-
1
-
-
77956229707
-
Leukemia inhibitory factor can mediate Ras/Raf/MEK/ERK-induced growth inhibitory signaling in medullary thyroid cancer cells
-
Arthan D, Hong S K, Park J I (2010). Leukemia inhibitory factor can mediate Ras/Raf/MEK/ERK-induced growth inhibitory signaling in medullary thyroid cancer cells. Cancer Lett, 297(1): 31-41.
-
(2010)
Cancer Lett
, vol.297
, Issue.1
, pp. 31-41
-
-
Arthan, D.1
Hong, S.K.2
Park, J.I.3
-
3
-
-
1242290740
-
Mek2 is dispensable for mouse growth and development
-
Bélanger L F, Roy S, Tremblay M, Brott B, Steff AM, Mourad W, Hugo P, Erikson R, Charron J (2003). Mek2 is dispensable for mouse growth and development. Mol Cell Biol, 23(14): 4778-4787.
-
(2003)
Mol Cell Biol
, vol.23
, Issue.14
, pp. 4778-4787
-
-
Bélanger, L.F.1
Roy, S.2
Tremblay, M.3
Brott, B.4
Steff, A.M.5
Mourad, W.6
Hugo, P.7
Erikson, R.8
Charron, J.9
-
4
-
-
51649125641
-
RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo
-
Bessard A, Frémin C, Ezan F, Fautrel A, Gailhouste L, Baffet G (2008). RNAi-mediated ERK2 knockdown inhibits growth of tumor cells in vitro and in vivo. Oncogene, 27(40): 5315-5325.
-
(2008)
Oncogene
, vol.27
, Issue.40
, pp. 5315-5325
-
-
Bessard, A.1
Frémin, C.2
Ezan, F.3
Fautrel, A.4
Gailhouste, L.5
Baffet, G.6
-
5
-
-
34247618721
-
Concise review: regulation of embryonic stem cell lineage commitment by mitogen-activated protein kinases
-
Binétruy B, Heasley L, Bost F, Caron L, Aouadi M (2007). Concise review: regulation of embryonic stem cell lineage commitment by mitogen-activated protein kinases. Stem Cells, 25(5): 1090-1095.
-
(2007)
Stem Cells
, vol.25
, Issue.5
, pp. 1090-1095
-
-
Binétruy, B.1
Heasley, L.2
Bost, F.3
Caron, L.4
Aouadi, M.5
-
6
-
-
0025290163
-
An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control
-
Boulton T G, Yancopoulos G D, Gregory J S, Slaughter C, Moomaw C, Hsu J, Cobb M H (1990). An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control. Science, 249(4964): 64-67.
-
(1990)
Science
, vol.249
, Issue.4964
, pp. 64-67
-
-
Boulton, T.G.1
Yancopoulos, G.D.2
Gregory, J.S.3
Slaughter, C.4
Moomaw, C.5
Hsu, J.6
Cobb, M.H.7
-
7
-
-
23244461708
-
Oncogene-induced senescence as an initial barrier in lymphoma development
-
Braig M, Lee S, Loddenkemper C, Rudolph C, Peters A H, Schlegelberger B, Stein H, Dörken B, Jenuwein T, Schmitt C A (2005). Oncogene-induced senescence as an initial barrier in lymphoma development. Nature, 436(7051): 660-665.
-
(2005)
Nature
, vol.436
, Issue.7051
, pp. 660-665
-
-
Braig, M.1
Lee, S.2
Loddenkemper, C.3
Rudolph, C.4
Peters, A.H.5
Schlegelberger, B.6
Stein, H.7
Dörken, B.8
Jenuwein, T.9
Schmitt, C.A.10
-
8
-
-
78951491639
-
Quantitative analysis of ERK2 interactions with substrate proteins: roles for kinase docking domains and activity in determining binding affinity
-
Burkhard K A, Chen F, Shapiro P (2011). Quantitative analysis of ERK2 interactions with substrate proteins: roles for kinase docking domains and activity in determining binding affinity. J Biol Chem, 286(4): 2477-2485.
-
(2011)
J Biol Chem
, vol.286
, Issue.4
, pp. 2477-2485
-
-
Burkhard, K.A.1
Chen, F.2
Shapiro, P.3
-
9
-
-
73649089980
-
ERK and cell death: mechanisms of ERK-induced cell death-apoptosis, autophagy and senescence
-
Cagnol S, Chambard J C (2010). ERK and cell death: mechanisms of ERK-induced cell death-apoptosis, autophagy and senescence. FEBS J, 277(1): 2-21.
-
(2010)
FEBS J
, vol.277
, Issue.1
, pp. 2-21
-
-
Cagnol, S.1
Chambard, J.C.2
-
10
-
-
0029006925
-
Ret gene silencing is associated with Raf-1-induced medullary thyroid carcinoma cell differentiation
-
Carson E B, McMahon M, Baylin S B, Nelkin B D (1995). Ret gene silencing is associated with Raf-1-induced medullary thyroid carcinoma cell differentiation. Cancer Res, 55(10): 2048-2052.
-
(1995)
Cancer Res
, vol.55
, Issue.10
, pp. 2048-2052
-
-
Carson, E.B.1
McMahon, M.2
Baylin, S.B.3
Nelkin, B.D.4
-
11
-
-
0032560857
-
Post-transcriptional silencing of RET occurs, but is not required, during raf-1 mediated differentiation of medullary thyroid carcinoma cells
-
Carson-Walter E B, Smith D P, Ponder B A, Baylin S B, Nelkin B D (1998). Post-transcriptional silencing of RET occurs, but is not required, during raf-1 mediated differentiation of medullary thyroid carcinoma cells. Oncogene, 17(3): 367-376.
-
(1998)
Oncogene
, vol.17
, Issue.3
, pp. 367-376
-
-
Carson-Walter, E.B.1
Smith, D.P.2
Ponder, B.A.3
Baylin, S.B.4
Nelkin, B.D.5
-
12
-
-
50549083633
-
Essential role of ERK dimers in the activation of cytoplasmic but not nuclear substrates by ERK-scaffold complexes
-
Casar B, Pinto A, Crespo P (2008). Essential role of ERK dimers in the activation of cytoplasmic but not nuclear substrates by ERK-scaffold complexes. Mol Cell, 31(5): 708-721.
-
(2008)
Mol Cell
, vol.31
, Issue.5
, pp. 708-721
-
-
Casar, B.1
Pinto, A.2
Crespo, P.3
-
13
-
-
0034944380
-
Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism
-
Chen J, Fujii K, Zhang L, Roberts T, Fu H (2001). Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism. Proc Natl Acad Sci USA, 98(14): 7783-7788.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, Issue.14
, pp. 7783-7788
-
-
Chen, J.1
Fujii, K.2
Zhang, L.3
Roberts, T.4
Fu, H.5
-
14
-
-
44849096481
-
Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development
-
Cheung M, Sharma A, Madhunapantula S V, Robertson G P (2008). Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development. Cancer Res, 68(9): 3429-3439.
-
(2008)
Cancer Res
, vol.68
, Issue.9
, pp. 3429-3439
-
-
Cheung, M.1
Sharma, A.2
Madhunapantula, S.V.3
Robertson, G.P.4
-
15
-
-
23244447893
-
Tumour biology: senescence in premalignant tumours
-
Collado M, Gil J, Efeyan A, Guerra C, Schuhmacher A J, Barradas M, Benguría A, Zaballos A, Flores J M, Barbacid M, Beach D, Serrano M (2005). Tumour biology: senescence in premalignant tumours. Nature, 436(7051): 642.
-
(2005)
Nature
, vol.436
, Issue.7051
, pp. 642
-
-
Collado, M.1
Gil, J.2
Efeyan, A.3
Guerra, C.4
Schuhmacher, A.J.5
Barradas, M.6
Benguría, A.7
Zaballos, A.8
Flores, J.M.9
Barbacid, M.10
Beach, D.11
Serrano, M.12
-
16
-
-
0024442034
-
A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae
-
Courchesne W E, Kunisawa R, Thorner J (1989). A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae. Cell, 58(6): 1107-1119.
-
(1989)
Cell
, vol.58
, Issue.6
, pp. 1107-1119
-
-
Courchesne, W.E.1
Kunisawa, R.2
Thorner, J.3
-
17
-
-
42949129074
-
Many roads lead to oncogene-induced senescence
-
Courtois-Cox S, Jones S L, Cichowski K (2008). Many roads lead to oncogene-induced senescence. Oncogene, 27(20): 2801-2809.
-
(2008)
Oncogene
, vol.27
, Issue.20
, pp. 2801-2809
-
-
Courtois-Cox, S.1
Jones, S.L.2
Cichowski, K.3
-
18
-
-
34248583886
-
MAP kinase signaling pathways in cancer
-
Dhillon A S, Hagan S, Rath O, Kolch W (2007). MAP kinase signaling pathways in cancer. Oncogene, 26(22): 3279-3290.
-
(2007)
Oncogene
, vol.26
, Issue.22
, pp. 3279-3290
-
-
Dhillon, A.S.1
Hagan, S.2
Rath, O.3
Kolch, W.4
-
19
-
-
0037373062
-
A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation
-
Dhillon A S, Meikle S, Peyssonnaux C, Grindlay J, Kaiser C, Steen H, Shaw P E, Mischak H, Eychène A, Kolch W (2003). A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation. Mol Cell Biol, 23(6): 1983-1993.
-
(2003)
Mol Cell Biol
, vol.23
, Issue.6
, pp. 1983-1993
-
-
Dhillon, A.S.1
Meikle, S.2
Peyssonnaux, C.3
Grindlay, J.4
Kaiser, C.5
Steen, H.6
Shaw, P.E.7
Mischak, H.8
Eychène, A.9
Kolch, W.10
-
20
-
-
84856529117
-
Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation
-
Duhamel S, Hébert J, Gaboury L, Bouchard A, Simon R, Sauter G, Basik M, Meloche S (2012). Sef downregulation by Ras causes MEK1/2 to become aberrantly nuclear localized leading to polyploidy and neoplastic transformation. Cancer Res, 72(3): 626-635.
-
(2012)
Cancer Res
, vol.72
, Issue.3
, pp. 626-635
-
-
Duhamel, S.1
Hébert, J.2
Gaboury, L.3
Bouchard, A.4
Simon, R.5
Sauter, G.6
Basik, M.7
Meloche, S.8
-
21
-
-
1542284071
-
Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion
-
Eblen S T, Slack-Davis J K, Tarcsafalvi A, Parsons J T, Weber M J, Catling A D (2004). Mitogen-activated protein kinase feedback phosphorylation regulates MEK1 complex formation and activation during cellular adhesion. Mol Cell Biol, 24(6): 2308-2317.
-
(2004)
Mol Cell Biol
, vol.24
, Issue.6
, pp. 2308-2317
-
-
Eblen, S.T.1
Slack-Davis, J.K.2
Tarcsafalvi, A.3
Parsons, J.T.4
Weber, M.J.5
Catling, A.D.6
-
22
-
-
0035379644
-
Dual growth arrest pathways in astrocytes and astrocytic tumors in response to Raf-1 activation
-
Fanton C P, McMahon M, Pieper R O (2001). Dual growth arrest pathways in astrocytes and astrocytic tumors in response to Raf-1 activation. J Biol Chem, 276(22): 18871-18877.
-
(2001)
J Biol Chem
, vol.276
, Issue.22
, pp. 18871-18877
-
-
Fanton, C.P.1
McMahon, M.2
Pieper, R.O.3
-
23
-
-
0030445778
-
Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs
-
Ferrell J E Jr (1996). Tripping the switch fantastic: how a protein kinase cascade can convert graded inputs into switch-like outputs. Trends Biochem Sci, 21(12): 460-466.
-
(1996)
Trends Biochem Sci
, vol.21
, Issue.12
, pp. 460-466
-
-
Ferrell Jr., J.E.1
-
24
-
-
26644459229
-
The role of erk1 and erk2 in multiple stages of T cell development
-
Fischer A M, Katayama C D, Pagès G, Pouysségur J, Hedrick S M (2005). The role of erk1 and erk2 in multiple stages of T cell development. Immunity, 23(4): 431-443.
-
(2005)
Immunity
, vol.23
, Issue.4
, pp. 431-443
-
-
Fischer, A.M.1
Katayama, C.D.2
Pagès, G.3
Pouysségur, J.4
Hedrick, S.M.5
-
25
-
-
0030972494
-
Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase
-
Fukuda M, Gotoh Y, Nishida E (1997). Interaction of MAP kinase with MAP kinase kinase: its possible role in the control of nucleocytoplasmic transport of MAP kinase. EMBO J, 16(8): 1901-1908.
-
(1997)
EMBO J
, vol.16
, Issue.8
, pp. 1901-1908
-
-
Fukuda, M.1
Gotoh, Y.2
Nishida, E.3
-
26
-
-
0033535584
-
Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta
-
Giroux S, Tremblay M, Bernard D, Cardin-Girard J F, Aubry S, Larouche L, Rousseau S, Huot J, Landry J, Jeannotte L, Charron J (1999). Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta. Curr Biol, 9(7): 369-372.
-
(1999)
Curr Biol
, vol.9
, Issue.7
, pp. 369-372
-
-
Giroux, S.1
Tremblay, M.2
Bernard, D.3
Cardin-Girard, J.F.4
Aubry, S.5
Larouche, L.6
Rousseau, S.7
Huot, J.8
Landry, J.9
Jeannotte, L.10
Charron, J.11
-
27
-
-
84896530281
-
MEK1/2 Overactivation can Promote Growth Arrest by Mediating ERK1/2-Dependent Phosphorylation of p70S6K
-
doi: 10. 1002/jcp. 24521
-
Guégan J P, Ezan F, Gailhouste L, Langouët S, Baffet G (2013b). MEK1/2 Overactivation can Promote Growth Arrest by Mediating ERK1/2-Dependent Phosphorylation of p70S6K. J Cell Physiol: doi: 10. 1002/jcp. 24521.
-
(2013)
J Cell Physiol
-
-
Guégan, J.P.1
Ezan, F.2
Gailhouste, L.3
Langouët, S.4
Baffet, G.5
-
28
-
-
84872141798
-
MAPK signaling in cisplatin-induced death: predominant role of ERK1 over ERK2 in human hepatocellular carcinoma cells
-
Guégan J P, Ezan F, Théret N, Langouët S, Baffet G (2013a). MAPK signaling in cisplatin-induced death: predominant role of ERK1 over ERK2 in human hepatocellular carcinoma cells. Carcinogenesis, 34(1): 38-47.
-
(2013)
Carcinogenesis
, vol.34
, Issue.1
, pp. 38-47
-
-
Guégan, J.P.1
Ezan, F.2
Théret, N.3
Langouët, S.4
Baffet, G.5
-
29
-
-
84934434947
-
Induction of cellular senescence by oncogenic RAS
-
Gupta R, Wajapeyee N (2013). Induction of cellular senescence by oncogenic RAS. Methods Mol Biol, 1048: 127-133.
-
(2013)
Methods Mol Biol
, vol.1048
, pp. 127-133
-
-
Gupta, R.1
Wajapeyee, N.2
-
30
-
-
84876188256
-
ERK2 suppresses self-renewal capacity of embryonic stem cells, but is not required for multi-lineage commitment
-
Hamilton WB, Kaji K, Kunath T (2013). ERK2 suppresses self-renewal capacity of embryonic stem cells, but is not required for multi-lineage commitment. PLoS ONE, 8(4): e60907.
-
(2013)
PLoS ONE
, vol.8
, Issue.4
-
-
Hamilton, W.B.1
Kaji, K.2
Kunath, T.3
-
31
-
-
80053574588
-
The Raf/MEK/extracellular signal-regulated kinase 1/2 pathway can mediate growth inhibitory and differentiation signaling via androgen receptor downregulation in prostate cancer cells
-
Hong S K, Kim J H, Lin M F, Park J I (2011). The Raf/MEK/extracellular signal-regulated kinase 1/2 pathway can mediate growth inhibitory and differentiation signaling via androgen receptor downregulation in prostate cancer cells. Exp Cell Res, 317(18): 2671-2682.
-
(2011)
Exp Cell Res
, vol.317
, Issue.18
, pp. 2671-2682
-
-
Hong, S.K.1
Kim, J.H.2
Lin, M.F.3
Park, J.I.4
-
32
-
-
70450230440
-
Noncatalytic function of ERK1/2 can promote Raf/MEK/ERK-mediated growth arrest signaling
-
Hong S K, Yoon S, Moelling C, Arthan D, Park J I (2009). Noncatalytic function of ERK1/2 can promote Raf/MEK/ERK-mediated growth arrest signaling. J Biol Chem, 284(48): 33006-33018.
-
(2009)
J Biol Chem
, vol.284
, Issue.48
, pp. 33006-33018
-
-
Hong, S.K.1
Yoon, S.2
Moelling, C.3
Arthan, D.4
Park, J.I.5
-
33
-
-
70350340058
-
Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling
-
Hu S, Xie Z, Onishi A, Yu X, Jiang L, Lin J, Rho H S, Woodard C, Wang H, Jeong J S, Long S, He X, Wade H, Blackshaw S, Qian J, Zhu H (2009). Profiling the human protein-DNA interactome reveals ERK2 as a transcriptional repressor of interferon signaling. Cell, 139(3): 610-622.
-
(2009)
Cell
, vol.139
, Issue.3
, pp. 610-622
-
-
Hu, S.1
Xie, Z.2
Onishi, A.3
Yu, X.4
Jiang, L.5
Lin, J.6
Rho, H.S.7
Woodard, C.8
Wang, H.9
Jeong, J.S.10
Long, S.11
He, X.12
Wade, H.13
Blackshaw, S.14
Qian, J.15
Zhu, H.16
-
34
-
-
67649205804
-
Extracellular signal-regulated kinase 2-dependent phosphorylation induces cytoplasmic localization and degradation of p21Cip1
-
Hwang C Y, Lee C, Kwon K S (2009). Extracellular signal-regulated kinase 2-dependent phosphorylation induces cytoplasmic localization and degradation of p21Cip1. Mol Cell Biol, 29(12): 3379-3389.
-
(2009)
Mol Cell Biol
, vol.29
, Issue.12
, pp. 3379-3389
-
-
Hwang, C.Y.1
Lee, C.2
Kwon, K.S.3
-
35
-
-
14244267810
-
IFI16 is an essential mediator of growth inhibition, but not differentiation, induced by the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells
-
Kim E J, Park J I, Nelkin B D (2005). IFI16 is an essential mediator of growth inhibition, but not differentiation, induced by the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells. J Biol Chem, 280(6): 4913-4920.
-
(2005)
J Biol Chem
, vol.280
, Issue.6
, pp. 4913-4920
-
-
Kim, E.J.1
Park, J.I.2
Nelkin, B.D.3
-
36
-
-
0028239101
-
Inhibition of v-rafdependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2
-
Kortenjann M, Thomae O, Shaw P E (1994). Inhibition of v-rafdependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2. Mol Cell Biol, 14(7): 4815-4824.
-
(1994)
Mol Cell Biol
, vol.14
, Issue.7
, pp. 4815-4824
-
-
Kortenjann, M.1
Thomae, O.2
Shaw, P.E.3
-
37
-
-
46349109999
-
Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation
-
Krens S F, He S, Lamers G E, Meijer A H, Bakkers J, Schmidt T, Spaink H P, Snaar-Jagalska B E (2008). Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation. Dev Biol, 319(2): 370-383.
-
(2008)
Dev Biol
, vol.319
, Issue.2
, pp. 370-383
-
-
Krens, S.F.1
He, S.2
Lamers, G.E.3
Meijer, A.H.4
Bakkers, J.5
Schmidt, T.6
Spaink, H.P.7
Snaar-Jagalska, B.E.8
-
38
-
-
70349772929
-
Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK
-
Kucharska A, Rushworth L K, Staples C, Morrice N A, Keyse S M (2009). Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK. Cell Signal, 21(12): 1794-1805.
-
(2009)
Cell Signal
, vol.21
, Issue.12
, pp. 1794-1805
-
-
Kucharska, A.1
Rushworth, L.K.2
Staples, C.3
Morrice, N.A.4
Keyse, S.M.5
-
39
-
-
41849088475
-
The roles of MAPKs in disease
-
Lawrence M C, Jivan A, Shao C, Duan L, Goad D, Zaganjor E, Osborne J, McGlynn K, Stippec S, Earnest S, Chen W, Cobb MH (2008). The roles of MAPKs in disease. Cell Res, 18(4): 436-442.
-
(2008)
Cell Res
, vol.18
, Issue.4
, pp. 436-442
-
-
Lawrence, M.C.1
Jivan, A.2
Shao, C.3
Duan, L.4
Goad, D.5
Zaganjor, E.6
Osborne, J.7
McGlynn, K.8
Stippec, S.9
Earnest, S.10
Chen, W.11
Cobb, M.H.12
-
40
-
-
37549016809
-
Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels
-
Lefloch R, Pouysségur J, Lenormand P (2008). Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels. Mol Cell Biol, 28(1): 511-527.
-
(2008)
Mol Cell Biol
, vol.28
, Issue.1
, pp. 511-527
-
-
Lefloch, R.1
Pouysségur, J.2
Lenormand, P.3
-
41
-
-
0032190629
-
Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling
-
Lin A W, Barradas M, Stone J C, van Aelst L, Serrano M, Lowe S W (1998). Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes Dev, 12(19): 3008-3019.
-
(1998)
Genes Dev
, vol.12
, Issue.19
, pp. 3008-3019
-
-
Lin, A.W.1
Barradas, M.2
Stone, J.C.3
van Aelst, L.4
Serrano, M.5
Lowe, S.W.6
-
42
-
-
0024334849
-
Insertion of the v-Ha-ras oncogene induces differentiation of calcitonin-producing human small cell lung cancer
-
Mabry M, Nakagawa T, Baylin S, Pettengill O, Sorenson G, Nelkin B (1989). Insertion of the v-Ha-ras oncogene induces differentiation of calcitonin-producing human small cell lung cancer. J Clin Invest, 84(1): 194-199.
-
(1989)
J Clin Invest
, vol.84
, Issue.1
, pp. 194-199
-
-
Mabry, M.1
Nakagawa, T.2
Baylin, S.3
Pettengill, O.4
Sorenson, G.5
Nelkin, B.6
-
43
-
-
0030033473
-
Constitutively active mitogen-activated protein kinase kinase 1 (MAPKK1) and MAPKK2 mediate similar transcriptional and morphological responses
-
Mansour S J, Candia J M, Gloor K K, Ahn N G (1996). Constitutively active mitogen-activated protein kinase kinase 1 (MAPKK1) and MAPKK2 mediate similar transcriptional and morphological responses. Cell Growth Differ, 7(2): 243-250.
-
(1996)
Cell Growth Differ
, vol.7
, Issue.2
, pp. 243-250
-
-
Mansour, S.J.1
Candia, J.M.2
Gloor, K.K.3
Ahn, N.G.4
-
44
-
-
84868628069
-
Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response
-
McCubrey J A, Steelman L S, Chappell W H, Abrams S L, Montalto G, Cervello M, Nicoletti F, Fagone P, Malaponte G, Mazzarino M C, Candido S, Libra M, Bäsecke J, Mijatovic S, Maksimovic-Ivanic D, Milella M, Tafuri A, Cocco L, Evangelisti C, Chiarini F, Martelli A M (2012). Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response. Oncotarget, 3(9): 954-987.
-
(2012)
Oncotarget
, vol.3
, Issue.9
, pp. 954-987
-
-
McCubrey, J.A.1
Steelman, L.S.2
Chappell, W.H.3
Abrams, S.L.4
Montalto, G.5
Cervello, M.6
Nicoletti, F.7
Fagone, P.8
Malaponte, G.9
Mazzarino, M.C.10
Candido, S.11
Libra, M.12
Bäsecke, J.13
Mijatovic, S.14
Maksimovic-Ivanic, D.15
Milella, M.16
Tafuri, A.17
Cocco, L.18
Evangelisti, C.19
Chiarini, F.20
Martelli, A.M.21
more..
-
45
-
-
77957757037
-
Jailbreak: oncogene-induced senescence and its evasion
-
McDuff F K, Turner S D (2011). Jailbreak: oncogene-induced senescence and its evasion. Cell Signal, 23(1): 6-13.
-
(2011)
Cell Signal
, vol.23
, Issue.1
, pp. 6-13
-
-
McDuff, F.K.1
Turner, S.D.2
-
46
-
-
65949119310
-
How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?
-
Mebratu Y, Tesfaigzi Y (2009). How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer? Cell Cycle, 8(8): 1168-1175.
-
(2009)
Cell Cycle
, vol.8
, Issue.8
, pp. 1168-1175
-
-
Mebratu, Y.1
Tesfaigzi, Y.2
-
47
-
-
23244447037
-
BRAFE600-associated senescence-like cell cycle arrest of human naevi
-
Michaloglou C, Vredeveld L C, Soengas M S, Denoyelle C, Kuilman T, van der Horst C M, Majoor D M, Shay J W, Mooi W J, Peeper D S (2005). BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature, 436(7051): 720-724.
-
(2005)
Nature
, vol.436
, Issue.7051
, pp. 720-724
-
-
Michaloglou, C.1
Vredeveld, L.C.2
Soengas, M.S.3
Denoyelle, C.4
Kuilman, T.5
van der Horst, C.M.6
Majoor, D.M.7
Shay, J.W.8
Mooi, W.J.9
Peeper, D.S.10
-
48
-
-
33748422079
-
Oncogene-induced cell senescence-halting on the road to cancer
-
Mooi WJ, Peeper D S (2006). Oncogene-induced cell senescence-halting on the road to cancer. N Engl J Med, 355(10): 1037-1046.
-
(2006)
N Engl J Med
, vol.355
, Issue.10
, pp. 1037-1046
-
-
Mooi, W.J.1
Peeper, D.S.2
-
49
-
-
67650770120
-
Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentation
-
Nadeau V, Guillemette S, Bélanger L F, Jacob O, Roy S, Charron J (2009). Map2k1 and Map2k2 genes contribute to the normal development of syncytiotrophoblasts during placentation. Development, 136(8): 1363-1374.
-
(2009)
Development
, vol.136
, Issue.8
, pp. 1363-1374
-
-
Nadeau, V.1
Guillemette, S.2
Bélanger, L.F.3
Jacob, O.4
Roy, S.5
Charron, J.6
-
50
-
-
0007912235
-
Introduction of v-Ha-ras oncogene induces differentiation of cultured human medullary thyroid carcinoma cells
-
Nakagawa T, Mabry M, de Bustros A, Ihle J N, Nelkin B D, Baylin S B (1987). Introduction of v-Ha-ras oncogene induces differentiation of cultured human medullary thyroid carcinoma cells. Proc Natl Acad Sci USA, 84(16): 5923-5927.
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, Issue.16
, pp. 5923-5927
-
-
Nakagawa, T.1
Mabry, M.2
de Bustros, A.3
Ihle, J.N.4
Nelkin, B.D.5
Baylin, S.B.6
-
51
-
-
0037068753
-
Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion
-
Olsen C L, Gardie B, Yaswen P, Stampfer M R (2002). Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion. Oncogene, 21(41): 6328-6339.
-
(2002)
Oncogene
, vol.21
, Issue.41
, pp. 6328-6339
-
-
Olsen, C.L.1
Gardie, B.2
Yaswen, P.3
Stampfer, M.R.4
-
52
-
-
17144458301
-
Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice
-
Pagès G, Guérin S, Grall D, Bonino F, Smith A, Anjuere F, Auberger P, Pouysségur J (1999). Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science, 286(5443): 1374-1377.
-
(1999)
Science
, vol.286
, Issue.5443
, pp. 1374-1377
-
-
Pagès, G.1
Guérin, S.2
Grall, D.3
Bonino, F.4
Smith, A.5
Anjuere, F.6
Auberger, P.7
Pouysségur, J.8
-
53
-
-
0027170451
-
Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation
-
Pagès G, Lenormand P, L'Allemain G, Chambard J C, Meloche S, Pouysségur J (1993). Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation. Proc Natl Acad Sci USA, 90(18): 8319-8323.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, Issue.18
, pp. 8319-8323
-
-
Pagès, G.1
Lenormand, P.2
L'Allemain, G.3
Chambard, J.C.4
Meloche, S.5
Pouysségur, J.6
-
54
-
-
9644295588
-
GDNF-induced leukemia inhibitory factor can mediate differentiation via the MEK/ERK pathway in pheochromocytoma cells derived from nf1-heterozygous knockout mice
-
Park J I, Powers J F, Tischler A S, Strock C J, Ball D W, Nelkin B D (2005b). GDNF-induced leukemia inhibitory factor can mediate differentiation via the MEK/ERK pathway in pheochromocytoma cells derived from nf1-heterozygous knockout mice. Exp Cell Res, 303(1): 79-88.
-
(2005)
Exp Cell Res
, vol.303
, Issue.1
, pp. 79-88
-
-
Park, J.I.1
Powers, J.F.2
Tischler, A.S.3
Strock, C.J.4
Ball, D.W.5
Nelkin, B.D.6
-
55
-
-
0037221065
-
The Ras/Raf/MEK/extracellular signal-regulated kinase pathway induces autocrineparacrine growth inhibition via the leukemia inhibitory factor/JAK/STAT pathway
-
Park J I, Strock C J, Ball D W, Nelkin B D (2003). The Ras/Raf/MEK/extracellular signal-regulated kinase pathway induces autocrineparacrine growth inhibition via the leukemia inhibitory factor/JAK/STAT pathway. Mol Cell Biol, 23(2): 543-554.
-
(2003)
Mol Cell Biol
, vol.23
, Issue.2
, pp. 543-554
-
-
Park, J.I.1
Strock, C.J.2
Ball, D.W.3
Nelkin, B.D.4
-
56
-
-
11144277904
-
Interleukin-1beta can mediate growth arrest and differentiation via the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells
-
Park J I, Strock C J, Ball DW, Nelkin B D (2005a). Interleukin-1beta can mediate growth arrest and differentiation via the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells. Cytokine, 29(3): 125-134.
-
(2005)
Cytokine
, vol.29
, Issue.3
, pp. 125-134
-
-
Park, J.I.1
Strock, C.J.2
Ball, D.W.3
Nelkin, B.D.4
-
57
-
-
0034997845
-
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions
-
Pearson G, Robinson F, Beers Gibson T, Xu B E, Karandikar M, Berman K, Cobb M H (2001). Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev, 22(2): 153-183.
-
(2001)
Endocr Rev
, vol.22
, Issue.2
, pp. 153-183
-
-
Pearson, G.1
Robinson, F.2
Beers Gibson, T.3
Xu, B.E.4
Karandikar, M.5
Berman, K.6
Cobb, M.H.7
-
58
-
-
75449097942
-
Medullary thyroid carcinoma: targeted therapies and future directions
-
Pinchot S N, Kunnimalaiyaan M, Sippel R S, Chen H (2009). Medullary thyroid carcinoma: targeted therapies and future directions. J Oncol, 2009: 183031.
-
(2009)
J Oncol
, vol.2009
, pp. 183031
-
-
Pinchot, S.N.1
Kunnimalaiyaan, M.2
Sippel, R.S.3
Chen, H.4
-
59
-
-
0028877441
-
Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical propertie s in NIH 3T3 cells
-
Pritchard C A, Samuels M L, Bosch E, McMahon M (1995). Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical propertie s in NIH 3T3 cells. Mol Cell Biol, 15(11): 6430-6442.
-
(1995)
Mol Cell Biol
, vol.15
, Issue.11
, pp. 6430-6442
-
-
Pritchard, C.A.1
Samuels, M.L.2
Bosch, E.3
McMahon, M.4
-
60
-
-
84879856767
-
ERK2 but not ERK1 mediates HGF-induced motility in non-small cell lung carcinoma cell lines
-
Radtke S, Milanovic M, Rossé C, De Rycker M, Lachmann S, Hibbert A, Kermorgant S, Parker P J (2013). ERK2 but not ERK1 mediates HGF-induced motility in non-small cell lung carcinoma cell lines. J Cell Sci, 126(Pt 11): 2381-2391.
-
(2013)
J Cell Sci
, vol.126
, Issue.Pt11
, pp. 2381-2391
-
-
Radtke, S.1
Milanovic, M.2
Rossé, C.3
De Rycker, M.4
Lachmann, S.5
Hibbert, A.6
Kermorgant, S.7
Parker, P.J.8
-
61
-
-
0033559698
-
Raf-1-induced cell cycle arrest in LNCaP human prostate cancer cells
-
Ravi R K, McMahon M, Yangang Z, Williams J R, Dillehay L E, Nelkin B D, Mabry M (1999b). Raf-1-induced cell cycle arrest in LNCaP human prostate cancer cells. J Cell Biochem, 72(4): 458-469.
-
(1999)
J Cell Biochem
, vol.72
, Issue.4
, pp. 458-469
-
-
Ravi, R.K.1
McMahon, M.2
Yangang, Z.3
Williams, J.R.4
Dillehay, L.E.5
Nelkin, B.D.6
Mabry, M.7
-
62
-
-
0033113378
-
Raf-1 causes growth suppression and alteration of neuroendocrine markers in DMS53 human small-cell lung cancer cells
-
Ravi R K, Thiagalingam A, Weber E, McMahon M, Nelkin B D, Mabry M (1999a). Raf-1 causes growth suppression and alteration of neuroendocrine markers in DMS53 human small-cell lung cancer cells. Am J Respir Cell Mol Biol, 20(4): 543-549.
-
(1999)
Am J Respir Cell Mol Biol
, vol.20
, Issue.4
, pp. 543-549
-
-
Ravi, R.K.1
Thiagalingam, A.2
Weber, E.3
McMahon, M.4
Nelkin, B.D.5
Mabry, M.6
-
63
-
-
0031985094
-
Activated Raf-1 causes growth arrest in human small cell lung cancer cells
-
Ravi R K, Weber E, McMahon M, Williams J R, Baylin S, Mal A, Harter M L, Dillehay L E, Claudio P P, Giordano A, Nelkin B D, Mabry M (1998). Activated Raf-1 causes growth arrest in human small cell lung cancer cells. J Clin Invest, 101(1): 153-159.
-
(1998)
J Clin Invest
, vol.101
, Issue.1
, pp. 153-159
-
-
Ravi, R.K.1
Weber, E.2
McMahon, M.3
Williams, J.R.4
Baylin, S.5
Mal, A.6
Harter, M.L.7
Dillehay, L.E.8
Claudio, P.P.9
Giordano, A.10
Nelkin, B.D.11
Mabry, M.12
-
64
-
-
0027532627
-
Regulation and properties of extracellular signalregulated protein kinases 1 and 2 in vitro
-
Robbins D J, Zhen E, Owaki H, Vanderbilt C A, Ebert D, Geppert T D, Cobb M H (1993). Regulation and properties of extracellular signalregulated protein kinases 1 and 2 in vitro. J Biol Chem, 268(7): 5097-5106.
-
(1993)
J Biol Chem
, vol.268
, Issue.7
, pp. 5097-5106
-
-
Robbins, D.J.1
Zhen, E.2
Owaki, H.3
Vanderbilt, C.A.4
Ebert, D.5
Geppert, T.D.6
Cobb, M.H.7
-
65
-
-
34248591612
-
Targeting the Raf-MEK-ERK mitogenactivated protein kinase cascade for the treatment of cancer
-
Roberts P J, Der C J (2007). Targeting the Raf-MEK-ERK mitogenactivated protein kinase cascade for the treatment of cancer. Oncogene, 26(22): 3291-3310.
-
(2007)
Oncogene
, vol.26
, Issue.22
, pp. 3291-3310
-
-
Roberts, P.J.1
Der, C.J.2
-
66
-
-
78649658934
-
ERK1/2 MAP kinases promote cell cycle entry by rapid, kinase-independent disruption of retinoblastoma-lamin A complexes
-
Rodríguez J, Calvo F, González J M, Casar B, Andrés V, Crespo P (2010). ERK1/2 MAP kinases promote cell cycle entry by rapid, kinase-independent disruption of retinoblastoma-lamin A complexes. J Cell Biol, 191(5): 967-979.
-
(2010)
J Cell Biol
, vol.191
, Issue.5
, pp. 967-979
-
-
Rodríguez, J.1
Calvo, F.2
González, J.M.3
Casar, B.4
Andrés, V.5
Crespo, P.6
-
67
-
-
84858236398
-
Working without kinase activity: phosphotransfer-independent functions of extracellular signal-regulated kinases
-
Rodríguez J, Crespo P (2011). Working without kinase activity: phosphotransfer-independent functions of extracellular signal-regulated kinases. Sci Signal, 4(196): re3.
-
(2011)
Sci Signal
, vol.4
, Issue.196
-
-
Rodríguez, J.1
Crespo, P.2
-
68
-
-
0034745388
-
p19ARF-independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes
-
Roper E, Weinberg W, Watt F M, Land H (2001). p19ARF-independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes. EMBO Rep, 2(2): 145-150.
-
(2001)
EMBO Rep
, vol.2
, Issue.2
, pp. 145-150
-
-
Roper, E.1
Weinberg, W.2
Watt, F.M.3
Land, H.4
-
69
-
-
84862294189
-
ERK1/2 MAP kinases: structure, function, and regulation
-
Roskoski R Jr (2012). ERK1/2 MAP kinases: structure, function, and regulation. Pharmacol Res, 66(2): 105-143.
-
(2012)
Pharmacol Res
, vol.66
, Issue.2
, pp. 105-143
-
-
Roskoski Jr., R.1
-
70
-
-
0026696359
-
Identification of Tyr-185 as the site of tyrosine autophosphorylation of recombinant mitogen-activated protein kinase p42mapk
-
Rossomando A J, Wu J, Michel H, Shabanowitz J, Hunt D F, Weber MJ, Sturgill T W (1992). Identification of Tyr-185 as the site of tyrosine autophosphorylation of recombinant mitogen-activated protein kinase p42mapk. Proc Natl Acad Sci USA, 89(13): 5779-5783.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, Issue.13
, pp. 5779-5783
-
-
Rossomando, A.J.1
Wu, J.2
Michel, H.3
Shabanowitz, J.4
Hunt, D.F.5
Weber, M.J.6
Sturgill, T.W.7
-
71
-
-
0242607637
-
An essential function of the mitogenactivated protein kinase Erk2 in mouse trophoblast development
-
Saba-El-Leil M K, Vella F D, Vernay B, Voisin L, Chen L, Labrecque N, Ang S L, Meloche S (2003). An essential function of the mitogenactivated protein kinase Erk2 in mouse trophoblast development. EMBO Rep, 4(10): 964-968.
-
(2003)
EMBO Rep
, vol.4
, Issue.10
, pp. 964-968
-
-
Saba-El-Leil, M.K.1
Vella, F.D.2
Vernay, B.3
Voisin, L.4
Chen, L.5
Labrecque, N.6
Ang, S.L.7
Meloche, S.8
-
72
-
-
0027385030
-
Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase
-
Samuels ML, Weber MJ, Bishop JM, McMahon M (1993). Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase. Mol Cell Biol, 13(10): 6241-6252.
-
(1993)
Mol Cell Biol
, vol.13
, Issue.10
, pp. 6241-6252
-
-
Samuels, M.L.1
Weber, M.J.2
Bishop, J.M.3
McMahon, M.4
-
73
-
-
0032508538
-
MP1: a MEK binding partner that enhances enzyma tic activation of the MAP kinase cascade
-
Schaeffer H J, Catling A D, Eblen S T, Collier L S, Krauss A, Weber MJ (1998). MP1: a MEK binding partner that enhances enzyma tic activation of the MAP kinase cascade. Science, 281(5383): 1668-1671.
-
(1998)
Science
, vol.281
, Issue.5383
, pp. 1668-1671
-
-
Schaeffer, H.J.1
Catling, A.D.2
Eblen, S.T.3
Collier, L.S.4
Krauss, A.5
Weber, M.J.6
-
74
-
-
65949116182
-
Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia
-
Scholl F A, Dumesic P A, Barragan D I, Harada K, Charron J, Khavari P A (2009). Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia. Cancer Res, 69(9): 3772-3778.
-
(2009)
Cancer Res
, vol.69
, Issue.9
, pp. 3772-3778
-
-
Scholl, F.A.1
Dumesic, P.A.2
Barragan, D.I.3
Harada, K.4
Charron, J.5
Khavari, P.A.6
-
75
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
-
Serrano M, Lin A W, McCurrach M E, Beach D, Lowe S W (1997). Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell, 88(5): 593-602.
-
(1997)
Cell
, vol.88
, Issue.5
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
76
-
-
0032961902
-
Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation
-
Shapiro P S, Whalen A M, Tolwinski N S, Wilsbacher J, Froelich-Ammon S J, Garcia M, Osheroff N, Ahn N G (1999). Extracellular signal-regulated kinase activates topoisomerase IIalpha through a mechanism independent of phosphorylation. Mol Cell Biol, 19(5): 3551-3560.
-
(1999)
Mol Cell Biol
, vol.19
, Issue.5
, pp. 3551-3560
-
-
Shapiro, P.S.1
Whalen, A.M.2
Tolwinski, N.S.3
Wilsbacher, J.4
Froelich-Ammon, S.J.5
Garcia, M.6
Osheroff, N.7
Ahn, N.G.8
-
77
-
-
68149132138
-
Specific phosphorylation and activation of ERK1c by MEK1b: a unique route in the ERK cascade
-
Shaul Y D, Gibor G, Plotnikov A, Seger R (2009). Specific phosphorylation and activation of ERK1c by MEK1b: a unique route in the ERK cascade. Genes Dev, 23(15): 1779-1790.
-
(2009)
Genes Dev
, vol.23
, Issue.15
, pp. 1779-1790
-
-
Shaul, Y.D.1
Gibor, G.2
Plotnikov, A.3
Seger, R.4
-
78
-
-
34547204160
-
The MEK/ERK cascade: from signaling specificity to diverse functions
-
Shaul Y D, Seger R (2007). The MEK/ERK cascade: from signaling specificity to diverse functions. Biochim Biophys Acta, 1773(8): 1213-1226.
-
(2007)
Biochim Biophys Acta
, vol.1773
, Issue.8
, pp. 1213-1226
-
-
Shaul, Y.D.1
Seger, R.2
-
79
-
-
84884332708
-
Depletion of ERK2 but not ERK1 abrogates oncogenic Ras-induced senescence
-
Shin J, Yang J, Lee J C, Baek K H (2013). Depletion of ERK2 but not ERK1 abrogates oncogenic Ras-induced senescence. Cell Signal, 25(12): 2540-2547.
-
(2013)
Cell Signal
, vol.25
, Issue.12
, pp. 2540-2547
-
-
Shin, J.1
Yang, J.2
Lee, J.C.3
Baek, K.H.4
-
80
-
-
77950353276
-
ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events
-
Shin S, Dimitri C A, Yoon S O, Dowdle W, Blenis J (2010). ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events. Mol Cell, 38(1): 114-127.
-
(2010)
Mol Cell
, vol.38
, Issue.1
, pp. 114-127
-
-
Shin, S.1
Dimitri, C.A.2
Yoon, S.O.3
Dowdle, W.4
Blenis, J.5
-
81
-
-
0038442134
-
Raf-1 activation suppresses neuroendocrine marker and hormone levels in human gastrointestinal carcinoid cells
-
Sippel R S, Carpenter J E, Kunnimalaiyaan M, Lagerholm S, Chen H (2003). Raf-1 activation suppresses neuroendocrine marker and hormone levels in human gastrointestinal carcinoid cells. Am J Physiol Gastrointest Liver Physiol, 285(2): G245-G254.
-
(2003)
Am J Physiol Gastrointest Liver Physiol
, vol.285
, Issue.2
-
-
Sippel, R.S.1
Carpenter, J.E.2
Kunnimalaiyaan, M.3
Lagerholm, S.4
Chen, H.5
-
82
-
-
84883464713
-
Recombinant leukemia inhibitory factor suppresses human medullary thyroid carcinoma cell line xenografts in mice
-
Starenki D, Singh N K, Jensen D R, Peterson F C, Park J I (2013). Recombinant leukemia inhibitory factor suppresses human medullary thyroid carcinoma cell line xenografts in mice. Cancer Lett, 339(1): 144-151.
-
(2013)
Cancer Lett
, vol.339
, Issue.1
, pp. 144-151
-
-
Starenki, D.1
Singh, N.K.2
Jensen, D.R.3
Peterson, F.C.4
Park, J.I.5
-
83
-
-
73649091056
-
ERK and cell death: ERK1/2 in neuronal death
-
Subramaniam S, Unsicker K (2010). ERK and cell death: ERK1/2 in neuronal death. FEBS J, 277: 22-29.
-
(2010)
FEBS J
, vol.277
, pp. 22-29
-
-
Subramaniam, S.1
Unsicker, K.2
-
84
-
-
29444432928
-
Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumor
-
Takahashi C, Contreras B, Iwanaga T, Takegami Y, Bakker A, Bronson R T, Noda M, Loda M, Hunt J L, Ewen M E (2006). Nras loss induces metastatic conversion of Rb1-deficient neuroendocrine thyroid tumor. Nat Genet, 38(1): 118-123.
-
(2006)
Nat Genet
, vol.38
, Issue.1
, pp. 118-123
-
-
Takahashi, C.1
Contreras, B.2
Iwanaga, T.3
Takegami, Y.4
Bakker, A.5
Bronson, R.T.6
Noda, M.7
Loda, M.8
Hunt, J.L.9
Ewen, M.E.10
-
85
-
-
84856051905
-
Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells
-
Taylor J R, Lehmann B D, Chappell W H, Abrams S L, Steelman L S, McCubrey J A (2011). Cooperative effects of Akt-1 and Raf-1 on the induction of cellular senescence in doxorubicin or tamoxifen treated breast cancer cells. Oncotarget, 2(8): 610-626.
-
(2011)
Oncotarget
, vol.2
, Issue.8
, pp. 610-626
-
-
Taylor, J.R.1
Lehmann, B.D.2
Chappell, W.H.3
Abrams, S.L.4
Steelman, L.S.5
McCubrey, J.A.6
-
86
-
-
33748132208
-
In-vivo activation of Raf-1 inhibits tumor growth and development in a xenograft model of human medullary thyroid cancer
-
Vaccaro A, Chen H, Kunnimalaiyaan M (2006). In-vivo activation of Raf-1 inhibits tumor growth and development in a xenograft model of human medullary thyroid cancer. Anticancer Drugs, 17(7): 849-853.
-
(2006)
Anticancer Drugs
, vol.17
, Issue.7
, pp. 849-853
-
-
Vaccaro, A.1
Chen, H.2
Kunnimalaiyaan, M.3
-
87
-
-
33845904217
-
ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially
-
Vantaggiato C, Formentini I, Bondanza A, Bonini C, Naldini L, Brambilla R (2006). ERK1 and ERK2 mitogen-activated protein kinases affect Ras-dependent cell signaling differentially. J Biol, 5(5): 14.
-
(2006)
J Biol
, vol.5
, Issue.5
, pp. 14
-
-
Vantaggiato, C.1
Formentini, I.2
Bondanza, A.3
Bonini, C.4
Naldini, L.5
Brambilla, R.6
-
88
-
-
57649211306
-
Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors
-
Voisin L, Julien C, Duhamel S, Gopalbhai K, Claveau I, Saba-El-Leil M K, Rodrigue-Gervais I G, Gaboury L, Lamarre D, Basik M, Meloche S (2008). Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors. BMC Cancer, 8(1): 337.
-
(2008)
BMC Cancer
, vol.8
, Issue.1
, pp. 337
-
-
Voisin, L.1
Julien, C.2
Duhamel, S.3
Gopalbhai, K.4
Claveau, I.5
Saba-El-Leil, M.K.6
Rodrigue-Gervais, I.G.7
Gaboury, L.8
Lamarre, D.9
Basik, M.10
Meloche, S.11
-
89
-
-
77953387301
-
Genetic demonstration of a redundant role of extracellular signalregulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation
-
Voisin L, Saba-El-Leil M K, Julien C, Frémin C, Meloche S (2010). Genetic demonstration of a redundant role of extracellular signalregulated kinase 1 (ERK1) and ERK2 mitogen-activated protein kinases in promoting fibroblast proliferation. Mol Cell Biol, 30(12): 2918-2932.
-
(2010)
Mol Cell Biol
, vol.30
, Issue.12
, pp. 2918-2932
-
-
Voisin, L.1
Saba-El-Leil, M.K.2
Julien, C.3
Frémin, C.4
Meloche, S.5
-
90
-
-
84861206864
-
ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2
-
von Thun A, Birtwistle M, Kalna G, Grindlay J, Strachan D, Kolch W, von Kriegsheim A, Norman J C (2012). ERK2 drives tumour cell migration in three-dimensional microenvironments by suppressing expression of Rab17 and liprin-β2. J Cell Sci, 125(Pt 6): 1465-1477.
-
(2012)
J Cell Sci
, vol.125
, Issue.Pt6
, pp. 1465-1477
-
-
von Thun, A.1
Birtwistle, M.2
Kalna, G.3
Grindlay, J.4
Strachan, D.5
Kolch, W.6
von Kriegsheim, A.7
Norman, J.C.8
-
91
-
-
0027164311
-
The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction
-
Wood K W, Qi H, D'Arcangelo G, Armstrong R C, Roberts T M, Halegoua S (1993). The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction. Proc Natl Acad Sci USA, 90(11): 5016-5020.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, Issue.11
, pp. 5016-5020
-
-
Wood, K.W.1
Qi, H.2
D'Arcangelo, G.3
Armstrong, R.C.4
Roberts, T.M.5
Halegoua, S.6
-
92
-
-
0030835430
-
Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1
-
Woods D, Parry D, Cherwinski H, Bosch E, Lees E, McMahon M (1997). Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol Cell Biol, 17(9): 5598-5611.
-
(1997)
Mol Cell Biol
, vol.17
, Issue.9
, pp. 5598-5611
-
-
Woods, D.1
Parry, D.2
Cherwinski, H.3
Bosch, E.4
Lees, E.5
McMahon, M.6
-
93
-
-
79960039308
-
The ERK Cascade: Distinct Functions within Various Subcellular Organelles
-
Wortzel I, Seger R (2011). The ERK Cascade: Distinct Functions within Various Subcellular Organelles. Genes Cancer, 2(3): 195-209.
-
(2011)
Genes Cancer
, vol.2
, Issue.3
, pp. 195-209
-
-
Wortzel, I.1
Seger, R.2
-
94
-
-
84886885205
-
A mortalin/HSPA9-mediated switch in tumorsuppressive signaling of Raf/MEK/extracellular signal-regulated kinase
-
Wu P K, Hong S K, Veeranki S, Karkhanis M, Starenki D, Plaza J A, Park J I (2013). A mortalin/HSPA9-mediated switch in tumorsuppressive signaling of Raf/MEK/extracellular signal-regulated kinase. Mol Cell Biol, 33(20): 4051-4067.
-
(2013)
Mol Cell Biol
, vol.33
, Issue.20
, pp. 4051-4067
-
-
Wu, P.K.1
Hong, S.K.2
Veeranki, S.3
Karkhanis, M.4
Starenki, D.5
Plaza, J.A.6
Park, J.I.7
-
95
-
-
0030062094
-
Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells
-
Wu X, Noh S J, Zhou G, Dixon J E, Guan K L (1996). Selective activation of MEK1 but not MEK2 by A-Raf from epidermal growth factor-stimulated Hela cells. J Biol Chem, 271(6): 3265-3271.
-
(1996)
J Biol Chem
, vol.271
, Issue.6
, pp. 3265-3271
-
-
Wu, X.1
Noh, S.J.2
Zhou, G.3
Dixon, J.E.4
Guan, K.L.5
-
96
-
-
30944447568
-
The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions
-
Yoon S, Seger R (2006). The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors, 24(1): 21-44.
-
(2006)
Growth Factors
, vol.24
, Issue.1
, pp. 21-44
-
-
Yoon, S.1
Seger, R.2
-
97
-
-
0032192153
-
Senescence of human fibroblasts induced by oncogenic Raf
-
Zhu J, Woods D, McMahon M, Bishop J M (1998). Senescence of human fibroblasts induced by oncogenic Raf. Genes Dev, 12(19): 2997-3007.
-
(1998)
Genes Dev
, vol.12
, Issue.19
, pp. 2997-3007
-
-
Zhu, J.1
Woods, D.2
McMahon, M.3
Bishop, J.M.4
|