Exercise-mimicking treatment fails to increase Fndc5 mRNA & irisin secretion in primary human myotubes

Peptides

Volumn 56, Issue , 2014, Pages 1-7

  Kurdiova, Timea ^a   Balaz, Miroslav ^a   Mayer, Alexander ^b   Maderova, Denisa ^a   Belan, Vitazoslav ^c   Wolfrum, Christian ^d   Ukropec, Jozef ^a   Ukropcova, Barbara ^a,e  

^a INSTITUTE OF EXPERIMENTAL ENDOCRINOLOGY   (Slovakia)

^b SLOVAK MEDICAL UNIVERSITY   (Slovakia)

^c UNIVERSITY HOSPITAL BRATISLAVA   (Slovakia)

^d ETH ZURICH   (Switzerland)

^e Faculty of Medicine of Comenius University and University Hospital Bratislava   (Slovakia)

Author keywords

Exercise mimicking treatment; Fndc5; Human myotubes; Irisin; Myokines; Type 2 diabetes

Indexed keywords

CD56 ANTIGEN; FIBRONECTIN TYPE III DOMAIN CONTAINING PROTEIN 5; FORSKOLIN; INSULIN; IONOMYCIN; IRISIN; MHC2 PROTEIN; MYOD PROTEIN; MYOGENIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; FIBRONECTIN; FNDC5 PROTEIN, HUMAN; MESSENGER RNA; PPARGC1A PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ADIPOSITY CONTENT AND DISTRIBUTION; ADULT; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; EUGLYCEMIC HYPERINSULINEMIC CLAMP; EXERCISE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN SENSITIVITY; LEAN BODY WEIGHT; METABOLIC PARAMETERS; MIDDLE AGED; MYOBLAST; MYOTUBE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SECRETION; RESTING ENERGY EXPENDITURE; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TRIACYLGLYCEROL BLOOD LEVEL; CYTOLOGY; DRUG EFFECTS; GENETICS; IMPAIRED GLUCOSE TOLERANCE; METABOLISM; PHYSIOLOGY; SECRETION (PROCESS);

CELLS, CULTURED; COLFORSIN; DIABETES MELLITUS, TYPE 2; EXERCISE; FIBRONECTINS; HUMANS; IONOMYCIN; MUSCLE FIBERS, SKELETAL; MUSCLE, SKELETAL; OBESITY; PREDIABETIC STATE; RNA, MESSENGER; TRANSCRIPTION FACTORS;

EID: 84897465484     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2014.03.003     Document Type: Article

References (24)

1. A. Besse-Patin, E. Montastier, C. Vinel, I. Castan-Laurell, K. Louche, and C. Dray et al. Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine Int J Obes (Lond) 2013 10.1038/ijo.2013.158 [Epub ahead of print]
2. P. Bostrom, J. Wu, M.P. Jedrychowski, A. Korde, L. Ye, and J.C. Lo et al. A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis Nature 481 2012 463 468
3. K. Bouzakri, P. Plomgaard, T. Berney, M.Y. Donath, B.K. Pedersen, and P.A. Halban Bimodal effect on pancreatic beta-cells of secretory products from normal or insulin-resistant human skeletal muscle Diabetes 60 2011 1111 1121
4. J. Henningsen, K.T. Rigbolt, B. Blagoev, B.K. Pedersen, and I. Kratchmarova Dynamics of the skeletal muscle secretome during myoblast differentiation Mol Cell Proteomics 9 2010 2482 2496
5. T. Hofmann, U. Elbelt, and A. Stengel Irisin as a muscle-derived hormone stimulating thermogenesis - a critical update Peptides 54C 2014 89 100
6. J.Y. Huh, G. Panagiotou, V. Mougios, M. Brinkoetter, M.T. Vamvini, and B.E. Schneider et al. FNDC5 and irisin in humans. I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise Metabolism 61 2012 1725 1738
7. L.Q. Jiang, D.E. Duque-Guimaraes, U.F. Machado, J.R. Zierath, and A. Krook Altered response of skeletal muscle to IL-6 in type 2 diabetic patients Diabetes 62 2013 355 361
8. R.R. Kraemer, P. Shockett, N.D. Webb, U. Shah, and V.D. Castracane A transient elevated irisin blood concentration in response to prolonged, moderate aerobic exercise in young men and women Horm Metab Res 46 2 2013 150 154
9. T. Kurdiova, M. Balaz, M. Vician, D. Maderova, M. Vlcek, and L. Valkovic et al. Effects of obesity, diabetes and exercise on Fndc5 gene expression and irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies J Physiol 592 2014 1091 1107
10. S.H. Lecker, A. Zavin, P. Cao, R. Arena, K. Allsup, and K.M. Daniels et al. Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure Circ Heart Fail 5 2012 812 818
11. C. Moraes, V.O. Leal, S.M. Marinho, S.G. Barroso, G.S. Rocha, and G.T. Boaventura et al. Resistance exercise training does not affect plasma irisin levels of hemodialysis patients Horm Metab Res 45 12 2013 900 904
12. J.M. Moreno-Navarrete, F. Ortega, M. Serrano, E. Guerra, G. Pardo, and F. Tinahones et al. Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance J Clin Endocrinol Metab 98 2013 E769 E778
13. F. Norheim, T.M. Langleite, M. Hjorth, T. Holen, A. Kielland, and H.K. Stadheim et al. The effects of acute and chronic exercise on PGC-1alpha, irisin and browning of subcutaneous adipose tissue in humans FEBS J 281 2014 739 749
14. F. Norheim, T. Raastad, B. Thiede, A.C. Rustan, C.A. Drevon, and F. Haugen Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength training Am J Physiol Endocrinol Metab 301 2011 E1013 E1021
15. S. Pekkala, P. Wiklund, J.J. Hulmi, J.P. Ahtiainen, M. Horttanainen, and E. Pollanen et al. Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health? J Physiol 591 Pt 21 2013 5393 5400
16. S.A. Polyzos, J. Kountouras, K. Shields, and C.S. Mantzoros Irisin: a renaissance in metabolism Metabolism 62 2013 1037 1044
17. S. Raschke, M. Elsen, H. Gassenhuber, M. Sommerfeld, U. Schwahn, and B. Brockmann et al. Evidence against a beneficial effect of irisin in humans PLoS ONE 8 2013 e73680
18. A. Roca-Rivada, C. Castelao, L.L. Senin, M.O. Landrove, J. Baltar, and A. Belen Crujeiras et al. FNDC5/irisin is not only a myokine but also an adipokine PLoS ONE 8 2013 e60563
19. M. Scheler, M. Irmler, S. Lehr, S. Hartwig, H. Staiger, and H. Al-Hasani et al. Cytokine response of primary human myotubes in an in vitro exercise model Am J Physiol Cell Physiol 305 2013 C877 C886
20. L.M. Sparks, C. Moro, B. Ukropcova, S. Bajpeyi, A.E. Civitarese, and M.W. Hulver et al. Remodeling lipid metabolism and improving insulin responsiveness in human primary myotubes PLoS ONE 6 2011 e21068
21. H. Staiger, A. Bohm, M. Scheler, L. Berti, J. Machann, and F. Schick et al. Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity PLoS ONE 8 2013 e61903
22. T.E. Thingholm, S. Bak, H. Beck-Nielsen, O.N. Jensen, and M. Gaster Characterization of human myotubes from type 2 diabetic and nondiabetic subjects using complementary quantitative mass spectrometric methods Mol Cell Proteomics 10 2011 M110 006650
23. J.A. Timmons, K. Baar, P.K. Davidsen, and P.J. Atherton Is irisin a human exercise gene? Nature 488 2012 E9 E10 discussion E10-11
24. B. Ukropcova, M. McNeil, O. Sereda, L. de Jonge, H. Xie, and G.A. Bray et al. Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor J Clin Invest 115 2005 1934 1941 (Pubitemid 40979733)