Expression by total flavonoids of Herba epimedii. Endocr J 53, 87-94.
13. Chen BL, Xie DH, Wang ZW, et al. (2009) Effect of total flavone of Epimedium on expression of bone OPG, OPGL mrRNA in ovariectomized rats. Zhongguo Gu Shang 22, 271-273.
14. Songlin P, Ge Z, Yixin H, et al. (2009) Epimedium-derived flavonoids promote osteoblastogenesis and suppress adipogenesis in bone marrow stromal cells while exerting an anabolic effect on osteoporotic bone. Bone 45, 534-544.
15. Han L-M, Liu B & Xu P (2003) Influence of Herba epimedii flavone on proliferation of osteoblast. Shanghai J Trad Chin Med 37, 56-58.
16. Wang JQ, Hu YG, Zheng HJ, et al. (2002) The effect of icariin on proliferation and differentiation of osteoblasts in vitro. Chin J Clin Rehab 6, 1037-1038.
17. Li Y, Ji H, Li P, et al. (2002) Effects of Epimedium pubescens flavonoids on osteoblast in vitro. J China Pharm Univ 33, 48-50. (Pubitemid 41819949)
18. Zhang DW, Cheng Y, Wang NL, et al. (2008) Effects of total flavonoids and flavonol glycosides from Epimedium koreanum Nakai on the proliferation and differentiation of primary osteoblasts. Phytomedicine 15, 55-61. (Pubitemid 350297899)
19. Zhang JF, Li G, Chan CY, et al. (2010) Flavonoids of Herba Epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt/b-catenin signaling pathway. Mol Cell Endocrinol 341, 70-74.
20. Xie F, Wu CF, Lai WP, et al. (2005) The osteoprotective effect of Herba Epimedii (HEP) extract in vivo and in vitro. Evid Based Complement Alternat Med 2, 353-361. (Pubitemid 41253347)
21. Zhang G, Qin L & Shi Y (2007) Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing bone loss in late postmenopausal women: a 24-month randomized, double-blind and placebo-controlled trial. J Bone Miner Res 22, 1072-1079. (Pubitemid 351343696)
22. Huang J, Yuan L, Wang X, et al. (2007) Icaritin and its glycosides enhance osteoblastic, but suppress osteoclastic, differentiation and activity in vitro. Life Sci 81, 832-840. (Pubitemid 47337100)
23. Chen KM, Ge BF, Liu XY, et al. (2007) Icariin inhibits the osteoclast formation induced by RANKL and macrophagecolony stimulating factor in mouse bone marrow culture. Pharmazie 62, 388-391. (Pubitemid 46847945)
24. Mok SK, Chen WF, Lai WP, et al. (2010) Icariin protects estrogen deficiency induced bone loss and activates estrogen receptor dependent osteoblastic functions in UMR 106 cells. Br J Pharmacol (Epublication ahead of print version 27 January 2010).
25. Nian H, Ma MH, Nian SS, et al. (2009) Antiosteoporotic activity of icariin in ovariectomized rats. Phytomedicine 16, 320-326.
26. Lind PM, Lind L, Larsson S, et al. (2001) Torsional testing and peripheral quantitative computed tomography in rat humerus. Bone 29, 265-270. (Pubitemid 32823570)
27. Lambers TT, Mahieu F, Oancea E, et al. (2006) Calbindin- D28K dynamically controls TRPV5-mediated Ca2\+ transport. EMBO J 25, 2978-2988. (Pubitemid 44106751)
28. Hoenderop JG, Nilius B & Bindels RJ (1994) Estrogen effects on calcitropic hormones and calcium homestasis. Endocr Rev 15, 301-309.
29. Young MM & Nordin BEC (1967) Effects of natural and arti- ficial menopause on plasma and urinary calcium and phosphorus. Lancet 2, 118-120.
30. Mahonen A, Jukkola A, Risteli L, et al. (1998) Type I procollagen synthesis is regulated by steroids and related hormones in human osteosarcoma cells. J Cell Biochem 68, 151-163. (Pubitemid 28028073)
31. Power RA, Iwaniec UT & Wronski TJ (2002) Changes in gene expression associated with the bone anabolic effects of basic fibroblast growth factor in aged ovariectomized rats. Bone 31, 143-148. (Pubitemid 34754440)
32. Bord S, Ireland DC, Beavan SR, et al. (2003) The effects of estrogen on osteoprotegerin, RANKL, and estrogen receptor expression in human osteoblasts. Bone 32, 136-141. (Pubitemid 36299141)
33. Cuzzocrea S, Mazzon E, Dugo L, et al. (2003) Inducible nitric oxide synthase mediates bone loss in ovariectomized mice. Endocrinology 144, 1098-1107. (Pubitemid 36262876)
34. Jilka R, Hangoc G, Girasole G, et al. (1992) Increased osteoclast development after estrogen loss: mediation by interleukin- 6. Science 257, 88-91.