Novel coumarin-dihydropyrazole thio-ethanone derivatives: Design, synthesis and anticancer activity

European Journal of Medicinal Chemistry

Volumn 74, Issue , 2014, Pages 717-725

  Wu, Xiao Qin ^a   Huang, Cheng ^a   Jia, Ying Ming ^a   Song, Bao An ^b   Li, Jun ^a   Liu, Xin Hua ^a,c  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b GUIZHOU UNIVERSITY   (China)

^c NANJING UNIVERSITY   (China)

Author keywords

Anticancer activity; Coumarin; Dihydropyrazole; Thio ethanone

Indexed keywords

1 (5 (3,5 DIBROMO 2 HYDROXYPHENYL) 3 METHYL 4,5 DIHYDROPYRAZOL 1 YL) 2 (PHENYLTHIO)ETHANONE; 1 (5 (3,5 DIBROMO 2 HYDROXYPHENYL) 3 METHYL 4,5 DIHYDROPYRAZOL 1 YL) 2 (PROPYLTHIO)ETHANONE; 1 (5 (3,5 DIBROMO 2 HYDROXYPHENYL) 3 METHYL 4,5 DIHYDROPYRAZOL 1 YL) 2 (PYRIDIN 2 YLTHIO)ETHANONE; 2 (4 BROMOPHENYLTHIO) 1 (5 (3,5 DIBROMO 2 HYDROXYPHENYL) 3 METHYL 4,5 DIHYDRO PYRAZOL 1 YL)ETHANONE; 2 (BENZO[D]THIAZOL 2 YLTHIO) 1 (5 (3,5 DIBROMO 2 HYDROXYPHENYL) 3 METHYL 4,5 DIHYDROPYRAZOL 1 YL)ETHANONE; 3 (1 (2 (4 BROMOPHENYLTHIO)ACETYL) 5 (2 (TRIFLUOROMETHYL)PHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL) 2H CHROMEN 2 ONE; 3 (1 (2 (4 BROMOPHENYLTHIO)ACETYL) 5 (4 (TRIFLUOROMETHYL)PHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL) 2H CHROMEN 2 ONE; 3 (1 (2 (4 BROMOPHENYLTHIO)ACETYL) 5 PHENYL 4,5 DIHYDRO 1H PYRAZOL 3 YL) 2H CHROMEN 2 ONE; 3 (1 (2 (4 NITROPHENYLTHIO)ACETYL) 5 (2 (TRIFLUOROMETHYL)PHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL) 2H CHROMEN 2 ONE; 3 (1 (2 (4 NITROPHENYLTHIO)ACETYL) 5 (4 (TRIFLUOROMETHYL)PHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL) 2H CHROMEN 2 ONE; 3 (1 (2 (BUTYLTHIO)ACETYL) 5 (2 (TRIFLUOROMETHYL)PHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL) 2H CHROMEN 2 ONE; 3 (1 (2 (BUTYLTHIO)ACETYL) 5 (4 (TRIFLUOROMETHYL) PHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL) 2H CHROMEN 2 ONE; 3 (1 (2 (BUTYLTHIO)ACETYL) 5 PHENYL 4,5 DIHYDRO 1H PYRAZOL 3 YL) 2H CHROMEN 2 ONE; 3 (1 (2 (FURAN 2 YLMETHYLTHIO)ACETYL) 5 (2 (TRIFLUOROMETHYL)PHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL) 2H CHROMEN 2 ONE; 3 (1 (2 (FURAN 2 YLMETHYLTHIO)ACETYL) 5 (4 (TRIFLUOROMETHYL)PHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL) 2H CHROMEN 2 ONE; 3 (1 (2 (PYRIMIDIN 2 YLTHIO)ACETYL) 5 (2 (TRIFLUOROMETHYL)PHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL) 2H CHROMEN 2 ONE; 3 (1 (2 (PYRIMIDIN 2 YLTHIO)ACETYL) 5 (4 (TRIFLUOROMETHYL)PHENYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL) 2H CHROMEN 2 ONE; 3 (5 PHENYL 1 (2 (PHENYLTHIO)ACETYL) 4,5 DIHYDRO 1H PYRAZOL 3 YL) 2H CHROMEN 2 ONE; ANTINEOPLASTIC AGENT; BIBR 1532; COUMARIN DERIVATIVE; ETHIDIUM BROMIDE; FLUOROURACIL; METHYL 2 (2 (5 (3,5 DIBROMO 2 HYDROXYPHENYL) 3 METHYL 4,5 DIHYDROPYRAZOL 1 YL) 2 OXOETHYLTHIO)ACETATE; PYRAZOLE DERIVATIVE; TELOMERASE; TELOMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOASSAY; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL LINE; CELL PROLIFERATION; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; TELOMERIC REPEAT AMPLIFICATION PROTOCOL;

ANTICANCER ACTIVITY; COUMARIN; DIHYDROPYRAZOLE; THIO-ETHANONE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; COUMARINS; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FLOW CYTOMETRY; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR DOCKING SIMULATION; PYRAZOLES; SULFHYDRYL COMPOUNDS;

EID: 84895554034     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.06.014     Document Type: Article

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