The gateway theory: Bridging neural and immune interactions in the CNS

Frontiers in Neuroscience

Volumn , Issue 7 OCT, 2013, Pages

  Kamimura, Daisuke ^a   Yamada, Moe ^a   Harada, Masaya ^a   Sabharwal, Lavannya ^a   Meng, Jie ^a   Bando, Hidenori ^a   Ogura, Hideki ^a   Atsumi, Toru ^a   Arima, Yasunobu ^a   Murakami, Masaaki ^a,b  

^a JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^b Center for Advanced Science and Innovation   (Japan)

Author keywords

Autoimmune diseases; Blood brain barrier; Cytokines; Gateway theory; Inflammation; Inflammatory diseases; Multiple sclerosis; Neural activation

Indexed keywords

ATENOLOL; GLYCOPROTEIN GP 130; INTERLEUKIN 17; INTERLEUKIN 6; MESSENGER RNA; PRAZOSIN; STAT3 PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ARTICLE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CHRONIC INFLAMMATION; GATEWAY THEORY; GRAVITY; HUMAN; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; MULTIPLE SCLEROSIS; NONHUMAN; PATHOGENESIS; RHEUMATOID ARTHRITIS; SENSORY NERVE CELL; SOLEUS MUSCLE; SPINAL GANGLION; STEADY STATE; T LYMPHOCYTE; THEORY;

EID: 84888790566     PISSN: 16624548     EISSN: 1662453X     Source Type: Journal    
DOI: 10.3389/fnins.2013.00204     Document Type: Article

References (22)

1. Arima, Y., Harada, M., Kamimura, D., Park, J. H., Kawano, F., Yull, F. E., et al. (2012). Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier. Cell 148, 447-457. doi: 10.1016/j.cell.2012.01.022
2. Atsumi, T., Ishihara, K., Kamimura, D., Ikushima, H., Ohtani, T., Hirota, S., et al. (2002). A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis. J. Exp. Med. 196, 979-990. doi: 10.1084/jem.20020619
3. Cao, L., Liu, X., Lin, E. J., Wang, C., Choi, E. Y., Riban, V., et al. (2010). Environmental and genetic activation of a brain-adipocyte BDNF/leptin axis causes cancer remission and inhibition. Cell 142, 52-64. doi: 10.1016/j.cell.2010.05.029
4. Feng, Z., Liu, L., Zhang, C., Zheng, T., Wang, J., Lin, M., et al. (2012). Chronic restraint stress attenuates p53 function and promotes tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 109, 7013-7018. doi: 10.1073/pnas.1203930109
5. Goldmann, J., Kwidzinski, E., Brandt, C., Mahlo, J., Richter, D., and Bechmann, I. (2006). T cells traffic from brain to cervical lymph nodes via the cribroid plate and the nasal mucosa. J. Leukoc. Biol. 80, 797-801. doi: 10.1189/jlb.0306176
6. Hamdani, N., Tamouza, R., and Leboyer, M. (2012). Immuno-inflammatory markers of bipolar disorder: a review of evidence. Front. Biosci. 4, 2170-2182. doi: 10.2741/534
7. Hassan, S., Karpova, Y., Baiz, D., Yancey, D., Pullikuth, A., Flores, A., et al. (2013). Behavioral stress accelerates prostate cancer development in mice. J. Clin. Invest. 123, 874-886. doi: 10.1172/JCI63324
8. International Multiple Sclerosis Genetics, C., Wellcome Trust Case Control, C., Sawcer, S., Hellenthal, G., Pirinen, M., Spencer, C. C., et al. (2011). Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476, 214-219. doi: 10.1038/nature10251
9. Kamimura, D., Ishihara, K., and Hirano, T. (2003). IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev. Physiol. Biochem. Pharmacol. 149, 1-38. doi: 10.1007/s10254-003-0012-2
10. Komiyama, Y., Nakae, S., Matsuki, T., Nambu, A., Ishigame, H., Kakuta, S., et al. (2006). IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis. J. Immunol. 177, 566-573.
11. Lee, J., Nakagiri, T., Oto, T., Harada, M., Morii, E., Shintani, Y., et al. (2012). IL-6 amplifier, NF-kappaB-triggered positive feedback for IL-6 signaling, in grafts is involved in allogeneic rejection responses. J. Immunol. 189, 1928-1936. doi: 10.4049/jimmunol.1103613
12. Mitsonis, C. I., Potagas, C., Zervas, I., and Sfagos, K. (2009). The effects of stressful life events on the course of multiple sclerosis: a review. Int. J. Neurosci. 119, 315-335. doi: 10.1080/00207450802480192
13. Murakami, M., Harada, M., Kamimura, D., Ogura, H., Okuyama, Y., Kumai, N., et al. (2013). Disease-association analysis of the IL-6-amplifier, an inflammation-related feedback loop. Cell Rep. 3, 946-959. doi: 10.1016/j.celrep.2013.01.028
14. Murakami, M., and Hirano, T. (2012). The pathological and physiological roles of IL-6 amplifier activation. Int. J. Biol. Sci. 8, 1267-1280. doi: 10.7150/ijbs.4828
15. Murakami, M., Kamimura, D., and Hirano, T. (2004). New IL-6 (gp130) family cytokine members, CLC/NNT1/BSF3 and IL-27. Growth Factors 22, 75-77. doi: 10.1080/08977190410001715181
16. Murakami, M., Okuyama, Y., Ogura, H., Asano, S., Arima, Y., Tsuruoka, M., et al. (2011). Local microbleeding facilitates IL-6-and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells. J. Exp. Med. 208, 103-114. doi: 10.1084/jem.20100900
17. Ogura, H., Murakami, M., Okuyama, Y., Tsuruoka, M., Kitabayashi, C., Kanamoto, M., et al. (2008). Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction. Immunity 29, 628-636. doi: 10.1016/j.immuni.2008.07.018
18. Ohira, Y., Kawano, F., Stevens, J. L., Wang, X. D., and Ishihara, A. (2004). Load-dependent regulation of neuromuscular system. J. Gravit. Physiol. 11, P127-P128.
19. Ohtani, T., Ishihara, K., Atsumi, T., Nishida, K., Kaneko, Y., Miyata, T., et al. (2000). Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3-and SHP2-mediated signals in immune responses. Immunity 12, 95-105. doi: 10.1016/S1074-7613(00)80162-4
20. Sawa, S., Kamimura, D., Jin, G. H., Morikawa, H., Kamon, H., Nishihara, M., et al. (2006). Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells. J. Exp. Med. 203, 1459-1470. doi: 10.1084/jem.20052187
21. Srivastava, S., and Boyer, J. L. (2010). Psychological stress is associated with relapse in type 1 autoimmune hepatitis. Liver Int. 30, 1439-1447. doi: 10.1111/j.1478-3231.2010.02333.x
22. Tabas, I., and Glass, C. K. (2013). Anti-inflammatory therapy in chronic disease: challenges and opportunities. Science 339, 166-172. doi: 10.1126/science.1230720