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Volumn 49, Issue , 2012, Pages 74-85
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Antitumor agents 292. Design, synthesis and pharmacological study of S- and O-substituted 7-mercapto- or hydroxy-coumarins and chromones as potent cytotoxic agents
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Author keywords
Cell cycle arrest; Coumarin; Cytotoxicity; Synthesis
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Indexed keywords
2 ETHYL 7 HYDROXY 4H CHROMEN 4 ONE;
2 ETHYL 7 HYDROXY 8 METHYL 4H CHROMEN 4 ONE;
2 ETHYL 7 MERCAPTO 4H CHROMEN 4 ONE;
2 ETHYL 7 MERCAPTO 8 METHYL 4H CHROMEN 4 ONE;
2 ETHYL 8 METHYL 4 OXO 4H CHROMEN 7 UL DIMETHYLCARBAMOTHIOATE;
3 [(4 METHYL 2 OXO 2H CHROMEN 7 YLTHIO)METHYL]BENZONITRILE;
3 BROMO 2 ETHYL 8 METHYL 7 [3 (TRIFLUOROMETHYL)BENZYLOXY] 4H CHROMEN 4 ONE;
4 METHYL 7 (3 TRIFLUOROMETHYL)BENZYLTHIO 2H CHROMEN 2 ONE;
4 METHYL 7 (PYRIDIN 2 YLMETHYLTHIO) 2H CHROMEN 2 ONE;
4 METHYL 7 (PYRIDIN 3 YLMETHYLTHIO) 2H CHROMEN 2 ONE;
4 METHYL 7 (PYRIDIN 4 YLMETHYLTHIO) 2H CHROMEN 2 ONE;
4 METHYL 7 [(2 OXO TETRAHYDROFURAN 3 YL)METHYLTHIO] 2H CHROMEN 2 ONE;
7 (2 BROMO 5 METHOXYBENZYLTHIO) 4 METHYL 2H CHROMEN 2 ONE;
7 (3 METHOXYBENZYLTHIO) 4 METHYL 2H CHROMEN 2 ONE;
7 (3 METHYLBENZYLTHIO) 4 METHYL 2H CHROMEN 2 ONE;
7 (3,5 DIMETHOXYBENZYLTHIO) 4 METHYL 2H CHROMEN 2 ONE;
7 (4,5 DIMETHOXY 2 NITROBENZYLTHIO) 4 METHYL 2H CHROMEN 2 ONE;
7 (6 CHLOROPYRIDIN 2 YLTHIO) 4 METHYL 2H CHROMEN 2 ONE;
7 [3 (TRIFLUOROMETHOXY)BENZYLTHIO] 4 METHYL 2H CHROMEN 2 ONE;
8 (BROMOMETHYL) 2 ETHYL 7 METHOXY 4H CHROMEN 4 ONE;
CHROMONE DERIVATIVE;
COUMARIN DERIVATIVE;
CYTOTOXIC AGENT;
METHYL 3 [(4 METHYL 2 OXO 2H CHROMEN 7 YLTHIO)METHYL]BENZOATE;
N OXIDE 7 (6 CHLOROPYRIDIN 2 YLTHIO) 4 METHYL 2H CHROMEN 2 ONE;
O 2 ETHYL 4 OXO 4H CHROMEN 7 YL DIMETHYLCARBAMOTHIOATE;
O 2 ETHYL 8 METHYL 4 OXO 4H CHROMEN 7 YL DIMETHYLCARBAMOTHIOATE;
PACLITAXEL;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
VINCRISTINE;
APOPTOSIS;
ARTICLE;
CELL CYCLE ARREST;
CELL CYCLE G2 PHASE;
CELL CYCLE M PHASE;
DRUG SYNTHESIS;
HUMAN;
HUMAN CELL;
IN VITRO STUDY;
LUNG CANCER;
MALE;
NASOPHARYNX CANCER;
PROSTATE CANCER;
ANTINEOPLASTIC AGENTS;
APOPTOSIS;
CELL CYCLE CHECKPOINTS;
CELL LINE, TUMOR;
CHROMONES;
COUMARINS;
CYTOTOXINS;
DRUG DESIGN;
DRUG SCREENING ASSAYS, ANTITUMOR;
HUMANS;
NEOPLASMS;
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EID: 84862782938
PISSN: 02235234
EISSN: 17683254
Source Type: Journal
DOI: 10.1016/j.ejmech.2011.12.025 Document Type: Article |
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Times cited : (82)
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References (14)
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