Effect of pirfenidone on proliferation, TGF-β-induced myofibroblast differentiation and fibrogenic activity of primary human lung fibroblasts

European Journal of Pharmaceutical Sciences

Volumn 58, Issue 1, 2014, Pages 13-19

  Conte, Enrico ^a   Gili, Elisa ^a   Fagone, Evelina ^a   Fruciano, Mary ^a   Iemmolo, Maria ^a   Vancheri, Carlo ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

Fibrogenic activity; IPF; Lung fibroblasts; Pirfenidone; Proliferation

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; MESSENGER RNA; PIRFENIDONE; PROCOLLAGEN; PROTEIN KINASE B; SMAD3 PROTEIN; SYNAPTOPHYSIN; TRANSFORMING GROWTH FACTOR BETA; ACTA2 PROTEIN, HUMAN; ACTIN; COLLAGEN TYPE I, ALPHA 1 CHAIN; MITOGEN ACTIVATED PROTEIN KINASE P38; NONSTEROID ANTIINFLAMMATORY AGENT; PYRIDONE DERIVATIVE; SMAD3 PROTEIN, HUMAN;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOTOXICITY; DRUG EFFECT; FIBROGENESIS; HUMAN; HUMAN CELL; LUNG FIBROBLAST; MYOFIBROBLAST; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; FIBROBLAST; GENETICS; LUNG; METABOLISM;

ACTINS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; COLLAGEN TYPE I; FIBROBLASTS; HUMANS; LUNG; MYOFIBROBLASTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDONES; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 84897543635     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2014.02.014     Document Type: Article

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