12-O-Tetradecanoyl phorbol-13-acetate (TPA)-induced growth arrest is increased by silibinin by the down-regulation of cyclin B1 and cdc2 and the up-regulation of p21 expression in MDA-MB231 human breast cancer cells

Phytomedicine

Volumn 17, Issue 14, 2010, Pages 1127-1132

  Kim, Sangmin ^a   Lee, Hye Sook ^a   Lee, Se Kyung ^a   Kim, Sung Hoon ^a   Hur, Sung Mo ^a   Kim, Jee Soo ^a   Kim, Jung Han ^a   Choe, Jun Ho ^a   Shin, Incheol ^b   Yang, Jung Hyun ^a   Lee, Jeong Eon ^a   Nam, Seok Jin ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

Cdc2; Cyclin B1; P21; Silibinin; Silybum marianum; TPA

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE B; PROTEIN P21; SILIBININ; UO 126;

ARTICLE; BREAST CANCER; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME REGULATION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BREAST NEOPLASMS; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CROTON OIL; CYCLIN B1; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MILK THISTLE; PHOSPHATIDYLINOSITOL 3-KINASES; PHYTOTHERAPY; PLANT EXTRACTS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SILYMARIN; TETRADECANOYLPHORBOL ACETATE;

SILYBUM MARIANUM;

EID: 78149416861     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2010.03.013     Document Type: Article

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