α-Mangostin induces apoptosis in human chondrosarcoma cells through downregulation of ERK/JNK and Akt signaling pathway

Journal of Agricultural and Food Chemistry

Volumn 59, Issue 10, 2011, Pages 5746-5754

  Krajarng, Aungkana ^a   Nakamura, Yukio ^b   Suksamrarn, Sunit ^a   Watanapokasin, Ramida ^a  

^a SRINAKHARINWIROT UNIVERSITY   (Thailand)

^b SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

mangostin; Akt; Apotosis; Chondrosarcoma; MAPK

Indexed keywords

AKT; ANNEXINS; ANTICANCER EFFECTS; ANTITUMOR PROPERTY; APOPTOSIS; APOTOSIS; CASPASE-3; CHONDROSARCOMA; CHONDROSARCOMA CELLS; CYTOCHROME C; DOSE-DEPENDENT MANNER; DOWN-REGULATION; HOECHST; INDUCED APOPTOSIS; MAPK; MITOCHONDRIAL DYSFUNCTION; PRIMARY BONE TUMORS; RADIATION THERAPY; SIGNALING PATHWAYS;

CELL CULTURE; CELL PROLIFERATION; CHEMOTHERAPY; DRUG PRODUCTS; ELECTROPHORESIS; FLOW CYTOMETRY; MITOCHONDRIA; PHOSPHORYLATION; SIGNALING;

CELL DEATH;

ANTINEOPLASTIC AGENT; MANGOSTIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; XANTHONE DERIVATIVE;

APOPTOSIS; ARTICLE; BONE TUMOR; CELL PROLIFERATION; CHONDROSARCOMA; DRUG EFFECT; HUMAN; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BONE NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CHONDROSARCOMA; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; XANTHONES;

GARCINIA MANGOSTANA;

EID: 79957964309     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf200620n     Document Type: Article

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