-
1
-
-
56749163948
-
Pulmonary complications of sickle cell disease
-
Gladwin MT, Vichinsky E. Pulmonary complications of sickle cell disease. N Engl J Med 2008;359:2254-2265.
-
(2008)
N Engl J Med
, vol.359
, pp. 2254-2265
-
-
Gladwin, M.T.1
Vichinsky, E.2
-
2
-
-
76449093221
-
Pleiotropic effects of intravascular haemolysis on vascular homeostasis
-
Kato GJ, Taylor JG VI. Pleiotropic effects of intravascular haemolysis on vascular homeostasis. Br J Haematol 2010;148:690-701.
-
(2010)
Br J Haematol
, vol.148
, pp. 690-701
-
-
Kato, G.J.1
Taylor, J.G.V.I.2
-
3
-
-
1242353138
-
Oxygen therapeutics: Can we tame haemoglobin?
-
Alayash AI. Oxygen therapeutics: can we tame haemoglobin? Nat Rev Drug Discov 2004;3:152-159.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 152-159
-
-
Alayash, A.I.1
-
4
-
-
77949513218
-
Toxicological consequences of extracellular hemoglobin: Biochemical and physiological perspectives
-
Buehler PW, D'Agnillo F. Toxicological consequences of extracellular hemoglobin: biochemical and physiological perspectives. Antioxid Redox Signal 2010;12:275-291.
-
(2010)
Antioxid Redox Signal
, vol.12
, pp. 275-291
-
-
Buehler, P.W.1
D'agnillo, F.2
-
5
-
-
70350418736
-
Oxidized hemoglobin is an endogenous proinflammatory agonist that targets vascular endothelial cells
-
Silva G, Jeney V, Chora A, Larsen R, Balla J, Soares MP. Oxidized hemoglobin is an endogenous proinflammatory agonist that targets vascular endothelial cells. J Biol Chem 2009;284:29582-29595.
-
(2009)
J Biol Chem
, vol.284
, pp. 29582-29595
-
-
Silva, G.1
Jeney, V.2
Chora, A.3
Larsen, R.4
Balla, J.5
Soares, M.P.6
-
6
-
-
79851471726
-
Evolutionary conserved regulation of HIF-1b by NF-kB
-
van Uden P, Kenneth NS, Webster R, M'ller HA, Mudie S, Rocha S. Evolutionary conserved regulation of HIF-1b by NF-kB. PLoS Genet 2011;7:e1001285.
-
(2011)
PLoS Genet
, vol.7
-
-
Van Uden, P.1
Kenneth, N.S.2
Webster, R.3
M'ller, H.A.4
Mudie, S.5
Rocha, S.6
-
7
-
-
45349097483
-
Regulation of hypoxia-inducible factor-1alpha by NF-kappaB
-
van Uden P, Kenneth NS, Rocha S. Regulation of hypoxia-inducible factor-1alpha by NF-kappaB. Biochem J 2008;412:477-484.
-
(2008)
Biochem J
, vol.412
, pp. 477-484
-
-
Van Uden, P.1
Kenneth, N.S.2
Rocha, S.3
-
8
-
-
67349199628
-
A potential role for reactive oxygen species and the HIF-1alpha-VEGF pathway in hypoxiainduced pulmonary vascular leak
-
Irwin DC,McCord JM, Nozik-Grayck E, Beckly G, Foreman B, Sullivan T, White M, Crossno J Jr, Bailey D, Flores SC, et al. A potential role for reactive oxygen species and the HIF-1alpha-VEGF pathway in hypoxiainduced pulmonary vascular leak. Free Radic Biol Med 2009;47:55-61.
-
(2009)
Free Radic Biol Med
, vol.47
, pp. 55-61
-
-
Irwin, D.C.1
McCord, J.M.2
Nozik-Grayck, E.3
Beckly, G.4
Foreman, B.5
Sullivan, T.6
White, M.7
Crossno Jr., J.8
Bailey, D.9
Flores, S.C.10
-
9
-
-
84863797941
-
Reversible pulmonary hypertension associated with vitamin C deficiency
-
Kupari M, Rapola J. Reversible pulmonary hypertension associated with vitamin C deficiency. Chest 2012;142:225-227.
-
(2012)
Chest
, vol.142
, pp. 225-227
-
-
Kupari, M.1
Rapola, J.2
-
10
-
-
70350140219
-
Hemoglobin induces the expression of indoleamine 2,3-dioxygenase in dendritic cells through the activation of PI3K, PKC, and NF-kappaB and the generation of reactive oxygen species
-
Ogasawara N, Oguro T, Sakabe T, Matsushima M, Takikawa O, Isobe K, Nagase F. Hemoglobin induces the expression of indoleamine 2,3-dioxygenase in dendritic cells through the activation of PI3K, PKC, and NF-kappaB and the generation of reactive oxygen species. J Cell Biochem 2009;108:716-725.
-
(2009)
J Cell Biochem
, vol.108
, pp. 716-725
-
-
Ogasawara, N.1
Oguro, T.2
Sakabe, T.3
Matsushima, M.4
Takikawa, O.5
Isobe, K.6
Nagase, F.7
-
11
-
-
0030902607
-
Modified hemoglobin solution, with desired pharmacological properties, does not activate nuclear transcription factor NF-kappa B in human vascular endothelial cells
-
Simoni J, Simoni G, Lox CD, Prien SD, Shires GT. Modified hemoglobin solution, with desired pharmacological properties, does not activate nuclear transcription factor NF-kappa B in human vascular endothelial cells. Artif Cells Blood Substit Immobil Biotechnol 1997;25:193-210.
-
(1997)
Artif Cells Blood Substit Immobil Biotechnol
, vol.25
, pp. 193-210
-
-
Simoni, J.1
Simoni, G.2
Lox, C.D.3
Prien, S.D.4
Shires, G.T.5
-
12
-
-
34548842263
-
Effects of endogenous ascorbate on oxidation, oxygenation, and toxicokinetics of cell-free modified hemoglobin after exchange transfusion in rat and guinea pig
-
Buehler PW, D'Agnillo F, Hoffman V, Alayash AI. Effects of endogenous ascorbate on oxidation, oxygenation, and toxicokinetics of cell-free modified hemoglobin after exchange transfusion in rat and guinea pig. J Pharmacol Exp Ther 2007;323:49-60.
-
(2007)
J Pharmacol Exp Ther
, vol.323
, pp. 49-60
-
-
Buehler, P.W.1
D'agnillo, F.2
Hoffman, V.3
Alayash, A.I.4
-
13
-
-
52449129502
-
Acellular haemoglobin attenuates hypoxia-inducible factor-1alpha (HIF-1alpha) and its target genes in haemodiluted rats
-
Manalo DJ, Buehler PW, Baek JH, Butt O, D'Agnillo F, AlayashAI. Acellular haemoglobin attenuates hypoxia-inducible factor-1alpha (HIF-1alpha) and its target genes in haemodiluted rats. Biochem J 2008;414:461-469.
-
(2008)
Biochem J
, vol.414
, pp. 461-469
-
-
Manalo, D.J.1
Buehler, P.W.2
Baek, J.H.3
Butt, O.4
D'agnillo, F.5
Alayash, A.I.6
-
14
-
-
7244221528
-
Effects of cell-free hemoglobin on hypoxia-inducible factor (HIF-1alpha) and heme oxygenase (HO-1) expressions in endothelial cells subjected to hypoxia
-
Yeh LH, Alayash AI. Effects of cell-free hemoglobin on hypoxia-inducible factor (HIF-1alpha) and heme oxygenase (HO-1) expressions in endothelial cells subjected to hypoxia. Antioxid Redox Signal 2004;6:944-953.
-
(2004)
Antioxid Redox Signal
, vol.6
, pp. 944-953
-
-
Yeh, L.H.1
Alayash, A.I.2
-
15
-
-
84862820762
-
Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage
-
Lin S, YinQ, ZhongQ, Lv FL, Zhou Y, Li JQ,Wang JZ, Su BY,YangQW. Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage. J Neuroinflammation 2012;9:46.
-
(2012)
J Neuroinflammation
, vol.9
, pp. 46
-
-
Lin, S.1
Yin, Q.2
Zhong, Q.3
Lv, F.L.4
Zhou, Y.5
Li, J.Q.6
Wang, J.Z.7
Su, B.Y.8
Yang, Q.W.9
-
16
-
-
77957288082
-
Hemin and a metabolic derivative coprohemin modulate the TLR4 pathway differently through different molecular targets
-
Piazza M, Damore G, Costa B, Gioannini TL, Weiss JP, Peri F. Hemin and a metabolic derivative coprohemin modulate the TLR4 pathway differently through different molecular targets. Innate Immun 2011; 17:293-301.
-
(2011)
Innate Immun
, vol.17
, pp. 293-301
-
-
Piazza, M.1
Damore, G.2
Costa, B.3
Gioannini, T.L.4
Weiss, J.P.5
Peri, F.6
-
17
-
-
68749115366
-
Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins
-
Carpenter S, O'Neill LA. Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins. Biochem J 2009;422:1-10.
-
(2009)
Biochem J
, vol.422
, pp. 1-10
-
-
Carpenter, S.1
O'neill, L.A.2
-
18
-
-
77957601692
-
Toll-like receptor-dependent lipid body formation in macrophage foam cell formation
-
Nicolaou G, Erridge C. Toll-like receptor-dependent lipid body formation in macrophage foam cell formation. Curr Opin Lipidol 2010;21:427-433.
-
(2010)
Curr Opin Lipidol
, vol.21
, pp. 427-433
-
-
Nicolaou, G.1
Erridge, C.2
-
19
-
-
72949115274
-
Role of Toll-like receptors, NOD-like receptors and RIG-I-like receptors in endothelial cells and systemic infections
-
Opitz B, Eitel J, Meixenberger K, Suttorp N. Role of Toll-like receptors, NOD-like receptors and RIG-I-like receptors in endothelial cells and systemic infections. Thromb Haemost 2009;102:1103-1109.
-
(2009)
Thromb Haemost
, vol.102
, pp. 1103-1109
-
-
Opitz, B.1
Eitel, J.2
Meixenberger, K.3
Suttorp, N.4
-
21
-
-
3142724031
-
Toll-like receptor signalling
-
Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004; 4:499-511.
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
22
-
-
17444408483
-
Direct ANP inhibition of hypoxia-induced inflammatory pathways in pulmonary microvascular and macrovascular endothelial monolayers
-
Irwin DC, Tissot van Patot MC, Tucker A, Bowen R. Direct ANP inhibition of hypoxia-induced inflammatory pathways in pulmonary microvascular and macrovascular endothelial monolayers. Am J Physiol Lung Cell Mol Physiol 2005;288:L849-L859.
-
(2005)
Am J Physiol Lung Cell Mol Physiol
, vol.288
-
-
Irwin, D.C.1
Tissot Van Patot, M.C.2
Tucker, A.3
Bowen, R.4
-
23
-
-
77954036224
-
Role of nuclear factor kappaB in cardiovascular health and disease
-
Van der Heiden K, Cuhlmann S, Luong A, Zakkar M, Evans PC. Role of nuclear factor kappaB in cardiovascular health and disease. Clin Sci (Lond) 2010;118:593-605.
-
(2010)
Clin Sci (Lond)
, vol.118
, pp. 593-605
-
-
Van Der Heiden, K.1
Cuhlmann, S.2
Luong, A.3
Zakkar, M.4
Evans, P.C.5
-
24
-
-
84856641109
-
NF-kB, the first quarter-century: Remarkable progress and outstanding questions
-
Hayden MS, Ghosh SNF. NF-kB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev 2012;26:203-234.
-
(2012)
Genes Dev
, vol.26
, pp. 203-234
-
-
Hayden, M.S.1
Ghosh, S.N.F.2
-
25
-
-
84857048135
-
Modulation of hypoxiainducible factors (HIF) from an integrative pharmacological perspective
-
Rodr'guez-Jim'nez FJ, Moreno-Manzano V. Modulation of hypoxiainducible factors (HIF) from an integrative pharmacological perspective. Cell Mol Life Sci 2012;69:519-534.
-
(2012)
Cell Mol Life Sci
, vol.69
, pp. 519-534
-
-
Rodr'Guez-Jim'Nez, F.J.1
Moreno-Manzano, V.2
-
26
-
-
37249017976
-
Acute hypobaric hypoxia (5486 M) induces greater pulmonary HIF-1 activation in Hilltop compared to Madison rats
-
Engebretsen BJ, Irwin D, Valdez ME, O'Donovan MK, Tucker A, van Patot MT. Acute hypobaric hypoxia (5486 M) induces greater pulmonary HIF-1 activation in Hilltop compared to Madison rats. High Alt Med Biol 2007;8:312-321.
-
(2007)
High Alt Med Biol
, vol.8
, pp. 312-321
-
-
Engebretsen, B.J.1
Irwin, D.2
Valdez, M.E.3
O'donovan, M.K.4
Tucker, A.5
Van Patot, M.T.6
-
27
-
-
84866940088
-
The role of hypoxia-inducible factor 1 in atherosclerosis
-
Gao L, Chen Q, Zhou X, Fan L. The role of hypoxia-inducible factor 1 in atherosclerosis. J Clin Pathol 2012;65:872-876.
-
(2012)
J Clin Pathol
, vol.65
, pp. 872-876
-
-
Gao, L.1
Chen, Q.2
Zhou, X.3
Fan, L.4
-
28
-
-
78349255916
-
Toll-like receptor signaling pathways: Therapeutic opportunities
-
Zhu J, Mohan C. Toll-like receptor signaling pathways: therapeutic opportunities. Mediators Inflamm 2010;2010:781235-781242.
-
(2010)
Mediators Inflamm
, vol.2010
, pp. 781235-781242
-
-
Zhu, J.1
Mohan, C.2
-
29
-
-
0036908599
-
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
-
Reiter CD, Wang X, Tanus-Santos JE, Hogg N, Cannon RO III, Schechter AN, Gladwin MT. Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat Med 2002;8:1383-1389.
-
(2002)
Nat Med
, vol.8
, pp. 1383-1389
-
-
Reiter, C.D.1
Wang, X.2
Tanus-Santos, J.E.3
Hogg, N.4
Cannon III, R.O.5
Schechter, A.N.6
Gladwin, M.T.7
-
30
-
-
0142116222
-
Methemoglobin is a potent activator of endothelial cells by stimulating IL-6 and IL-8 production and E-selectin membrane expression
-
Liu X, Spolarics Z.Methemoglobin is a potent activator of endothelial cells by stimulating IL-6 and IL-8 production and E-selectin membrane expression. Am J Physiol Cell Physiol 2003;285:C1036-C1046.
-
(2003)
Am J Physiol Cell Physiol
, vol.285
-
-
Liu, X.1
Spolarics, Z.2
-
31
-
-
84865129051
-
Free hemoglobin induction of pulmonary vascular disease: Evidence for an inflammatory mechanism
-
Buehler PW, Baek JH, Lisk C, Connor I, Sullivan T, Kominsky D, Majka S, Stenmark KR, Nozik-Grayck E, Bonaventura J, et al. Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism. Am J Physiol Lung Cell Mol Physiol 2012;303:L312-L326.
-
(2012)
Am J Physiol Lung Cell Mol Physiol
, vol.303
-
-
Buehler, P.W.1
Baek, J.H.2
Lisk, C.3
Connor, I.4
Sullivan, T.5
Kominsky, D.6
Majka, S.7
Stenmark, K.R.8
Nozik-Grayck, E.9
Bonaventura, J.10
-
32
-
-
44449174536
-
Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia
-
Kuhlicke J, Frick JS, Morote-Garcia JC, Rosenberger P, Eltzschig HK. Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia. PLoS ONE 2007;2:e1364.
-
(2007)
PLoS ONE
, vol.2
-
-
Kuhlicke, J.1
Frick, J.S.2
Morote-Garcia, J.C.3
Rosenberger, P.4
Eltzschig, H.K.5
|