-
1
-
-
38649110420
-
-
M. B. d'Yvoire, P. Prieto, B. J. Blaauboer, F. Y. Bois, A. Boobis, C. Brochot, S. Coecke, A. Freidig, U. Gundert-Remy, T. Hartung, M. Jacobs, T. Lave, D. E. Leahy, H. Lennernas, G. D. Loizou, B. Meek, C. Pease, M. Rowland, M. Spendiff, J. Yang and M. Zeilmaker, Altern. Lab. Anim., 2007, 35, 661.
-
(2007)
Altern. Lab. Anim.
, vol.35
, pp. 661
-
-
D'Yvoire, M.B.1
Prieto, P.2
Blaauboer, B.J.3
Bois, F.Y.4
Boobis, A.5
Brochot, C.6
Coecke, S.7
Freidig, A.8
Gundert-Remy, U.9
Hartung, T.10
Jacobs, M.11
Lave, T.12
Leahy, D.E.13
Lennernas, H.14
Loizou, G.D.15
Meek, B.16
Pease, C.17
Rowland, M.18
Spendiff, M.19
Yang, J.20
Zeilmaker, M.21
more..
-
3
-
-
0033968028
-
-
S. Haddad, P. Poulin and K. Krishnan, Chemosphere, 2000, 40, 839.
-
(2000)
Chemosphere
, vol.40
, pp. 839
-
-
Haddad, S.1
Poulin, P.2
Krishnan, K.3
-
4
-
-
46749128531
-
-
S. Kortagere, D. Chekmarev, W. J. Welsh and S. Ekins, Pharm. Res., 2008, 25, 1836.
-
(2008)
Pharm. Res.
, vol.25
, pp. 1836
-
-
Kortagere, S.1
Chekmarev, D.2
Welsh, W.J.3
Ekins, S.4
-
5
-
-
54949152672
-
-
J. Shen, Y. P. Du, Z. Y. Zhao, G. X. Liu and Y. Tang, QSAR Comb. Sci., 2008, 27, 704.
-
(2008)
QSAR Comb. Sci.
, vol.27
, pp. 704
-
-
Shen, J.1
Du, Y.P.2
Zhao, Z.Y.3
Liu, G.X.4
Tang, Y.5
-
7
-
-
34547666859
-
-
D. A. Konovalov, D. Coomans, E. Deconinck and Y. V. Heyden, J. Chem. Inf. Model., 2007, 47, 1648.
-
(2007)
J. Chem. Inf. Model.
, vol.47
, pp. 1648
-
-
Konovalov, D.A.1
Coomans, D.2
Deconinck, E.3
Heyden, Y.V.4
-
8
-
-
26944502743
-
-
H. Li, C. W. Yap, C. Y. Ung, Y. Xue, Z. W. Cao and Y. Z. Chen, J. Chem. Inf. Model., 2005, 45, 1376.
-
(2005)
J. Chem. Inf. Model.
, vol.45
, pp. 1376
-
-
Li, H.1
Yap, C.W.2
Ung, C.Y.3
Xue, Y.4
Cao, Z.W.5
Chen, Y.Z.6
-
9
-
-
33846892037
-
-
Y. H. Zhao, M. H. Abraham, A. Ibrahim, P. V. Fish, S. Cole, M. L. Lewis, M. J. deGroot and D. P. Reynolds, J. Chem. Inf. Model, 2007, 47, 170.
-
(2007)
J. Chem. Inf. Model
, vol.47
, pp. 170
-
-
Zhao, Y.H.1
Abraham, M.H.2
Ibrahim, A.3
Fish, P.V.4
Cole, S.5
Lewis, M.L.6
Degroot, M.J.7
Reynolds, D.P.8
-
10
-
-
33847044104
-
-
M. Hewitt, J. C. Madden, P. H. Rowe and M. T. D. Cronin, SAR QSAR Environ. Res., 2007, 18, 57.
-
(2007)
SAR QSAR Environ. Res.
, vol.18
, pp. 57
-
-
Hewitt, M.1
Madden, J.C.2
Rowe, P.H.3
Cronin, M.T.D.4
-
11
-
-
84897565446
-
-
in press
-
M. Hewitt, C. M. Ellison, S. J. Enoch, J. C. Madden and M. T. D. Cronin, Reprod. Toxicol. 2010, 29, in press..
-
(2010)
Reprod. Toxicol
, vol.29
-
-
Hewitt, M.1
Ellison, C.M.2
Enoch, S.J.3
Madden, J.C.4
Cronin, M.T.D.5
-
12
-
-
64249110582
-
-
M. H. Abraham, J. Gil-Lostes and M. Fatemi, Eur. J. Med. Chem., 2009, 44, 2452.
-
(2009)
Eur. J. Med. Chem.
, vol.44
, pp. 2452
-
-
Abraham, M.H.1
Gil-Lostes, J.2
Fatemi, M.3
-
13
-
-
0037142350
-
-
S. Agatonovic, L. H. Ling, S. Y. Tham and R. G. Alany, J. Pharm. Biomed. Anal., 2002, 29, 103.
-
(2002)
J. Pharm. Biomed. Anal.
, vol.29
, pp. 103
-
-
Agatonovic, S.1
Ling, L.H.2
Tham, S.Y.3
Alany, R.G.4
-
15
-
-
70449134221
-
-
E. J. D. Lee, C. B. Lean and L. M. G. Limenta, Expert Opin. Drug Metab. Toxicol., 2009, 5, 1369.
-
(2009)
Expert Opin. Drug Metab. Toxicol.
, vol.5
, pp. 1369
-
-
Lee, E.J.D.1
Lean, C.B.2
Limenta, L.M.G.3
-
16
-
-
33749488939
-
-
B. Sarkadi, L. Homolya, G. Szakacs and A. Varadi, Physiol. Rev., 2006, 86, 1179.
-
(2006)
Physiol. Rev.
, vol.86
, pp. 1179
-
-
Sarkadi, B.1
Homolya, L.2
Szakacs, G.3
Varadi, A.4
-
17
-
-
77955875098
-
-
ed. W. O. Foye, T. L. Lemke and D. A. Williams, Wolters Kluwer Health, Lippincott, Williams & Wilkins, Baltimore, MD
-
D. A. Williams, in Foye's Principles of Medicinal Chemistry, ed. W. O. Foye, T. L. Lemke and D. A. Williams, Wolters Kluwer Health, Lippincott, Williams & Wilkins, Baltimore, MD, 2007, pp. 253-326.
-
(2007)
Foye's Principles of Medicinal Chemistry
, pp. 253-326
-
-
Williams, D.A.1
-
18
-
-
0002485410
-
-
10th Edition ed. J. G. Hardman and L. E. Limbird, McGraw Hill, New York
-
G. R. Wilkinson, in Goodman and Gilman's: The Pharmacological Basis of Therapeutics, 10th Edition ed. J. G. Hardman and L. E. Limbird, McGraw Hill, New York, 2001, pp. 3-29.
-
(2001)
Goodman and gilman'S: The Pharmacological Basis of Therapeutics
, pp. 3-29
-
-
Wilkinson, G.R.1
-
19
-
-
43149118341
-
-
G. Szakacs, A. Varadi, C. Ozvegy-Laczka and B. Sarkadi, Drug Discov. Today, 2008, 13, 379.
-
(2008)
Drug Discov. Today
, vol.13
, pp. 379
-
-
Szakacs, G.1
Varadi, A.2
Ozvegy-Laczka, C.3
Sarkadi, B.4
-
20
-
-
84882088781
-
-
Elsevier, Burlington, VT
-
E. H. Kerns and L. Di, Drug-Like Properties: Concepts, Structure Design and Methods, Elsevier, Burlington, VT, 2008.
-
(2008)
Drug-Like Properties: Concepts, Structure Design and Methods
-
-
Kerns, E.H.1
Di, L.2
-
21
-
-
85073143422
-
-
ed. T. Puzyn, J. Leszczynski, M. T. D. Cronin, Springer, London
-
J. C. Madden, in Recent Advances In QSAR Studies, ed. T. Puzyn, J. Leszczynski, M. T. D. Cronin, Springer, London, 2010, pp. 283-304.
-
(2010)
Recent Advances in QSAR Studies
, pp. 283-304
-
-
Madden, J.C.1
-
22
-
-
33846855555
-
-
T. Hou T, J. Wang, W. Zhang and X. Xu, J. Chem. Inf. Model., 2007, 47, 208.
-
(2007)
J. Chem. Inf. Model.
, vol.47
, pp. 208
-
-
Hou, T.T.1
Wang, J.2
Zhang, W.3
Xu, X.4
-
23
-
-
84897536387
-
-
accessed March 2010
-
http://modem.ucsd.edu/adme/databases/databases-bioavailability.htm [accessed March 2010].
-
-
-
-
24
-
-
35348864556
-
-
T. L. Moda, C. A. Monanari and A. D. Andricopulo, Bioorg. Med. Chem., 2007, 15, 7738.
-
(2007)
Bioorg. Med. Chem.
, vol.15
, pp. 7738
-
-
Moda, T.L.1
Monanari, C.A.2
Andricopulo, A.D.3
-
25
-
-
77249122159
-
-
M. V. S. Varma, R. S. Obach, C. Rotter, H. R. Miller, G. Chang, S. J. Steyn, A. El-Kattan and M. D. Troutman, J. Med. Chem., 2010, 53, 1098.
-
(2010)
J. Med. Chem.
, vol.53
, pp. 1098
-
-
Varma, M.V.S.1
Obach, R.S.2
Rotter, C.3
Miller, H.R.4
Chang, G.5
Steyn, S.J.6
El-Kattan, A.7
Troutman, M.D.8
-
27
-
-
33847057785
-
-
S. C. Basak, D. Mills and M.M. Mumtaz, SAR QSAR Environ. Res., 2007, 18, 45.
-
(2007)
SAR QSAR Environ. Res.
, vol.18
, pp. 45
-
-
Basak, S.C.1
Mills, D.2
Mumtaz, M.M.3
-
28
-
-
33845352185
-
-
J. R. Votano, M. Parham, M. L. Hall, L. H. Hall, L. B. Kier, S. Oloff and A. Tropsha, J. Med. Chem., 2006, 49, 7169.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 7169
-
-
Votano, J.R.1
Parham, M.2
Hall, M.L.3
Hall, L.H.4
Kier, L.B.5
Oloff, S.6
Tropsha, A.7
-
29
-
-
33645404135
-
-
M. P. Gleeson, N. J. Waters, S.W. Paine and A. Ma Davis, J. Med. Chem., 2006, 49, 1953.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 1953
-
-
Gleeson, M.P.1
Waters, N.J.2
Paine, S.W.3
Ma Davis, A.4
-
30
-
-
33749421205
-
-
S. C. Basak, D. Mills and B. D. Gute, QSAR SAR Environ. Res., 2006, 17, 515.
-
(2006)
QSAR SAR Environ. Res.
, vol.17
, pp. 515
-
-
Basak, S.C.1
Mills, D.2
Gute, B.D.3
-
32
-
-
33646152539
-
-
M. H. Abraham, A. Ibrahim and W. E. Acree Jr, Eur. J. Med. Chem., 2006, 41, 494.
-
(2006)
Eur. J. Med. Chem.
, vol.41
, pp. 494
-
-
Abraham, M.H.1
Ibrahim, A.2
Acree Jr., W.E.3
-
33
-
-
33746874714
-
-
M. H. Abraham, A. Ibrahim, Y. Zhao and W. E. Acree Jr, J Pharm. Sci., 2006, 95, 2091.
-
(2006)
J Pharm. Sci.
, vol.95
, pp. 2091
-
-
Abraham, M.H.1
Ibrahim, A.2
Zhao, Y.3
Acree Jr., W.E.4
-
34
-
-
33644616650
-
-
C. W. Yap, Z. R. Li and Y. Z. Chen, J. Mol. Graph. Model., 2006, 24, 383.
-
(2006)
J. Mol. Graph. Model.
, vol.24
, pp. 383
-
-
Yap, C.W.1
Li, Z.R.2
Chen, Y.Z.3
-
35
-
-
19944399431
-
-
A. S. Kalgutkar, I. Gardner, R. S. Obach, C. L. Schaffer, E. Callegari, K. R. Henne, A. E. Mutlib, D. K. Dalvie, J. S. Lee, Y. Nakai, J. P. O'Donnell, J. Boer and S. P. Harriman, Curr. Drug Metab., 2005, 6, 161.
-
(2005)
Curr. Drug Metab.
, vol.6
, pp. 161
-
-
Kalgutkar, A.S.1
Gardner, I.2
Obach, R.S.3
Schaffer, C.L.4
Callegari, E.5
Henne, K.R.6
Mutlib, A.E.7
Dalvie, D.K.8
Lee, J.S.9
Nakai, Y.10
O'Donnell, J.P.11
Boer, J.12
Harriman, S.P.13
-
36
-
-
18244391004
-
-
N. Manga, J. C. Duffy, P. H. Rowe and M. T. D. Cronin, SAR QSAR Environ. Res., 2005, 16, 43.
-
(2005)
SAR QSAR Environ. Res.
, vol.16
, pp. 43
-
-
Manga, N.1
Duffy, J.C.2
Rowe, P.H.3
Cronin, M.T.D.4
-
37
-
-
0346391120
-
-
J. V. Turner, D. J. Maddalena and D. J. Cutler, Int. J. Pharmacol., 2004, 270, 209.
-
(2004)
Int. J. Pharmacol.
, vol.270
, pp. 209
-
-
Turner, J.V.1
Maddalena, D.J.2
Cutler, D.J.3
-
38
-
-
28444484982
-
-
M. Takano, R. Yumoto and T. Murakami, Pharmacol. Ther., 2006, 109, 137.
-
(2006)
Pharmacol. Ther.
, vol.109
, pp. 137
-
-
Takano, M.1
Yumoto, R.2
Murakami, T.3
-
39
-
-
33645357793
-
-
M. A. Cabrera, I. Gonzalez I, C. Fernandez, C. Navarro and M. Bermejo, J. Pharm. Sci., 2006, 95, 589.
-
(2006)
J. Pharm. Sci.
, vol.95
, pp. 589
-
-
Cabrera, M.A.1
Gonzalez, I.I.2
Fernandez, C.3
Navarro, C.4
Bermejo, M.5
-
40
-
-
0003495102
-
-
10th edn., J. Hardman and E. Limbird, McGraw-Hill, New York
-
K. E. Thummel and G. G. Shen, in Goodman and Gilman's The Pharmacological Basis of Therapeutics, 10th edn., J. Hardman and E. Limbird, McGraw-Hill, New York, 2001, pp. 1917-2023.
-
(2001)
Goodman and Gilman's the Pharmacological Basis of Therapeutics
, pp. 1917-2023
-
-
Thummel, K.E.1
Shen, G.G.2
-
42
-
-
33845370513
-
-
F. Holló sy, K. Valkó, A. Hersey, S. Nunhuck, G. Keri and C. Bevan, J. Med. Chem., 2006, 49, 6958.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 6958
-
-
Holló Sy, F.1
Valkó, K.2
Hersey, A.3
Nunhuck, S.4
Keri, G.5
Bevan, C.6
-
44
-
-
0031024171
-
-
C. A. Lipinski, F. Lombardo, B. W. Dominy and P. J. Feeney, Adv. Drug Deliv. Rev., 1997, 23, 3.
-
(1997)
Adv. Drug Deliv. Rev.
, vol.23
, pp. 3
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
46
-
-
33751239466
-
-
M. Lobell, M. Hendrix, B. Hinzen and J. Keldenrich, Chem. Med. Chem., 2006, 1, 1229.
-
(2006)
Chem. Med. Chem.
, vol.1
, pp. 1229
-
-
Lobell, M.1
Hendrix, M.2
Hinzen, B.3
Keldenrich, J.4
-
49
-
-
0037030653
-
-
D. F. Veber, S. R. Johnson, H. Y. Cheng, B. R. Smith and K. D. Kopple, J. Med. Chem., 2002, 45, 2615.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 2615
-
-
Veber, D.F.1
Johnson, S.R.2
Cheng, H.Y.3
Smith, B.R.4
Kopple, K.D.5
-
50
-
-
72149102463
-
-
P. H. Lee, R. Conradi and V. Shanmugasundaram, Bioorg. Med. Chem. Lett., 2010, 20, 69.
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, pp. 69
-
-
Lee, P.H.1
Conradi, R.2
Shanmugasundaram, V.3
-
52
-
-
33745884678
-
-
T. Ghafourian, M. Barzegar-Jalali, S. Dastmalchi, T. Khavari-Khorasani, N. Hakimiha and A. Nokhodchi, Int. J. Pharm., 319, 82.
-
Int. J. Pharm.
, vol.319
, pp. 82
-
-
Ghafourian, T.1
Barzegar-Jalali, M.2
Dastmalchi, S.3
Khavari-Khorasani, T.4
Hakimiha, N.5
Nokhodchi, A.6
-
53
-
-
1242273811
-
-
F. Lombardo, R. S. Obach, M. Y. Shalaeva and F. Gao, J. Med. Chem., 2004, 47, 1242.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 1242
-
-
Lombardo, F.1
Obach, R.S.2
Shalaeva, M.Y.3
Gao, F.4
-
54
-
-
47749149564
-
-
X. F. Sui, J. Sun, X. Wu, H. Y. Li, J. F. Liu and Z. G. He, Curr. Drug Metab., 2008, 9, 574.
-
(2008)
Curr. Drug Metab.
, vol.9
, pp. 574
-
-
Sui, X.F.1
Sun, J.2
Wu, X.3
Li, H.Y.4
Liu, J.F.5
He, Z.G.6
-
57
-
-
12244307373
-
-
ed. M. T. D. Cronin and D. J. Livingstone, CRC Press, Boca Raton, FL
-
M. P. Payne, in Predicting Chemical Toxicity and Fate, ed. M. T. D. Cronin and D. J. Livingstone, CRC Press, Boca Raton, FL, 2004, pp. 205-227.
-
(2004)
Predicting Chemical Toxicity and Fate
, pp. 205-227
-
-
Payne, M.P.1
-
58
-
-
0034525030
-
-
C. Quinones, J. Caceres, M. Stud and A. Martinez, Quant. Struct.-Act. Relat., 2000, 19, 448.
-
(2000)
Quant. Struct.-Act. Relat.
, vol.19
, pp. 448
-
-
Quinones, C.1
Caceres, J.2
Stud, M.3
Martinez, A.4
-
59
-
-
0035885206
-
-
C. Quinones-Torrelo, S. Sagrado, R. M. Villaneuva-Camanas and M. J. Medina-Hernandez, J. Chromatogr. B, 2001, 761, 13.
-
(2001)
J. Chromatogr. B
, vol.761
, pp. 13
-
-
Quinones-Torrelo, C.1
Sagrado, S.2
Villaneuva-Camanas, R.M.3
Medina-Hernandez, M.J.4
-
60
-
-
33845965001
-
-
J. Gola, O. Obrezanova, E. Champness and M. Segall M, QSAR Comb. Sci., 2006, 25, 1172.
-
(2006)
QSAR Comb. Sci.
, vol.25
, pp. 1172
-
-
Gola, J.1
Obrezanova, O.2
Champness, E.3
Segall, M.M.4
-
62
-
-
0034460173
-
-
S. Ekins, C. L. Waller and P. W. Swann, J. Pharmacol. Toxicol. Meth., 2000, 44, 251.
-
(2000)
J. Pharmacol. Toxicol. Meth.
, vol.44
, pp. 251
-
-
Ekins, S.1
Waller, C.L.2
Swann, P.W.3
-
64
-
-
84897511574
-
-
www.oecd.org/document/23/0,3343,en-2649-34379-33957015-1-1-1-1,00.html.
-
-
-
-
66
-
-
58149142515
-
-
C. M. Thompson, D. O. Johns, B. Sonawane, H. A. Barton, D. Hattis, R. Tardif and K. Krishnan, J. Toxicol. Environ. Health B, 2009, 12, 1.
-
(2009)
J. Toxicol. Environ. Health B
, vol.12
, pp. 1
-
-
Thompson, C.M.1
Johns, D.O.2
Sonawane, B.3
Barton, H.A.4
Hattis, D.5
Tardif, R.6
Krishnan, K.7
-
67
-
-
46749124350
-
-
C. M. Thompson, B. Sonawane, H. A. Barton, R. S. DeWoskin, J. C. Lipscomb, P. Schlosser, W. A. Chiu and K. Krishnan, J. Toxicol. Environ. Health B, 2008, 11, 519.
-
(2008)
J. Toxicol. Environ. Health B
, vol.11
, pp. 519
-
-
Thompson, C.M.1
Sonawane, B.2
Barton, H.A.3
Dewoskin, R.S.4
Lipscomb, J.C.5
Schlosser, P.6
Chiu, W.A.7
Krishnan, K.8
-
68
-
-
80054009647
-
-
second edition, ed. C. J. van Leeuwen and T. G. Vermeire, Springer, The Netherlands
-
T. G. Vermeire, A. J. Baars, J. G. M. Bessems, B. J. Blaauboer, W. Slob and J. J. A. Muller in Risk Assessment of Chemicals: An Introduction, second edition, ed. C. J. van Leeuwen and T. G. Vermeire, Springer, The Netherlands, 2007, pp. 227-280.
-
(2007)
Risk Assessment of Chemicals: An Introduction
, pp. 227-280
-
-
Vermeire, T.G.1
Baars, A.J.2
Bessems, J.G.M.3
Blaauboer, B.J.4
Slob, W.5
Muller, J.J.A.6
|