Intestinal inhibition of the Na+/H+ exchanger 3 prevents cardiorenal damage in rats and inhibits Na+ uptake in humans

Science Translational Medicine

Volumn 6, Issue 227, 2014, Pages

  Spencer, Andrew G ^a   Labonte, Eric D ^a   Rosenbaum, David P ^a   Plato, Craig F ^b   Carreras, Christopher W ^a   Leadbetter, Michael R ^a   Kozuka, Kenji ^a   Kohler, Jill ^a   Koo Mccoy, Samantha ^a   He, Limin ^a   Bell, Noah ^a   Tabora, Jocelyn ^a   Joly, Kristin M ^b   Navre, Marc ^a   Jacobs, Jeffrey W ^a   Charmot, Dominique ^a  

^a Ardelyx Inc   (United States)

^b Plato BioPharma   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; SODIUM PROTON EXCHANGE PROTEIN 3; TENAPANOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIORENAL SYNDROME; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOG; DOUBLE BLIND PROCEDURE; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG EXCRETION; DRUG METABOLISM; DRUG SAFETY; DRUG TOLERABILITY; DRUG URINE LEVEL; FEMALE; GASTROINTESTINAL TRACT; HEART FAILURE; HEART LEFT VENTRICLE HYPERTROPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HYPERTENSION; HYPERVOLEMIA; MALE; MINIMUM INHIBITORY CONCENTRATION; NATRIURESIS; NONHUMAN; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PHARMACODYNAMICS; PRIORITY JOURNAL; PULSE WAVE; RANDOMIZED CONTROLLED TRIAL; RAT; SINGLE DRUG DOSE; SODIUM INTAKE; SODIUM TRANSPORT; SYSTOLIC BLOOD PRESSURE; UREA NITROGEN BLOOD LEVEL;

ALBUMINURIA; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROLYTES; ENALAPRIL; FECES; HEALTHY VOLUNTEERS; HUMANS; HYPERTROPHY; INTESTINES; ISOQUINOLINES; KIDNEY; MALE; MYOCARDIUM; NEPHRECTOMY; RATS; RATS, SPRAGUE-DAWLEY; RENAL INSUFFICIENCY, CHRONIC; SODIUM; SODIUM CHLORIDE, DIETARY; SODIUM-HYDROGEN ANTIPORTER;

EID: 84897502191     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3007790     Document Type: Article

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