Defective jejunal and colonic salt absorption and alteredNa +/H+ exchanger 3 (NHE3) activity in NHE regulatory factor 1 (NHERF1) adaptor protein-deficient mice

Pflugers Archiv European Journal of Physiology

Volumn 457, Issue 5, 2009, Pages 1079-1091

  Broere, N ^a   Chen, M ^b   Cinar, A ^b   Singh, A K ^b   Hillesheim, J ^b   Riederer, B ^b   Lunnemann M ^b   Rottinghaus, I ^b   Krabbenhoft A ^b   Engelhardt, R ^b   Rausch, B ^b   Weinman, E J ^c   Donowitz, M ^d   Hubbard, A ^d   Kocher, O ^e   De Jonge, H R ^a   Hogema, B M ^a   Seidler, U ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

EPAC; Intestinal electrolyte transport; Knockout mice; NHERF1; PDZ domain proteins; PDZK1

Indexed keywords

ADAPTOR PROTEIN; CYCLIC AMP; CYCLIC GMP; PROTEIN NHERF1; PROTEIN PDZK1; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 1; SODIUM PROTON EXCHANGE PROTEIN 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRUSH BORDER; IN VITRO STUDY; IN VIVO STUDY; INTESTINE FLUID; LARGE INTESTINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SMALL INTESTINE; WESTERN BLOTTING;

ANIMALS; COLON; IMMUNOHISTOCHEMISTRY; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; JEJUNUM; MICE; MICROVILLI; PHOSPHOPROTEINS; SODIUM CHLORIDE; SODIUM-HYDROGEN ANTIPORTER;

EID: 59849104969     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-008-0579-1     Document Type: Article

References (36)

1. + exchanger isoform 2 is the predominant NHE isoform in murine colonic crypts and its lack causes NHE3 upregulation Am J Physiol Gastrointest Liver Physiol 287 G125 G133
2. - cotransporter subtype pNBC1 Am J Physiol Gastrointest Liver Physiol 284 G37 G45
3. - cotransporter NKCC1 in the normal and CFTR-deficient murine colon J Physiol 549 525 536
4. - Am J Physiol 255 C844 C856
5. + exchanger 3 regulatory factor 1 (NHERF-1) but not NHERF-2-deficient mice J Biol Chem 282 37575 37584
6. H Chiba N Sakai M Murata M Osanai T Ninomiya T Kojima N Sawada 2006 The nuclear receptor hepatocyte nuclear factor 4alpha acts as a morphogen to induce the formation of microvilli J Cell Biol 175 971 980
7. 2+ is abolished in PDZ-domain protein PDZK1-deficient murine enterocytes J Physiol 581 1235 1246
8. M Donowitz B Cha NC Zachos CL Brett A Sharma CM Tse X Li 2005 NHERF family and NHE3 regulation J Physiol 567 3 11
9. M Donowitz X Li 2007 Regulatory binding partners and complexes of NHE3 Physiol Rev 87 825 872
10. M Field 2003 Intestinal ion transport and the pathophysiology of diarrhea J Clin Invest 111 931 943
11. SM Gisler C Madjdpour D Bacic S Pribanic SS Taylor J Biber H Murer 2003 PDZK1: II. an anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells Kidney Int 64 1746 1754
12. SM Gisler S Pribanic D Bacic P Forrer A Gantenbein LA Sabourin A Tsuji ZS Zhao E Manser J Biber H Murer 2003 PDZK1: I. a major scaffolder in brush borders of proximal tubular cells Kidney Int 64 1733 1745
13. A Hanono D Garbett D Reczek DN Chambers A Bretscher 2006 EPI64 regulates microvillar subdomains and structure J Cell Biol 175 803 813
14. J Hillesheim B Riederer B Tuo M Chen M Manns J Biber C Yun O Kocher U Seidler 2007 Down regulation of small intestinal ion transport in PDZK1- (CAP70/NHERF3) deficient mice Pflügers Arch 454 575 586
15. KJ Honegger P Capuano C Winter D Bacic G Stange CA Wagner J Biber H Murer N Hernando 2006 Regulation of sodium-proton exchanger isoform 3 (NHE3) by PKA and exchange protein directly activated by cAMP (EPAC) Proc Natl Acad Sci U S A 103 803 808
16. O Kocher R Pal M Roberts C Cirovic A Gilchrist 2003 Targeted disruption of the PDZK1 gene by homologous recombination Mol Cell Biol 23 1175 1180
17. G Lamprecht U Seidler 2006 The emerging role of PDZ adapter proteins for regulation of intestinal ion transport Am J Physiol Gastrointest Liver Physiol 291 G766 G777
18. G Lamprecht EJ Weinman CH Yun 1998 The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3 J Biol Chem 273 29972 29978
19. 2+-dependent inhibition of NHE3 requires PKC alpha which binds to E3KARP to decrease surface NHE3 containing plasma membrane complexes Am J Physiol Cell Physiol 285 C1527 C1536
20. JH Lee W Richter W Namkung KH Kim E Kim M Conti MG Lee 2007 Dynamic regulation of cystic fibrosis transmembrane conductance regulator by competitive interactions of molecular adaptors J Biol Chem 282 10414 10422
21. FC Morales Y Takahashi EL Kreimann MM Georgescu 2004 Ezrin-radixin-moesin (ERM)-binding phosphoprotein 50 organizes ERM proteins at the apical membrane of polarized epithelia Proc Natl Acad Sci U S A 101 17705 17710
22. + exchanger regulatory factor 1 (NHERF1) null mice. cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus proximal tubule J Biol Chem 282 25141 25151
23. - exchanger DRA in rabbit small intestinal mucosa Biochemistry 44 4477 4487
24. I Saotome M Curto AI McClatchey 2004 Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine Dev Cell 6 855 864
25. + exchanger Nat Genet 19 282 285
26. CW Schweinfest DD Spyropoulos KW Henderson JH Kim JM Chapman S Barone RT Worrell Z Wang M Soleimani 2006 slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon J Biol Chem 281 37962 37971
27. U Seidler I Rottinghaus J Hillesheim M Chen B Riederer A Krabbenhoft R Engelhardt M Wiemann Z Wang S Barone MP Manns M Soleimani 2008 Sodium and chloride absorptive defects in the small intestine in Slc26a6 null mice Pflügers Arch 455 757 766
28. M Sheng C Sala 2001 PDZ domains and the organization of supramolecular complexes Annu Rev Neurosci 24 1 29
29. S Shenolikar JW Voltz R Cunningham EJ Weinman 2004 Regulation of ion transport by the NHERF family of PDZ proteins Physiology (Bethesda) 19 362 369
30. S Shenolikar JW Voltz CM Minkoff JB Wade EJ Weinman 2002 Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting Proc Natl Acad Sci U S A 99 11470 11475
31. EJ Weinman S Shenolikar 1997 The Na-H exchanger regulatory factor Exp Nephrol 5 449 452
32. EJ Weinman D Steplock S Shenolikar 2003 NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes FEBS Lett 536 141 144
33. + exchanger J Clin Invest 95 2143 2149
34. + exchanger, NHE3, requires an associated regulatory protein Proc Natl Acad Sci U S A 94 3010 3015
35. + exchange Annu Rev Physiol 67 411 443
36. + exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor J Biol Chem 274 24753 24758