Binding of a hairpin polyamide in the minor groove of DNA: Sequence-specific enthalpic discrimination

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 16, 1996, Pages 8306-8311

  Pilch, Daniel S ^a,b   Poklar, Nataša ^a   Gelfand, Craig A ^a   Law, Scott M ^a   Breslauer, Kenneth J ^a,b   Baird, Eldon E ^c   Dervan, Peter B ^c  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^c CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

2:1 pyrrole imidazole DNA binding motif; Imidazole guanine interaction; Isothermal calorimetry; Polyamide base hydrogen bonds; Polyamide DNA binding affinity

Indexed keywords

4 AMINOBUTYRIC ACID; BETA ALANINE; DOUBLE STRANDED DNA; IMIDAZOLE; POLYAMIDE; PYRROLE;

ABSORPTION SPECTROPHOTOMETRY; ARTICLE; BASE PAIRING; BINDING AFFINITY; CALORIMETRY; CHIRALITY; CIRCULAR DICHROISM; DNA BINDING; ENTHALPY; HYDROGEN BOND; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; THERMOSTABILITY;

AMIDES; BASE SEQUENCE; DNA; HYDROGEN BONDING; LIGANDS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; NUCLEIC ACID DENATURATION; OLIGODEOXYRIBONUCLEOTIDES; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 0029776688     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.16.8306     Document Type: Article

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