MicroRNA-29b inhibits diabetic nephropathy in db/db mice

Molecular Therapy

Volumn 22, Issue 4, 2014, Pages 842-853

  Chen, Hai Yong ^a   Zhong, Xiang ^a   Huang, Xiao R ^a,b   Meng, Xiao Ming ^a   You, Yongke ^a   Chung, Arthur C K ^a,b   Lan, Hui Y ^a,b  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b THE CHINESE UNIVERSITY OF HONG KONG   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT; DOXYCYCLINE; MICRORNA 29B; SMAD3 PROTEIN; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR T BET; TRANSFORMING GROWTH FACTOR BETA; MICRORNA; MIRN29 MICRORNA, MOUSE; SMAD3 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DRUG MECHANISM; GENE OVEREXPRESSION; GENE SILENCING; GENE THERAPY; GENE TRANSFER; IN VITRO STUDY; IN VIVO STUDY; KIDNEY FIBROSIS; MALE; MICROALBUMINURIA; MOUSE; NEPHRITIS; NONHUMAN; RAT; RENAL PROTECTION; TH1 CELL; ANIMAL; COMPLICATION; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; DISEASE MODEL; FIBROSIS; GENETICS; HUMAN; INFLAMMATION; PATHOLOGY; SIGNAL TRANSDUCTION;

MUS;

ANIMALS; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; DISEASE MODELS, ANIMAL; FIBROSIS; GENETIC THERAPY; HUMANS; INFLAMMATION; MICE; MICRORNAS; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84897577501     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2013.235     Document Type: Article

References (43)

1. Declèves, AE and Sharma, K (2010). New pharmacological treatments for improving renal outcomes in diabetes. Nat Rev Nephrol 6: 371-380
2. Reeves, WB and Andreoli, TE (2000). Transforming growth factor beta contributes to progressive diabetic nephropathy. Proc Natl Acad Sci USA 97: 7667-7669
3. Goldfarb, S and Ziyadeh, FN (2001). TGF-beta: A crucial component of the pathogenesis of diabetic nephropathy. Trans Am Clin Climatol Assoc 112: 27-32; discussion 33
4. Huang, C, Kim, Y, Caramori, ML, Fish, AJ, Rich, SS, Miller, ME et al. (2002). Cellular basis of diabetic nephropathy: II. The transforming growth factorbeta system and diabetic nephropathy lesions in type 1 diabetes. Diabetes 51: 3577-3581
5. Chen, HY, Huang, XR, Wang, W, Li, JH, Heuchel, RL, Chung, AC et al. (2011). The protective role of Smad7 in diabetic kidney disease: Mechanism and therapeutic potential. Diabetes 60: 590-601
6. Belghith, M, Bluestone, JA, Barriot, S, Mégret, J, Bach, JF and Chatenoud, L (2003). TGF-beta-dependent mechanisms mediate restoration of self-Tolerance induced by antibodies to CD3 in overt autoimmune diabetes. Nat Med 9: 1202-1208
7. Filippi, CM, Juedes, AE, Oldham, JE, Ling, E, Togher, L, Peng, Y et al. (2008). Transforming growth factor-beta suppresses the activation of CD8+ T-cells when naive but promotes their survival and function once antigen experienced: A two-faced impact on autoimmunity. Diabetes 57: 2684-2692
8. Duncan, BB, Schmidt, MI, Pankow, JS, Ballantyne, CM, Couper, D, Vigo, A et al.; Atherosclerosis Risk in Communities Study. (2003). Low-grade systemic inflammation and the development of type 2 diabetes: The atherosclerosis risk in communities study. Diabetes 52: 1799-1805
9. Pradhan, AD, Manson, JE, Rifai, N, Buring, JE and Ridker, PM (2001). C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286: 327-334
10. Pickup, JC (2004). Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 27: 813-823
11. Crook, M (2004). Type 2 diabetes mellitus: A disease of the innate immune system? An update. Diabet Med 21: 203-207
12. Sasaki, Y, Ihara, K, Matsuura, N, Kohno, H, Nagafuchi, S, Kuromaru, R et al. (2004). Identification of a novel type 1 diabetes susceptibility gene, T-bet. Hum Genet 115: 177-184
13. Jagannathan-Bogdan, M, McDonnell, ME, Shin, H, Rehman, Q, Hasturk, H, Apovian, CM et al. (2011). Elevated proinflammatory cytokine production by a skewed T cell compartment requires monocytes and promotes inflammation in type 2 diabetes. J Immunol 186: 1162-1172
14. Navarro-González, JF, Mora-Fernández, C, Muros de Fuentes, M and García-Pérez, J (2011). Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy. Nat Rev Nephrol 7: 327-340
15. van Rooij, E, Sutherland, LB, Thatcher, JE, DiMaio, JM, Naseem, RH, Marshall, WS et al. (2008). Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci USA 105: 13027-13032
16. Maurer, B, Stanczyk, J, Jüngel, A, Akhmetshina, A, Trenkmann, M, Brock, M et al. (2010). MicroRNA-29, a key regulator of collagen expression in systemic sclerosis. Arthritis Rheum 62: 1733-1743
17. Cushing, L, Kuang, PP, Qian, J, Shao, F, Wu, J, Little, F et al. (2011). miR-29 is a major regulator of genes associated with pulmonary fibrosis. Am J Respir Cell Mol Biol 45: 287-294
18. Xiao, J, Meng, XM, Huang, XR, Chung, AC, Feng, YL, Hui, DS et al. (2012). miR-29 inhibits bleomycin-induced pulmonary fibrosis in mice. Mol Ther 20: 1251-1260
19. Roderburg, C, Urban, GW, Bettermann, K, Vucur, M, Zimmermann, H, Schmidt, S et al. (2011). Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis. Hepatology 53: 209-218
20. Qin, W, Chung, AC, Huang, XR, Meng, XM, Hui, DS, Yu, CM et al. (2011). TGF-ß/ Smad3 signaling promotes renal fibrosis by inhibiting miR-29. J Am Soc Nephrol 22: 1462-1474
21. Du, B, Ma, LM, Huang, MB, Zhou, H, Huang, HL, Shao, P et al. (2010). High glucose down-regulates miR-29a to increase collagen IV production in HK-2 cells. FEBS Lett 584: 811-816
22. Zampetaki, A, Kiechl, S, Drozdov, I, Willeit, P, Mayr, U, Prokopi, M et al. (2010). Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes. Circ Res 107: 810-817
23. Long, J, Wang, Y, Wang, W, Chang, BH and Danesh, FR (2011). MicroRNA-29c is a signature microRNA under high glucose conditions that targets Sprouty homolog 1, and its in vivo knockdown prevents progression of diabetic nephropathy. J Biol Chem 286: 11837-11848
24. Steiner, DF, Thomas, MF, Hu, JK, Yang, Z, Babiarz, JE, Allen, CD et al. (2011). MicroRNA-29 regulates T-box transcription factors and interferon-? production in helper T cells. Immunity 35: 169-181
25. Liu, S, Wu, LC, Pang, J, Santhanam, R, Schwind, S, Wu, YZ et al. (2010). Sp1/ NFkappaB/HDAC/miR-29b regulatory network in KIT-driven myeloid leukemia. Cancer Cell 17: 333-347
26. Wang, B, Komers, R, Carew, R, Winbanks, CE, Xu, B, Herman-Edelstein, M et al. (2012). Suppression of microRNA-29 expression by TGF-ß1 promotes collagen expression and renal fibrosis. J Am Soc Nephrol 23: 252-265
27. Chung, AC, Dong, Y, Yang, W, Zhong, X, Li, R and Lan, HY (2013). Smad7 suppresses renal fibrosis via altering expression of TGF-ß/Smad3-regulated microRNAs. Mol Ther 21: 388-398
28. Luna, C, Li, G, Qiu, J, Epstein, DL and Gonzalez, P (2011). Cross-Talk between miR-29 and transforming growth factor-betas in trabecular meshwork cells. Invest Ophthalmol Vis Sci 52: 3567-3572
29. Liu, F, Chen, HY, Huang, XR, Chung, AC, Zhou, L, Fu, P et al. (2011). C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes. Diabetologia 54: 2713-2723
30. Poncelet, AC and Schnaper, HW (2001). Sp1 and Smad proteins cooperate to mediate transforming growth factor-beta 1-induced alpha 2(I) collagen expression in human glomerular mesangial cells. J Biol Chem 276: 6983-6992
31. Chow, FY, Nikolic-Paterson, DJ, Ma, FY, Ozols, E, Rollins, BJ and Tesch, GH (2007). Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice. Diabetologia 50: 471-480
32. Ninichuk, V, Khandoga, AG, Segerer, S, Loetscher, P, Schlapbach, A, Revesz, L et al. (2007). The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice. Am J Pathol 170: 1267-1276
33. Wang, H, Garzon, R, Sun, H, Ladner, KJ, Singh, R, Dahlman, J et al. (2008). NF-kappaB-YY1-miR-29 regulatory circuitry in skeletal myogenesis and rhabdomyosarcoma. Cancer Cell 14: 369-381
34. Li, N, Cui, J, Duan, X, Chen, H and Fan, F (2012). Suppression of type I collagen expression by miR-29b via PI3K, Akt, and Sp1 pathway in human Tenon's fibroblasts. Invest Ophthalmol Vis Sci 53: 1670-1678
35. Lago, R, Gómez, R, Lago, F, Gómez-Reino, J and Gualillo, O (2008). Leptin beyond body weight regulation-current concepts concerning its role in immune function and inflammation. Cell Immunol 252: 139-145
36. Eller, K, Kirsch, A, Wolf, AM, Sopper, S, Tagwerker, A, Stanzl, U et al. (2011). Potential role of regulatory T cells in reversing obesity-linked insulin resistance and diabetic nephropathy. Diabetes 60: 2954-2962
37. Szabo, SJ, Kim, ST, Costa, GL, Zhang, X, Fathman, CG and Glimcher, LH (2000). A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100: 655-669
38. Mensah-Brown, EP, Obineche, EN, Galadari, S, Chandranath, E, Shahin, A, Ahmed, I et al. (2005). Streptozotocin-induced diabetic nephropathy in rats: The role of inflammatory cytokines. Cytokine 31: 180-190
39. Moon, JY, Jeong, KH, Lee, TW, Ihm, CG, Lim, SJ and Lee, SH (2012). Aberrant recruitment and activation of T cells in diabetic nephropathy. Am J Nephrol 35: 164-174
40. Ma, F, Xu, S, Liu, X, Zhang, Q, Xu, X, Liu, M et al. (2011). The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-? Nat Immunol 12: 861-869
41. Chung, AC, Huang, XR, Zhou, L, Heuchel, R, Lai, KN and Lan, HY (2009). Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice. Nephrol Dial Transplant 24: 1443-1454
42. Wang, W, Huang, XR, Li, AG, Liu, F, Li, JH, Truong, LD et al. (2005). Signaling mechanism of TGF-beta1 in prevention of renal inflammation: Role of Smad7. J Am Soc Nephrol 16: 1371-1383
43. Lan, HY, Mu, W, Nikolic-Paterson, DJ and Atkins, RC (1995). A novel, simple, reliable, and sensitive method for multiple immunoenzyme staining: Use of microwave oven heating to block antibody crossreactivity and retrieve antigens. J Histochem Cytochem 43: 97-102.