Tailoring chimeric ligands for studying and biasing ErbB receptor family interactions

Angewandte Chemie - International Edition

Volumn 53, Issue 10, 2014, Pages 2662-2666

  Krueger, Andrew T ^a   Kroll, Carsten ^a   Sanchez, Edgar ^b   Griffith, Linda G ^b   Imperiali, Barbara ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

biological activity; ligand design; protein modifications; receptors; structure activity relationships

Indexed keywords

CELL MOTILITY ASSAY; DEVELOPMENT AND APPLICATIONS; EPIDERMAL GROWTH FACTORS; LIGAND DESIGN; PROTEIN MODIFICATIONS; RECEPTORS; STRUCTURE ACTIVITY RELATIONSHIPS; STRUCTURE-FUNCTION STUDIES;

BIOACTIVITY; DIMERIZATION; LIGANDS; RECOMBINANT PROTEINS;

CELL SIGNALING;

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; LIGAND;

ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; LIGAND DESIGN; MESENCHYMAL STROMA CELL; METABOLISM; PROTEIN MODIFICATIONS; RECEPTORS; STRUCTURE-ACTIVITY RELATIONSHIPS;

BIOLOGICAL ACTIVITY; LIGAND DESIGN; PROTEIN MODIFICATIONS; RECEPTORS; STRUCTURE-ACTIVITY RELATIONSHIPS;

HUMANS; LIGANDS; MESENCHYMAL STROMAL CELLS; MODELS, MOLECULAR; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2;

EID: 84897657880     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201307869     Document Type: Article

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