Pirfenidone induces intercellular adhesion molecule-1 (ICAM-1) down- regulation on cultured human synovial fibroblasts

Clinical and Experimental Immunology

Volumn 113, Issue 1, 1998, Pages 72-76

  Kaneko, M ^a,b   Inoue, H ^a   Nakazawa, R ^b   Azuma, N ^b   Suzuki, M ^b   Yamauchi, S ^c   Margolin, S B ^d   Tsubota, K ^a   Saito, I ^e  

^a TOKYO DENTAL COLLEGE   (Japan)

^b Tokatsu Clinic Hospital   (Japan)

^c KDL Inc   (Japan)

^d Marnac Inc   (United States)

^e UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Cell adhesion molecules; ICAM 1; Pirfenidone; Synovial fibroblasts

Indexed keywords

ANTIFIBROTIC AGENT; COLLAGEN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1ALPHA; MONOCLONAL ANTIBODY; PIRFENIDONE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; HUMAN; HUMAN CELL; LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SYNOVIUM;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-1; PYRIDONES; SYNOVIAL MEMBRANE;

EID: 0031820998     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1998.00618.x     Document Type: Article

References (30)

1. Hale LP, Martin ME, McCollum DE et al. Immunohistologic analysis of the distribution of cell adhesion molecules within the inflammatory synovial microenvironment. Arthritis Rheum 1989; 32:22-29.
2. Schwachula A, Riemann D, Kehlen A et al. Characterization of the immunophenotype and functional properties of fibroblast-like synoviocytes in comparison to skin fibroblasts and umbilical vein endothelial cells. Immunobiol 1994; 190:67-92.
3. Marlor CW, Webb DL, Bombara MP et al. Expression of vascular cell adhesion molecule-1 in fibroblasts like synoviocytes after stimulation with tumor necrosis factor. Am J Pathol 1992; 140:1055-60.
4. Rothein R, Dustin ML, Marlin SD et al. A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J Immunol 1986; 137:1270-3.
5. Dustin ML, Rothlein AK, Bhan CA et al. Induction by IL-1 and interferon-γ, tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol 1986; 137:245-53.
6. Marlin SD, Springer TA. Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1). Cell 1987; 51:813.
7. Albelda SM, Buck CA. Integrins and other cell adhesion molecules. FASEB J 1990; 4:2868-80.
8. Sanchez-Madrid F, Nagy J, Robbins E et al. A human leukocyte differentiation antigen family with district α-subunits and a common β-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule. J Exp Med 1983; 158:1785-801.
9. x determinant on myeloid and tumor cells. Science 1990; 250:1132-5.
10. Munro JM, Lo SK, Corless C et al. Expression of sialyl-Lex, an E-selectin (ELAM-1) ligand, in inflammation, immune processes, and lymphoid tissues. Am J Pathol 1992; 141:1397-408.
11. Piela TH, Korn JH. ICAM-1-dependent fibroblast-lymphocyte adhesion: discordance between surface expression and function of ICAM-1. Cell Immunol 1990; 129:125-37.
12. Piela TH, Korn JH. Lymphocyte-fibroblast adhesion induced by interferon-γ. Cell Immunol 1988; 114:149-60.
13. Chin JE, Winterrowd GE, Krzesieki RF et al. Role of cytokines in inflammatory synovitis: the coordinate regulation of intercellular adhesion molecule 1 and HLA class I and class II antigens in rheumatoid synovial fibroblasts. Arthritis Rheum 1990; 33:1776-86.
14. Miyasaka N, Sato K, Goto M et al. Augmented interleukin-1 production and HLA-DR expression in the synovium of rheumatoid arthritis patients. Arthritis Rheum 1988: 31:480-6.
15. Rothlein R, Czajkowski M, O'Neill MM et al. Induction of intercellular adhesion molecule 1 on primary and continuous cell lines by proinflammatory cytokines: regulation by pharmacologic agents and neutralizing antibodies. J Immunol 1988; 141:1665-9.
16. Birdsall HH, Lane C, Ramser MN et al. Induction of VCAM-1 and ICAM-1 on human neural cells and mechanisms of mononuclear leukocyte adherence. J Immunol 1992; 148:2717-23.
17. Cavender D, Haskard D, Yu CL et al. Pathways to chronic inflammation in rheumatoid synovitis. Fed Proc 1987; 46:113-7.
18. Selvaraj P, Pluckett ML, Dustin M et al. The T lymphocyte glycoprotein CD2 binds the cell surface ligand LFA-3. Nature 1987; 326:400-3.
19. Needleman BW. Increased expression of intercellular adhesion molecule 1 on the fibroblasts of scleroderma patients. Arthritis Rheum 1990; 33:1847-6.
20. Piela-Smith TH, Broketa G, Hand A et al. Regulation of ICAM-1 expression and function in human dermal fibroblasts by IL-4. J Immunol 1992; 148:1375-81.
21. Iigo Y, Takashi T, Tamatani T et al. ICAM-1 dependent pathway is critically involved in the pathogenesis of adjuvant arthritis in rats. J Immunol 1991; 147:4167-71.
22. Shetla MR, Schiedt CL. Effect of antifibrosis drug on the survivel of keloid transplants in athymic mice. FASEB J 1995; 9:A967.
23. Margolin SB, Lefkowitz S. Pirfenidone: a novel pharmacologic agent for prevention and resolution (removal) of lung fibrosis. FASEB J 1994; 8:4:A117.
24. Margolin S, Margolin B, Margolin D. Removal of interstitial pulmonary fibrosis (Asvestos-induced) by oral chemotherapy with pirfenidone. Fed Proc 1982; 41:1550.
25. Suga H, Teraoka S, Ota K et al. Preventive effect of pirfenidone against experimental sclerosing peritonitis in rats. Exp Toxicol Pathol 1995; 47:287-91.
26. Iyer SN, Wild JS, Schiedt MJ et al. Dietary intake of pirfenidone ameliorates bleomycin induced lung fibrosis in hamster. J Lab Clin Med 1995; 125:779-85.
27. Miyasaka N, Inoue H, Tolsuka T et al. An immunomodulatory protein, Ling Zhi-8, facilitates cellular interaction through modulation of adhesion molecules. Biochem Biophys Res Commun 1992; 186:385-90.
28. Inoue H, Saito I, Nakazawa R et al. Expression of inflammatory cytokines and adhesion molecules in haemodialysis-associated amyloidosis. Nephrol Dial Transplant 1995; 10:2077-82.
29. Hayashi J, Saito I, Ishikawa I et al. Effects of cytokines and periodontopathic bacteria on the leukocyte function-associated antigen 1/ intercellular adhesion molecule 1 pathway in gingival fibroblasts in adult periodontitis. Infect Immun 1994; 62:5205-12.
30. Bevilacqua MP, Pober JS, Mendrick DL et al. Identification of an inducible endothelial-leukocyte adhesion molecule. Proc Natl Acac Sci USA 1987; 84:9238-42.