메뉴 건너뛰기




Volumn 192, Issue 7, 2014, Pages 3029-3042

Relapsing-remitting central nervous system autoimmunity mediated by GFAP-specific CD8 T cells

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; MYELIN ASSOCIATED GLYCOPROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN;

EID: 84897568734     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1302911     Document Type: Article
Times cited : (95)

References (88)
  • 1
    • 33644607018 scopus 로고    scopus 로고
    • Multiple sclerosis - The plaque and its pathogenesis
    • Frohman, E. M., M. K. Racke, and C. S. Raine. 2006. Multiple sclerosis-the plaque and its pathogenesis. N. Engl. J. Med. 354: 942-955.
    • (2006) N. Engl. J. Med. , vol.354 , pp. 942-955
    • Frohman, E.M.1    Racke, M.K.2    Raine, C.S.3
  • 2
    • 33947509525 scopus 로고    scopus 로고
    • The immunopathology of multiple sclerosis: An overview
    • Lassmann, H., W. Brück, and C. F. Lucchinetti. 2007. The immunopathology of multiple sclerosis: an overview. Brain Pathol. 17: 210-218.
    • (2007) Brain Pathol. , vol.17 , pp. 210-218
    • Lassmann, H.1    Brück, W.2    Lucchinetti, C.F.3
  • 4
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra, M., and R. Martin. 2005. Immunology of multiple sclerosis. Annu. Rev. Immunol. 23: 683-747.
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 5
    • 67349216357 scopus 로고    scopus 로고
    • Autoimmune T cell responses in the central nervous system
    • Goverman, J. 2009. Autoimmune T cell responses in the central nervous system. Nat. Rev. Immunol. 9: 393-407.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 393-407
    • Goverman, J.1
  • 6
    • 0036219003 scopus 로고    scopus 로고
    • T cell response in experimental autoimmune encephalomyelitis (EAE): Role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire
    • Kuchroo, V. K., A. C. Anderson, H. Waldner, M. Munder, E. Bettelli, and L. B. Nicholson. 2002. T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire. Annu. Rev. Immunol. 20: 101-123.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 101-123
    • Kuchroo, V.K.1    Anderson, A.C.2    Waldner, H.3    Munder, M.4    Bettelli, E.5    Nicholson, L.B.6
  • 7
    • 33644836341 scopus 로고    scopus 로고
    • Mechanisms of immunopathology in murine models of central nervous system demyelinating disease
    • Ercolini, A. M., and S. D. Miller. 2006. Mechanisms of immunopathology in murine models of central nervous system demyelinating disease. J. Immunol. 176: 3293-3298.
    • (2006) J. Immunol. , vol.176 , pp. 3293-3298
    • Ercolini, A.M.1    Miller, S.D.2
  • 8
    • 67349213676 scopus 로고    scopus 로고
    • A molecular trio in relapse and remission in multiple sclerosis
    • Steinman, L. 2009. A molecular trio in relapse and remission in multiple sclerosis. Nat. Rev. Immunol. 9: 440-447.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 440-447
    • Steinman, L.1
  • 9
    • 17644398787 scopus 로고    scopus 로고
    • Anti-alpha4 integrin therapy for multiple sclerosis: Mechanisms and rationale
    • Rice, G. P., H. P. Hartung, and P. A. Calabresi. 2005. Anti-alpha4 integrin therapy for multiple sclerosis: mechanisms and rationale. Neurology 64: 1336-1342.
    • (2005) Neurology , vol.64 , pp. 1336-1342
    • Rice, G.P.1    Hartung, H.P.2    Calabresi, P.A.3
  • 10
    • 0030880011 scopus 로고    scopus 로고
    • Treatment of multiple sclerosis with the monoclonal anti-CD4 antibody cM-T412: Results of a randomized, double-blind, placebo-controlled, MR-monitored phase II trial
    • van Oosten, B. W., M. Lai, S. Hodgkinson, F. Barkhof, D. H. Miller, I. F. Moseley, A. J. Thompson, P. Rudge, A. McDougall, J. G. McLeod, et al. 1997. Treatment of multiple sclerosis with the monoclonal anti-CD4 antibody cM-T412: results of a randomized, double-blind, placebo-controlled, MR-monitored phase II trial. Neurology 49: 351-357.
    • (1997) Neurology , vol.49 , pp. 351-357
    • Van Oosten, B.W.1    Lai, M.2    Hodgkinson, S.3    Barkhof, F.4    Miller, D.H.5    Moseley, I.F.6    Thompson, A.J.7    Rudge, P.8    McDougall, A.9    McLeod, J.G.10
  • 12
    • 0021079164 scopus 로고
    • Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis
    • Booss, J., M. M. Esiri, W. W. Tourtellotte, and D. Y. Mason. 1983. Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis. J. Neurol. Sci. 62: 219-232.
    • (1983) J. Neurol. Sci. , vol.62 , pp. 219-232
    • Booss, J.1    Esiri, M.M.2    Tourtellotte, W.W.3    Mason, D.Y.4
  • 13
    • 0020962424 scopus 로고
    • Multiple sclerosis. Distribution of T cells, T cell subsets and Ia-positive macrophages in lesions of different ages
    • Traugott, U., E. L. Reinherz, and C. S. Raine. 1983. Multiple sclerosis. Distribution of T cells, T cell subsets and Ia-positive macrophages in lesions of different ages. J. Neuroimmunol. 4: 201-221.
    • (1983) J. Neuroimmunol. , vol.4 , pp. 201-221
    • Traugott, U.1    Reinherz, E.L.2    Raine, C.S.3
  • 14
    • 0022459287 scopus 로고
    • Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions
    • Hauser, S. L., A. K. Bhan, F. Gilles, M. Kemp, C. Kerr, and H. L. Weiner. 1986. Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions. Ann. Neurol. 19: 578-587.
    • (1986) Ann. Neurol. , vol.19 , pp. 578-587
    • Hauser, S.L.1    Bhan, A.K.2    Gilles, F.3    Kemp, M.4    Kerr, C.5    Weiner, H.L.6
  • 15
    • 0034618094 scopus 로고    scopus 로고
    • Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction
    • Babbe, H., A. Roers, A. Waisman, H. Lassmann, N. Goebels, R. Hohlfeld, M. Friese, R. Schröder, M. Deckert, S. Schmidt, et al. 2000. Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction. J. Exp. Med. 192: 393-404.
    • (2000) J. Exp. Med. , vol.192 , pp. 393-404
    • Babbe, H.1    Roers, A.2    Waisman, A.3    Lassmann, H.4    Goebels, N.5    Hohlfeld, R.6    Friese, M.7    Schröder, R.8    Deckert, M.9    Schmidt, S.10
  • 16
    • 84874139422 scopus 로고    scopus 로고
    • Pathogenic CD8 T cells in multiple sclerosis and its experimental models
    • Huseby, E. S., P. G. Huseby, S. Shah, R. Smith, and B. D. Stadinski. 2012. Pathogenic CD8 T cells in multiple sclerosis and its experimental models. Front. Immunol. 3: 64.
    • (2012) Front. Immunol. , vol.3 , pp. 64
    • Huseby, E.S.1    Huseby, P.G.2    Shah, S.3    Smith, R.4    Stadinski, B.D.5
  • 18
    • 0031573209 scopus 로고    scopus 로고
    • Autoantigen recognition by human CD8 T cell clones: Enhanced agonist response induced by altered peptide ligands
    • Dressel, A., J. L. Chin, A. Sette, R. Gausling, P. Höllsberg, and D. A. Hafler. 1997. Autoantigen recognition by human CD8 T cell clones: enhanced agonist response induced by altered peptide ligands. J. Immunol. 159: 4943-4951.
    • (1997) J. Immunol. , vol.159 , pp. 4943-4951
    • Dressel, A.1    Chin, J.L.2    Sette, A.3    Gausling, R.4    Höllsberg, P.5    Hafler, D.A.6
  • 21
    • 0034842960 scopus 로고    scopus 로고
    • Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes
    • Medana, I., M. A. Martinic, H. Wekerle, and H. Neumann. 2001. Transection of major histocompatibility complex class I-induced neurites by cytotoxic T lymphocytes. Am. J. Pathol. 159: 809-815.
    • (2001) Am. J. Pathol. , vol.159 , pp. 809-815
    • Medana, I.1    Martinic, M.A.2    Wekerle, H.3    Neumann, H.4
  • 24
    • 0035801332 scopus 로고    scopus 로고
    • A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis
    • Huseby, E. S., D. Liggitt, T. Brabb, B. Schnabel, C. Ohlén, and J. Goverman. 2001. A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis. J. Exp. Med. 194: 669-676.
    • (2001) J. Exp. Med. , vol.194 , pp. 669-676
    • Huseby, E.S.1    Liggitt, D.2    Brabb, T.3    Schnabel, B.4    Ohlén, C.5    Goverman, J.6
  • 25
    • 0035877190 scopus 로고    scopus 로고
    • Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice
    • Sun, D., J. N. Whitaker, Z. Huang, D. Liu, C. Coleclough, H. Wekerle, and C. S. Raine. 2001. Myelin antigen-specific CD8+ T cells are encephalitogenic and produce severe disease in C57BL/6 mice. J. Immunol. 166: 7579-7587.
    • (2001) J. Immunol. , vol.166 , pp. 7579-7587
    • Sun, D.1    Whitaker, J.N.2    Huang, Z.3    Liu, D.4    Coleclough, C.5    Wekerle, H.6    Raine, C.S.7
  • 26
    • 12344280009 scopus 로고    scopus 로고
    • Specificity, magnitude, and kinetics of MOG-specific CD8+ T cell responses during experimental autoimmune encephalomyelitis
    • Ford, M. L., and B. D. Evavold. 2005. Specificity, magnitude, and kinetics of MOG-specific CD8+ T cell responses during experimental autoimmune encephalomyelitis. Eur. J. Immunol. 35: 76-85.
    • (2005) Eur. J. Immunol. , vol.35 , pp. 76-85
    • Ford, M.L.1    Evavold, B.D.2
  • 29
    • 0026694021 scopus 로고
    • Less mortality but more relapses in experimental allergic encephalomyelitis in CD82/2 mice
    • Koh, D. R., W. P. Fung-Leung, A. Ho, D. Gray, H. Acha-Orbea, and T. W. Mak. 1992. Less mortality but more relapses in experimental allergic encephalomyelitis in CD82/2 mice. Science 256: 1210-1213.
    • (1992) Science , vol.256 , pp. 1210-1213
    • Koh, D.R.1    Fung-Leung, W.P.2    Ho, A.3    Gray, D.4    Acha-Orbea, H.5    Mak, T.W.6
  • 30
    • 0026647293 scopus 로고
    • Role of CD8+ T cells in murine experimental allergic encephalomyelitis
    • Jiang, H., S. I. Zhang, and B. Pernis. 1992. Role of CD8+ T cells in murine experimental allergic encephalomyelitis. Science 256: 1213-1215.
    • (1992) Science , vol.256 , pp. 1213-1215
    • Jiang, H.1    Zhang, S.I.2    Pernis, B.3
  • 31
    • 82755189880 scopus 로고    scopus 로고
    • Regulation of self-tolerance by Qa-1-restricted CD8(+) regulatory T cells
    • Kim, H. J., and H. Cantor. 2011. Regulation of self-tolerance by Qa-1-restricted CD8(+) regulatory T cells. Semin. Immunol. 23: 446-452.
    • (2011) Semin. Immunol. , vol.23 , pp. 446-452
    • Kim, H.J.1    Cantor, H.2
  • 32
    • 84879634299 scopus 로고    scopus 로고
    • The disease-ameliorating function of autoregulatory CD8 T cells is mediated by targeting of encephalitogenic CD4 T cells in experimental autoimmune encephalomyelitis
    • Ortega, S. B., V. P. Kashi, A. F. Tyler, K. Cunnusamy, J. P. Mendoza, and N. J. Karandikar. 2013. The disease-ameliorating function of autoregulatory CD8 T cells is mediated by targeting of encephalitogenic CD4 T cells in experimental autoimmune encephalomyelitis. J. Immunol. 191: 117-126.
    • (2013) J. Immunol. , vol.191 , pp. 117-126
    • Ortega, S.B.1    Kashi, V.P.2    Tyler, A.F.3    Cunnusamy, K.4    Mendoza, J.P.5    Karandikar, N.J.6
  • 33
    • 33644982044 scopus 로고    scopus 로고
    • Regulation of immune responses by T cells
    • Jiang, H., and L. Chess. 2006. Regulation of immune responses by T cells. N. Engl. J. Med. 354: 1166-1176.
    • (2006) N. Engl. J. Med. , vol.354 , pp. 1166-1176
    • Jiang, H.1    Chess, L.2
  • 35
    • 0027448708 scopus 로고
    • MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination
    • Zhang, J., R. Medaer, P. Stinissen, D. Hafler, and J. Raus. 1993. MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination. Science 261: 1451-1454.
    • (1993) Science , vol.261 , pp. 1451-1454
    • Zhang, J.1    Medaer, R.2    Stinissen, P.3    Hafler, D.4    Raus, J.5
  • 39
    • 0032526853 scopus 로고    scopus 로고
    • Endogenous myelin basic protein inactivates the high avidity T cell repertoire
    • Targoni, O. S., and P. V. Lehmann. 1998. Endogenous myelin basic protein inactivates the high avidity T cell repertoire. J. Exp. Med. 187: 2055-2063.
    • (1998) J. Exp. Med. , vol.187 , pp. 2055-2063
    • Targoni, O.S.1    Lehmann, P.V.2
  • 40
    • 0344299188 scopus 로고    scopus 로고
    • Cutting edge: Myelin basic protein-specific cytotoxic T cell tolerance is maintained in vivo by a single dominant epitope in H-2k mice
    • Huseby, E. S., C. Ohlén, and J. Goverman. 1999. Cutting edge: myelin basic protein-specific cytotoxic T cell tolerance is maintained in vivo by a single dominant epitope in H-2k mice. J. Immunol. 163: 1115-1118.
    • (1999) J. Immunol. , vol.163 , pp. 1115-1118
    • Huseby, E.S.1    Ohlén, C.2    Goverman, J.3
  • 41
    • 0033984067 scopus 로고    scopus 로고
    • Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells
    • Klein, L., M. Klugmann, K. A. Nave, V. K. Tuohy, and B. Kyewski. 2000. Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. Nat. Med. 6: 56-61.
    • (2000) Nat. Med. , vol.6 , pp. 56-61
    • Klein, L.1    Klugmann, M.2    Nave, K.A.3    Tuohy, V.K.4    Kyewski, B.5
  • 42
    • 80051873375 scopus 로고    scopus 로고
    • CD8(+) T cells: Foot soldiers of the immune system
    • Zhang, N., and M. J. Bevan. 2011. CD8(+) T cells: foot soldiers of the immune system. Immunity 35: 161-168.
    • (2011) Immunity , vol.35 , pp. 161-168
    • Zhang, N.1    Bevan, M.J.2
  • 43
    • 84871990243 scopus 로고    scopus 로고
    • Viral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection
    • Vanguri, V., C. C. Govern, R. Smith, and E. S. Huseby. 2013. Viral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection. Proc. Natl. Acad. Sci. USA 110: 288-293.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 288-293
    • Vanguri, V.1    Govern, C.C.2    Smith, R.3    Huseby, E.S.4
  • 45
    • 0029037960 scopus 로고
    • Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice
    • Zhumabekov, T., P. Corbella, M. Tolaini, and D. Kioussis. 1995. Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice. J. Immunol. Methods 185: 133-140.
    • (1995) J. Immunol. Methods , vol.185 , pp. 133-140
    • Zhumabekov, T.1    Corbella, P.2    Tolaini, M.3    Kioussis, D.4
  • 46
    • 0035041538 scopus 로고    scopus 로고
    • Age-dependent T cell tolerance and autoimmunity to myelin basic protein
    • Huseby, E. S., B. Sather, P. G. Huseby, and J. Goverman. 2001. Age-dependent T cell tolerance and autoimmunity to myelin basic protein. Immunity 14: 471-481.
    • (2001) Immunity , vol.14 , pp. 471-481
    • Huseby, E.S.1    Sather, B.2    Huseby, P.G.3    Goverman, J.4
  • 47
    • 80055101576 scopus 로고    scopus 로고
    • A simple composite phenotype scoring system for evaluating mouse models of cerebellar ataxia
    • Guyenet, S. J., S. A. Furrer, V. M. Damian, T. D. Baughan, A. R. La Spada, and G. A. Garden. 2010. A simple composite phenotype scoring system for evaluating mouse models of cerebellar ataxia. J. Vis. Exp. 39: 1787.
    • (2010) J. Vis. Exp. , vol.39 , pp. 1787
    • Guyenet, S.J.1    Furrer, S.A.2    Damian, V.M.3    Baughan, T.D.4    La Spada, A.R.5    Garden, G.A.6
  • 49
    • 79958251745 scopus 로고    scopus 로고
    • T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    • Moran, A. E., K. L. Holzapfel, Y. Xing, N. R. Cunningham, J. S. Maltzman, J. Punt, and K. A. Hogquist. 2011. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J. Exp. Med. 208: 1279-1289.
    • (2011) J. Exp. Med. , vol.208 , pp. 1279-1289
    • Moran, A.E.1    Holzapfel, K.L.2    Xing, Y.3    Cunningham, N.R.4    Maltzman, J.S.5    Punt, J.6    Hogquist, K.A.7
  • 50
    • 84876910443 scopus 로고    scopus 로고
    • The integration of T cell migration, differentiation and function
    • Masopust, D., and J. M. Schenkel. 2013. The integration of T cell migration, differentiation and function. Nat. Rev. Immunol. 13: 309-320.
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 309-320
    • Masopust, D.1    Schenkel, J.M.2
  • 51
  • 52
    • 0027537456 scopus 로고
    • A new family of transcripts of the myelin basic protein gene: Expression in brain and in immune system
    • Zelenika, D., B. Grima, and B. Pessac. 1993. A new family of transcripts of the myelin basic protein gene: expression in brain and in immune system. J. Neurochem. 60: 1574-1577.
    • (1993) J. Neurochem. , vol.60 , pp. 1574-1577
    • Zelenika, D.1    Grima, B.2    Pessac, B.3
  • 54
    • 41349092053 scopus 로고    scopus 로고
    • Direct presentation of antigen by lymph node stromal cells protects against CD8 T-cell-mediated intestinal autoimmunity
    • Magnusson, F. C., R. S. Liblau, H. von Boehmer, M. J. Pittet, J. W. Lee, S. J. Turley, and K. Khazaie. 2008. Direct presentation of antigen by lymph node stromal cells protects against CD8 T-cell-mediated intestinal autoimmunity. Gastroenterology 134: 1028-1037.
    • (2008) Gastroenterology , vol.134 , pp. 1028-1037
    • Magnusson, F.C.1    Liblau, R.S.2    Von Boehmer, H.3    Pittet, M.J.4    Lee, J.W.5    Turley, S.J.6    Khazaie, K.7
  • 55
    • 0030612196 scopus 로고    scopus 로고
    • Induction of experimental autoimmune encephalomyelitis by CD4+ T cells specific for an astrocyte protein, S100 beta
    • Kojima, K., H. Wekerle, H. Lassmann, T. Berger, and C. Linington. 1997. Induction of experimental autoimmune encephalomyelitis by CD4+ T cells specific for an astrocyte protein, S100 beta. J. Neural Transm. Suppl. 49: 43-51.
    • (1997) J. Neural Transm. Suppl. , vol.49 , pp. 43-51
    • Kojima, K.1    Wekerle, H.2    Lassmann, H.3    Berger, T.4    Linington, C.5
  • 56
    • 0030961807 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis: The antigen specificity of T lymphocytes determines the topography of lesions in the central and peripheral nervous system
    • Berger, T., S. Weerth, K. Kojima, C. Linington, H. Wekerle, and H. Lassmann. 1997. Experimental autoimmune encephalomyelitis: the antigen specificity of T lymphocytes determines the topography of lesions in the central and peripheral nervous system. Lab. Invest. 76: 355-364.
    • (1997) Lab. Invest. , vol.76 , pp. 355-364
    • Berger, T.1    Weerth, S.2    Kojima, K.3    Linington, C.4    Wekerle, H.5    Lassmann, H.6
  • 57
    • 2942666042 scopus 로고    scopus 로고
    • CD8+ T cells maintain tolerance to myelin basic protein by 'epitope theft'
    • Perchellet, A., I. Stromnes, J. M. Pang, and J. Goverman. 2004. CD8+ T cells maintain tolerance to myelin basic protein by 'epitope theft'. Nat. Immunol. 5: 606-614.
    • (2004) Nat. Immunol. , vol.5 , pp. 606-614
    • Perchellet, A.1    Stromnes, I.2    Pang, J.M.3    Goverman, J.4
  • 58
    • 77953758560 scopus 로고    scopus 로고
    • Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs
    • Ji, Q., A. Perchellet, and J. M. Goverman. 2010. Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs. Nat. Immunol. 11: 628-634.
    • (2010) Nat. Immunol. , vol.11 , pp. 628-634
    • Ji, Q.1    Perchellet, A.2    Goverman, J.M.3
  • 59
    • 0034842126 scopus 로고    scopus 로고
    • Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions
    • Peterson, J. W., L. Bö, S. Mörk, A. Chang, and B. D. Trapp. 2001. Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann. Neurol. 50: 389-400.
    • (2001) Ann. Neurol. , vol.50 , pp. 389-400
    • Peterson, J.W.1    Bö, L.2    Mörk, S.3    Chang, A.4    Trapp, B.D.5
  • 61
    • 54849431166 scopus 로고    scopus 로고
    • Gray matter atrophy in multiple sclerosis: A longitudinal study
    • Fisher, E., J. C. Lee, K. Nakamura, and R. A. Rudick. 2008. Gray matter atrophy in multiple sclerosis: a longitudinal study. Ann. Neurol. 64: 255-265.
    • (2008) Ann. Neurol. , vol.64 , pp. 255-265
    • Fisher, E.1    Lee, J.C.2    Nakamura, K.3    Rudick, R.A.4
  • 63
    • 79951786397 scopus 로고    scopus 로고
    • GFAP in health and disease
    • Middeldorp, J., and E. M. Hol. 2011. GFAP in health and disease. Prog. Neurobiol. 93: 421-443.
    • (2011) Prog. Neurobiol. , vol.93 , pp. 421-443
    • Middeldorp, J.1    Hol, E.M.2
  • 66
    • 70449580916 scopus 로고    scopus 로고
    • Proteome profiling in murine models of multiple sclerosis: Identification of stage specific markers and culprits for tissue damage
    • Linker, R. A., P. Brechlin, S. Jesse, P. Steinacker, D. H. Lee, A. R. Asif, O. Jahn, H. Tumani, R. Gold, and M. Otto. 2009. Proteome profiling in murine models of multiple sclerosis: identification of stage specific markers and culprits for tissue damage. PLoS ONE 4: e7624.
    • (2009) PLoS ONE , vol.4
    • Linker, R.A.1    Brechlin, P.2    Jesse, S.3    Steinacker, P.4    Lee, D.H.5    Asif, A.R.6    Jahn, O.7    Tumani, H.8    Gold, R.9    Otto, M.10
  • 67
    • 71049147858 scopus 로고    scopus 로고
    • Naturally presented peptides on major histocompatibility complex i and II molecules eluted from central nervous system of multiple sclerosis patients
    • Fissolo, N., S. Haag, K. L. de Graaf, O. Drews, S. Stevanovic, H. G. Rammensee, and R. Weissert. 2009. Naturally presented peptides on major histocompatibility complex I and II molecules eluted from central nervous system of multiple sclerosis patients. Mol. Cell. Proteomics 8: 2090-2101.
    • (2009) Mol. Cell. Proteomics , vol.8 , pp. 2090-2101
    • Fissolo, N.1    Haag, S.2    De Graaf, K.L.3    Drews, O.4    Stevanovic, S.5    Rammensee, H.G.6    Weissert, R.7
  • 68
    • 33845533220 scopus 로고    scopus 로고
    • Identification of Novel HLA-A*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives
    • Standifer, N. E., Q. Ouyang, C. Panagiotopoulos, C. B. Verchere, R. Tan, C. J. Greenbaum, C. Pihoker, and G. T. Nepom. 2006. Identification of Novel HLA-A*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives. Diabetes 55: 3061-3067.
    • (2006) Diabetes , vol.55 , pp. 3061-3067
    • Standifer, N.E.1    Ouyang, Q.2    Panagiotopoulos, C.3    Verchere, C.B.4    Tan, R.5    Greenbaum, C.J.6    Pihoker, C.7    Nepom, G.T.8
  • 69
    • 66549102332 scopus 로고    scopus 로고
    • CD8+ T-cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery
    • Schwab, N., C. G. Bien, A. Waschbisch, A. Becker, G. H. Vince, K. Dornmair, and H. Wiendl. 2009. CD8+ T-cell clones dominate brain infiltrates in Rasmussen encephalitis and persist in the periphery. Brain 132: 1236-1246.
    • (2009) Brain , vol.132 , pp. 1236-1246
    • Schwab, N.1    Bien, C.G.2    Waschbisch, A.3    Becker, A.4    Vince, G.H.5    Dornmair, K.6    Wiendl, H.7
  • 70
    • 1642458745 scopus 로고    scopus 로고
    • The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis
    • Kawakami, N., S. Lassmann, Z. Li, F. Odoardi, T. Ritter, T. Ziemssen, W. E. Klinkert, J. W. Ellwart, M. Bradl, K. Krivacic, et al. 2004. The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. J. Exp. Med. 199: 185-197.
    • (2004) J. Exp. Med. , vol.199 , pp. 185-197
    • Kawakami, N.1    Lassmann, S.2    Li, Z.3    Odoardi, F.4    Ritter, T.5    Ziemssen, T.6    Klinkert, W.E.7    Ellwart, J.W.8    Bradl, M.9    Krivacic, K.10
  • 71
    • 73349109145 scopus 로고    scopus 로고
    • Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes
    • Jäger, A., V. Dardalhon, R. A. Sobel, E. Bettelli, and V. K. Kuchroo. 2009. Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J. Immunol. 183: 7169-7177.
    • (2009) J. Immunol. , vol.183 , pp. 7169-7177
    • Jäger, A.1    Dardalhon, V.2    Sobel, R.A.3    Bettelli, E.4    Kuchroo, V.K.5
  • 72
    • 84862736185 scopus 로고    scopus 로고
    • Mechanisms regulating regional localization of inflammation during CNS autoimmunity
    • Pierson, E., S. B. Simmons, L. Castelli, and J. M. Goverman. 2012. Mechanisms regulating regional localization of inflammation during CNS autoimmunity. Immunol. Rev. 248: 205-215.
    • (2012) Immunol. Rev. , vol.248 , pp. 205-215
    • Pierson, E.1    Simmons, S.B.2    Castelli, L.3    Goverman, J.M.4
  • 73
    • 84877890808 scopus 로고    scopus 로고
    • Monoclonal antibodies in neuroinflammatory diseases
    • Klotz, L., and H. Wiendl. 2013. Monoclonal antibodies in neuroinflammatory diseases. Expert Opin. Biol. Ther. 13: 831-846.
    • (2013) Expert Opin. Biol. Ther. , vol.13 , pp. 831-846
    • Klotz, L.1    Wiendl, H.2
  • 74
    • 33748319513 scopus 로고    scopus 로고
    • Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Deviclike disease in mice
    • Bettelli, E., D. Baeten, A. Jäger, R. A. Sobel, and V. K. Kuchroo. 2006. Myelin oligodendrocyte glycoprotein-specific T and B cells cooperate to induce a Deviclike disease in mice. J. Clin. Invest. 116: 2393-2402.
    • (2006) J. Clin. Invest. , vol.116 , pp. 2393-2402
    • Bettelli, E.1    Baeten, D.2    Jäger, A.3    Sobel, R.A.4    Kuchroo, V.K.5
  • 77
    • 79952697696 scopus 로고    scopus 로고
    • B-lymphocyte effector functions in health and disease
    • DiLillo, D. J., M. Horikawa, and T. F. Tedder. 2011. B-lymphocyte effector functions in health and disease. Immunol. Res. 49: 281-292.
    • (2011) Immunol. Res. , vol.49 , pp. 281-292
    • Dilillo, D.J.1    Horikawa, M.2    Tedder, T.F.3
  • 78
    • 84893418455 scopus 로고    scopus 로고
    • B cells promote induction of experimental autoimmune encephalomyelitis by facilitating reactivation of T cells in the central nervous system
    • Pierson, E. R., I. M. Stromnes, and J. M. Goverman. 2014. B cells promote induction of experimental autoimmune encephalomyelitis by facilitating reactivation of T cells in the central nervous system. J. Immunol. 192: 929-939.
    • (2014) J. Immunol. , vol.192 , pp. 929-939
    • Pierson, E.R.1    Stromnes, I.M.2    Goverman, J.M.3
  • 80
    • 26244468314 scopus 로고    scopus 로고
    • Cross-presentation: Underlying mechanisms and role in immune surveillance
    • Rock, K. L., and L. Shen. 2005. Cross-presentation: underlying mechanisms and role in immune surveillance. Immunol. Rev. 207: 166-183.
    • (2005) Immunol. Rev. , vol.207 , pp. 166-183
    • Rock, K.L.1    Shen, L.2
  • 81
    • 38749143286 scopus 로고    scopus 로고
    • Interleukin-17 production in central nervous systeminfiltrating T cells and glial cells is associated with active disease in multiple sclerosis
    • Tzartos, J. S., M. A. Friese, M. J. Craner, J. Palace, J. Newcombe, M. M. Esiri, and L. Fugger. 2008. Interleukin-17 production in central nervous systeminfiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am. J. Pathol. 172: 146-155.
    • (2008) Am. J. Pathol. , vol.172 , pp. 146-155
    • Tzartos, J.S.1    Friese, M.A.2    Craner, M.J.3    Palace, J.4    Newcombe, J.5    Esiri, M.M.6    Fugger, L.7
  • 82
    • 0036602982 scopus 로고    scopus 로고
    • Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases
    • Neumann, H., I. M. Medana, J. Bauer, and H. Lassmann. 2002. Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases. Trends Neurosci. 25: 313-319.
    • (2002) Trends Neurosci. , vol.25 , pp. 313-319
    • Neumann, H.1    Medana, I.M.2    Bauer, J.3    Lassmann, H.4
  • 85
    • 34247160776 scopus 로고    scopus 로고
    • Increased CD8+ central memory T cells in patients with multiple sclerosis
    • Liu, G. Z., L. B. Fang, P. Hjelmström, and X. G. Gao. 2007. Increased CD8+ central memory T cells in patients with multiple sclerosis. Mult. Scler. 13: 149-155.
    • (2007) Mult. Scler. , vol.13 , pp. 149-155
    • Liu, G.Z.1    Fang, L.B.2    Hjelmström, P.3    Gao, X.G.4
  • 86
    • 58149159798 scopus 로고    scopus 로고
    • Regional CNS responses to IFN-gamma determine lesion localization patterns during EAE pathogenesis
    • Lees, J. R., P. T. Golumbek, J. Sim, D. Dorsey, and J. H. Russell. 2008. Regional CNS responses to IFN-gamma determine lesion localization patterns during EAE pathogenesis. J. Exp. Med. 205: 2633-2642.
    • (2008) J. Exp. Med. , vol.205 , pp. 2633-2642
    • Lees, J.R.1    Golumbek, P.T.2    Sim, J.3    Dorsey, D.4    Russell, J.H.5
  • 88
    • 77949973725 scopus 로고    scopus 로고
    • Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis
    • Kang, Z., C. Z. Altuntas, M. F. Gulen, C. Liu, N. Giltiay, H. Qin, L. Liu, W. Qian, R. M. Ransohoff, C. Bergmann, et al. 2010. Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis. Immunity 32: 414-425.
    • (2010) Immunity , vol.32 , pp. 414-425
    • Kang, Z.1    Altuntas, C.Z.2    Gulen, M.F.3    Liu, C.4    Giltiay, N.5    Qin, H.6    Liu, L.7    Qian, W.8    Ransohoff, R.M.9    Bergmann, C.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.