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Volumn 20, Issue 4, 2014, Pages 268-277

Inappropriate expression of hepcidin by liver congestion contributes to anemia and relative iron deficiency

Author keywords

bone morphogenetic protein; cytokine; Heart failure; Toll like receptor 4

Indexed keywords

BONE MORPHOGENETIC PROTEIN 6; HEME; HEMOGLOBIN; HEMOSIDERIN; HEPCIDIN; INTERLEUKIN 6; IRON; PHENYLHYDRAZINE; TOLL LIKE RECEPTOR 4; TRANSFERRIN; RNA;

EID: 84897469013     PISSN: 10719164     EISSN: 15328414     Source Type: Journal    
DOI: 10.1016/j.cardfail.2014.01.008     Document Type: Article
Times cited : (21)

References (60)
  • 1
    • 0037458095 scopus 로고    scopus 로고
    • Anemia is common in heart failure and is associated with poor outcomes: Insights from a cohort of 12 065 patients with new-onset heart failure
    • DOI 10.1161/01.CIR.0000052622.51963.FC
    • J.A. Ezekowitz, F.A. McAlister, and P.W. Armstrong Anemia is common in heart failure and is associated with poor outcomes: insights from a cohort of 12 065 patients with new-onset heart failure Circulation 107 2003 223 225 (Pubitemid 36135214)
    • (2003) Circulation , vol.107 , Issue.2 , pp. 223-225
    • Ezekowitz, J.A.1    McAlister, F.A.2    Armstrong, P.W.3
  • 2
    • 62249145007 scopus 로고    scopus 로고
    • Anemia and heart failure
    • J.K. Ghali Anemia and heart failure Curr Opin Cardiol 24 2009 172 178
    • (2009) Curr Opin Cardiol , vol.24 , pp. 172-178
    • Ghali, J.K.1
  • 3
    • 33847053226 scopus 로고    scopus 로고
    • Anaemia in chronic heart failure is not only related to impaired renal perfusion and blunted erythropoietin production, but to fluid retention as well
    • B.D. Westenbrink, F.W. Visser, A.A. Voors, T.D. Smilde, E. Lipsic, and G. Navis et al. Anaemia in chronic heart failure is not only related to impaired renal perfusion and blunted erythropoietin production, but to fluid retention as well Eur Heart J 28 2007 166 171
    • (2007) Eur Heart J , vol.28 , pp. 166-171
    • Westenbrink, B.D.1    Visser, F.W.2    Voors, A.A.3    Smilde, T.D.4    Lipsic, E.5    Navis, G.6
  • 5
    • 53249107656 scopus 로고    scopus 로고
    • Chronic heart failure leads to an expanded plasma volume and pseudoanaemia, but does not lead to a reduction in the body's red cell volume
    • C. Adlbrecht, S. Kommata, M. Hulsmann, T. Szekeres, C. Bieglmayer, and G. Strunk et al. Chronic heart failure leads to an expanded plasma volume and pseudoanaemia, but does not lead to a reduction in the body's red cell volume Eur Heart J 29 2008 2343 2350
    • (2008) Eur Heart J , vol.29 , pp. 2343-2350
    • Adlbrecht, C.1    Kommata, S.2    Hulsmann, M.3    Szekeres, T.4    Bieglmayer, C.5    Strunk, G.6
  • 6
    • 14744278436 scopus 로고    scopus 로고
    • Anemia of chronic disease
    • G. Weiss, and L.T. Goodnough Anemia of chronic disease N Engl J Med 352 2005 1011 1023
    • (2005) N Engl J Med , vol.352 , pp. 1011-1023
    • Weiss, G.1    Goodnough, L.T.2
  • 7
    • 0036232280 scopus 로고    scopus 로고
    • Anemia management in chronic kidney disease: Role of factors affecting epoetin responsiveness
    • DOI 10.1097/01.ASN.0000016440.52271.F7
    • J.W. Eschbach Anemia management in chronic kidney disease: role of factors affecting epoetin responsiveness J Am Soc Nephrol 13 2002 1412 1414 (Pubitemid 34441425)
    • (2002) Journal of the American Society of Nephrology , vol.13 , Issue.5 , pp. 1412-1414
    • Eschbach, J.W.1
  • 8
    • 84874669974 scopus 로고    scopus 로고
    • Review of surgical prosthetic paravalvular leaks: Diagnosis and catheter-based closure
    • C. Kliger, R. Eiros, G. Isasti, B. Einhorn, V. Jelnin, and H. Cohen et al. Review of surgical prosthetic paravalvular leaks: diagnosis and catheter-based closure Eur Heart J 34 2013 638 649
    • (2013) Eur Heart J , vol.34 , pp. 638-649
    • Kliger, C.1    Eiros, R.2    Isasti, G.3    Einhorn, B.4    Jelnin, V.5    Cohen, H.6
  • 9
    • 72649093672 scopus 로고    scopus 로고
    • Hemolytic anemia in a patient with hypertrophic obstructive cardiomyopathy
    • T. Kubo, H. Kitaoka, Y. Terauchi, S. Tamura, M. Okawa, and N. Yamasaki et al. Hemolytic anemia in a patient with hypertrophic obstructive cardiomyopathy J Cardiol 55 2010 125 129
    • (2010) J Cardiol , vol.55 , pp. 125-129
    • Kubo, T.1    Kitaoka, H.2    Terauchi, Y.3    Tamura, S.4    Okawa, M.5    Yamasaki, N.6
  • 10
    • 84875409962 scopus 로고    scopus 로고
    • Small bowel angiodysplasia and novel disease associations: A cohort study
    • G. Holleran, B. Hall, M. Hussey, and D. McNamara Small bowel angiodysplasia and novel disease associations: a cohort study Scand J Gastroenterol 48 2013 433 438
    • (2013) Scand J Gastroenterol , vol.48 , pp. 433-438
    • Holleran, G.1    Hall, B.2    Hussey, M.3    McNamara, D.4
  • 17
    • 80052862992 scopus 로고    scopus 로고
    • Disordered iron homeostasis in chronic heart failure: Prevalence, predictors, and relation to anemia, exercise capacity, and survival
    • D.O. Okonko, A.K. Mandal, C.G. Missouris, and P.A. Poole-Wilson Disordered iron homeostasis in chronic heart failure: prevalence, predictors, and relation to anemia, exercise capacity, and survival J Am Coll Cardiol 58 2011 1241 1251
    • (2011) J Am Coll Cardiol , vol.58 , pp. 1241-1251
    • Okonko, D.O.1    Mandal, A.K.2    Missouris, C.G.3    Poole-Wilson, P.A.4
  • 19
    • 80052102921 scopus 로고    scopus 로고
    • Anemia and iron deficiency in heart failure: Mechanisms and therapeutic approaches
    • D.J. van Veldhuisen, S.D. Anker, P. Ponikowski, and I.C. Macdougall Anemia and iron deficiency in heart failure: mechanisms and therapeutic approaches Nat Rev Cardiol 8 2011 485 493
    • (2011) Nat Rev Cardiol , vol.8 , pp. 485-493
    • Van Veldhuisen, D.J.1    Anker, S.D.2    Ponikowski, P.3    Macdougall, I.C.4
  • 22
    • 71049116042 scopus 로고    scopus 로고
    • Rationale and design of Ferinject Assessment in Patients with Iron Deficiency and Chronic Heart Failure (FAIR-HF) study: A randomized, placebo-controlled study of intravenous iron supplementation in patients with and without anaemia
    • S.D. Anker, J.C. Colet, G. Filippatos, R. Willenheimer, K. Dickstein, and H. Drexler et al. Rationale and design of Ferinject Assessment in Patients With Iron Deficiency and Chronic Heart Failure (FAIR-HF) study: a randomized, placebo-controlled study of intravenous iron supplementation in patients with and without anaemia Eur J Heart Fail 11 2009 1084 1091
    • (2009) Eur J Heart Fail , vol.11 , pp. 1084-1091
    • Anker, S.D.1    Colet, J.C.2    Filippatos, G.3    Willenheimer, R.4    Dickstein, K.5    Drexler, H.6
  • 23
    • 0041672570 scopus 로고    scopus 로고
    • Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
    • DOI 10.1182/blood-2003-03-0672
    • T. Ganz Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation Blood 102 2003 783 788 (Pubitemid 36917762)
    • (2003) Blood , vol.102 , Issue.3 , pp. 783-788
    • Ganz, T.1
  • 24
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • DOI 10.1126/science.1104742
    • E. Nemeth, M.S. Tuttle, J. Powelson, M.B. Vaughn, A. Donovan, and D.M. Ward et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization Science 306 2004 2090 2093 (Pubitemid 40007660)
    • (2004) Science , vol.306 , Issue.5704 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.D.4    Donovan, A.5    Ward, D.M.6    Ganz, T.7    Kaplan, J.8
  • 25
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • DOI 10.1182/blood-2002-10-3235
    • E. Nemeth, E.V. Valore, M. Territo, G. Schiller, A. Lichtenstein, and T. Ganz Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein Blood 101 2003 2461 2463 (Pubitemid 36857598)
    • (2003) Blood , vol.101 , Issue.7 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3    Schiller, G.4    Lichtenstein, A.5    Ganz, T.6
  • 27
    • 79955958017 scopus 로고    scopus 로고
    • Hepcidin and iron regulation, 10 years later
    • T. Ganz Hepcidin and iron regulation, 10 years later Blood 117 2011 4425 4433
    • (2011) Blood , vol.117 , pp. 4425-4433
    • Ganz, T.1
  • 28
    • 0036791486 scopus 로고    scopus 로고
    • The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    • G. Nicolas, C. Chauvet, L. Viatte, J.L. Danan, X. Bigard, and I. Devaux et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation J Clin Invest 110 2002 1037 1044
    • (2002) J Clin Invest , vol.110 , pp. 1037-1044
    • Nicolas, G.1    Chauvet, C.2    Viatte, L.3    Danan, J.L.4    Bigard, X.5    Devaux, I.6
  • 29
    • 34548825938 scopus 로고    scopus 로고
    • Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4
    • DOI 10.1182/blood-2007-04-087593
    • L. Lin, E.V. Valore, E. Nemeth, J.B. Goodnough, V. Gabayan, and T. Ganz Iron transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4 Blood 110 2007 2182 2189 (Pubitemid 47443938)
    • (2007) Blood , vol.110 , Issue.6 , pp. 2182-2189
    • Lin, L.1    Valore, E.V.2    Nemeth, E.3    Goodnough, J.B.4    Gabayan, V.5    Ganz, T.6
  • 30
    • 84859417866 scopus 로고    scopus 로고
    • The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders
    • T. Ganz, and E. Nemeth The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders Hematology Am Soc Hematol Educ Program 2011 2011 538 542
    • (2011) Hematology Am Soc Hematol Educ Program , vol.2011 , pp. 538-542
    • Ganz, T.1    Nemeth, E.2
  • 31
    • 75749095641 scopus 로고    scopus 로고
    • Iron regulatory hormone hepcidin decreases in chronic heart failure patients with anemia
    • M. Matsumoto, T. Tsujino, M. Lee-Kawabata, Y. Naito, H. Akahori, and T. Sakoda et al. Iron regulatory hormone hepcidin decreases in chronic heart failure patients with anemia Circ J 74 2010 301 306
    • (2010) Circ J , vol.74 , pp. 301-306
    • Matsumoto, M.1    Tsujino, T.2    Lee-Kawabata, M.3    Naito, Y.4    Akahori, H.5    Sakoda, T.6
  • 33
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • C.H. Park, E.V. Valore, A.J. Waring, and T. Ganz Hepcidin, a urinary antimicrobial peptide synthesized in the liver J Biol Chem 276 2001 7806 7810
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 34
    • 77954657943 scopus 로고    scopus 로고
    • Expression of the peptide hormone hepcidin increases in cardiomyocytes under myocarditis and myocardial infarction
    • M. Isoda, H. Hanawa, R. Watanabe, T. Yoshida, K. Toba, and K. Yoshida et al. Expression of the peptide hormone hepcidin increases in cardiomyocytes under myocarditis and myocardial infarction J Nutr Biochem 21 2010 749 756
    • (2010) J Nutr Biochem , vol.21 , pp. 749-756
    • Isoda, M.1    Hanawa, H.2    Watanabe, R.3    Yoshida, T.4    Toba, K.5    Yoshida, K.6
  • 35
    • 0019452846 scopus 로고
    • Hepatic morphology in cardiac dysfunction. A clinicopathologic study of 1000 subjects at autopsy
    • J.M. Arcidi Jr., G.W. Moore, and G.M. Hutchins Hepatic morphology in cardiac dysfunction: a clinicopathologic study of 1000 subjects at autopsy Am J Pathol 104 1981 159 166 (Pubitemid 11052586)
    • (1981) American Journal of Pathology , vol.104 , Issue.2 , pp. 159-166
    • Arcidi Jr., J.M.1    Moore, G.W.2    Hutchins, G.M.3
  • 36
    • 84861183246 scopus 로고    scopus 로고
    • Improvement of anemia with decreasing hepcidin levels following valve replacement for severe tricuspid regurgitation
    • T. Suzuki, H. Hanawa, L. Ding, M. Ito, T. Kashimura, and H. Obata et al. Improvement of anemia with decreasing hepcidin levels following valve replacement for severe tricuspid regurgitation Eur J Haematol 88 2012 551 552
    • (2012) Eur J Haematol , vol.88 , pp. 551-552
    • Suzuki, T.1    Hanawa, H.2    Ding, L.3    Ito, M.4    Kashimura, T.5    Obata, H.6
  • 37
    • 84861784710 scopus 로고    scopus 로고
    • Thrombin and hemin as central factors in the mechanisms of intracerebral hemorrhage-induced secondary brain injury and as potential targets for intervention
    • 1-12
    • R. Babu, J.H. Bagley, C. Di, A.H. Friedman, and C. Adamson Thrombin and hemin as central factors in the mechanisms of intracerebral hemorrhage-induced secondary brain injury and as potential targets for intervention Neurosurg Focus 32 2012 E8 1-12
    • (2012) Neurosurg Focus , vol.32 , pp. 8
    • Babu, R.1    Bagley, J.H.2    Di, C.3    Friedman, A.H.4    Adamson, C.5
  • 38
    • 79954622511 scopus 로고    scopus 로고
    • Free heme is a danger signal inducing expression of proinflammatory proteins in cultured cells derived from normal rat hearts
    • K. Hao, H. Hanawa, L. Ding, Y. Ota, K. Yoshida, and K. Toba et al. Free heme is a danger signal inducing expression of proinflammatory proteins in cultured cells derived from normal rat hearts Mol Immunol 48 2011 1191 1202
    • (2011) Mol Immunol , vol.48 , pp. 1191-1202
    • Hao, K.1    Hanawa, H.2    Ding, L.3    Ota, Y.4    Yoshida, K.5    Toba, K.6
  • 39
    • 33744493616 scopus 로고    scopus 로고
    • Heme as key regulator of major mammalian cellular functions: Molecular, cellular, and pharmacological aspects
    • DOI 10.1016/j.pharmthera.2005.10.017, PII S0163725805002780
    • A.S. Tsiftsoglou, A.I. Tsamadou, and L.C. Papadopoulou Heme as key regulator of major mammalian cellular functions: molecular, cellular, and pharmacological aspects Pharmacol Ther 111 2006 327 345 (Pubitemid 43832008)
    • (2006) Pharmacology and Therapeutics , vol.111 , Issue.2 , pp. 327-345
    • Tsiftsoglou, A.S.1    Tsamadou, A.I.2    Papadopoulou, L.C.3
  • 40
    • 84862820762 scopus 로고    scopus 로고
    • Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage
    • S. Lin, Q. Yin, Q. Zhong, F.L. Lv, Y. Zhou, and J.Q. Li et al. Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage J Neuroinflammation 9 2012 46
    • (2012) J Neuroinflammation , vol.9 , pp. 46
    • Lin, S.1    Yin, Q.2    Zhong, Q.3    Lv, F.L.4    Zhou, Y.5    Li, J.Q.6
  • 41
    • 84886576144 scopus 로고    scopus 로고
    • Hemoglobin-induced endothelial cell permeability is controlled, in-part, via an MyD88-dependent signaling mechanism
    • C. Lisk, D. Kominsky, S. Ehrentraut, J. Bonaventura, R. Nuss, and K. Hassell et al. Hemoglobin-induced endothelial cell permeability is controlled, in-part, via an MyD88-dependent signaling mechanism Am J Respir Cell Mol Biol 49 2013 619 626
    • (2013) Am J Respir Cell Mol Biol , vol.49 , pp. 619-626
    • Lisk, C.1    Kominsky, D.2    Ehrentraut, S.3    Bonaventura, J.4    Nuss, R.5    Hassell, K.6
  • 42
    • 0032995353 scopus 로고    scopus 로고
    • Centrilobular and perisinusoidal fibrosis in experimental congestive liver in the rat
    • DOI 10.1016/S0168-8278(99)80102-0
    • H. Akiyoshi, and T. Terada Centrilobular and perisinusoidal fibrosis in experimental congestive liver in the rat J Hepatol 30 1999 433 439 (Pubitemid 29113232)
    • (1999) Journal of Hepatology , vol.30 , Issue.3 , pp. 433-439
    • Akiyoshi, H.1    Terada, T.2
  • 43
    • 80355128178 scopus 로고    scopus 로고
    • A simple and efficient method to isolate macrophages from mixed primary cultures of adult liver cells
    • H. Kitani, T. Takenouchi, M. Sato, M. Yoshioka, and N. Yamanaka A simple and efficient method to isolate macrophages from mixed primary cultures of adult liver cells J Vis Exp 51 2011 e2757
    • (2011) J Vis Exp , vol.51 , pp. 2757
    • Kitani, H.1    Takenouchi, T.2    Sato, M.3    Yoshioka, M.4    Yamanaka, N.5
  • 47
    • 79961085126 scopus 로고    scopus 로고
    • Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors
    • S.R. Pasricha, Z. McQuilten, M. Westerman, A. Keller, E. Nemeth, and T. Ganz et al. Serum hepcidin as a diagnostic test of iron deficiency in premenopausal female blood donors Haematologica 96 2011 1099 1105
    • (2011) Haematologica , vol.96 , pp. 1099-1105
    • Pasricha, S.R.1    McQuilten, Z.2    Westerman, M.3    Keller, A.4    Nemeth, E.5    Ganz, T.6
  • 48
    • 84859399056 scopus 로고    scopus 로고
    • Unraveling mechanisms regulating systemic iron homeostasis
    • K.E. Finberg Unraveling mechanisms regulating systemic iron homeostasis Hematology Am Soc Hematol Educ Program 2011 2011 532 537
    • (2011) Hematology Am Soc Hematol Educ Program , vol.2011 , pp. 532-537
    • Finberg, K.E.1
  • 50
    • 84872366958 scopus 로고    scopus 로고
    • Activation of Toll-like receptor 3 attenuates alcoholic liver injury by stimulating Kupffer cells and stellate cells to produce interleukin-10 in mice
    • J.S. Byun, Y.G. Suh, H.S. Yi, Y.S. Lee, and W.I. Jeong Activation of Toll-like receptor 3 attenuates alcoholic liver injury by stimulating Kupffer cells and stellate cells to produce interleukin-10 in mice J Hepatol 58 2013 342 349
    • (2013) J Hepatol , vol.58 , pp. 342-349
    • Byun, J.S.1    Suh, Y.G.2    Yi, H.S.3    Lee, Y.S.4    Jeong, W.I.5
  • 51
    • 70450218686 scopus 로고    scopus 로고
    • Kupffer cell activation by ambient air particulate matter exposure may exacerbate nonalcoholic fatty liver disease
    • H.H. Tan, M.I. Fiel, Q. Sun, J. Guo, R.E. Gordon, and L.C. Chen et al. Kupffer cell activation by ambient air particulate matter exposure may exacerbate nonalcoholic fatty liver disease J Immunotoxicol 6 2009 266 275
    • (2009) J Immunotoxicol , vol.6 , pp. 266-275
    • Tan, H.H.1    Fiel, M.I.2    Sun, Q.3    Guo, J.4    Gordon, R.E.5    Chen, L.C.6
  • 52
    • 84872162386 scopus 로고    scopus 로고
    • High-mobility group box 1 (HMGB1)-Toll-like receptor (TLR)4-interleukin (IL)-23-IL-17A axis in drug-induced damage-associated lethal hepatitis: Interaction of gammadelta T cells with macrophages
    • X. Wang, R. Sun, H. Wei, and Z. Tian High-mobility group box 1 (HMGB1)-Toll-like receptor (TLR)4-interleukin (IL)-23-IL-17A axis in drug-induced damage-associated lethal hepatitis: interaction of gammadelta T cells with macrophages Hepatology 57 2013 373 384
    • (2013) Hepatology , vol.57 , pp. 373-384
    • Wang, X.1    Sun, R.2    Wei, H.3    Tian, Z.4
  • 54
    • 0025727704 scopus 로고
    • Clinical significance of hyperbilirubinemia in patients with pulmonary hypertension undergoing heart-lung transplantation
    • M.R. Kramer, S.E. Marshall, A. Tiroke, N.J. Lewiston, V.A. Starnes, and J. Theodore Clinical significance of hyperbilirubinemia in patients with pulmonary hypertension undergoing heart-lung transplantation J Heart Lung Transplant 10 1991 317 321
    • (1991) J Heart Lung Transplant , vol.10 , pp. 317-321
    • Kramer, M.R.1    Marshall, S.E.2    Tiroke, A.3    Lewiston, N.J.4    Starnes, V.A.5    Theodore, J.6
  • 55
    • 84897412071 scopus 로고
    • Laboratory diagnosis of gastrointestinal bleeding
    • L. Steingold, and A.A. Roberts Laboratory diagnosis of gastrointestinal bleeding Gut 2 1961 75 81
    • (1961) Gut , vol.2 , pp. 75-81
    • Steingold, L.1    Roberts, A.A.2
  • 58
    • 79960031695 scopus 로고    scopus 로고
    • Iron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension: Clinical prevalence, outcomes, and mechanistic insights
    • C.J. Rhodes, L.S. Howard, M. Busbridge, D. Ashby, E. Kondili, and J.S. Gibbs et al. Iron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension: clinical prevalence, outcomes, and mechanistic insights J Am Coll Cardiol 58 2011 300 309
    • (2011) J Am Coll Cardiol , vol.58 , pp. 300-309
    • Rhodes, C.J.1    Howard, L.S.2    Busbridge, M.3    Ashby, D.4    Kondili, E.5    Gibbs, J.S.6
  • 59
    • 84874050324 scopus 로고    scopus 로고
    • Serum hepcidin levels and iron parameters in children with iron deficiency
    • H.S. Choi, S.H. Song, J.H. Lee, H.J. Kim, and H.R. Yang Serum hepcidin levels and iron parameters in children with iron deficiency Korean J Hematol 47 2012 286 292
    • (2012) Korean J Hematol , vol.47 , pp. 286-292
    • Choi, H.S.1    Song, S.H.2    Lee, J.H.3    Kim, H.J.4    Yang, H.R.5
  • 60
    • 36048948342 scopus 로고    scopus 로고
    • Serum erythropoietin concentrations and responses to anaemia in patients with or without chronic kidney disease
    • DOI 10.1093/ndt/gfm316
    • F. Artunc, and T. Risler Serum erythropoietin concentrations and responses to anaemia in patients with or without chronic kidney disease Nephrol Dial Transplant 22 2007 2900 2908 (Pubitemid 350093434) Technology
    • (2007) Nephrology Dialysis Transplantation , vol.22 , Issue.10 , pp. 2900-2908
    • Artunc, F.1    Risler, T.2


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