Epidermal growth factor mutant with wild-type affinity for both ErbB1 and ErbB3

Biochemistry

Volumn 45, Issue 14, 2006, Pages 4703-4710

  Wingens, Miriam ^a   Jacobs Oomen, Saskia ^a   Van Der Woning, Sebastian P ^a   Stortelers, Catelijne ^a,b   Van Zoelen, Everardus J J ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DIMERS; GENETIC ENGINEERING; MOLECULAR STRUCTURE; OPTIMIZATION;

AFFINITY BINDING; LIGAND-BINDING CHARACTERISTICS; MUTANT; PHOSPHORYLATION ANALYSIS;

GROWTH KINETICS;

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 3; HETERODIMER;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CELL SURVIVAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; RECEPTOR SENSITIVITY;

ANIMALS; BINDING, COMPETITIVE; CELL LINE; DIMERIZATION; EPIDERMAL GROWTH FACTOR; HUMANS; LIGANDS; MICE; PROTEIN STRUCTURE, QUATERNARY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECEPTOR, ERBB-3;

ANIMALIA;

EID: 33645655564     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060087m     Document Type: Article

References (33)

1. Alroy, I., and Yarden, Y. (1997) The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions, FEBS Lett. 410, 83-86.
2. Jorissen, R. N., Walker, F., Pouliot, N., Garrett, T. P., Ward, C. W., and Burgess, A. W. (2003) Epidermal growth factor receptor: mechanisms of activation and signaling, Exp. Cell Res. 284, 31-53.
3. Holbro, T., Civenni, G., and Hynes, N. E. (2003) The ErbB receptors and their role in cancer progression, Exp. Cell Res. 284, 99-110.
4. Dancey, J., and Sausville, E. A. (2003) Issues and progress with protein kinase inhibitors for cancer treatment, Nat. Rev. Drug Discovery 2, 296-313.
5. Arteaga, C. L. (2003) ErbB-targeted therapeutic approaches in human cancer, Exp. Cell Res. 284, 122-130.
6. Riese, D. J., II, and Stern, D. F. (1998) Specificity within the EGF family/ErbB receptor family signaling network, BioEssays 20, 41-48.
7. Harari, D., Tzahar, E., Romano, J., Shelly, M., Pierce, J. H., Andrews, G. C., and Yarden, Y. (1999) Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase, Oncogene 18, 2681-2689.
8. Ogiso, H., Ishitani, R., Nureki, O., Fukai, S., Yamanaka, M., Kim, J. H., Saito, K., Sakamoto, A., Inoue, M., Shirouzu, M., and Yokoyama, S. (2002) Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains, Cell 110, 775-787.
9. Garrett, T. P., McKern, N. M., Lou, M., Elleman, T. C., Adams, T. E., Lovrecz, G. O., Zhu, H. J., Walker, F., Frenkel, M. J., Hoyne, P. A., Jorissen, R. N., Nice, E. C., Burgess, A. W., and Ward, C. W. (2002) Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha, Cell 110, 763-773.
10. Burgess, A. W., Cho, H. S., Eigenbrot, C., Ferguson, K. M., Garrett, T. P., Leahy, D. J., Lemmon, M. A., Sliwkowski, M. X., Ward, C. W., and Yokoyama, S. (2003) An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors, Mol. Cell 12, 541-552.
11. Cho, H. S., and Leahy, D. J. (2002) Structure of the extracellular region of HER3 reveals an interdomain tether, Science 297, 1330-1333.
12. Van Zoelen, E. J., Stortelers, C., Lenferink, A. E., and Van de Poll, M. L. (2000) The EGF domain: requirements for binding to receptors of the ErbB family, Vitam. Horm. 59, 99-131.
13. Groenen, L. C., Nice, E. C., and Burgess, A. W. (1994) Structure-function relationships for the EGF/TGF-alpha family of mitogens, Growth Factors 11, 235-257.
14. Campion, S. R., and Niyogi, S. K. (1994) Interaction of epidermal growth factor with its receptor, Prog. Nucleic Acid Res. Mol. Biol. 49, 353-383.
15. Tzahar, E., Pinkas-Kramarski, R., Moyer, J. D., Klapper, L. N., Alroy, I., Levkowitz, G., Shelly, M., Henis, S., Eisenstein, M., Ratzkin, B. J., Sela, M., Andrews, G. C., and Yarden, Y. (1997) Bivalence of EGF-like ligands drives the ErbB signaling network, EMBO J. 16, 4938-4950.
16. Jones, J. T., Ballinger, M. D., Pisacane, P. I., Lofgren, J. A., Fitzpatrick, V. D., Fairbrother, W. J., Wells, J. A., and Sliwkowski, M. X. ( 1998) Binding interaction of the heregulinbeta egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis, J. Biol. Chem. 273, 11667-11674.
17. Ballinger, M. D., Jones, J. T., Lofgren, J. A., Fairbrother, W. J., Akita, R. W., Sliwkowski, M. X., and Wells, J. A. (1998) Selection of heregulin variants having higher affinity for the ErbB3 receptor by monovalent phage display, J. Biol. Chem. 273, 11675-11684.
18. Singer, E., Landgraf, R., Horan, T., Slamon, D., and Eisenberg, D. (2001) Identification of a heregulin binding site in HER3 extracellular domain, J. Biol. Chem. 276, 44266-44274.
19. Stortelers, C., van de Poll, M. L., Lenferink, A. E., Gadellaa, M. M., van Zoelen, C., and van Zoelen, E. J. (2002) Epidermal growth factor contains both positive and negative determinants for interaction with ErbB-2/ErbB-3 heterodimers, Biochemistry 41, 4292-4301.
20. Barbacci, E. G., Guarino, B. C., Stroh, J. G., Singleton, D. H., Rosnack, K. J., Moyer, J. D., and Andrews, G. C. (1995) The structural basis for the specificity of epidermal growth factor and heregulin binding, J. Biol. Chem. 270, 9585-9589.
21. Stortelers, C., Souriau, C., van Liempt, E., van de Poll, M. L., and van Zoelen, E. J. (2002) Role of the N-terminus of epidermal growth factor in ErbB-2/ErbB-3 binding studied by phage display, Biochemistry 41, 8732-8741.
22. Stortelers, C., Van der Woning, S. P., Jacobs-Oomen, S., Wingens, M., and Van Zoelen, E. J. (2003) Selective formation of ErbB-2/ErbB-3 heterodimers depends on the ErbB-3 affinity of epidermal growth factor-like ligands, J. Biol. Chem. 278, 12055-12063.
23. Pinkas-Kramarski, R., Soussan, L., Waterman, H., Levkowitz, G., Alroy, L, Klapper, L., Lavi, S., Seger, R., Ratzkin, B. J., Sela, M., and Yarden, Y. (1996) Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions, EMBO J. 15, 2452-2467.
24. Kramer, R. H., Lenferink, A. E., van Bueren-Koornneef, I. L., van der Meer, A., van de Poll, M. L., and van Zoelen, E. J. (1994) Identification of the high affinity binding site of transforming growth factor-alpha (TGF-alpha) for the chicken epidermal growth factor (EGF) receptor using EGF/TGF-alpha chimeras, J. Biol. Chem. 269, 8708-8711.
25. van de Poll, M. L., Lenferink, A. E., van Vugt, M. J., Jacobs, J. J., Janssen, J. W., Joldersma, M., and van Zoelen, E. J. (1995) A single amino acid exchange, Arg-45 to Ala, generates an epidermal growth factor (EGF) mutant with high affinity for the chicken EGF receptor, J. Biol. Chem. 270, 22337-22343.
26. Horton, R. M. (1995) PCR-mediated recombination and mutagenesis. SOEing together tailor-made genes, Mol. Biotechnol. 3, 93-99.
27. Wingens, M., Walma, T., van Ingen, H., Stortelers, C., van Leeuwen, J. E., van Zoelen, E. J., and Vuister, G. W. (2003) Structural analysis of an epidermal growth factor/transforming growth factor-alpha chimera with unique ErbB binding specificity, J. Biol. Chem. 278, 39114-39123.
28. Pinkas-Kramarski, R., Shelly, M., Glathe, S., Ratzkin, B. J., and Yarden, Y. (1996) Neu differentiation factor/neuregulin isoforms activate distinct receptor combinations, J. Biol. Chem. 271, 19029-19032.
29. van Zoelen, E. J., van Oostwaard, T. M., van der Saag, P. T., and de Laat, S. W. (1985) Phenotypic transformation of normal rat kidney cells in a growth-factor-defined medium: induction by a neuroblastoma-derived transforming growth factor independently of the EGF receptor, J. Cell. Physiol. 123, 151-160.
30. Matsunami, R. K., Yette, M. L., Stevens, A., and Niyogi, S. K. (1991) Mutational analysis of leucine 47 in human epidermal growth factor, J. Cell. Biochem. 46, 242-249.
31. Riese, D. J., II, van Raaij, T. M., Plowman, G. D., Andrews, G. C., and Stern, D. F. (1995) The cellular response to neuregulins is governed by complex interactions of the erbB receptor family, Mol. Cell Biol. 15, 5770-5776.
32. Ferguson, K. M., Berger, M. B., Mendrola, J. M., Cho, H. S., Leahy, D. J., and Lemmon, M. A. (2003) EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization, Mol. Cell 11, 507-517.
33. Nagy, P., Vereb, G., Sebestyen, Z., Horvath, G., Lockett, S. J., Damjanovich, S., Park, J. W., Jovin, T. M., and Szollosi, J. (2002) Lipid rafts and the local density of ErbB proteins influence the biological role of homo- and heteroassociations of ErbB2, J. Cell Sci. 115, 4251-4262.